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Entry version 80 (11 Dec 2019)
Sequence version 1 (02 Oct 2007)
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Protein
Submitted name:

TNC protein

Gene

TNC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TNC proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNCImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500271323820 – 1927Sequence analysisAdd BLAST1908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi190 ↔ 200PROSITE-ProRule annotation
Disulfide bondi207 ↔ 216PROSITE-ProRule annotation
Disulfide bondi284 ↔ 294PROSITE-ProRule annotation
Disulfide bondi301 ↔ 310PROSITE-ProRule annotation
Disulfide bondi376 ↔ 386PROSITE-ProRule annotation
Disulfide bondi393 ↔ 402PROSITE-ProRule annotation
Disulfide bondi469 ↔ 479PROSITE-ProRule annotation
Disulfide bondi486 ↔ 495PROSITE-ProRule annotation
Disulfide bondi562 ↔ 572PROSITE-ProRule annotation
Disulfide bondi579 ↔ 588PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A7MBN2

PRoteomics IDEntifications database

More...
PRIDEi
A7MBN2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A7MBN2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini186 – 217EGF-likeInterPro annotationAdd BLAST32
Domaini280 – 311EGF-likeInterPro annotationAdd BLAST32
Domaini372 – 403EGF-likeInterPro annotationAdd BLAST32
Domaini465 – 496EGF-likeInterPro annotationAdd BLAST32
Domaini558 – 589EGF-likeInterPro annotationAdd BLAST32
Domaini624 – 714Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini715 – 803Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini804 – 893Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini894 – 989Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini990 – 1074Fibronectin type-IIIInterPro annotationAdd BLAST85
Domaini1075 – 1164Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1166 – 1256Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini1257 – 1349Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini1350 – 1437Fibronectin type-IIIInterPro annotationAdd BLAST88
Domaini1438 – 1527Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1528 – 1614Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1615 – 1703Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1701 – 1916Fibrinogen C-terminalInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 139Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234355

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 12 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC

