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Entry version 69 (02 Dec 2020)
Sequence version 1 (11 Sep 2007)
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Protein

Sialoadhesin

Gene

SIGLEC1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis (By similarity).

Acts as an endocytic receptor mediating clathrin dependent endocytosis. In case of porcine reproductive and respiratory syndrome virus (PRRSV), mediates virion attachment and internalization into alveolar macrophages through a clathrin-coated dependent process.

By similarity3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63Sialic acidBy similarity1
Binding sitei116Sialic acidBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHost cell receptor for virus entry, Receptor
Biological processCell adhesion, Endocytosis, Host-virus interaction
LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sialoadhesin
Short name:
pSn
Alternative name(s):
Sialic acid-binding Ig-like lectin 1
Short name:
Siglec-1
p210
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIGLEC1
Synonyms:SA, SN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced
  • UP000008227 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini20 – 1642ExtracellularSequence analysisAdd BLAST1623
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1643 – 1663HelicalSequence analysisAdd BLAST21
Topological domaini1664 – 1730CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi116R → E: Loss of sialic acid binding. Inhibits PRRSV virus attachment and internalization to alveolar macrophages. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000039817820 – 1730SialoadhesinAdd BLAST1711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi36 ↔ 166PROSITE-ProRule annotation
Disulfide bondi41 ↔ 98PROSITE-ProRule annotation
Disulfide bondi160 ↔ 217PROSITE-ProRule annotation
Disulfide bondi262 ↔ 305PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi346 ↔ 390PROSITE-ProRule annotation
Disulfide bondi433 ↔ 491PROSITE-ProRule annotation
Glycosylationi499N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi531 ↔ 575PROSITE-ProRule annotation
Disulfide bondi624 ↔ 689PROSITE-ProRule annotation
Glycosylationi726N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi729 ↔ 773PROSITE-ProRule annotation
Glycosylationi730N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi816 ↔ 875PROSITE-ProRule annotation
Disulfide bondi915 ↔ 959PROSITE-ProRule annotation
Disulfide bondi1004 ↔ 1066PROSITE-ProRule annotation
Glycosylationi1103N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1193 ↔ 1241PROSITE-ProRule annotation
Disulfide bondi1281 ↔ 1324PROSITE-ProRule annotation
Disulfide bondi1367 ↔ 1426PROSITE-ProRule annotation
Disulfide bondi1466 ↔ 1512PROSITE-ProRule annotation
Disulfide bondi1555 ↔ 1614PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A7LCJ3

