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Protein

Lantibiotic

Gene

tepA

Organism
Streptococcus thermophilus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Bacteriocin, LantibioticUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
LantibioticUniRule annotation
Gene namesi
Name:tepAImported
OrganismiStreptococcus thermophilusImported
Taxonomic identifieri1308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Post-translational modificationi

Maturation of lantibiotics involves the enzymic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor.UniRule annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

SMRiA7M695
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the type A lantibiotic family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR007682 Lantibiotic_typ-A_Lactobact
PfamiView protein in Pfam
PF04604 L_biotic_typeA, 1 hit

Sequencei

Sequence statusi: Complete.

A7M695-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNATENQIF VETVSDQELE MLIGGADRGW IKTLTKDCPN VISSICAGTI

ITACKNCA
Length:58
Mass (Da):6,250
Last modified:October 2, 2007 - v1
Checksum:i8E3555B7069F6C43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB232046 Genomic DNA Translation: BAF75720.1
AB434921 Genomic DNA Translation: BAJ10685.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB232046 Genomic DNA Translation: BAF75720.1
AB434921 Genomic DNA Translation: BAJ10685.1

3D structure databases

SMRiA7M695
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR007682 Lantibiotic_typ-A_Lactobact
PfamiView protein in Pfam
PF04604 L_biotic_typeA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA7M695_STRTR
AccessioniPrimary (citable) accession number: A7M695
Entry historyiIntegrated into UniProtKB/TrEMBL: October 2, 2007
Last sequence update: October 2, 2007
Last modified: May 23, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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