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Entry version 59 (16 Jan 2019)
Sequence version 1 (02 Oct 2007)
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Protein

DNA-directed RNA polymerase subunit

Gene

v1g229643

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotation, Transferase
Biological processTranscription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase subunitUniRule annotation (EC:2.7.7.6UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:v1g229643Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNematostella vectensis (Starlet sea anemone)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri45351 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001593 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymeraseUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
45351.NEMVEDRAFT_v1g229643-PA

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini251 – 554RPOLA_NInterPro annotationAdd BLAST304

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili938 – 965Sequence analysisAdd BLAST28

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0260 Eukaryota
COG0086 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000222975

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7S8F9

KEGG Orthology (KO)

More...
KOi
K03006

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDGLCGE

Database of Orthologous Groups

More...
OrthoDBi
591636at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.132.30, 1 hit
3.30.1360.140, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000722 RNA_pol_asu
IPR000684 RNA_pol_II_repeat_euk
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR007075 RNA_pol_Rpb1_6
IPR007073 RNA_pol_Rpb1_7
IPR038593 RNA_pol_Rpb1_7_sf
IPR038120 Rpb1_funnel_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
PF04992 RNA_pol_Rpb1_6, 1 hit
PF04990 RNA_pol_Rpb1_7, 1 hit
PF05001 RNA_pol_Rpb1_R, 18 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00663 RPOLA_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00115 RNA_POL_II_REPEAT, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7S8F9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALVSGSPAP LRDVKRVQFG ILSPDEIKQM SVTTDGGVKY SETMEGGRPK
60 70 80 90 100
LNGLMDPRQG TIDRFSRCQT CAGNMTECPG HFGHIELAKP VFHVGFMTKI
110 120 130 140 150
VKTLRCVCFY CSKLLVDLNN PRVKEILSKS HGQPRKRMMH MYDLCKGKNI
160 170 180 190 200
CEGGDEVDAG VLAQDNPNEA EKKLVRIYLP NAYCNHGGCG RYQPKFRKTA
210 220 230 240 250
LELTAEWKHV NEDANEKKIT LTAERVYEIF KRISDEECNA LGMDPKNARP
260 270 280 290 300
DWMIVTVLPV PPLPVRPSIV LSGTARSQDD LTHKLADIVK ANNNLRRNEL
310 320 330 340 350
NGAAAHIIAE DTRLLQYHVA TLTDNEIPGL PRAMQKSGRP LKSVKQRLKS
360 370 380 390 400
KEGRIRGNLM GKRVDFSARA VITPDPNLSI DQVGVPRTIA QNLTFPEIVT
410 420 430 440 450
PFNIDSMQEL VRRGNNQYPG AKYIIRDNGE RVDLRFHPKP SDLHLQFGYK
460 470 480 490 500
VERHIRDNDV IIFNRQPTLH KMSMMGHRVK ILPWSTFRLN LSVTTPYNAD
510 520 530 540 550
FDGDEMNLHV PQSLESKAEI TEIMMVPRNI VTPQSNKPVM GIVQDSLTAV
560 570 580 590 600
RKFTKRDVFI EKDAMMNLLM WIPTWDGKIP QPAILKPRPL WTGKQICSMI
610 620 630 640 650
IPGNVNVIRT HSTHPDDEDS GPYKHISPGD TKARILCKKS LGTSSGSLIH
660 670 680 690 700
IIAMELGHDI ARMFYSDVQC VVNNWLLLEG HSIGIGDCIA DSDTYDEIQR
710 720 730 740 750
ATKKAKKEVI EVIEKAHNDE LEPTPGNTLR QTFENQVNRI LNDCRDKTGG
760 770 780 790 800
SAQKSLSEFN NFKAMVVAGS KGSKINISQV IAVVGQQNVE GKRIPFGFRH
810 820 830 840 850
RTLPHFIKDD YGPESRGFVE NSYLAGLTPT EFFFHAMGGR EGLIDTAVKT
860 870 880 890 900
SETGYIQRRL VKAMEGLSVA YDGTVRNSNN QLIQLRYGED GMDGIAIEFQ
910 920 930 940 950
NMPTMRPSKT AFERKFHFDP TNDRWMTRYL QEDLVRDLSG SATALQELEG
960 970 980 990 1000
EFNKLQEDRE ILRKIQPSGN ARVALPVNLS RLIWNAQKTF HITNRSASDL
1010 1020 1030 1040 1050
HPLRVIEGVR ELSKKLVIVA GEDHISKQAQ FNATLLFNIL LRSTLCTKRV
1060 1070 1080 1090 1100
AEEFHLSSEA FEWLLGEIET RFNHSHVKPG EMVGALAAQS LGEPATQMTL
1110 1120 1130 1140 1150
NTFHYAGVSA KNVTLGVPRL KEIINVSKKP KTPSLTVFLI GQAARDAEMA
1160 1170 1180 1190 1200
KAVLCRLEHT TLRKVTANTA IYYDPDPQNT VIAEDQDFVN VYYEMPDFDV
1210 1220 1230 1240 1250
ARISPWLLRI ELDRKRMTDK KLTMEQISEK INLGFGDDLN CIFNDDNAEK
1260 1270 1280 1290 1300
LVLRIRIMNN DDGKMQDDED VDKMDDDVFL RCIEANMLTD MTLQGIESIS
1310 1320 1330 1340 1350
KVYMNLPHED KKKRIVVTEQ GEFKAIQEWL LETDGVSLMR VLSERDVDPV
1360 1370 1380 1390 1400
RTTSNDICEI FSVLGIEAVR KAVEREMDHV ISFDGSYVNY RHLALLCDIM
1410 1420 1430 1440 1450
TCRGHLMAIT RHGINRQEVG ALMRSSFEET VDVLMDAAAH AETDYLRGVS
1460 1470 1480 1490 1500
ECIIMGKLPR IGTGSFDLML DAEKCKHGME IPTNIMGPGM GGAMAAIGVF
1510 1520 1530 1540 1550
FGAAGSPSAM SPQMTPWNMG ATPAYMEAWS PGMGSGMTPG AASFSPSAAS
1560 1570 1580 1590 1600
DASGMSPGGF SPSWMSPTPG SPVSPGPTSP YIPSPAAASP GYSPSSPAFM
1610 1620 1630 1640 1650
PSSPSMSPAS PSYSPTSPGY SPSSPSSGYS PASPSYSPTS PSYSPTSPSY
1660 1670 1680 1690 1700
SPTSPSYSPT SPSYSPTSPS YSPTSPSYSP TSPSYSPTSP SYSPTSPSYS
1710 1720 1730 1740 1750
PTSPSYSPTS PSYSPTSPSY SPTSPSYSPT SPSYSPTSPS YSPTSPSYSP
1760 1770 1780 1790 1800
TSPSYSPTSP SYSPSSPSYS PSSPSYSPQS PSYASPSSPK YSPASPSYSP
1810 1820 1830 1840 1850
TSPKYSPTSP NYSPASPSYS PSSPKYSPTS PSYTPASPSY SPASPSYSPS
1860 1870 1880 1890 1900
SPSYSPSSPR YTPTSPQYSP TSPKYSPASP NYSPTTPSYT PMSGHIVPLL
1910 1920
HSIVQLLLDP PHLLNTRPHH PTTLQSKIG
Length:1,929
Mass (Da):212,524
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i887A875BCC6A231D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS469598 Genomic DNA Translation: EDO39976.1

