UniProtKB - A7KVC2 (AB4C_MAIZE)
Protein
ABC transporter C family MRP4
Gene
MRP4
Organism
Zea mays (Maize)
Status
Functioni
ABC transporter that may affect phytic acid transport and compartmentalization. May function directly or indirectly in removing phytic acid from the cytosol or in vesicle trafficking. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 664 – 671 | ATPPROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1301 – 1308 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: InterPro
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- transmembrane transport Source: UniProtKB
Keywordsi
Molecular function | Translocase |
Biological process | Transport |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
TCDBi | 3.A.1.208.42, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ABC transporter C family MRP4Curated (EC:7.-.-.-Curated)Alternative name(s): Multidrug resistance-associated protein 4Curated Short name: ZmMRP41 Publication Protein LOW PHYTIC ACID 11 Publication |
Gene namesi | Name:MRP41 Publication Synonyms:LPA11 Publication |
Organismi | Zea mays (Maize) |
Taxonomic identifieri | 4577 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › Liliopsida › Poales › Poaceae › PACMAD clade › Panicoideae › Andropogonodae › Andropogoneae › Tripsacinae › Zea |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane Sequence analysis; Multi-pass membrane protein Sequence analysis
Vacuole
- plant-type vacuole Source: GO_Central
- vacuolar membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 12 – 32 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 55 – 75 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Transmembranei | 78 – 98 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 109 – 129 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 138 – 158 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 177 – 197 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Transmembranei | 319 – 339 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Transmembranei | 342 – 362 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Transmembranei | 373 – 393 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Transmembranei | 427 – 447 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Transmembranei | 453 – 473 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Transmembranei | 540 – 560 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Transmembranei | 945 – 965 | Helical; Name=13Sequence analysisAdd BLAST | 21 | |
Transmembranei | 985 – 1005 | Helical; Name=14Sequence analysisAdd BLAST | 21 | |
Transmembranei | 1060 – 1082 | Helical; Name=15Sequence analysisAdd BLAST | 23 | |
Transmembranei | 1086 – 1108 | Helical; Name=16Sequence analysisAdd BLAST | 23 | |
Transmembranei | 1154 – 1174 | Helical; Name=17Sequence analysisAdd BLAST | 21 | |
Transmembranei | 1179 – 1199 | Helical; Name=18Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Disruption phenotypei
Strong reduction in seed phytic acid, and strong increase of inorganic phosphate and myo-inositol levels in seeds.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000431885 | 1 – 1510 | ABC transporter C family MRP4Add BLAST | 1510 |
Proteomic databases
PaxDbi | A7KVC2 |
PRIDEi | A7KVC2 |
Expressioni
Tissue specificityi
Expressed in roots, leaves, stalks, tassels, silks, developing seeds and developing embryos.1 Publication
Gene expression databases
ExpressionAtlasi | A7KVC2, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 320 – 595 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 276 | |
Domaini | 629 – 852 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 224 | |
Domaini | 950 – 1220 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 271 | |