PRoteomics IDEntifications database

More...
PRIDEi
A7LCJ3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with porcine reproductive respiratory syndrome virus glycoprotein 5.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A7LCJ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini23 – 135Ig-like V-typeAdd BLAST113
Domaini139 – 227Ig-like C2-type 1Add BLAST89
Domaini238 – 316Ig-like C2-type 2Add BLAST79
Domaini317 – 405Ig-like C2-type 3Add BLAST89
Domaini415 – 505Ig-like C2-type 4Add BLAST91
Domaini511 – 593Ig-like C2-type 5Add BLAST83
Domaini601 – 705Ig-like C2-type 6Add BLAST105
Domaini708 – 790Ig-like C2-type 7Add BLAST83
Domaini798 – 893Ig-like C2-type 8Add BLAST96
Domaini897 – 976Ig-like C2-type 9Add BLAST80
Domaini983 – 1082Ig-like C2-type 10Add BLAST100
Domaini1083 – 1165Ig-like C2-type 11Add BLAST83
Domaini1172 – 1257Ig-like C2-type 12Add BLAST86
Domaini1259 – 1335Ig-like C2-type 13Add BLAST77
Domaini1346 – 1442Ig-like C2-type 14Add BLAST97
Domaini1443 – 1529Ig-like C2-type 15Add BLAST87
Domaini1537 – 1630Ig-like C2-type 16Add BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni19 – 150Necessary for PRRSV virus attachment to alveolar macrophageAdd BLAST132
Regioni122 – 126Sialic acid bindingBy similarity5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The sialic acid-binding domain is essential for efficient PRRSV virus attachment and internalization to alveolar macrophages.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7LCJ3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 17 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08205, C2-set_2, 1 hit
PF07679, I-set, 2 hits
PF13895, Ig_2, 5 hits
PF07686, V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 16 hits
SM00408, IGc2, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 14 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A7LCJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFLLLLLLL ASSALAGLAS WTVSRPETVQ GIKGSCLIIP CTFGFPANVE
60 70 80 90 100
VPHGITAIWY YDYSGKRLVV SHSRNPKVVE NHFQGRALLL GQAEQRTCSL
110 120 130 140 150
LLKDLQPQDS GSYNFRFEIS EGNRWSDVKG TVVTVTEVPS VPTIALPAKL
160 170 180 190 200
HEGMEVDFNC STPYVCPTEP VNLQWQGQDP TRSVTSHLQK LEPSGTSHME
210 220 230 240 250
TLHMALSWQD HGRILSCQVS AAERRMQKEI HLQVQHAPKG VEILFSHSGR
260 270 280 290 300
NVLPGDLVTL SCQVNSSNPQ VSSVQWVKDG TKLKDQKRVL QLRRAAWADA
310 320 330 340 350
GVYTCQAGNA VGSSVSPPVS LHVFMAEVQV SPVGSILENQ TVTLACNTPK
360 370 380 390 400
EAPSELRYSW CKNHALLEGS HSRTLRLHSV TRADSGFYFC EVQNARGRER
410 420 430 440 450
SPPVSVVVSH PPLTPDLTAF PETQAGLVGI LQCSVVSEPP ATLVLSHGGL
460 470 480 490 500
ISASTSGEGD HSPRFSVASA PNSLRLEIQD LGPTDSGEYM CSASSSLGNA
510 520 530 540 550
SSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSSLSLMPD TRFSWYLNGA
560 570 580 590 600
LILEGPSSSL LLPAASSTDA GSYHCRAQNS HSTSGPSPPA VLTVLRAPRQ
610 620 630 640 650
PVFTAQLDPD TAGAGAGRQG LLLCRVDSDP PAQLQLLHRG RVVASSLSWG
660 670 680 690 700
GGCCTCGGCF QRMKVTKAPN LLRVEIRDPA LEDEGVYLCE ASSALGNASA
710 720 730 740 750
SATLDAQATV LVITPSHTLQ EGIEANLTCN VSREASGPAN FSWFRDGALW
760 770 780 790 800
AQGPLDTVTL LPVSRTDAAL YACRIVTEAG AGLSTPVALN VLYPPDPPKL
810 820 830 840 850
SALLDVDQGH TAVFVCTVDS HPLAQLALFR GEHLLAASSA LRLPPRGRLQ
860 870 880 890 900
AKASANSLQL EVRDLSLGDS GSYHCEATNI LGSANTSLTF QVRGAWVRVS
910 920 930 940 950
PSPELQEGQA VVLSCQVPIG VLEGTSYRWY RDGQPLQEST SATLRFAAIT
960 970 980 990 1000
LSQAGAYHCQ AQASGSATTD LAAPVSLHVT YAPRQATLTT LMDSGLGRLG
1010 1020 1030 1040 1050
LLLCRVNSDP PAQLRLLHGS RLVASTLQGV EELAGSSPRL QVATAPNTLR
1060 1070 1080 1090 1100
LEIHNAVLED EGVYTCEATN TLGQTLASAA LDAQAMRVQV WPNATVQEGQ
1110 1120 1130 1140 1150
LVNLTRLVWT THLAQLTYTW YRDQQQLPGA AHSILLPNVT VTDAASYRCG
1160 1170 1180 1190 1200
ILIPGQALRL SRPVALDVLY APRRLRLTHL LESRGGQLAV VLCTVDSRPA
1210 1220 1230 1240 1250
AQLTLSHAGR LLASSTAASV PNTLRLELWE PRPSDEGLYS CSARSPLGQA
1260 1270 1280 1290 1300
NTSLELRLEG VQVALAPSAT VPEGAPVTVT CEDPAARPPT LYVWYHNSRW
1310 1320 1330 1340 1350
LQEGSAASLS FPAATRAHAG AYTCQVQDAQ GTRISQPAAL HILYAPRDAV
1360 1370 1380 1390 1400
LSSFWDSRAS PMAVVQCTVD SEPPAEMTLS HDGKVLATSQ GVHGLAVGTG
1410 1420 1430 1440 1450
HVQVARNALQ LRVQNVPSRD KDTYVCMDRN SLGSVSTMGQ LQPEGVHVVA
1460 1470 1480 1490 1500
EPGLDVPEGT ALNLSCRLPS GPGHIGNSTF AWFRNGRQLH TESVPTFTFT
1510 1520 1530 1540 1550
HVARAQAGLY HCQAELPAGA ATSAPVLLRV LYPPKTPTMT VFVEPEGGIQ
1560 1570 1580 1590 1600
GILDCRVDSE PLASLTLHLG SRLVASSQPQ AAPAKPHIRV SASPNALRVD
1610 1620 1630 1640 1650
MEELKPSDQG EYVCSASNAL GSASAATYFG TRALHRLHLF QHLLWFLGLL
1660 1670 1680 1690 1700
ASLLFLLLGL GVWYAWRRGN FHKLRMGEYS VEMVSRKETT QMSTDQEEVT
1710 1720 1730
GIGDDAGSVN QAAFDPAHLC ENTQSVKSTV
Length:1,730
Mass (Da):184,912
