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Protein

TANK-binding kinase 1-binding protein 1

Gene

TBKBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity.1 Publication

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
TANK-binding kinase 1-binding protein 1
Short name:
TBK1-binding protein 1
Gene namesi
Name:TBKBP1Imported
Synonyms:KIAA0775Imported, SINTBAD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198933.9
HGNCiHGNC:30140 TBKBP1
MIMi608476 gene
neXtProtiNX_A7MCY6

Pathology & Biotechi

Organism-specific databases

DisGeNETi9755
OpenTargetsiENSG00000198933
PharmGKBiPA142670830

Polymorphism and mutation databases

BioMutaiTBKBP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246541 – 615TANK-binding kinase 1-binding protein 1Add BLAST615

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei379PhosphoserineCombined sources1
Modified residuei385PhosphoserineCombined sources1
Modified residuei400PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei534PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA7MCY6
MaxQBiA7MCY6
PaxDbiA7MCY6
PRIDEiA7MCY6
ProteomicsDBi1810
1811 [A7MCY6-2]

PTM databases

iPTMnetiA7MCY6
PhosphoSitePlusiA7MCY6

Expressioni

Tissue specificityi

Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus.1 Publication

Gene expression databases

BgeeiENSG00000198933 Expressed in 176 organ(s), highest expression level in blood
CleanExiHS_TBKBP1
ExpressionAtlasiA7MCY6 baseline and differential
GenevisibleiA7MCY6 HS

Organism-specific databases

HPAiHPA062347
HPA064856

Interactioni

Subunit structurei

Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE.2 Publications
(Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi115103, 20 interactors
CORUMiA7MCY6
DIPiDIP-27604N
IntActiA7MCY6, 14 interactors
MINTiA7MCY6
STRINGi9606.ENSP00000354777

Structurei

3D structure databases

ProteinModelPortaliA7MCY6
SMRiA7MCY6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 279HomodimerizationBy similarityAdd BLAST279
Regioni280 – 329Interaction with TBK1 and IKBKEBy similarityAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili48 – 162Sequence analysisAdd BLAST115
Coiled coili221 – 276Sequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi343 – 434Pro-richSequence analysisAdd BLAST92

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGJJ Eukaryota
ENOG410ZK7E LUCA
GeneTreeiENSGT00390000008865
HOGENOMiHOG000154514
HOVERGENiHBG108550
InParanoidiA7MCY6
KOiK12652
OMAiLSHAGWP
OrthoDBiEOG091G06LV
PhylomeDBiA7MCY6
TreeFamiTF331289

Family and domain databases

InterProiView protein in InterPro
IPR024581 TBD
PfamiView protein in Pfam
PF12845 TBD, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 12 Publications (identifier: A7MCY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESMFEDDIS ILTQEALGPS EVWLDSPGDP SLGGDMCSAS HFALITAYGD
60 70 80 90 100
IKERLGGLER ENATLRRRLK VYEIKYPLIS DFGEEHGFSL YEIKDGSLLE
110 120 130 140 150
VEKVSLQQRL NQFQHELQKN KEQEEQLGEM IQAYEKLCVE KSDLETELRE
160 170 180 190 200
MRALVETHLR QICGLEQQLR QQQGLQDAAF SNLSPPPAPA PPCTDLDLHY
210 220 230 240 250
LALRGGSGLS HAGWPGSTPS VSDLERRRLE EALEAAQGEA RGAQLREEQL
260 270 280 290 300
QAECERLQGE LKQLQETRAQ DLASNQSERD MAWVKRVGDD QVNLALAYTE
310 320 330 340 350
LTEELGRLRE LSSLQGRILR TLLQEQARSG GQRHSPLSQR HSPAPQCPSP
360 370 380 390 400
SPPARAAPPC PPCQSPVPQR RSPVPPCPSP QQRRSPASPS CPSPVPQRRS
410 420 430 440 450
PVPPSCQSPS PQRRSPVPPS CPAPQPRPPP PPPPGERTLA ERAYAKPPSH
460 470 480 490 500
HVKAGFQGRR SYSELAEGAA YAGASPPWLQ AEAATLPKPR AYGSELYGPG
510 520 530 540 550
RPLSPRRAFE GIRLRFEKQP SEEDEWAVPT SPPSPEVGTI RCASFCAGFP
560 570 580 590 600
IPESPAATAY AHAEHAQSWP SINLLMETVG SDIRSCPLCQ LGFPVGYPDD
610
ALIKHIDSHL ENSKI
Length:615
Mass (Da):67,702
Last modified:October 2, 2007 - v1
Checksum:iC8F42919164A554E
GO
Isoform 21 Publication (identifier: A7MCY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     186-222: PPAPAPPCTDLDLHYLALRGGSGLSHAGWPGSTPSVS → RRARAVLAVHQLADGDGGLRHPQLPPLPAGFPCRVPG
     223-615: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:222
Mass (Da):25,043
Checksum:iE52578DA01C2B322
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H1U4F5H1U4_HUMAN
TANK-binding kinase 1-binding prote...
TBKBP1
208Annotation score:
J3KS71J3KS71_HUMAN
TANK-binding kinase 1-binding prote...
TBKBP1
195Annotation score:

