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Entry version 79 (08 May 2019)
Sequence version 1 (02 Oct 2007)
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Protein

SKI family transcriptional corepressor 2

Gene

Skor2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a TGF-beta antagonist in the nervous system (By similarity). Exhibits transcriptional repressor activity.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SKI family transcriptional corepressor 2
Alternative name(s):
Fussel-18 homolog
LBX1 corepressor 1-like protein
Ladybird homeobox corepressor 1-like protein
Transcriptional corepressor Corl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Skor2
Synonyms:Corl2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3645984 Skor2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003346121 – 1008SKI family transcriptional corepressor 2Add BLAST1008

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A7M7C7

PRoteomics IDEntifications database

More...
PRIDEi
A7M7C7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A7M7C7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A7M7C7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is restricted to adult and embryonic central nervous system. Expressed at high levels in the developing cerebellum, ventral metencephalon and myelencephalon at 12.5 dpc (at protein level). In the adult cerebellum, expressed specifically in Purkinje cells.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected at 11 dpc and expression continues into adulthood with higher levels in embryonic than adult brain. In developing brain, not expressed in neural progenitors during the proliferative phase but expression is detected in postmitotic neural precursors shortly after exiting the cell cycle.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000091519 Expressed in 8 organ(s), highest expression level in dorsal root ganglion

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMAD2 and SMAD3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000132338

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A7M7C7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi261 – 371Ala-richAdd BLAST111
Compositional biasi285 – 293Pro-rich9
Compositional biasi464 – 705Pro-richAdd BLAST242
Compositional biasi601 – 665His-richAdd BLAST65
Compositional biasi723 – 766Glu-richAdd BLAST44
Compositional biasi829 – 835Poly-Pro7

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SKI family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEFD Eukaryota
ENOG410XPY0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160474

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7M7C7

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLQMIPY

Database of Orthologous Groups

More...
OrthoDBi
1034068at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A7M7C7

TreeFam database of animal gene trees

More...
TreeFami
TF324133

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.260.20, 1 hit
3.10.390.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR003380 SKI/SNO/DAC
IPR028376 SKI_corepress_2
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN

The PANTHER Classification System

More...
PANTHERi
PTHR10005 PTHR10005, 1 hit
PTHR10005:SF7 PTHR10005:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7M7C7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASSPLPGPN DILLASPSSA FQPDALSQPR PGHANLKPNQ VGQVILYGIP
60 70 80 90 100
IVSLVIDGQE RLCLAQISNT LLKNFSYNEI HNRRVALGIT CVQCTPVQLE
110 120 130 140 150
ILRRAGAMPI SSRRCGMITK REAERLCKSF LGENRPPKLP DNFAFDVSHE
160 170 180 190 200
CAWGCRGSFI PARYNSSRAK CIKCSYCNMY FSPNKFIFHS HRTPDAKYTQ
210 220 230 240 250
PDAANFNSWR RHLKLTDKSP QDELVFAWED VKAMFNGGSR KRALPQPSAH
260 270 280 290 300
PACHPLSSVK AAAVAAAAAV AGGGGLLGPH LLGAPPPPPP PPPLAELAGA
310 320 330 340 350
PHAHHKRPRF DDDDDSLQEA AVVAAASLSA AAASLSVAAA TGGAGPGAGG
360 370 380 390 400
PGGGCVAGVG VGASAGAGAA AGTKGPRSYP VIPVPSKGSF GGVLQKFPGC
410 420 430 440 450
GGLFPHPYTF PAAAAAFGLC HKKEDAGTAA EALGGAGAGS AGAAPKAGLS
460 470 480 490 500
GLFWPAGRKD AFYPPFCMFW PPRTPGGLPV PTYLQPPPQP PSALGCALGD
510 520 530 540 550
SPALLRQAFL DLAEPGGAGG SAEAAPPPGQ PPPVVANGPG SGPPATGGTG
560 570 580 590 600
ARDTLFESPP GGSGGDCSAG STPPAEQGVT SGTGSASSGA GSVGTRVPAP
610 620 630 640 650
HHPHLLEGRK AGGGSYHHSS AFRPVGGKDD AESLAKLHGA SAGTPHSAPA
660 670 680 690 700
HHHHHHHHPH HHHHHPPQPP SPLLLLQPQP DEPGSERHHP APPPPPPPPP
710 720 730 740 750
LAPQPHHRGL LSPEGTSCSY PSEDSSEDEE DEEEEQEVDV EGHKPLEGEE
760 770 780 790 800
EEDGRDPEDE EEEDEETRVL LGDSLVGGGR FLQGRGLSEK GSGRDRTTPA
810 820 830 840 850
VGAFPLALNS SRLLQEDGKL GDSGGSDLPA PPPPPLAPQK ASSSGGSRPG
860 870 880 890 900
SPVHHPSLEE EPSYKDNQKP KENNQVIIST KDDNFSDKNK GHGFFITDSD
910 920 930 940 950
SSGDFWRERS GEHTQETNSP HSLKKDVENM GKEELQKVLF EQIDLRRRLE
960 970 980 990 1000
QEFQVLKGNT SFPVFNNFQD QMKRELAYRE EMVQQLQIIP YAASLIRKEK

LGAHLSKS
Length:1,008
Mass (Da):105,616
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i365AD6D63C0D50C4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB358976 mRNA Translation: BAF76044.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50322.1

NCBI Reference Sequences

More...
RefSeqi
NP_001103213.1, NM_001109743.1
XP_006526499.1, XM_006526436.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000166956; ENSMUSP00000132338; ENSMUSG00000091519

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
664805

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:664805

UCSC genome browser

More...
UCSCi
uc008fqq.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB358976 mRNA Translation: BAF76044.1
CCDSiCCDS50322.1
RefSeqiNP_001103213.1, NM_001109743.1
XP_006526499.1, XM_006526436.3

3D structure databases

SMRiA7M7C7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132338

PTM databases

iPTMnetiA7M7C7
PhosphoSitePlusiA7M7C7

Proteomic databases

PaxDbiA7M7C7
PRIDEiA7M7C7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000166956; ENSMUSP00000132338; ENSMUSG00000091519
GeneIDi664805
KEGGimmu:664805
UCSCiuc008fqq.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
652991
MGIiMGI:3645984 Skor2

Phylogenomic databases

eggNOGiENOG410IEFD Eukaryota
ENOG410XPY0 LUCA
GeneTreeiENSGT00940000160474
InParanoidiA7M7C7
OMAiQLQMIPY
OrthoDBi1034068at2759
PhylomeDBiA7M7C7
TreeFamiTF324133

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A7M7C7

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000091519 Expressed in 8 organ(s), highest expression level in dorsal root ganglion

Family and domain databases

Gene3Di3.10.260.20, 1 hit
3.10.390.10, 1 hit
InterProiView protein in InterPro
IPR014890 c-SKI_SMAD4-bd_dom
IPR009061 DNA-bd_dom_put_sf
IPR010919 SAND-like_dom_sf
IPR003380 SKI/SNO/DAC
IPR028376 SKI_corepress_2
IPR037000 Ski_DNA-bd_sf
IPR023216 Tscrpt_reg_SKI_SnoN
PANTHERiPTHR10005 PTHR10005, 1 hit
PTHR10005:SF7 PTHR10005:SF7, 1 hit
PfamiView protein in Pfam
PF08782 c-SKI_SMAD_bind, 1 hit
PF02437 Ski_Sno, 1 hit
SMARTiView protein in SMART
SM01046 c-SKI_SMAD_bind, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF63763 SSF63763, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKOR2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7M7C7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: October 2, 2007
Last modified: May 8, 2019
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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