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Protein

Rho GTPase-activating protein 32

Gene

ARHGAP32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity).By similarity7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • phosphatidylinositol binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-194840 Rho GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
A7KAX9

SIGNOR Signaling Network Open Resource

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SIGNORi
A7KAX9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 32
Alternative name(s):
Brain-specific Rho GTPase-activating protein
GAB-associated Cdc42/Rac GTPase-activating protein
GC-GAP
GTPase regulator interacting with TrkA
Rho-type GTPase-activating protein 32
Rho/Cdc42/Rac GTPase-activating protein RICS
RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
p200RhoGAP
p250GAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP32
Synonyms:GRIT, KIAA0712, RICS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000134909.18

Human Gene Nomenclature Database

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HGNCi
HGNC:17399 ARHGAP32

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608541 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A7KAX9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi173Y → A: Loss of binding to phospholipids. Cytoplasmic localization. 1 Publication1
Mutagenesisi407R → A: Mild effect on GAP activity and neurite-promotion upon nerve growth factor stimulation. 5 Publications1
Mutagenesisi407R → I: Loss of GAP activity. 5 Publications1
Mutagenesisi407R → M: Loss of GAP activity. In isoform 1, no inhibitory effect on neurite extension. 5 Publications1
Mutagenesisi447K → A: Loss of GAP activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9743

Open Targets

More...
OpenTargetsi
ENSG00000134909

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165543138

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARHGAP32

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003452031 – 2087Rho GTPase-activating protein 32Add BLAST2087

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei706PhosphoserineCombined sources1
Modified residuei709PhosphoserineBy similarity1
Modified residuei732PhosphoserineBy similarity1
Modified residuei738PhosphoserineBy similarity1
Modified residuei852PhosphoserineBy similarity1
Modified residuei856PhosphoserineBy similarity1
Modified residuei892PhosphoserineCombined sources1
Modified residuei952PhosphoserineCombined sources1
Modified residuei1203PhosphoserineCombined sources1
Modified residuei1523Asymmetric dimethylarginineBy similarity1
Modified residuei1533Asymmetric dimethylarginineBy similarity1
Modified residuei1585PhosphoserineBy similarity1
Modified residuei2037Omega-N-methylarginineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Isoform 2 is phosphorylated on multiple tyrosine residues by FYN. Phosphorylated tyrosine residues undergo dephosphorylation after stimulation of NMDA receptors (By similarity). Phosphorylated in vitro by CaMK2 in the presence of calmodulin and calcium; which inhibits GAP activity (By similarity).By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
A7KAX9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
A7KAX9

MaxQB - The MaxQuant DataBase

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MaxQBi
A7KAX9

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
A7KAX9

PRoteomics IDEntifications database

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PRIDEi
A7KAX9

ProteomicsDB human proteome resource

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ProteomicsDBi
1805
1806 [A7KAX9-2]
1807 [A7KAX9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A7KAX9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A7KAX9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000134909 Expressed in 205 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
A7KAX9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
A7KAX9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038382
HPA038389
HPA061505

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NTRK1 (via cytoplasmic domain); the interaction is independent of the phosphorylation state of NTRK1 (PubMed:12446789). Interacts with SHC3 (via SH2 domain) (PubMed:12446789). Interacts with RASA1 (via SH3 domain); the interaction is necessary for the Ras activation and cell transforming activities of ARHGAP32 (By similarity). Interacts with GAB1 and GAB2 (PubMed:12819203). Interacts with CRK and CRKL (PubMed:12819203, PubMed:12446789). Found in a complex with CRKL and BCAR1; upon EGF stimulation BCAR1 may be replaced by EGFR (PubMed:12446789, PubMed:12819203). Interacts with NCK1 (via SH3 domain); NCK1 recruits phosphorylated BCAR1 to the complex (PubMed:12819203). Isoform 2 interacts with FYN; the interaction appears to be dependent on tyrosine phosphorylation of ARHGAP32 (PubMed:12788081). Interacts with EGFR; the interaction requires EGF stimulation and is increased by SHC3 (PubMed:12446789). Interacts with CDC42; the interaction requires constitutively active CDC42. Interacts with CTNNB1 (PubMed:12531901). Interacts with GRIN2B (PubMed:12857875). Interacts with DLG4 and CDH2 (By similarity). Interacts with GPHN (By similarity).By similarity5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115091, 45 interactors

Protein interaction database and analysis system

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IntActi
A7KAX9, 23 interactors