Sequence cautioni

The sequence BAA34495 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052714186 – 222PPAPA…TPSVS → RRARAVLAVHQLADGDGGLR HPQLPPLPAGFPCRVPG in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_052715223 – 615Missing in isoform 2. 1 PublicationAdd BLAST393

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018318 mRNA Translation: BAA34495.2 Different initiation.
BC111418 mRNA Translation: AAI11419.1
BC152407 mRNA Translation: AAI52408.1
BC167150 mRNA Translation: AAI67150.1
CCDSiCCDS45722.1 [A7MCY6-1]
RefSeqiNP_055541.1, NM_014726.2 [A7MCY6-1]
XP_005257916.1, XM_005257859.4 [A7MCY6-1]
XP_005257917.1, XM_005257860.4 [A7MCY6-1]
XP_005257918.1, XM_005257861.4 [A7MCY6-1]
XP_005257919.1, XM_005257862.3 [A7MCY6-1]
UniGeneiHs.94790

Genome annotation databases

EnsembliENST00000361722; ENSP00000354777; ENSG00000198933 [A7MCY6-1]
ENST00000622396; ENSP00000484395; ENSG00000198933 [A7MCY6-2]
GeneIDi9755
KEGGihsa:9755
UCSCiuc002ilu.4 human [A7MCY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018318 mRNA Translation: BAA34495.2 Different initiation.
BC111418 mRNA Translation: AAI11419.1
BC152407 mRNA Translation: AAI52408.1
BC167150 mRNA Translation: AAI67150.1
CCDSiCCDS45722.1 [A7MCY6-1]
RefSeqiNP_055541.1, NM_014726.2 [A7MCY6-1]
XP_005257916.1, XM_005257859.4 [A7MCY6-1]
XP_005257917.1, XM_005257860.4 [A7MCY6-1]
XP_005257918.1, XM_005257861.4 [A7MCY6-1]
XP_005257919.1, XM_005257862.3 [A7MCY6-1]
UniGeneiHs.94790

3D structure databases

ProteinModelPortaliA7MCY6
SMRiA7MCY6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115103, 20 interactors
CORUMiA7MCY6
DIPiDIP-27604N
IntActiA7MCY6, 14 interactors
MINTiA7MCY6
STRINGi9606.ENSP00000354777

PTM databases

iPTMnetiA7MCY6
PhosphoSitePlusiA7MCY6

Polymorphism and mutation databases

BioMutaiTBKBP1

Proteomic databases

EPDiA7MCY6
MaxQBiA7MCY6
PaxDbiA7MCY6
PRIDEiA7MCY6
ProteomicsDBi1810
1811 [A7MCY6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361722; ENSP00000354777; ENSG00000198933 [A7MCY6-1]
ENST00000622396; ENSP00000484395; ENSG00000198933 [A7MCY6-2]
GeneIDi9755
KEGGihsa:9755
UCSCiuc002ilu.4 human [A7MCY6-1]

Organism-specific databases

CTDi9755
DisGeNETi9755
EuPathDBiHostDB:ENSG00000198933.9
GeneCardsiTBKBP1
HGNCiHGNC:30140 TBKBP1
HPAiHPA062347
HPA064856
MIMi608476 gene
neXtProtiNX_A7MCY6
OpenTargetsiENSG00000198933
PharmGKBiPA142670830
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGJJ Eukaryota
ENOG410ZK7E LUCA
GeneTreeiENSGT00390000008865
HOGENOMiHOG000154514
HOVERGENiHBG108550
InParanoidiA7MCY6
KOiK12652
OMAiLSHAGWP
OrthoDBiEOG091G06LV
PhylomeDBiA7MCY6
TreeFamiTF331289

Miscellaneous databases

GenomeRNAii9755
PROiPR:A7MCY6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198933 Expressed in 176 organ(s), highest expression level in blood
CleanExiHS_TBKBP1
ExpressionAtlasiA7MCY6 baseline and differential
GenevisibleiA7MCY6 HS

Family and domain databases

InterProiView protein in InterPro
IPR024581 TBD
PfamiView protein in Pfam
PF12845 TBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTBKB1_HUMAN
AccessioniPrimary (citable) accession number: A7MCY6
Secondary accession number(s): B2RZG6, O94873, Q14DW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 2, 2007
Last modified: November 7, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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