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  1. 1
    "Alterations of CDKN2A/2B and its 5Mb telomeric SH3GL2 loci are independently associated with the development of early dysplastic lesions of head and neck: correlation with HPV infection and tobacco habit."
    Panda C.K., Ghosh A., Roychoudhury S.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Category: Sequences.
    Source: UniProtKB/TrEMBL (unreviewed).
  2. 2
    "Frequent deletion and methylation in SH3GL2 and CDKN2A loci are associated with early- and late-onset breast carcinoma."
    Sinha S., Chunder N., Mukherjee N., Alam N., Roy A., Roychoudhury S., Kumar Panda C.
    Ann Surg Oncol 15:1070-1080(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Expression, Sequences.
    Annotation: Alterations of SH3GL2 and CDKN2A loci have a synergistic role in the development of early-onset breast cancer.
    Source: GeneRIF:6456.

    This publication is mapped to 9 other entries.

  3. 3
    "Ataxin-2 associates with the endocytosis complex and affects EGF receptor trafficking."
    Nonis D., Schmidt M.H., van de Loo S., Eich F., Dikic I., Nowock J., Auburger G.
    Cell. Signal. 20:1725-1739(2008) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: These data implicate ataxin-2 to play a role in endocytic receptor cycling.
    Source: GeneRIF:6456.

    This publication is cited by 7 and mapped to 65 other entries.

  4. 4
    Category: Pathology & Biotech.
    Annotation: Associated with IMMUNE: multiple sclerosis.
    Source: GAD:599607.

    This publication is mapped to 129 other entries.

  5. 5
    "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia."
    Martins-de-Souza D., Gattaz W.F., Schmitt A., Rewerts C., Maccarrone G., Dias-Neto E., Turck C.W.
    Eur Arch Psychiatry Clin Neurosci 259:151-163(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Subcellular Location.
    Annotation: Using shotgun mass spectrometry we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
    Source: GeneRIF:6456.

    This publication is mapped to 495 other entries.

  6. 6
    "Multi-ethnic genetic association study of carotid intima-media thickness using a targeted cardiovascular SNP microarray."
    Lanktree M.B., Hegele R.A., Yusuf S., Anand S.S.
    Stroke 40:3173-3179(2009) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Pathology & Biotech.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:6456.

    This publication is mapped to 50 other entries.

  7. 7
    Category: Pathology & Biotech.
    Annotation: Associated with NEUROLOGICAL: Cognitive performance.
    Source: GAD:599606.

    This publication is mapped to 166 other entries.

  8. 8
    "Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement."
    Uhl G.R., Drgon T., Johnson C., Walther D., David S.P., Aveyard P., Murphy M., Johnstone E.C., Munafo M.R.
    Pharmacogenomics 11:357-367(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Pathology & Biotech.
    Annotation: Associated with CHEMDEPENDENCY: smoking cessation.
    Source: GAD:600364.

    This publication is mapped to 646 other entries.

  9. 9
    "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score."
    Rose J.E., Behm F.M., Drgon T., Johnson C., Uhl G.R.
    Mol Med 16:247-253(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator).
    Source: GeneRIF:6456.

    This publication is mapped to 11673 other entries.

  10. 10
    "SH3GL2 gene participates in MEK-ERK signal pathway partly by regulating EGFR in the laryngeal carcinoma cell line Hep2."
    Shang C., Guo Y., Fu S., Fu W., Sun K.
    Med Sci Monit 16:BR168-73(2010) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: SH3GL2 participates in the regulation of apoptosis through the MEK-ERK signal pathway by adjusting EGFR in the laryngeal carcinoma cell line Hep2.
    Source: GeneRIF:6456.

    This publication is mapped to 60 other entries.

  11. 11
    Category: Pathology & Biotech, Sequences.
    Annotation: Observational study of gene-disease association. (HuGE Navigator).
    Source: GeneRIF:6456.

    This publication is mapped to 33 other entries.

  12. 12
    "Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin."
    Huang L., Pan C.Q., Li B., Tucker-Kellogg L., Tidor B., Chen Y., Low B.C.
    PLoS One 6:e22933-e22933(2011) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1 co-regulated by Cbl-CIN85 and Endophilin A1.
    Source: GeneRIF:6456.

    This publication is mapped to 53 other entries.

  13. 13
    "SH3GL2 is frequently deleted in non-small cell lung cancer and downregulates tumor growth by modulating EGFR signaling."
    Dasgupta S., Jang J.S., Shao C., Mukhopadhyay N.D., Sokhi U.K., Das S.K., Brait M., Talbot C., Yung R.C., Begum S., Westra W.H., Hoque M.O., Yang P., Yi J.E., Lam S., Gazdar A.F., Fisher P.B., Jen J., Sidransky D.
    J Mol Med (Berl) 91:381-393(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: Our results indicate that SH3GL2 is frequently deleted in NSCLC and regulates cellular growth and invasion by modulating EGFR function.
    Source: GeneRIF:6456.

    This publication is mapped to 50 other entries.

  14. 14
    "Comparative study on the histomorphology and molecular biology of radial artery conduits in patients with diabetes mellitus who underwent coronary bypass surgery."
    Zou L., Chen X., Chen W., Li L., Huang F., Xiang F., Chen X.
    Diab Vasc Dis Res 10:208-215(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Data suggest that expression of endothelin-1 and vWF (von Willebrand factor) is up-regulated and eNOS (endothelial nitric oxide synthase) activity is increased in radial artery in diabetic patients with coronary artery disease.
    Source: GeneRIF:6456.

    This publication is mapped to 25 other entries.