Domaini | 1267 – 1501 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
OrthoDBi | 138195at2759 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
A7KVC2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPPSFPSLPL PEAVAATAHA ALLALAALLL LLRAARALAS RCASCLKAPR
60 70 80 90 100
RRGGPAVVVG DGAGGALAAA TAGAWHRAVL ASCAYALLSQ VAVLSYEVAV
110 120 130 140 150
AGSRVSARAL LLPAVQAVSW AALLALALQA RAVGWARFPA LVRLWWVVSF
160 170 180 190 200
ALCVVIAYDD SRRLIGQGAR AVDYAHMVAN FASVPALGFL CLVGVMGSTG
210 220 230 240 250
LELEFTEDGN GLHEPLLLGR QRREAEEELG CLRVTPYADA GILSLATLSW
260 270 280 290 300
LSPLLSVGAQ RPLELADIPL LAHKDRAKSC YKAMSAHYER QRLEYPGREP
310 320 330 340 350
SLTWAILKSF WREAAVNGTF AAVNTIVSYV GPYLISYFVD YLSGNIAFPH
360 370 380 390 400
EGYILASIFF VAKLLETLTA RQWYLGVDIM GIHVKSGLTA MVYRKGLRLS
410 420 430 440 450
NASRQSHTSG EIVNYMAVDV QRVGDYAWYF HDIWMLPLQI ILALAILYKN
460 470 480 490 500
VGIAMVSTLV ATVLSIAASV PVAKLQEHYQ DKLMASKDER MRKTSECLKN
510 520 530 540 550
MRILKLQAWE DRYRLQLEEM RNVECRWLRW ALYSQAAVTF VFWSSPIFVA
560 570 580 590 600
VITFGTCILL GGQLTAGGVL SALATFRILQ EPLRNFPDLI SMMAQTRVSL
610 620 630 640 650
DRLSHFLQQE ELPDDATINV PQSSTDKAVD IKDGAFSWNP YTLTPTLSDI
660 670 680 690 700
HLSVVRGMRV AVCGVIGSGK SSLLSSILGE IPKLCGHVRI SGTAAYVPQT
710 720 730 740 750
AWIQSGNIEE NILFGSQMDR QRYKRVIAAC CLKKDLELLQ YGDQTVIGDR
760 770 780 790 800
GINLSGGQKQ RVQLARALYQ DADIYLLDDP FSAVDAHTGS ELFKEYILTA
810 820 830 840 850
LATKTVIYVT HQVEFLPAAD LILVLKDGHI TQAGKYDDLL QAGTDFNALV
860 870 880 890 900
SAHKEAIETM DIFEDSDSDT VSSIPNKRLT PSISNIDNLK NKMCENGQPS
910 920 930 940 950
NTRGIKEKKK KEERKKKRTV QEEERERGKV SSKVYLSYMG EAYKGTLIPL
960 970 980 990 1000
IILAQTMFQV LQIASNWWMA WANPQTEGDA PKTDSVVLLV VYMSLAFGSS
1010 1020 1030 1040 1050
LFVFMRSLLV ATFGLAAAQK LFIKMLRCVF RAPMSFFDTT PSGRILNRVS
1060 1070 1080 1090 1100
VDQSVVDLDI AFRLGGFAST TIQLLGIVAV MSKVTWQVLI LIVPMAVACM
1110 1120 1130 1140 1150
WMQRYYIASS RELTRILSVQ KSPVIHLFSE SIAGAATIRG FGQEKRFMKR
1160 1170 1180 1190 1200
NLYLLDCFAR PLFSSLAAIE WLCLRMELLS TFVFAFCMAI LVSFPPGTIE
1210 1220 1230 1240 1250
PSMAGLAVTY GLNLNARMSR WILSFCKLEN RIISVERIYQ YCRLPSEAPL
1260 1270 1280 1290 1300
IIENCRPPSS WPQNGNIELI DLKVRYKDDL PLVLHGVSCM FPGGKKIGIV
1310 1320 1330 1340 1350
GRTGSGKSTL IQALFRLIEP TGGKIIIDNI DISAIGLHDL RSRLSIIPQD
1360 1370 1380 1390 1400
PTLFEGTIRM NLDPLEECTD QEIWEALEKC QLGEVIRSKE EKLDSPVLEN
1410 1420 1430 1440 1450
GDNWSVGQRQ LIALGRALLK QAKILVLDEA TASVDTATDN LIQKIIRSEF
1460 1470 1480 1490 1500
KDCTVCTIAH RIPTVIDSDL VLVLSDGKIA EFDTPQRLLE DKSSMFIQLV
1510
SEYSTRSSCI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF586878 mRNA Translation: ABS81429.1 |
RefSeqi | NP_001106060.1, NM_001112590.1 |
Genome annotation databases
GeneIDi | 100125659 |
KEGGi | zma:100125659 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF586878 mRNA Translation: ABS81429.1 |
RefSeqi | NP_001106060.1, NM_001112590.1 |
3D structure databases
SMRi | A7KVC2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4577.GRMZM5G820122_P01 |
Protein family/group databases
TCDBi | 3.A.1.208.42, the atp-binding cassette (abc) superfamily |
Proteomic databases
PaxDbi | A7KVC2 |
PRIDEi | A7KVC2 |
Genome annotation databases
GeneIDi | 100125659 |
KEGGi | zma:100125659 |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
OrthoDBi | 138195at2759 |
Gene expression databases
ExpressionAtlasi | A7KVC2, baseline and differential |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like IPR017871, ABC_transporter_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AB4C_MAIZE | |
Accessioni | A7KVC2Primary (citable) accession number: A7KVC2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 4, 2015 |
Last sequence update: | September 11, 2007 | |
Last modified: | October 7, 2020 | |
This is version 78 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families