UniProtKB - A7MBC7 (NEMP1_BOVIN)
Protein
Nuclear envelope integral membrane protein 1
Gene
NEMP1
Organism
Bos taurus (Bovine)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Nuclear envelope integral membrane protein 1 |
Gene namesi | Name:NEMP1 Synonyms:TMEM194A |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:56223, NEMP1 |
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity; Multi-pass membrane protein Sequence analysis; Nucleoplasmic side By similarity
- Nucleus envelope By similarity
Note: Colocalizes with lamins and RAN-GTP at the nuclear envelope.By similarity
Nucleus
- nuclear envelope Source: UniProtKB
- nuclear inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 161 – 181 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 186 – 206 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 216 – 236 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 245 – 265 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 289 – 309 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 44 | Sequence analysisAdd BLAST | 44 | |
ChainiPRO_0000343659 | 45 – 445 | Nuclear envelope integral membrane protein 1Add BLAST | 401 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 368 | PhosphoserineBy similarity | 1 | |
Modified residuei | 424 | PhosphoserineBy similarity | 1 | |
Modified residuei | 425 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Phosphorylation may regulate its interaction with RAN-GTP.By similarity
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | A7MBC7 |
PRIDEi | A7MBC7 |
Interactioni
Subunit structurei
Homooligomer.
Interacts with RAN-GTP.
By similarityProtein-protein interaction databases
STRINGi | 9913.ENSBTAP00000019519 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 186 – 297 | A; required for its colocalization with lamins at the nuclear envelopeBy similarityAdd BLAST | 112 | |
Regioni | 336 – 445 | Required for nuclear localizationBy similarityAdd BLAST | 110 | |
Regioni | 336 – 405 | B; required for interaction with RAN-GTPBy similarityAdd BLAST | 70 |
Domaini
The transmembrane domains are required and sufficient for its oligomerization.By similarity
Sequence similaritiesi
Belongs to the NEMP family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3817, Eukaryota |
GeneTreei | ENSGT00390000002174 |
HOGENOMi | CLU_025225_0_0_1 |
InParanoidi | A7MBC7 |
OrthoDBi | 536946at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR019358, NEMP_fam |
PANTHERi | PTHR13598, PTHR13598, 1 hit |
Pfami | View protein in Pfam PF10225, NEMP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A7MBC7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGGMKVAVL PAVGAGPWSW GAGGCGAVRL LLVLFGCFVC GSAGIDLNVV
60 70 80 90 100
TLRESEILFM NTSRQSCYKN VLIPKWHDIW TRIQIRVNSS KLVRVTQVEN
110 120 130 140 150
EDKLKELEQF SIWNFFSSFL KEKLNDTYIN VGLYSTKTCL KVEILEEDTK
160 170 180 190 200
YSVIVTRRFD PKLFLIFLLG LTLFFCGDLL SRSQIFYYST GMSVGIVASL
210 220 230 240 250
LIIIFIVSKF MPKKSPIYII LVGGWSFSLY LIQLVFKNLQ EIWRCYWQYL
260 270 280 290 300
LSYVLAVGFM SFAVCYKYGP LENERSINLL TWTLQLLGLC FMYSSIQIPH
310 320 330 340 350
IALAIVVIAL CTKNLDYPIH WLYITYRKMC KATEKTVPPR LLTEEEYRLQ
360 370 380 390 400
GEVETRKALE QLREYCNSPD CSAWKTVSRI QSPKRFADFV EGSFHLTPNE
410 420 430 440
VSVHEQEYGL GSIIAQDELS EETSSEEEDS DSRYPLVVQQ NSFLT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC151486 mRNA Translation: AAI51487.1 |
RefSeqi | NP_001095631.1, NM_001102161.1 |
Genome annotation databases
Ensembli | ENSBTAT00000019519; ENSBTAP00000019519; ENSBTAG00000014659 |
GeneIDi | 533988 |
KEGGi | bta:533988 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC151486 mRNA Translation: AAI51487.1 |
RefSeqi | NP_001095631.1, NM_001102161.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000019519 |
Proteomic databases
PaxDbi | A7MBC7 |
PRIDEi | A7MBC7 |
Genome annotation databases
Ensembli | ENSBTAT00000019519; ENSBTAP00000019519; ENSBTAG00000014659 |
GeneIDi | 533988 |
KEGGi | bta:533988 |
Organism-specific databases
CTDi | 23306 |
VGNCi | VGNC:56223, NEMP1 |
Phylogenomic databases
eggNOGi | KOG3817, Eukaryota |
GeneTreei | ENSGT00390000002174 |
HOGENOMi | CLU_025225_0_0_1 |
InParanoidi | A7MBC7 |
OrthoDBi | 536946at2759 |
Gene expression databases
ExpressionAtlasi | A7MBC7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR019358, NEMP_fam |
PANTHERi | PTHR13598, PTHR13598, 1 hit |
Pfami | View protein in Pfam PF10225, NEMP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NEMP1_BOVIN | |
Accessioni | A7MBC7Primary (citable) accession number: A7MBC7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 22, 2008 |
Last sequence update: | October 2, 2007 | |
Last modified: | February 10, 2021 | |
This is version 62 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families