  15. 15
    "MicroRNA-330 is an oncogenic factor in glioblastoma cells by regulating SH3GL2 gene."
    Qu S., Yao Y., Shang C., Xue Y., Ma J., Li Z., Liu Y.
    PLoS One 7:e46010-e46010(2012) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: SH3GL2 gene was identified as the target of miR-330. miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma.
    Source: GeneRIF:6456.

    This publication is mapped to 9 other entries.

  16. 16
    "Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes."
    Maiti G.P., Mondal P., Mukherjee N., Ghosh A., Ghosh S., Dey S., Chakrabarty J., Roy A., Biswas J., Roychoudhury S., Panda C.K.
    PLoS One 8:e63440-e63440(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes.
    Source: GeneRIF:6456.

    This publication is mapped to 55 other entries.

  17. 17
    "Loss of Sh3gl2/endophilin A1 is a common event in urothelial carcinoma that promotes malignant behavior."
    Majumdar S., Gong E.M., Di Vizio D., Dreyfuss J., Degraff D.J., Hager M.H., Park P.J., Bellmunt J., Matusik R.J., Rosenberg J.E., Adam R.M.
    Neoplasia 15:749-760(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: these findings identify loss of Sh3gl2 as a frequent event in Urothelial carcinoma (UC) development that promotes disease progression.
    Source: GeneRIF:6456.

    This publication is mapped to 9 other entries.

  18. 18
    "Endophilin, Lamellipodin, and Mena cooperate to regulate F-actin-dependent EGF-receptor endocytosis."
    Vehlow A., Soong D., Vizcay-Barrena G., Bodo C., Law A.L., Perera U., Krause M.
    EMBO J 32:2722-2734(2013) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin.
    Source: GeneRIF:6456.

    This publication is mapped to 64 other entries.

  19. 19
    "MiR-330-mediated regulation of SH3GL2 expression enhances malignant behaviors of glioblastoma stem cells by activating ERK and PI3K/AKT signaling pathways."
    Yao Y., Xue Y., Ma J., Shang C., Wang P., Liu L., Liu W., Li Z., Qu S., Li Z., Liu Y.
    PLoS One 9:e95060-e95060(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: miR-330 negatively regulated the expression of SH3GL2 in GSCs which promoted the oncogenic progression of GSCs through activating ERK and PI3K/AKT signaling pathways.
    Source: GeneRIF:6456.

    This publication is mapped to 9 other entries.

  20. 20
    "Endophilin-1 regulates blood-brain barrier permeability by controlling ZO-1 and occludin expression via the EGFR-ERK1/2 pathway."
    Liu W., Wang P., Shang C., Chen L., Cai H., Ma J., Yao Y., Shang X., Xue Y.
    Brain Res 1573:17-26(2014) [PubMed] [Europe PMC] [Abstract]
    Category: Function, Interaction.
    Annotation: study described that endophilin-1 is expressed in hCMEC/D3 cells where it regulates the permeability of blood-brain barrier by altering the expression of ZO-1 and occludin via the EGFR-ERK1/2 pathway.
    Source: GeneRIF:6456.

    This publication is mapped to 9 other entries.

  21. 21
    "Endophilin-1 regulates blood-brain barrier permeability via EGFR-JNK signaling pathway."
    Chen L., Liu W., Wang P., Xue Y., Su Q., Zeng C., Shang X.
    Brain Res 1606:44-53(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Function.
    Annotation: Endophilin-1 positively regulated blood-brain barrier permeability via the EGFR-JNK signaling pathway in hCMEC/D3 cells which would provide an experimental basis for further research on endophilin-1 mediated the opening of blood-brain barrier .
    Source: GeneRIF:6456.

    This publication is mapped to 9 other entries.

  22. 22
    "SNP rs1049430 in the 3'-UTR of SH3GL2 regulates its expression: Clinical and prognostic implications in head and neck squamous cell carcinoma."
    Maiti G.P., Ghosh A., Mondal P., Baral A., Datta S., Samadder S., Nayak S.P., Chakrabarti J., Biswas J., Sikdar N., Chowdhury S., Roy B., Roychowdhury S., Panda C.K.
    Biochim Biophys Acta 1852:1059-1067(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Sequences.
    Annotation: Data indicate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3-domain GRB2-like 2 protein (SH3GL2) and could be used as a prognostic marker of head and neck squamous cell carcinoma (HNSCC).
    Source: GeneRIF:6456.

    This publication is mapped to 9 other entries.

  23. 23
    "Endophilin A1 regulates dendritic spine morphogenesis and stability through interaction with p140Cap."
    Yang Y., Wei M., Xiong Y., Du X., Zhu S., Yang L., Zhang C., Liu J.J.
    Cell Res 25:496-516(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Interaction.
    Annotation: these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis stabilization and synaptic function through the regulation of p140Cap.
    Source: GeneRIF:6456.

    This publication is mapped to 15 other entries.

  24. 24
    "Aberrant promoter methylation of SH3GL2 gene in vulvar squamous cell carcinoma correlates with clinicopathological characteristics and HPV infection status."
    Li B., He Y., Han X., Zhang S., Xu Y., Zhou Y., Song Z., Ouyang L.
    Int J Clin Exp Pathol 8:15442-15447(2015) [PubMed] [Europe PMC] [Abstract]
    Category: Expression.
    Annotation: Methylation status of SH3GL2 gene was associated with the TNM staging and HPV infection status of vulvar squamous cell carcinoma.
    Source: GeneRIF:6456.

    This publication is mapped to 9 other entries.

  25. 25
    Category: Expression, Sequences.
    Annotation: This study identified a new mitochondria reprogramming pathway influencing breast cancer progression through SH3GL2 and MFN2. These proteins were frequently lost in breast cancer which was traceable in the circulating exosomes.
    Source: GeneRIF:6456.

    This publication is mapped to 14 other entries.

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