SRRM4

Functionⁱ

Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts. Promotes alternative splicing of REST transcripts to produce a REST isoform (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells. Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (By similarity).By similarity

GO - Molecular functionⁱ

mRNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell differentiation Source: UniProtKB
mRNA processing Source: UniProtKB
nervous system development Source: UniProtKB
regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
regulation of RNA splicing Source: UniProtKB
RNA splicing Source: UniProtKB-KW
sensory perception of sound Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	RNA-binding
Biological process	Differentiation, mRNA processing, mRNA splicing

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/arginine repetitive matrix protein 4 Alternative name(s): Medulloblastoma antigen MU-MB-2.76 Neural-specific serine/arginine repetitive splicing factor of 100 kDa Short name: Neural-specific SR-related protein of 100 kDa Short name: nSR100
Gene namesⁱ	Name:SRRM4 Synonyms:KIAA1853
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000139767.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29389 SRRM4
MIMⁱ	613103 gene
neXtProtⁱ	NX_A7MD48

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84530
Open Targets More...OpenTargetsⁱ	ENSG00000139767
PharmGKBⁱ	PA165513415

Polymorphism and mutation databases

BioMutaⁱ	SRRM4

BioMutaⁱ

SRRM4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000311911	1 – 611	Serine/arginine repetitive matrix protein 4Add BLAST		611

Post-translational modificationⁱ

Phosphorylated.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	A7MD48
PaxDbⁱ	A7MD48
PRIDEⁱ	A7MD48
ProteomicsDBⁱ	1812

PTM databases

iPTMnetⁱ	A7MD48
PhosphoSitePlusⁱ	A7MD48

Expressionⁱ

Tissue specificityⁱ

Specifically expressed in neuronal cells (at protein level). Expressed in the cerebellum.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000139767 Expressed in 87 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_KIAA1853
ExpressionAtlasⁱ	A7MD48 baseline and differential
Genevisibleⁱ	A7MD48 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA052783

HPAⁱ

HPA052783

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
AKAP17A	Q02040	4	EBI-3867173,EBI-1042725
LUZP4	Q9P127	4	EBI-3867173,EBI-10198848
SRSF11	Q05519-2	4	EBI-3867173,EBI-11975029

Protein-protein interaction databases

BioGridⁱ	124121, 2 interactors
IntActⁱ	A7MD48, 28 interactors
STRINGⁱ	9606.ENSP00000267260

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A7MD48
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	109 – 171	Lys-richAdd BLAST	63
Compositional biasⁱ	123 – 608	Ser-richAdd BLAST	486
Compositional biasⁱ	442 – 598	Arg-richAdd BLAST	157

Sequence similaritiesⁱ

Belongs to the nSR100 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IEGN Eukaryota ENOG4112C96 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000111247
HOGENOMⁱ	HOG000013098
HOVERGENⁱ	HBG108046
InParanoidⁱ	A7MD48
OMAⁱ	CKDSPEA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FNP
PhylomeDBⁱ	A7MD48

Family and domain databases

InterProⁱ	View protein in InterPro IPR029360 SRRM_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15230 SRRM_C, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

A7MD48-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MASVQQGEKQ LFEKFWRGTF KAVATPRPES IIVASITARK PLPRTEPQNN 
        60         70         80         90        100
PVVPAQDGPS EKLGQHLATE PLGTNSWERD KTCRELGATR GHSASHDKDL 
       110        120        130        140        150
TPPPSSRGKK KKKKSTRKKR RRSSSYSPSP VKKKKKKSSK KHKRRRSFSK 
       160        170        180        190        200
KRRHSSSSPK SKRRDEKRHK KQSRSRPRKS HRHRHHRCPS RSQSSESRPS 
       210        220        230        240        250
SCESRHRGRS PEEGQKSRRR HSRRCSKTLC KDSPEAQSSR PPSQPLQMLG 
       260        270        280        290        300
YLSARGVITG SGSAADLFTK TASPLTTSRG RSQEYDSGND TSSPPSTQTS 
       310        320        330        340        350
SARSRGQEKG SPSGGLSKSR ELNSGNTSDS GNSFTTSSPQ NKGAMLENLS 
       360        370        380        390        400
PTSRGRESRG FQSPCLECAE VKKSSLVPST ARSSPMKGCS RSSSYASTRS 
       410        420        430        440        450
SSHSSRSPNP RASPRYTQSR STSSEKRSYS RSPSYSSKSG KRSPPSRSSR 
       460        470        480        490        500
SRRSPSYSRY SPSRERDPKY SEKDSQQRER ERARRRRRSY SPMRKRRRDS 
       510        520        530        540        550
PSHLEARRIT SARKRPIPYY RPSPSSSGSL SSTSSWYSSS SSRSASRSYS 
       560        570        580        590        600
RSRSRSRSRR RSRTRTSSSS SSRSPSPGSR SRSRSRSRSR SRSRSQSRSY 
       610 
SSADSYSSTR R

Length:611

Mass (Da):68,559

Last modified:December 15, 2009 - v2

Checksum:ⁱ2D8B551D7C9DE43D

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A286YF08	A0A286YF08_HUMAN		Serine/arginine repetitive matrix p... Serine/arginine repetitive matrix protein 4	SRRM4	66	Annotation score:

Sequence cautionⁱ

The sequence BAB47482 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	553	R → W in BAB47482 (PubMed:11347906).Curated	1
Sequence conflictⁱ	553	R → W in AAI52472 (PubMed:15489334).Curated	1
Sequence conflictⁱ	553	R → W in AAI67162 (PubMed:15489334).Curated	1
Sequence conflictⁱ	553	R → W in AAI67163 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_037339	243	S → N. Corresponds to variant dbSNP:rs7297606Ensembl.	1
Natural variantⁱVAR_037340	406	R → Q. Corresponds to variant dbSNP:rs2723880Ensembl.	1
Natural variantⁱVAR_037341	547	R → S. Corresponds to variant dbSNP:rs2555273Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB058756 mRNA Translation: BAB47482.1 Different initiation. AK291361 mRNA Translation: BAF84050.1 AC087885 Genomic DNA No translation available. AC084361 Genomic DNA No translation available. BC152471 mRNA Translation: AAI52472.1 BC167162 mRNA Translation: AAI67162.1 BC167163 mRNA Translation: AAI67163.1 AY130006 mRNA Translation: AAN05090.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44994.1
NCBI Reference Sequences More...RefSeqⁱ	NP_919262.2, NM_194286.3
UniGeneⁱ	Hs.744964

Genome annotation databases

Ensemblⁱ	ENST00000267260; ENSP00000267260; ENSG00000139767
GeneIDⁱ	84530
KEGGⁱ	hsa:84530

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A7MD48	Serine/arginine repetitive matrix 4		HUMAN		611	UniRef100_A7MD48

Protein	Similar proteins		Species	Score	Length	Source
A7MD48	Serine/arginine repetitive matrix 4		HUMAN		611	UniRef90_A7MD48
Uncharacterized protein		OTOGA		613
SRRM4 isoform 1		PANTR		611
Uncharacterized protein		Cebus capucinus imitator		609
Uncharacterized protein		PROCO		603
+12

Protein	Similar proteins		Species	Score	Length	Source
A7MD48	Serine/arginine repetitive matrix 4		HUMAN		611	UniRef50_A7MD48
Uncharacterized protein		OTOGA		613
SRRM4 isoform 1		PANTR		611
Uncharacterized protein		Cebus capucinus imitator		609
Uncharacterized protein		PROCO		603
+161

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB058756 mRNA Translation: BAB47482.1 Different initiation. AK291361 mRNA Translation: BAF84050.1 AC087885 Genomic DNA No translation available. AC084361 Genomic DNA No translation available. BC152471 mRNA Translation: AAI52472.1 BC167162 mRNA Translation: AAI67162.1 BC167163 mRNA Translation: AAI67163.1 AY130006 mRNA Translation: AAN05090.1
CCDSⁱ	CCDS44994.1
RefSeqⁱ	NP_919262.2, NM_194286.3
UniGeneⁱ	Hs.744964

3D structure databases

ProteinModelPortalⁱ	A7MD48
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124121, 2 interactors
IntActⁱ	A7MD48, 28 interactors
STRINGⁱ	9606.ENSP00000267260

PTM databases

iPTMnetⁱ	A7MD48
PhosphoSitePlusⁱ	A7MD48

Polymorphism and mutation databases

BioMutaⁱ	SRRM4

BioMutaⁱ

SRRM4

Proteomic databases

EPDⁱ	A7MD48
PaxDbⁱ	A7MD48
PRIDEⁱ	A7MD48
ProteomicsDBⁱ	1812

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84530
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000267260; ENSP00000267260; ENSG00000139767
GeneIDⁱ	84530
KEGGⁱ	hsa:84530

Organism-specific databases

CTDⁱ	84530
DisGeNETⁱ	84530
EuPathDBⁱ	HostDB:ENSG00000139767.8
GeneCardsⁱ	SRRM4
H-InvDBⁱ	HIX0011050
HGNCⁱ	HGNC:29389 SRRM4
HPAⁱ	HPA052783
MIMⁱ	613103 gene
neXtProtⁱ	NX_A7MD48
OpenTargetsⁱ	ENSG00000139767
PharmGKBⁱ	PA165513415
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEGN Eukaryota ENOG4112C96 LUCA
GeneTreeⁱ	ENSGT00730000111247
HOGENOMⁱ	HOG000013098
HOVERGENⁱ	HBG108046
InParanoidⁱ	A7MD48
OMAⁱ	CKDSPEA
OrthoDBⁱ	EOG091G0FNP
PhylomeDBⁱ	A7MD48

Miscellaneous databases

ChiTaRSⁱ	SRRM4 human
GenomeRNAiⁱ	84530
Protein Ontology More...PROⁱ	PR:A7MD48
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000139767 Expressed in 87 organ(s), highest expression level in cerebellar vermis
CleanExⁱ	HS_KIAA1853
ExpressionAtlasⁱ	A7MD48 baseline and differential
Genevisibleⁱ	A7MD48 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029360 SRRM_C
Pfamⁱ	View protein in Pfam PF15230 SRRM_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SRRM4_HUMAN
Accessionⁱ	A7MD48Primary (citable) accession number: A7MD48 Secondary accession number(s): A8K5P6 , B2RZH7, Q7Z5F0, Q96JH4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
	Last sequence update:	December 15, 2009
	Last modified:	November 7, 2018
	This is version 82 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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UniProtKB - A7MD48 (SRRM4_HUMAN)

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Serine/arginine repetitive matrix protein 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