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Protein
Submitted name:

Squalene epoxidase

Gene

sqle

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • flavin adenine dinucleotide binding Source: InterPro
  • squalene monooxygenase activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SSC-191273 Cholesterol biosynthesis

Names & Taxonomyi

Protein namesi
Submitted name:
Squalene epoxidaseImported
Gene namesi
Name:sqleImported
Synonyms:SQLEImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 42HelicalSequence analysisAdd BLAST23
Transmembranei63 – 81HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5436

PTM / Processingi

Proteomic databases

PRIDEiA7L861

Expressioni

Gene expression databases

BgeeiENSSSCG00000005970 Expressed in 6 organ(s), highest expression level in liver

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006378

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini277 – 548SEInterPro annotationAdd BLAST272

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1298 Eukaryota
COG0654 LUCA
GeneTreeiENSGT00390000011759
HOGENOMiHOG000174713
HOVERGENiHBG005603
KOiK00511
OMAiSSHFVGC
OrthoDBiEOG091G03XY
TreeFamiTF331056

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR013698 Squalene_epoxidase
PfamiView protein in Pfam
PF08491 SE, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A7L861-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTFLGIATF TYFYKKCGDF VSLANKELLL GVLVFLSLGL VLSYRCRYRN
60 70 80 90 100
GALLGRQQSG SQFAVFSDIL SALPLIGFFW AKSPTGSEKK EQLGSRRGKK
110 120 130 140 150
GSNISETTLV GAAASPLISS QNDPEIIIVG SGVLGSALAA VLSRDGRKVT
160 170 180 190 200
VIERDLKEPD RILGEYLQPG GCHVLKDLGL EDTMEGIDAQ VVDGYIIHDQ
210 220 230 240 250
ESKSEVQIPF PLSENNHVQS GRAFRHGRFI MGLRKAAMAE PNAKFIEGTV
260 270 280 290 300
LQLLEEEDVV LGVQYRDKET GDIKELHAPL TIVADGLFSK FRKNLISNKV
310 320 330 340 350
SVSSHFVGFL MENAPQFKAN HAELVLANPS PVLIYQISPS ETRVLVDIRG
360 370 380 390 400
EMPRNLREYM IENIYPQLPD HLKEPFLEAS QNSHLRSMPA SFLPSSPVNK
410 420 430 440 450
RGVLLLGDAH NMRHPLTGGG MTVAFNDIKL WRKLLKGIPD LYDDAAILQA
460 470 480 490 500
KKSFYWTRKM SHSFVVNVLA QALYELFSAT DDSLYQLRKA CFFYFKLGGE
510 520 530 540 550
CISGPVALIS VLSPNPLVLI GHFFAVAVYA TYFCFKSEPW ITKPRAIFSS
560 570
GAVLYRACSV LFPLIYSEIK YLVH
Length:574
Mass (Da):63,755
Last modified:September 11, 2007 - v1
Checksum:iE6DB88308F69593C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6PY11F6PY11_PIG
Uncharacterized protein
SQLE
489Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000022 Genomic DNA No translation available.
EF683117 mRNA Translation: ABS57428.1
AB530156 mRNA Translation: BAI48103.1
RefSeqiNP_001094496.1, NM_001101026.1
UniGeneiSsc.81599

Genome annotation databases

EnsembliENSSSCT00000059547; ENSSSCP00000057656; ENSSSCG00000005970
GeneIDi100113409
KEGGissc:100113409

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEMK02000022 Genomic DNA No translation available.
EF683117 mRNA Translation: ABS57428.1
AB530156 mRNA Translation: BAI48103.1
RefSeqiNP_001094496.1, NM_001101026.1
UniGeneiSsc.81599

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000006378

Chemistry databases

ChEMBLiCHEMBL5436

Proteomic databases

PRIDEiA7L861

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000059547; ENSSSCP00000057656; ENSSSCG00000005970
GeneIDi100113409
KEGGissc:100113409

Organism-specific databases

CTDi6713

Phylogenomic databases

eggNOGiKOG1298 Eukaryota
COG0654 LUCA
GeneTreeiENSGT00390000011759
HOGENOMiHOG000174713
HOVERGENiHBG005603
KOiK00511
OMAiSSHFVGC
OrthoDBiEOG091G03XY
TreeFamiTF331056

Enzyme and pathway databases

ReactomeiR-SSC-191273 Cholesterol biosynthesis

Gene expression databases

BgeeiENSSSCG00000005970 Expressed in 6 organ(s), highest expression level in liver

Family and domain databases

Gene3Di3.50.50.60, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR013698 Squalene_epoxidase
PfamiView protein in Pfam
PF08491 SE, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA7L861_PIG
AccessioniPrimary (citable) accession number: A7L861
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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