The PANTHER Classification System

More...
PANTHERi
PTHR46708:SF1 PTHR46708:SF1, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 4 hits
PF18720 EGF_Tenascin, 9 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 13 hits
SM00186 FBG, 1 hit
SM00060 FN3, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 9 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7MBN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF
60 70 80 90 100
NHVYNIKLPV GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TAGAGCCLQP
160 170 180 190 200
ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PGNCHLRGRC
210 220 230 240 250
IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE GYAGADCSRE
260 270 280 290 300
ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV
310 320 330 340 350
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEGFTGEDC GKPTCPHACH
360 370 380 390 400
TQGRCEEGQC VCDEGFAGVD CSEKRCPADC HNRGRCVDGR CECDDGFTGA
410 420 430 440 450
DCGELKCPNG CSGHGRCVNG QCVCDEGYTG EDCSQLRCPN DCHSRGRCVE
460 470 480 490 500
GKCVCEQGFK GYDCSDMSCP NDCHQHGRCV NGMCVCDDGY TGEDCRDRQC
510 520 530 540 550
PRDCSNRGLC VDGQCVCEDG FTGPDCAELS CPNDCHGRGR CVNGQCVCHE
560 570 580 590 600
GFMGKDCKGQ RCPSDCHGQG RCVDGQCICH EGFTGLDCGQ HSCPSDCNNL
610 620 630 640 650
GQCVSGRCIC NEGYSGEDCS EVSPPKDLVV TEVTEETVNL AWDNEMRVTE
660 670 680 690 700
YLVVYTPTHE GGLEMQFRVP GDQTSTIIQE LEPGVEYFIR VFAILENKKS
710 720 730 740 750
IPVSARVATY LPAPEGLKFK SIKETSVEVE WDPLDIAFET WEIIFRNMNK
760 770 780 790 800
EDEGEITKSL RRPETSYRQT GLAPGQEYEI SLHIVKNNTR GPGLKRVTTT
810 820 830 840 850
RLDAPSQIEV KDVTDTTALI TWFKPLAEID GIELTYGIKD VPGDRTTIDL
860 870 880 890 900
TEDENQYSIG NLKPDTEYEV SLISRRGDMS SNPAKETFTT GLDAPRNLRR
910 920 930 940 950
VSQTDNSITL EWRNGKAAID SYRIKYAPIS GGDHAEVDVP KSQQATTKTT
960 970 980 990 1000
LTGLRPGTEY GIGVSAVKED KESNPATINA ATELDTPKDL QVSETAETSL
1010 1020 1030 1040 1050
TLLWKTPLAK FDRYRLNYSL PTGQWVGVQL PRNTTSYVLR GLEPGQEYNV
1060 1070 1080 1090 1100
LLTAEKGRHK SKPAHVKAST EQAPELENLT VTEVGWDGLR LNWTAADQAY
1110 1120 1130 1140 1150
EHFIIQVQEA NKVEAARNLT VPGSLRAVDI PGLKAATPYT VSIYGVIQGY
1160 1170 1180 1190 1200
RTPVLSAEAS TGETPNLGEV VVAEVGWDAL KLNWTAPEGA YEYFFIQVQE
1210 1220 1230 1240 1250
ADTVEAAQNL TVPGGLGSTD LPGLKAATHY TITIRGVTQD FSTTPLSVGV
1260 1270 1280 1290 1300
LTEEVPDMGN LTVTEVSWDA LRLNWTTPDG TYDQFTIQVQ EADQVEEAHN
1310 1320 1330 1340 1350
LTVPGSLRSM EIPGLRAGTP YTVTLHGEVR GHSTRPLAVE VVTEDLPQLG
1360 1370 1380 1390 1400
DLAVSEVGWD GLRLNWTAAD NAYEHFVIQV QEVNKVEAAQ NLTLPGSLRA
1410 1420 1430 1440 1450
VDIPGLEAAT PYRVSIYGVI RGYRTPVLSA EASTAMGSPK EVIFSDITEN
1460 1470 1480 1490 1500
SATVSWRAPT AQVESFRITY VPITGGTPSM VTVDGTKTQT RLVKLIPGVE
1510 1520 1530 1540 1550
YLVSIIAMKG FEESEPVSGS FTTALDGPSG LVTANITDSE ALARWQPAIA
1560 1570 1580 1590 1600
TVDSYVISYT GEKVPEITRT VSGNTVEYAL TDLEPATEYT LRIFAEKGPQ
1610 1620 1630 1640 1650
KSSTITAKFT TDLDSPRDLT ATEVQSETAL LTWRPPRASV TGYLLVYESV
1660 1670 1680 1690 1700
DGTVKEVIVG PDTTSYSLAD LSPSTHYTAK IQALNGPLRS NMIQTIFTTI
1710 1720 1730 1740 1750
GLLYPFPKDC SQAMLNGDTT SGLYTIYLNG DKAQALEVFC DMTSDGGGWI
1760 1770 1780 1790 1800
VFLRRKNGRE NFYQNWKAYA AGFGDRREEF WLGLDNLNKI TAQGQYELRV
1810 1820 1830 1840 1850
DLRDHGETAF AVYDKFSVGD AKTRYKLKVE GYSGTAGDSM AYHNGRSFST
1860 1870 1880 1890 1900
FDKDTDSAIT NCALSYKGAF WYRNCHRVNL MGRYGDNNHS QGVNWFHWKG
1910 1920
HEHSIQFAEM KLRPSNFRNL EGRRKRA
Length:1,927
Mass (Da):210,489
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12EF655F61614E2B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC151843 mRNA Translation: AAI51844.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151843 mRNA Translation: AAI51844.1

3D structure databases

SMRiA7MBN2
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA7MBN2
PRIDEiA7MBN2

Phylogenomic databases

HOGENOMiHOG000234355

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TNC human

Family and domain databases

CDDicd00063 FN3, 12 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 12 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR033078 TNC
PANTHERiPTHR46708:SF1 PTHR46708:SF1, 2 hits
PfamiView protein in Pfam
PF07974 EGF_2, 4 hits
PF18720 EGF_Tenascin, 9 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 12 hits
SMARTiView protein in SMART
SM00181 EGF, 13 hits
SM00186 FBG, 1 hit
SM00060 FN3, 12 hits
SUPFAMiSSF49265 SSF49265, 9 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 5 hits
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA7MBN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7MBN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: December 11, 2019
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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