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UniProtKB - A7SK27 (EKI_NEMVE)
Protein
Probable ethanolamine kinase
Gene
etnk
Organism
Nematostella vectensis (Starlet sea anemone)
Status
Functioni
Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis (By similarity).
By similarityCatalytic activityi
- EC:2.7.1.82
: phosphatidylethanolamine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine. This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ethanolamine kinase activity Source: GO_Central
GO - Biological processi
- phosphatidylethanolamine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00558;UER00741 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:etnk ORF Names:v1g190677 |
Organismi | Nematostella vectensis (Starlet sea anemone) |
Taxonomic identifieri | 45351 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Cnidaria › Anthozoa › Hexacorallia › Actiniaria › Edwardsiidae › Nematostella |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332723 | 1 – 349 | Probable ethanolamine kinaseAdd BLAST | 349 |
Family & Domainsi
Sequence similaritiesi
Belongs to the choline/ethanolamine kinase family.Curated
Phylogenomic databases
eggNOGi | KOG4720, Eukaryota |
HOGENOMi | CLU_012712_1_0_1 |
InParanoidi | A7SK27 |
OMAi | WTVLQKW |
OrthoDBi | 349250at2759 |
PhylomeDBi | A7SK27 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf |
SUPFAMi | SSF56112, SSF56112, 1 hit |
i Sequence
Sequence statusi: Complete.
A7SK27-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVPHIQHRL DPDDPNTSIK AVIKEIKPEL DPENLEFFEF TEGISNKLVG
60 70 80 90 100
CRPTGGSDQE ILLFRIYGNK TELFIDRKKE IATYSILNPL GYAPPVYATF
110 120 130 140 150
ENGFCYGFMV GSVMCPKTVC DPHISSLIAK HVADLHAIKL QEENPQPSWY
160 170 180 190 200
KAILHFFSII PDKFPDAAKE NRFKEVLASK AYLLEEVKLL KSKLDKLESA
210 220 230 240 250
IVFAHNDLLC KNIIYNKDKD SVCTIDFEYA NPNPIAYDIA NHFCEYAGVD
260 270 280 290 300
EVDYSLYPQK DHQVKFLESY LKRAMELQGE KDVNPSSREI EKLYVHVNQF
310 320 330 340
ALAAHFFWGV WGLVQAHYSE IDFDFLEYAI TRLNEYYLRK EKFLSLTCE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS469683 Genomic DNA Translation: EDO35939.1 |
RefSeqi | XP_001628002.1, XM_001627952.1 |
Genome annotation databases
EnsemblMetazoai | EDO35939; EDO35939; NEMVEDRAFT_v1g190677 |
GeneIDi | 5507359 |
KEGGi | nve:5507359 |
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DS469683 Genomic DNA Translation: EDO35939.1 |
RefSeqi | XP_001628002.1, XM_001627952.1 |
3D structure databases
SMRi | A7SK27 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 45351.EDO35939 |
Genome annotation databases
EnsemblMetazoai | EDO35939; EDO35939; NEMVEDRAFT_v1g190677 |
GeneIDi | 5507359 |
KEGGi | nve:5507359 |
Phylogenomic databases
eggNOGi | KOG4720, Eukaryota |
HOGENOMi | CLU_012712_1_0_1 |
InParanoidi | A7SK27 |
OMAi | WTVLQKW |
OrthoDBi | 349250at2759 |
PhylomeDBi | A7SK27 |
Enzyme and pathway databases
UniPathwayi | UPA00558;UER00741 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf |
SUPFAMi | SSF56112, SSF56112, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EKI_NEMVE | |
Accessioni | A7SK27Primary (citable) accession number: A7SK27 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 23, 2022 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families