NCBI Reference Sequences

More...
RefSeqi
XP_001632039.1, XM_001631989.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Nve.3630

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EDO39976; EDO39976; NEMVEDRAFT_v1g229643

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5511617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nve:NEMVE_v1g229643

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469598 Genomic DNA Translation: EDO39976.1
RefSeqiXP_001632039.1, XM_001631989.1
UniGeneiNve.3630

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi45351.NEMVEDRAFT_v1g229643-PA

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiEDO39976; EDO39976; NEMVEDRAFT_v1g229643
GeneIDi5511617
KEGGinve:NEMVE_v1g229643

Phylogenomic databases

eggNOGiKOG0260 Eukaryota
COG0086 LUCA
HOGENOMiHOG000222975
InParanoidiA7S8F9
KOiK03006
OMAiEDGLCGE
OrthoDBi591636at2759

Family and domain databases

Gene3Di1.10.132.30, 1 hit
3.30.1360.140, 1 hit
InterProiView protein in InterPro
IPR000722 RNA_pol_asu
IPR000684 RNA_pol_II_repeat_euk
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR007075 RNA_pol_Rpb1_6
IPR007073 RNA_pol_Rpb1_7
IPR038593 RNA_pol_Rpb1_7_sf
IPR038120 Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
PF04992 RNA_pol_Rpb1_6, 1 hit
PF04990 RNA_pol_Rpb1_7, 1 hit
PF05001 RNA_pol_Rpb1_R, 18 hits
SMARTiView protein in SMART
SM00663 RPOLA_N, 1 hit
PROSITEiView protein in PROSITE
PS00115 RNA_POL_II_REPEAT, 16 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA7S8F9_NEMVE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7S8F9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: January 16, 2019
This is version 59 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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