Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Docking protein 2

Gene

DOK2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-210993 Tie2 Signaling
R-BTA-8853659 RET signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Docking protein 2
Alternative name(s):
Downstream of tyrosine kinase 2
Gene namesi
Name:DOK2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 8

Organism-specific databases

VGNCiVGNC:28166 DOK2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003562801 – 413Docking protein 2Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei271PhosphotyrosineBy similarity1
Modified residuei300PhosphotyrosineBy similarity1
Modified residuei346PhosphotyrosineBy similarity1

Post-translational modificationi

On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-346 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-300 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA7MBB8
PRIDEiA7MBB8

Expressioni

Gene expression databases

BgeeiENSBTAG00000003341 Expressed in 10 organ(s), highest expression level in spleen

Interactioni

Subunit structurei

Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000004337

Structurei

3D structure databases

ProteinModelPortaliA7MBB8
SMRiA7MBB8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 114PHPROSITE-ProRule annotationAdd BLAST111
Domaini147 – 252IRS-type PTBPROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi250 – 290Pro-richAdd BLAST41
Compositional biasi322 – 364Pro-richAdd BLAST43

Domaini

PTB domain mediates receptor interaction.By similarity

Sequence similaritiesi

Belongs to the DOK family. Type A subfamily.Curated

Phylogenomic databases

eggNOGiKOG4047 Eukaryota
ENOG410XS2S LUCA
GeneTreeiENSGT00730000110348
HOGENOMiHOG000112245
HOVERGENiHBG018962
InParanoidiA7MBB8
KOiK20234
OMAiEYAVPFD
OrthoDBiEOG091G075T
TreeFamiTF324994

Family and domain databases

CDDicd01203 PTB_DOK1_DOK2_DOK3, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR037751 Dok1/2/3_PTB
IPR002404 IRS_PTB
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PfamiView protein in Pfam
PF02174 IRS, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SM00310 PTBI, 1 hit
PROSITEiView protein in PROSITE
PS51064 IRS_PTB, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequencei

Sequence statusi: Complete.

A7MBB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDVVVKQGF LYLQQQQTFG KKWRRFGAAL YGGSGCALAR LELQEGSEKS
60 70 80 90 100
RRGEAPRRVI RLNDCLRVSE ASGEASSPRD TSTFFLETTE RLYLLAAPTA
110 120 130 140 150
ERGDWIQAIC LLAFPGRRKE LSGLEGKGGR PRMEENELYS STTAGTPQKE
160 170 180 190 200
FAVTVRPTEV SERCRLRGSY TLRVGESALE LWGGPESGTQ LYEWPYRFLR
210 220 230 240 250
RFGRDKVTFS FEAGRRCVSG EGNFEFETRQ GNEIFLALEE AISAQKNAAP
260 270 280 290 300
PGPQTQPVPV PAVLPRPESP YARPHDSLPP PSPTVPVPTP RQQRGLEGEY
310 320 330 340 350
AVPFDAVARS LGKSLRGVLA VPPQLPADPL YDSIEDHPPP RPDHIYDEPE
360 370 380 390 400
GMAALALYDS PQEPRGEAWR RQATADRDSS GLKHGYIVGQ DFAASGWPQG
410
TEYDNVVLKK GPK
Length:413
Mass (Da):45,729
Last modified:October 2, 2007 - v1
Checksum:i86A6B66F6EA11B11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151468 mRNA Translation: AAI51469.1
RefSeqiNP_001095472.1, NM_001102002.2
UniGeneiBt.2069

Genome annotation databases

EnsembliENSBTAT00000004337; ENSBTAP00000004337; ENSBTAG00000003341
GeneIDi514616
KEGGibta:514616

Similar proteinsi

Entry informationi

Entry nameiDOK2_BOVIN
AccessioniPrimary (citable) accession number: A7MBB8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: October 2, 2007
Last modified: September 12, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again