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UniProtKB - A7MCY6 (TBKB1_HUMAN)

Entry version 109 (02 Jun 2021)
Sequence version 1 (02 Oct 2007)
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Protein

TANK-binding kinase 1-binding protein 1

Gene

TBKBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.

1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri583 – 609UBZ1-typePROSITE-ProRule annotationAdd BLAST27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction, Immunity, Innate immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A7MCY6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TANK-binding kinase 1-binding protein 1
Short name:
TBK1-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBKBP1Imported
Synonyms:KIAA0775Imported, SINTBAD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30140, TBKBP1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608476, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A7MCY6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198933.9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		9755

Open Targets

More...OpenTargetsi		ENSG00000198933

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142670830

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A7MCY6, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523108

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TBKBP1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003246541 – 615TANK-binding kinase 1-binding protein 1Add BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei184PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A7MCY6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A7MCY6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A7MCY6

MaxQB - The MaxQuant DataBase

More...MaxQBi		A7MCY6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A7MCY6

PeptideAtlas

More...PeptideAtlasi		A7MCY6

PRoteomics IDEntifications database

More...PRIDEi		A7MCY6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1810 [A7MCY6-1]
1811 [A7MCY6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A7MCY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A7MCY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198933, Expressed in blood and 193 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A7MCY6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A7MCY6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198933, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. May form a heterodimer with NAP1.

Interacts with TKB1 and IKBKE. Weakly interacts with DDX3X (PubMed:27980081).

3 Publications

(Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115103, 44 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6090, TBK1-IKKepsilon-SINTBAD complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		A7MCY6

Database of interacting proteins

More...DIPi		DIP-27604N

Protein interaction database and analysis system

More...IntActi		A7MCY6, 16 interactors

Molecular INTeraction database

More...MINTi		A7MCY6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000354777

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A7MCY6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A7MCY6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 279HomodimerizationBy similarityAdd BLAST279
Regioni280 – 329Interaction with TBK1 and IKBKEBy similarityAdd BLAST50
Regioni326 – 458DisorderedSequence analysisAdd BLAST133

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili48 – 162Sequence analysisAdd BLAST115
Coiled coili221 – 276Sequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi326 – 342Polar residuesSequence analysisAdd BLAST17
Compositional biasi343 – 437Pro residuesSequence analysisAdd BLAST95

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri583 – 609UBZ1-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVP4, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153704

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_029090_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A7MCY6

Identification of Orthologs from Complete Genome Data

More...OMAi		QRHSPIQ

Database of Orthologous Groups

More...OrthoDBi		621943at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A7MCY6

TreeFam database of animal gene trees

More...TreeFami		TF331289

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR041641, CALCOCO1/2_Zn_UBZ1
IPR024581, TBD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12845, TBD, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51905, ZF_UBZ1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: A7MCY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD 
        60         70         80         90        100
IKERLGGLER ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE 
       110        120        130        140        150
VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELRE 
       160        170        180        190        200
MRALVETHLR QICGLEQQLR QQQGLQDAAF SNLSPPPAPA PPCTDLDLHY 
       210        220        230        240        250
LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA RGAQLREEQL 
       260        270        280        290        300
QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE 
       310        320        330        340        350
LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP 
       360        370        380        390        400
SPPARAAPPC PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS 
       410        420        430        440        450
PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPPPGERTLA ERAYAKPPSH 
       460        470        480        490        500
HVKAGFQGRR SYSELAEGAA YAGASPPWLQ AEAATLPKPR AYGSELYGPG 
       510        520        530        540        550
RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI RCASFCAGFP 
       560        570        580        590        600
IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD 
       610 
ALIKHIDSHL ENSKI
Length:615
Mass (Da):67,702
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8F42919164A554E
GO
Isoform 21 Publication (identifier: A7MCY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-222: PPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVS → RRARAVLAVHQLADGDGGLRHPQLPPLPAGFPCRVPG
     223-615: Missing.

