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Protein

Cardiolipin synthase A

Gene

clsA

Organism
Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.UniRule annotation

Catalytic activityi

2 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a cardiolipin + glycerol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei224UniRule annotation1
Active sitei226UniRule annotation1
Active sitei231UniRule annotation1
Active sitei404UniRule annotation1
Active sitei406UniRule annotation1
Active sitei411UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiolipin synthase AUniRule annotation (EC:2.7.8.-UniRule annotation)
Short name:
CL synthaseUniRule annotation
Gene namesi
Name:clsAUniRule annotation
Synonyms:cls
Ordered Locus Names:ESA_01548
OrganismiCronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii)
Taxonomic identifieri290339 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeCronobacter
Proteomesi
  • UP000000260 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000584871 – 486Cardiolipin synthase AAdd BLAST486

Interactioni

Protein-protein interaction databases

STRINGi290339.ESA_01548

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini219 – 246PLD phosphodiesterase 1UniRule annotationAdd BLAST28
Domaini399 – 426PLD phosphodiesterase 2UniRule annotationAdd BLAST28

Sequence similaritiesi

Belongs to the phospholipase D family. Cardiolipin synthase subfamily. ClsA sub-subfamily.UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CQX Bacteria
COG1502 LUCA
HOGENOMiHOG000077403
KOiK06131
OMAiGGHNVGD

Family and domain databases

HAMAPiMF_00190 Cardiolipin_synth_ClsA, 1 hit
InterProiView protein in InterPro
IPR022924 Cardiolipin_synthase
IPR030840 CL_synthase_A
IPR027379 CLS_N
IPR025202 PLD-like_dom
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13091 PLDc_2, 2 hits
PF13396 PLDc_N, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
TIGRFAMsiTIGR04265 bac_cardiolipin, 1 hit
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

A7MNA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTFYTVVSW LIILGYWLLI AGVTLRILMK RRAVPSAMAW LLVIYILPLV
60 70 80 90 100
GIVAYLSVGE LHLGKRRAER ARAMWPSTAK WLNDLKACKH IFAEENSAVA
110 120 130 140 150
SALFQLCERR QGIAGVKGNQ LQLLTSSDDV MQALIRDIQL ARHNIEMVFY
160 170 180 190 200
IWQPGGMADQ VAESLMAAAR RGVHCRLMLD SAGSVAFFRS PWAGMMRNAG
210 220 230 240 250
IEVVEALKVN LMRVFLRRMD LRQHRKMIMI DNYIAYTGSM NMVDPRYFKQ
260 270 280 290 300
DAGVGQWVDL MARMEGPVAT AMGIVYSCDW EIETGKRLLP PPPDANIMPF
310 320 330 340 350
EQASGHTIHT IASGPGFPED LIHQALLTSV YAAREYLIMT TPYFVPSDDL
360 370 380 390 400
LHAICTAAQR GVDVSIILPR KNDSLLVGWA SRAFFSELLA AGVKIYQFEG
410 420 430 440 450
GLLHTKSVLV DGELSLVGTV NLDMRSLWLN FEITLVIDDA GFGADLAEVQ
460 470 480
DDYISRSRLL DARLWVKRPF WQRVVERLFY FFSPLL
Length:486
Mass (Da):54,709
Last modified:October 2, 2007 - v1
Checksum:iEE2786C2EE5174E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000783 Genomic DNA Translation: ABU76802.1
RefSeqiWP_007850578.1, NC_009778.1

Genome annotation databases

EnsemblBacteriaiABU76802; ABU76802; ESA_01548
GeneIDi29459773
KEGGiesa:ESA_01548

Similar proteinsi

Entry informationi

Entry nameiCLSA_CROS8
AccessioniPrimary (citable) accession number: A7MNA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 2, 2007
Last modified: September 12, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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