UniProtKB - A7MCY6 (TBKB1_HUMAN)
Protein
TANK-binding kinase 1-binding protein 1
Gene
TBKBP1
Organism
Homo sapiens (Human)
Status
Functioni
Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 583 – 609 | UBZ1-typePROSITE-ProRule annotationAdd BLAST | 27 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- I-kappaB kinase/NF-kappaB signaling Source: GO_Central
- innate immune response Source: UniProtKB-KW
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Immunity, Innate immunity |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | A7MCY6 |
Names & Taxonomyi
Protein namesi | Recommended name: TANK-binding kinase 1-binding protein 1Short name: TBK1-binding protein 1 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30140, TBKBP1 |
MIMi | 608476, gene |
neXtProti | NX_A7MCY6 |
VEuPathDBi | HostDB:ENSG00000198933.9 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 9755 |
OpenTargetsi | ENSG00000198933 |
PharmGKBi | PA142670830 |
Miscellaneous databases
Pharosi | A7MCY6, Tbio |
Genetic variation databases
BioMutai | TBKBP1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000324654 | 1 – 615 | TANK-binding kinase 1-binding protein 1Add BLAST | 615 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 184 | PhosphoserineCombined sources | 1 | |
Modified residuei | 365 | PhosphoserineCombined sources | 1 | |
Modified residuei | 372 | PhosphoserineCombined sources | 1 | |
Modified residuei | 379 | PhosphoserineCombined sources | 1 | |
Modified residuei | 385 | PhosphoserineCombined sources | 1 | |
Modified residuei | 400 | PhosphoserineCombined sources | 1 | |
Modified residuei | 415 | PhosphoserineCombined sources | 1 | |
Modified residuei | 504 | PhosphoserineCombined sources | 1 | |
Modified residuei | 534 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | A7MCY6 |
jPOSTi | A7MCY6 |
MassIVEi | A7MCY6 |
MaxQBi | A7MCY6 |
PaxDbi | A7MCY6 |
PeptideAtlasi | A7MCY6 |
PRIDEi | A7MCY6 |
ProteomicsDBi | 1810 [A7MCY6-1] 1811 [A7MCY6-2] |
PTM databases
iPTMneti | A7MCY6 |
PhosphoSitePlusi | A7MCY6 |
Expressioni
Tissue specificityi
Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.1 Publication
Gene expression databases
Bgeei | ENSG00000198933, Expressed in blood and 192 other tissues |
ExpressionAtlasi | A7MCY6, baseline and differential |
Genevisiblei | A7MCY6, HS |
Organism-specific databases
HPAi | ENSG00000198933, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. May form a heterodimer with NAP1.
Interacts with TKB1 and IKBKE. Weakly interacts with DDX3X (PubMed:27980081).
3 Publications(Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).
1 PublicationBinary interactionsi
Hide detailsA7MCY6
Protein-protein interaction databases
BioGRIDi | 115103, 43 interactors |
ComplexPortali | CPX-6090, TBK1-IKKepsilon-SINTBAD complex |
CORUMi | A7MCY6 |
DIPi | DIP-27604N |
IntActi | A7MCY6, 16 interactors |
MINTi | A7MCY6 |
STRINGi | 9606.ENSP00000354777 |
Miscellaneous databases
RNActi | A7MCY6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 279 | HomodimerizationBy similarityAdd BLAST | 279 | |
Regioni | 280 – 329 | Interaction with TBK1 and IKBKEBy similarityAdd BLAST | 50 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 48 – 162 | Sequence analysisAdd BLAST | 115 | |
Coiled coili | 221 – 276 | Sequence analysisAdd BLAST | 56 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 343 – 434 | Pro-richSequence analysisAdd BLAST | 92 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 583 – 609 | UBZ1-typePROSITE-ProRule annotationAdd BLAST | 27 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502QVP4, Eukaryota |
GeneTreei | ENSGT00940000153704 |
HOGENOMi | CLU_029090_0_0_1 |
InParanoidi | A7MCY6 |
OMAi | QRHSPIQ |
OrthoDBi | 621943at2759 |
PhylomeDBi | A7MCY6 |
TreeFami | TF331289 |
Family and domain databases
InterProi | View protein in InterPro IPR041641, CALCOCO1/2_Zn_UBZ1 IPR024581, TBD |
Pfami | View protein in Pfam PF12845, TBD, 1 hit |
PROSITEi | View protein in PROSITE PS51905, ZF_UBZ1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 12 Publications (identifier: A7MCY6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD
60 70 80 90 100
IKERLGGLER ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE
110 120 130 140 150
VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELRE
160 170 180 190 200
MRALVETHLR QICGLEQQLR QQQGLQDAAF SNLSPPPAPA PPCTDLDLHY
210 220 230 240 250
LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA RGAQLREEQL
260 270 280 290 300
QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE
310 320 330 340 350
LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP
360 370 380 390 400