Molecular INTeraction database

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MINTi
A7KAX9

STRING: functional protein association networks

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STRINGi
9606.ENSP00000310561

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

12087
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IUGX-ray1.77A/B367-577[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
A7KAX9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
A7KAX9

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
A7KAX9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini131 – 245PX; atypicalAdd BLAST115
Domaini259 – 321SH3PROSITE-ProRule annotationAdd BLAST63
Domaini372 – 567Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1391 – 1711Interaction with GAB21 PublicationAdd BLAST321
Regioni1685 – 2087Interaction with FYN1 PublicationAdd BLAST403

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1031 – 1036Poly-Pro6
Compositional biasi1305 – 1310Poly-Pro6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal PX domain interacts specifically with phosphatidylinositides.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PX domain-containing GAP family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1449 Eukaryota
ENOG410Y1FN LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000090208

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG108407

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
A7KAX9

KEGG Orthology (KO)

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KOi
K20647

Identification of Orthologs from Complete Genome Data

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OMAi
DQPPSYL

Database of Orthologous Groups

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OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
A7KAX9

TreeFam database of animal gene trees

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TreeFami
TF351451

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.555.10, 1 hit
3.30.1520.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00787 PX, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A7KAX9-1) [UniParc]FASTAAdd to basket
Also known as: PX-RICS