Show »
Length:222
Mass (Da):25,043
Checksum:iE52578DA01C2B322
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H1U4F5H1U4_HUMAN
TANK-binding kinase 1-binding prote...
TBKBP1
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KS71J3KS71_HUMAN
TANK-binding kinase 1-binding prote...
TBKBP1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34495 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052714186 – 222PPAPA…TPSVS → RRARAVLAVHQLADGDGGLR HPQLPPLPAGFPCRVPG in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_052715223 – 615Missing in isoform 2. 1 PublicationAdd BLAST393

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB018318 mRNA Translation: BAA34495.2 Different initiation.
BC111418 mRNA Translation: AAI11419.1
BC152407 mRNA Translation: AAI52408.1
BC167150 mRNA Translation: AAI67150.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45722.1 [A7MCY6-1]

NCBI Reference Sequences

More...RefSeqi		NP_055541.1, NM_014726.2 [A7MCY6-1]
XP_005257916.1, XM_005257859.4 [A7MCY6-1]
XP_005257917.1, XM_005257860.4 [A7MCY6-1]
XP_005257918.1, XM_005257861.4 [A7MCY6-1]
XP_005257919.1, XM_005257862.3 [A7MCY6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361722; ENSP00000354777; ENSG00000198933 [A7MCY6-1]
ENST00000622396; ENSP00000484395; ENSG00000198933 [A7MCY6-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9755

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9755

UCSC genome browser

More...UCSCi		uc002ilu.4, human [A7MCY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018318 mRNA Translation: BAA34495.2 Different initiation.
BC111418 mRNA Translation: AAI11419.1
BC152407 mRNA Translation: AAI52408.1
BC167150 mRNA Translation: AAI67150.1
CCDSiCCDS45722.1 [A7MCY6-1]
RefSeqiNP_055541.1, NM_014726.2 [A7MCY6-1]
XP_005257916.1, XM_005257859.4 [A7MCY6-1]
XP_005257917.1, XM_005257860.4 [A7MCY6-1]
XP_005257918.1, XM_005257861.4 [A7MCY6-1]
XP_005257919.1, XM_005257862.3 [A7MCY6-1]

3D structure databases

SMRiA7MCY6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi115103, 44 interactors
ComplexPortaliCPX-6090, TBK1-IKKepsilon-SINTBAD complex
CORUMiA7MCY6
DIPiDIP-27604N
IntActiA7MCY6, 16 interactors
MINTiA7MCY6
STRINGi9606.ENSP00000354777

Chemistry databases

ChEMBLiCHEMBL4523108

PTM databases

iPTMnetiA7MCY6
PhosphoSitePlusiA7MCY6

Genetic variation databases

BioMutaiTBKBP1

Proteomic databases

EPDiA7MCY6
jPOSTiA7MCY6
MassIVEiA7MCY6
MaxQBiA7MCY6
PaxDbiA7MCY6
PeptideAtlasiA7MCY6
PRIDEiA7MCY6
ProteomicsDBi1810 [A7MCY6-1]
1811 [A7MCY6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30174, 155 antibodies

The DNASU plasmid repository

More...DNASUi		9755

Genome annotation databases

EnsembliENST00000361722; ENSP00000354777; ENSG00000198933 [A7MCY6-1]
ENST00000622396; ENSP00000484395; ENSG00000198933 [A7MCY6-2]
GeneIDi9755
KEGGihsa:9755
UCSCiuc002ilu.4, human [A7MCY6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9755
DisGeNETi9755

GeneCards: human genes, protein and diseases

More...GeneCardsi		TBKBP1
HGNCiHGNC:30140, TBKBP1
HPAiENSG00000198933, Low tissue specificity
MIMi608476, gene
neXtProtiNX_A7MCY6
OpenTargetsiENSG00000198933
PharmGKBiPA142670830
VEuPathDBiHostDB:ENSG00000198933.9

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVP4, Eukaryota
GeneTreeiENSGT00940000153704
HOGENOMiCLU_029090_0_0_1
InParanoidiA7MCY6
OMAiQRHSPIQ
OrthoDBi621943at2759
PhylomeDBiA7MCY6
TreeFamiTF331289

Enzyme and pathway databases

PathwayCommonsiA7MCY6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9755, 17 hits in 1000 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9755
PharosiA7MCY6, Tbio

Protein Ontology

More...PROi		PR:A7MCY6
RNActiA7MCY6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000198933, Expressed in blood and 193 other tissues
ExpressionAtlasiA7MCY6, baseline and differential
GenevisibleiA7MCY6, HS

Family and domain databases

InterProiView protein in InterPro
IPR041641, CALCOCO1/2_Zn_UBZ1
IPR024581, TBD
PfamiView protein in Pfam
PF12845, TBD, 1 hit
PROSITEiView protein in PROSITE
PS51905, ZF_UBZ1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBKB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7MCY6
Secondary accession number(s): B2RZG6, O94873, Q14DW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 2, 2007
Last modified: June 2, 2021
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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