SPPARAAPPC PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS
410 420 430 440 450
PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPPPGERTLA ERAYAKPPSH
460 470 480 490 500
HVKAGFQGRR SYSELAEGAA YAGASPPWLQ AEAATLPKPR AYGSELYGPG
510 520 530 540 550
RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI RCASFCAGFP
560 570 580 590 600
IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD
610
ALIKHIDSHL ENSKI
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H1U4 | F5H1U4_HUMAN | TANK-binding kinase 1-binding prote... | TBKBP1 | 208 | Annotation score: | ||
J3KS71 | J3KS71_HUMAN | TANK-binding kinase 1-binding prote... | TBKBP1 | 195 | Annotation score: |
Sequence cautioni
The sequence BAA34495 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_052714 | 186 – 222 | PPAPA…TPSVS → RRARAVLAVHQLADGDGGLR HPQLPPLPAGFPCRVPG in isoform 2. 1 PublicationAdd BLAST | 37 | |
Alternative sequenceiVSP_052715 | 223 – 615 | Missing in isoform 2. 1 PublicationAdd BLAST | 393 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018318 mRNA Translation: BAA34495.2 Different initiation. BC111418 mRNA Translation: AAI11419.1 BC152407 mRNA Translation: AAI52408.1 BC167150 mRNA Translation: AAI67150.1 |
CCDSi | CCDS45722.1 [A7MCY6-1] |
RefSeqi | NP_055541.1, NM_014726.2 [A7MCY6-1] XP_005257916.1, XM_005257859.4 [A7MCY6-1] XP_005257917.1, XM_005257860.4 [A7MCY6-1] XP_005257918.1, XM_005257861.4 [A7MCY6-1] XP_005257919.1, XM_005257862.3 [A7MCY6-1] |
Genome annotation databases
Ensembli | ENST00000361722; ENSP00000354777; ENSG00000198933 [A7MCY6-1] ENST00000622396; ENSP00000484395; ENSG00000198933 [A7MCY6-2] |
GeneIDi | 9755 |
KEGGi | hsa:9755 |
UCSCi | uc002ilu.4, human [A7MCY6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018318 mRNA Translation: BAA34495.2 Different initiation. BC111418 mRNA Translation: AAI11419.1 BC152407 mRNA Translation: AAI52408.1 BC167150 mRNA Translation: AAI67150.1 |
CCDSi | CCDS45722.1 [A7MCY6-1] |
RefSeqi | NP_055541.1, NM_014726.2 [A7MCY6-1] XP_005257916.1, XM_005257859.4 [A7MCY6-1] XP_005257917.1, XM_005257860.4 [A7MCY6-1] XP_005257918.1, XM_005257861.4 [A7MCY6-1] XP_005257919.1, XM_005257862.3 [A7MCY6-1] |
3D structure databases
SMRi | A7MCY6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115103, 43 interactors |
ComplexPortali | CPX-6090, TBK1-IKKepsilon-SINTBAD complex |
CORUMi | A7MCY6 |
DIPi | DIP-27604N |
IntActi | A7MCY6, 16 interactors |
MINTi | A7MCY6 |
STRINGi | 9606.ENSP00000354777 |
PTM databases
iPTMneti | A7MCY6 |
PhosphoSitePlusi | A7MCY6 |
Genetic variation databases
BioMutai | TBKBP1 |
Proteomic databases
EPDi | A7MCY6 |
jPOSTi | A7MCY6 |
MassIVEi | A7MCY6 |
MaxQBi | A7MCY6 |
PaxDbi | A7MCY6 |
PeptideAtlasi | A7MCY6 |
PRIDEi | A7MCY6 |
ProteomicsDBi | 1810 [A7MCY6-1] 1811 [A7MCY6-2] |
Protocols and materials databases
Antibodypediai | 30174, 155 antibodies |
Genome annotation databases
Ensembli | ENST00000361722; ENSP00000354777; ENSG00000198933 [A7MCY6-1] ENST00000622396; ENSP00000484395; ENSG00000198933 [A7MCY6-2] |
GeneIDi | 9755 |
KEGGi | hsa:9755 |
UCSCi | uc002ilu.4, human [A7MCY6-1] |
Organism-specific databases
CTDi | 9755 |
DisGeNETi | 9755 |
GeneCardsi | TBKBP1 |
HGNCi | HGNC:30140, TBKBP1 |
HPAi | ENSG00000198933, Low tissue specificity |
MIMi | 608476, gene |
neXtProti | NX_A7MCY6 |
OpenTargetsi | ENSG00000198933 |
PharmGKBi | PA142670830 |
VEuPathDBi | HostDB:ENSG00000198933.9 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVP4, Eukaryota |
GeneTreei | ENSGT00940000153704 |
HOGENOMi | CLU_029090_0_0_1 |
InParanoidi | A7MCY6 |
OMAi | QRHSPIQ |
OrthoDBi | 621943at2759 |
PhylomeDBi | A7MCY6 |
TreeFami | TF331289 |
Enzyme and pathway databases
PathwayCommonsi | A7MCY6 |
Miscellaneous databases
BioGRID-ORCSi | 9755, 17 hits in 1000 CRISPR screens |
GenomeRNAii | 9755 |
Pharosi | A7MCY6, Tbio |
PROi | PR:A7MCY6 |
RNActi | A7MCY6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198933, Expressed in blood and 192 other tissues |
ExpressionAtlasi | A7MCY6, baseline and differential |
Genevisiblei | A7MCY6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR041641, CALCOCO1/2_Zn_UBZ1 IPR024581, TBD |
Pfami | View protein in Pfam PF12845, TBD, 1 hit |
PROSITEi | View protein in PROSITE PS51905, ZF_UBZ1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TBKB1_HUMAN | |
Accessioni | A7MCY6Primary (citable) accession number: A7MCY6 Secondary accession number(s): B2RZG6, O94873, Q14DW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 18, 2008 |
Last sequence update: | October 2, 2007 | |
Last modified: | April 7, 2021 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot