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UniProtKB - A7LXS9 (BGH2A_BACO1)

Entry version 68 (25 May 2022)
Sequence version 1 (02 Oct 2007)
Previous versions | rss
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Protein

Beta-galactosidase BoGH2A

Gene

BACOVA_02645

Organism
Bacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides in xyloglucan degradation, converting 'L' units to 'X' units.

1 Publication

Miscellaneous

Gut bacteria supply the human body with energy from dietary polysaccharides through glycosidases that are absent in the human genome. Xyloglucans are a ubiquitous family of highly branched plant cell wall polysaccharides present in the vegetables we consume. Enzymes involved in xyloglucan degradation mediate the conversion of otherwise indigestible plant polysaccharides to short-chain fatty acids (PubMed:24463512).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 4.0 sec(-1) for Gal-beta-PNP.
  1. KM=0.087 mM for Gal-beta-PNP1 Publication

pH dependencei

Optimum pH is 6.0-7.0.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: xyloglucan degradation

This protein is involved in the pathway xyloglucan degradation, which is part of Glucan metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway xyloglucan degradation and in Glucan metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei437Proton donorBy similarity1
Active sitei544NucleophileBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation

Enzyme and pathway databases

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		A7LXS9

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA01045

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GH2, Glycoside Hydrolase Family 2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-galactosidase BoGH2A (EC:3.2.1.23)
Short name:
Beta-gal
Alternative name(s):
Glycosyl hydrolase family protein 2A
Short name:
BoGH2A
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:BACOVA_02645
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacteroides ovatus (strain ATCC 8483 / DSM 1896 / JCM 5824 / BCRC 10623 / CCUG 4943 / NCTC 11153)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri411476 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Bacteroidetes › Bacteroidia › Bacteroidales › Bacteroidaceae › Bacteroides ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005475 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000042589120 – 851Beta-galactosidase BoGH2AAdd BLAST832

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi20N-palmitoyl cysteineSequence analysis1
Lipidationi20S-diacylglycerol cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		A7LXS9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		411476.BACOVA_02645

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		A7LXS9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A7LXS9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG3250, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006501_0_1_10

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036156, Beta-gal/glucu_dom_sf
IPR032311, DUF4982
IPR008979, Galactose-bd-like_sf
IPR040605, Glyco_hydro2_dom5
IPR006101, Glyco_hydro_2
IPR023232, Glyco_hydro_2_AS
IPR006103, Glyco_hydro_2_cat
IPR006102, Glyco_hydro_2_Ig-like
IPR006104, Glyco_hydro_2_N
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold
IPR008964, Invasin/intimin_cell_adhesion

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16355, DUF4982, 1 hit
PF18565, Glyco_hydro2_C5, 1 hit
PF00703, Glyco_hydro_2, 1 hit
PF02836, Glyco_hydro_2_C, 1 hit
PF02837, Glyco_hydro_2_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00132, GLHYDRLASE2

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49303, SSF49303, 1 hit
SSF49373, SSF49373, 1 hit
SSF49785, SSF49785, 1 hit
SSF51445, SSF51445, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00608, GLYCOSYL_HYDROL_F2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A7LXS9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMIGKLKYLM LGGCLILGSC LALGGCLMLL GACSSSSLVS PRERSDFNAD 
        60         70         80         90        100
WRFHLGDGLQ AAQPGFADND WRVLDLPHDW AIEGDFSQEN PSGTGGGALP 
       110        120        130        140        150
GGVGWYRKTF SVDKADAGKI FRIEFDGVYM NSEVFINGVS LGVRPYGYIS 
       160        170        180        190        200
FSYDLTPYLK WDEPNVLAVR VDNAEQPNSR WYSGCGIYRN VWLSKTGPIH 
       210        220        230        240        250
VGGWGTYVTT SSVDEKQAVL NLATTLVNES DTNENVTVCS SLQDAEGREV 
       260        270        280        290        300
AETRSSGEAE AGKEVVFTQQ LTVKQPQLWD IDTPYLYTLV TKVMRNEECM 
       310        320        330        340        350
DRYTTPVGIR TFSLDARKGF TLNGRQTKIN GVCMHHDLGC LGAAVNTRAI 
       360        370        380        390        400
ERHLQILKEM GCNGIRCSHN PPAPELLDLC DRMGFIVMDE AFDMWRKKKT 
       410        420        430        440        450
AHDYARYFNE WHERDLNDFI LRDRNHPSVF MWSIGNEVLE QWSDAKADTL 
       460        470        480        490        500
SLEEANLILN FGHSSEMLAK EGEESVNSLL TKKLVSFVKG LDPTRPVTAG 
       510        520        530        540        550
CNEPNSGNHL FRSGVLDVIG YNYHNKDIPN VPANFPDKPF IITESNSALM 
       560        570        580        590        600
TRGYYRMPSD RMFIWPKRWD KSFADSTFAC SSYENCHVPW GNTHEESLKL 
       610        620        630        640        650
VRDNDFISGQ YVWTGFDYIG EPTPYGWPAR SSYFGIVDLA GFPKDVYYLY 
       660        670        680        690        700
QSEWTDKQVL HLFPHWNWTP GQEIDMWCYY NQADEVELFV NGKSQGVKRK 
       710        720        730        740        750
DLDNLHVAWR VKFEPGTVKV IARESGKVVA EKEICTAGKP AEIRLTPDRS 
       760        770        780        790        800
ILTADGKDLC FVTVEVLDEK GNLCPDADNL VNFTVQGNGF IAGVDNGNPV 
       810        820        830        840        850
SMERFKDEKR KAFYGKCLVV IQNDGKPGKA KLTATSEGLR QAVLKISAEE 

L
Length:851
Mass (Da):95,475
Last modified:October 2, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8D45DE63D7DAD6D4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAXF02000049 Genomic DNA Translation: EDO11436.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		EDO11436; EDO11436; BACOVA_02645

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAXF02000049 Genomic DNA Translation: EDO11436.1

3D structure databases

AlphaFoldDBiA7LXS9
SMRiA7LXS9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi411476.BACOVA_02645

Protein family/group databases

CAZyiGH2, Glycoside Hydrolase Family 2

Proteomic databases

PRIDEiA7LXS9

Genome annotation databases

EnsemblBacteriaiEDO11436; EDO11436; BACOVA_02645

Phylogenomic databases

eggNOGiCOG3250, Bacteria
HOGENOMiCLU_006501_0_1_10

Enzyme and pathway databases

UniPathwayiUPA01045
SABIO-RKiA7LXS9

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR036156, Beta-gal/glucu_dom_sf
IPR032311, DUF4982
IPR008979, Galactose-bd-like_sf
IPR040605, Glyco_hydro2_dom5
IPR006101, Glyco_hydro_2
IPR023232, Glyco_hydro_2_AS
IPR006103, Glyco_hydro_2_cat
IPR006102, Glyco_hydro_2_Ig-like
IPR006104, Glyco_hydro_2_N
IPR017853, Glycoside_hydrolase_SF
IPR013783, Ig-like_fold
IPR008964, Invasin/intimin_cell_adhesion
PfamiView protein in Pfam
PF16355, DUF4982, 1 hit
PF18565, Glyco_hydro2_C5, 1 hit
PF00703, Glyco_hydro_2, 1 hit
PF02836, Glyco_hydro_2_C, 1 hit
PF02837, Glyco_hydro_2_N, 1 hit
PRINTSiPR00132, GLHYDRLASE2
SUPFAMiSSF49303, SSF49303, 1 hit
SSF49373, SSF49373, 1 hit
SSF49785, SSF49785, 1 hit
SSF51445, SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00608, GLYCOSYL_HYDROL_F2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBGH2A_BACO1
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7LXS9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 19, 2014
Last sequence update: October 2, 2007
Last modified: May 25, 2022
This is version 68 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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