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Protein

Renalase

Gene

Rnls

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)+. The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.By similarity

Catalytic activityi

1,2-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2.By similarity
1,6-dihydro-beta-NAD(P) + H+ + O2 = beta-NAD(P)+ + H2O2.By similarity

Cofactori

FADBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12FADBy similarity1
Binding sitei42FADBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD, NADP

Enzyme and pathway databases

BRENDAi1.6.3.5 3474

Names & Taxonomyi

Protein namesi
Recommended name:
Renalase1 Publication (EC:1.6.3.5By similarity)
Alternative name(s):
Monoamine oxidase-C1 Publication
Short name:
MAO-C
Short name:
mMAO-C1 Publication
Gene namesi
Name:RnlsImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915045 Rnls

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000037685818 – 342RenalaseSequence analysisAdd BLAST325

Proteomic databases

MaxQBiA7RDN6
PaxDbiA7RDN6
PRIDEiA7RDN6

PTM databases

PhosphoSitePlusiA7RDN6

Expressioni

Tissue specificityi

Expressed predominantly in kidney and testis with lower levels in liver, heart and embryo and weak expression in brain and skeletal muscle.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093825

Structurei

3D structure databases

ProteinModelPortaliA7RDN6
SMRiA7RDN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni61 – 62FAD-bindingBy similarity2

Sequence similaritiesi

Belongs to the renalase family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IE15 Eukaryota
ENOG410XV8B LUCA
HOGENOMiHOG000007721
InParanoidiA7RDN6
KOiK18208
PhylomeDBiA7RDN6
TreeFamiTF332799

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: A7RDN6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRVLVVGAG LTGSLCAALL RKEITAPLYL GLWDKGGDIG GRMITASSPH
60 70 80 90 100
NPRCTADLGA QYITCSPHYV KEHQNFYEEL LAHGILKPLT SPIEGMKGKE
110 120 130 140 150
GDCNFVAPQG FSSVIKYYLK KSGAEVSLKH CVTQIHLKDN KWEVSTDTGS
160 170 180 190 200
AEQFDLVILT MPAPQILELQ GDIVNLISER QREQLKSVSY SSRYALGLFY
210 220 230 240 250
EVGMKIGVPW SCRYLSSHPC ICFISIDNKK RNIESSECGP SVVIQTTVPF
260 270 280 290 300
GVQHLEASEA DVQKLMIQQL ETILPGLPQP VATICHKWTY SQVTSSVSDR
310 320 330 340
PGQMTLHLKP FLVCGGDGFT HSNFNGCISS ALSVMKVLKR YI
Length:342
Mass (Da):37,597
Last modified:June 16, 2009 - v2
Checksum:i0445A137C6E1F981
GO
Isoform 21 Publication (identifier: A7RDN6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-123: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:259
Mass (Da):28,457
Checksum:i5F3898120A31E513
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J156A0A0R4J156_MOUSE
Renalase
Rnls
300Annotation score:
E9Q243E9Q243_MOUSE
Renalase
Rnls
182Annotation score:

Sequence cautioni

The sequence AAH52355 differs from that shown. Reason: Erroneous termination at position 33. Translated as Trp.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31G → A in ABG82016 (PubMed:17846919).Curated1
Sequence conflicti31G → A in BAE41716 (PubMed:16141072).Curated1
Sequence conflicti36G → A in ABG82016 (PubMed:17846919).Curated1
Sequence conflicti36G → A in BAE41716 (PubMed:16141072).Curated1
Sequence conflicti138K → E in BAE41716 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05311441 – 123Missing in isoform 2. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ788834 mRNA Translation: ABG82016.1
AK170321 mRNA Translation: BAE41716.1
BC052355 mRNA Translation: AAH52355.2 Sequence problems.
RefSeqiNP_001139814.2, NM_001146342.2
NP_001161290.1, NM_001167818.1
UniGeneiMm.204591

Genome annotation databases

GeneIDi67795
KEGGimmu:67795
UCSCiuc008hft.2 mouse [A7RDN6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ788834 mRNA Translation: ABG82016.1
AK170321 mRNA Translation: BAE41716.1
BC052355 mRNA Translation: AAH52355.2 Sequence problems.
RefSeqiNP_001139814.2, NM_001146342.2
NP_001161290.1, NM_001167818.1
UniGeneiMm.204591

3D structure databases

ProteinModelPortaliA7RDN6
SMRiA7RDN6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093825

PTM databases

PhosphoSitePlusiA7RDN6

Proteomic databases

MaxQBiA7RDN6
PaxDbiA7RDN6
PRIDEiA7RDN6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi67795
KEGGimmu:67795
UCSCiuc008hft.2 mouse [A7RDN6-1]

Organism-specific databases

CTDi55328
MGIiMGI:1915045 Rnls

Phylogenomic databases

eggNOGiENOG410IE15 Eukaryota
ENOG410XV8B LUCA
HOGENOMiHOG000007721
InParanoidiA7RDN6
KOiK18208
PhylomeDBiA7RDN6
TreeFamiTF332799

Enzyme and pathway databases

BRENDAi1.6.3.5 3474

Miscellaneous databases

PROiPR:A7RDN6
SOURCEiSearch...

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR002937 Amino_oxidase
IPR036188 FAD/NAD-bd_sf
PfamiView protein in Pfam
PF01593 Amino_oxidase, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNLS_MOUSE
AccessioniPrimary (citable) accession number: A7RDN6
Secondary accession number(s): Q3TD88, Q80W75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: June 16, 2009
Last modified: November 7, 2018
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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