Last modified:September 11, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA1F1EBB6F33150C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti25R → S in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti25R → S in ABA55712 (Ref. 3) Curated1
Sequence conflicti93A → V in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti93A → V in ABA55712 (Ref. 3) Curated1
Sequence conflicti236H → Y in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti236H → Y in ABA55712 (Ref. 3) Curated1
Sequence conflicti361C → Y in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti361C → Y in ABA55712 (Ref. 3) Curated1
Sequence conflicti421P → L in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti421P → L in ABA55712 (Ref. 3) Curated1
Sequence conflicti452S → L in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti452S → L in ABA55712 (Ref. 3) Curated1
Sequence conflicti547L → R in ABA55712 (Ref. 3) Curated1
Sequence conflicti552I → L in ABA55712 (Ref. 3) Curated1
Sequence conflicti579N → S in ABA55712 (Ref. 3) Curated1
Sequence conflicti583T → A in ABA55712 (Ref. 3) Curated1
Sequence conflicti588P → S in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti588P → S in ABA55712 (Ref. 3) Curated1
Sequence conflicti596R → Y in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti596R → Y in ABA55712 (Ref. 3) Curated1
Sequence conflicti661Q → H in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti661Q → H in ABA55712 (Ref. 3) Curated1
Sequence conflicti680A → V in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti680A → V in ABA55712 (Ref. 3) Curated1
Sequence conflicti764S → A in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti764S → A in ABA55712 (Ref. 3) Curated1
Sequence conflicti821H → R in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti821H → R in ABA55712 (Ref. 3) Curated1
Sequence conflicti839S → L in ABA55712 (Ref. 3) Curated1
Sequence conflicti846R → H in ABA55712 (Ref. 3) Curated1
Sequence conflicti874H → R in ABA55712 (Ref. 3) Curated1
Sequence conflicti964S → P in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti964S → P in ABA55712 (Ref. 3) Curated1
Sequence conflicti1081L → F in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti1081L → F in ABA55712 (Ref. 3) Curated1
Sequence conflicti1106R → C in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti1106R → C in ABA55712 (Ref. 3) Curated1
Sequence conflicti1275A → T in ABA55712 (Ref. 3) Curated1
Sequence conflicti1381H → R in ABA55712 (Ref. 3) Curated1
Sequence conflicti1390Q → H in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti1392V → A in ABA55712 (Ref. 3) Curated1
Sequence conflicti1425V → I in ABA55712 (Ref. 3) Curated1
Sequence conflicti1428D → A in ABA55712 (Ref. 3) Curated1
Sequence conflicti1468L → F in ABA55712 (Ref. 3) Curated1
Sequence conflicti1475I → M in ABA55712 (Ref. 3) Curated1
Sequence conflicti1497F → L in AAP47136 (PubMed:12857889).Curated1
Sequence conflicti1497F → L in ABA55712 (Ref. 3) Curated1
Sequence conflicti1672H → Y in AAP47136 (PubMed:12857889).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF509585 mRNA Translation: AAP47136.1
EU003993 mRNA Translation: ABS19664.1
DQ176853 mRNA Translation: ABA55712.1

NCBI Reference Sequences

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RefSeqi
NP_999511.1, NM_214346.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
397623

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ssc:397623

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF509585 mRNA Translation: AAP47136.1
EU003993 mRNA Translation: ABS19664.1
DQ176853 mRNA Translation: ABA55712.1
RefSeqiNP_999511.1, NM_214346.1

3D structure databases

SMRiA7LCJ3
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA7LCJ3
PRIDEiA7LCJ3

Genome annotation databases

GeneIDi397623
KEGGissc:397623

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6614

Phylogenomic databases

InParanoidiA7LCJ3

Family and domain databases

Gene3Di2.60.40.10, 17 hits
InterProiView protein in InterPro
IPR013162, CD80_C2-set
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
PfamiView protein in Pfam
PF08205, C2-set_2, 1 hit
PF07679, I-set, 2 hits
PF13895, Ig_2, 5 hits
PF07686, V-set, 1 hit
SMARTiView protein in SMART
SM00409, IG, 16 hits
SM00408, IGc2, 14 hits
SUPFAMiSSF48726, SSF48726, 14 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 15 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSN_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7LCJ3
Secondary accession number(s): Q2VF24, Q7YRQ7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: September 11, 2007
Last modified: December 2, 2020
This is version 69 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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