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Entry version 56 (29 Sep 2021)
Sequence version 1 (02 Oct 2007)
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Protein

Nck-associated protein 1 homolog

Gene

napA

Organism
Nematostella vectensis (Starlet sea anemone)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulation of actin and microtubule organization. Involved in cell adhesion (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nck-associated protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:napA
ORF Names:v1g182004
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNematostella vectensis (Starlet sea anemone)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri45351 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaCnidariaAnthozoaHexacoralliaActiniariaEdwardsiidaeNematostella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001593 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003313901 – 1120Nck-associated protein 1 homologAdd BLAST1120

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a Scar/WAVE complex containing brk1, scrA, abiA, pirA and napA.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
45351.EDO45022

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A7RU46

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HEM-1/HEM-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1917, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004450_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7RU46

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGMVMYN

Database of Orthologous Groups

More...
OrthoDBi
138196at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A7RU46

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019137, Nck-associated_protein-1

The PANTHER Classification System

More...
PANTHERi
PTHR12093, PTHR12093, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09735, Nckap1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7RU46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERGLSVTEQ KLAEKLTILN ERGEGMLTRI YNIKKACSDP KSRPGFLMDK
60 70 80 90 100
ALEPSIKYIV RKFPQMDTKA TQLQAVQSIQ NEVMKGLSNY YFTFVDIMEF
110 120 130 140 150
KDNASELLTA IDASFVHFDI TLNFDLTKAY LDLIVTLTAL MIMVSRVDDR
160 170 180 190 200
RSVLGLFNHA FEMRNGRSEE SFPRLGQMIL DYDSPLKKLA EQFVPHQQRV
210 220 230 240 250
STALQSLHEI YLRKSMTGEQ WRQGQILSII NAPANILVPG QSKVPAVEYL
260 270 280 290 300
EVSVIQRWIM FGYTMCHQQL AMPGITDIWK MALQDGFCIT LFRDEIFMFH
310 320 330 340 350
KEFHNMLDGM KGYGKRIKDI QDAANQMAAS VGIHKERRNY LRSALTEMTL
360 370 380 390 400
ILADQPGLLG PKMLIILHGL SIAHDEILWL VRHCCNPAPR SRKLTQEDFF
410 420 430 440 450
DSKLPHLLFA VEELRSMVQK YSSVLQRYFI QYLSGFDVYM LKQVVQKISI
460 470 480 490 500
CSEDISLIMT SFIDELSSLS VKQVESGELF HFSGLRLDWL RLQAYTSVRG
510 520 530 540 550
SSPELKDNRD LVELMNNVVF HSKLVDLQDE TLAEVSDLSI FCFYPGFFEE
560 570 580 590 600
SFVRCLEDIT QSRYCIAFPL ICGHFMTCTS DFCPEERHPI GDRSLSAVNL
610 620 630 640 650
FLDSMAKEAR NIMSQVCSEH IQQHQQLWHT HAVRMMTEMA SERRTKDKNK
660 670 680 690 700
KNVHVEFKPP GIESFRKSRE TLTSLDTKLL SLTELCHAIT HTEAIPVWEH
710 720 730 740 750
IFAPKEYLSS QLEEFFAKAV VSMAQYDIDN QRIARPSEVL SNVKAMMSSL
760 770 780 790 800
RSLENYTGVD TARVFNHVLL QQTQPQDSQG ANTITQMYTT WYLDVFLRRV
810 820 830 840 850
MTDGIVYSPR RMAFVNRPGM PFRAEEYTDV NELQALAELL GAYGMRYLGE
860 870 880 890 900
KMMLQIASQV SELKKLVIMN KDVLVALRTN FDKPEQCIEL IRRLRNMDDV
910 920 930 940 950
MLRMIIIGVI LSFRQLIQQA LDSVLKTRVP YMMSCITDMR KNFPHGNNDR
960 970 980 990 1000
QVVDEMATSA GQECVVDPLL CAALRTLKEK KSEDDILTWS LLLVFVAVGL
1010 1020 1030 1040 1050
PSLAYKDASE YNGELEAHDN NAHCISSSVN SITGALCSNN GDNPEDRLRE
1060 1070 1080 1090 1100
FLAITSSSLL KLGMEAEKDL KARESVYLLL DMVVQQSPYL TMDVLESCFP
1110 1120
YALLRNAYHE VYQKRKEPFL
Length:1,120
Mass (Da):128,390
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFCB7E96DFD399AF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DS469539 Genomic DNA Translation: EDO45022.1

NCBI Reference Sequences

More...
RefSeqi
XP_001637085.1, XM_001637035.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
EDO45022; EDO45022; NEMVEDRAFT_v1g182004

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5517043

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
nve:5517043

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS469539 Genomic DNA Translation: EDO45022.1
RefSeqiXP_001637085.1, XM_001637035.1

3D structure databases

SMRiA7RU46
ModBaseiSearch...

Protein-protein interaction databases

STRINGi45351.EDO45022

Genome annotation databases

EnsemblMetazoaiEDO45022; EDO45022; NEMVEDRAFT_v1g182004
GeneIDi5517043
KEGGinve:5517043

Phylogenomic databases

eggNOGiKOG1917, Eukaryota
HOGENOMiCLU_004450_0_0_1
InParanoidiA7RU46
OMAiVGMVMYN
OrthoDBi138196at2759
PhylomeDBiA7RU46

Family and domain databases

InterProiView protein in InterPro
IPR019137, Nck-associated_protein-1
PANTHERiPTHR12093, PTHR12093, 1 hit
PfamiView protein in Pfam
PF09735, Nckap1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAPA_NEMVE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7RU46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 2, 2007
Last modified: September 29, 2021
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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