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
METESESSTL GDDSVFWLES EVIIQVTDCE EEEREEKFRK MKSSVHSEED
60 70 80 90 100
DFVPELHRNV HPRERPDWEE TLSAMARGAD VPEIPGDLTL KTCGSTASMK
110 120 130 140 150
VKHVKKLPFT KGHFPKMAEC AHFHYENVEF GSIQLSLSEE QNEVMKNGCE
160 170 180 190 200
SKELVYLVQI ACQGKSWIVK RSYEDFRVLD KHLHLCIYDR RFSQLSELPR
210 220 230 240 250
SDTLKDSPES VTQMLMAYLS RLSAIAGNKI NCGPALTWME IDNKGNHLLV
260 270 280 290 300
HEESSINTPA VGAAHVIKRY TARAPDELTL EVGDIVSVID MPPKVLSTWW
310 320 330 340 350
RGKHGFQVGL FPGHCVELIN QKVPQSVTNS VPKPVSKKHG KLITFLRTFM
360 370 380 390 400
KSRPTKQKLK QRGILKERVF GCDLGEHLLN SGFEVPQVLQ SCTAFIERYG
410 420 430 440 450
IVDGIYRLSG VASNIQRLRH EFDSEHVPDL TKEPYVQDIH SVGSLCKLYF
460 470 480 490 500
RELPNPLLTY QLYEKFSDAV SAATDEERLI KIHDVIQQLP PPHYRTLEFL
510 520 530 540 550
MRHLSLLADY CSITNMHAKN LAIVWAPNLL RSKQIESACF SGTAAFMEVR
560 570 580 590 600
IQSVVVEFIL NHVDVLFSGR ISMAMQEGAA SLSRPKSLLV SSPSTKLLTL
610 620 630 640 650
EEAQARTQAQ VNSPIVTENK YIEVGEGPAA LQGKFHTIIE FPLERKRPQN
660 670 680 690 700
KMKKSPVGSW RSFFNLGKSS SVSKRKLQRN ESEPSEMKAM ALKGGRAEGT
710 720 730 740 750
LRSAKSEESL TSLHAVDGDS KLFRPRRPRS SSDALSASFN GEMLGNRCNS
760 770 780 790 800
YDNLPHDNES EEEGGLLHIP ALMSPHSAED VDLSPPDIGV ASLDFDPMSF
810 820 830 840 850
QCSPPKAESE CLESGASFLD SPGYSKDKPS ANKKDAETGS SQCQTPGSTA
860 870 880 890 900
SSEPVSPLQE KLSPFFTLDL SPTEDKSSKP SSFTEKVVYA FSPKIGRKLS
910 920 930 940 950
KSPSMSISEP ISVTLPPRVS EVIGTVSNTT AQNASSSTWD KCVEERDATN
960 970 980 990 1000
RSPTQIVKMK TNETVAQEAY ESEVQPLDQV AAEEVELPGK EDQSVSSSQS
1010 1020 1030 1040 1050
KAVASGQTQT GAVTHDPPQD SVPVSSVSLI PPPPPPKNVA RMLALALAES
1060 1070 1080 1090 1100
AQQASTQSLK RPGTSQAGYT NYGDIAVATT EDNLSSSYSA VALDKAYFQT
1110 1120 1130 1140 1150
DRPAEQFHLQ NNAPGNCDHP LPETTATGDP THSNTTESGE QHHQVDLTGN
1160 1170 1180 1190 1200
QPHQAYLSGD PEKARITSVP LDSEKSDDHV SFPEDQSGKN SMPTVSFLDQ
1210 1220 1230 1240 1250
DQSPPRFYSG DQPPSYLGAS VDKLHHPLEF ADKSPTPPNL PSDKIYPPSG
1260 1270 1280 1290 1300
SPEENTSTAT MTYMTTTPAT AQMSTKEASW DVAEQPTTAD FAAATLQRTH
1310 1320 1330 1340 1350
RTNRPLPPPP SQRSAEQPPV VGQVQAATNI GLNNSHKVQG VVPVPERPPE
1360 1370 1380 1390 1400
PRAMDDPASA FISDSGAAAA QCPMATAVQP GLPEKVRDGA RVPLLHLRAE
1410 1420 1430 1440 1450
SVPAHPCGFP APLPPTRMME SKMIAAIHSS SADATSSSNY HSFVTASSTS
1460 1470 1480 1490 1500
VDDALPLPLP VPQPKHASQK TVYSSFARPD VTTEPFGPDN CLHFNMTPNC
1510 1520 1530 1540 1550
QYRPQSVPPH HNKLEQHQVY GARSEPPASM GLRYNTYVAP GRNASGHHSK
1560 1570 1580 1590 1600
PCSRVEYVSS LSSSVRNTCY PEDIPPYPTI RRVQSLHAPP SSMIRSVPIS
1610 1620 1630 1640 1650
RTEVPPDDEP AYCPRPLYQY KPYQSSQARS DYHVTQLQPY FENGRVHYRY
1660 1670 1680 1690 1700
SPYSSSSSSY YSPDGALCDV DAYGTVQLRP LHRLPNRDFA FYNPRLQGKS
1710 1720 1730 1740 1750
LYSYAGLAPR PRANVTGYFS PNDHNVVSMP PAADVKHTYT SWDLEDMEKY
1760 1770 1780 1790 1800
RMQSIRRESR ARQKVKGPVM SQYDNMTPAV QDDLGGIYVI HLRSKSDPGK
1810 1820 1830 1840 1850
TGLLSVAEGK ESRHAAKAIS PEGEDRFYRR HPEAEMDRAH HHGGHGSTQP
1860 1870 1880 1890 1900
EKPSLPQKQS SLRSRKLPDM GCSLPEHRAH QEASHRQFCE SKNGPPYPQG
1910 1920 1930 1940 1950
AGQLDYGSKG IPDTSEPVSY HNSGVKYAAS GQESLRLNHK EVRLSKEMER
1960 1970 1980 1990 2000
PWVRQPSAPE KHSRDCYKEE EHLTQSIVPP PKPERSHSLK LHHTQNVERD
2010 2020 2030 2040 2050
PSVLYQYQPH GKRQSSVTVV SQYDNLEDYH SLPQHQRGVF GGGGMGTYVP
2060 2070 2080
PGFPHPQSRT YATALGQGAF LPAELSLQHP ETQIHAE
Length:2,087
Mass (Da):230,529
Last modified:September 11, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i075E5B4902857D06
GO
Isoform 2 (identifier: A7KAX9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-349: Missing.

Show »
Length:1,738
Mass (Da):190,970
Checksum:i49B5C6F92BDE9A27
GO
Isoform 3 (identifier: A7KAX9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-290: Missing.
     567-612: FSGRISMAMQ...AQARTQAQVN → LPHFSARTEL...LVQITVCISI
     613-2087: Missing.

Show »
Length:322
Mass (Da):36,669
Checksum:iCE60526885AED792
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V174G3V174_HUMAN
Rho GTPase-activating protein 32
ARHGAP32 RICS, hCG_2042955
946Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRH3E9PRH3_HUMAN
Rho GTPase-activating protein 32
ARHGAP32
178Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA34432 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0349331 – 349Missing in isoform 2. 5 PublicationsAdd BLAST349
Alternative sequenceiVSP_0349341 – 290Missing in isoform 3. 1 PublicationAdd BLAST290
Alternative sequenceiVSP_034935567 – 612FSGRI…QAQVN → LPHFSARTELIVPFPLRLLR KQFTPPLLGPMSPLNPLVQI TVCISI in isoform 3. 1 PublicationAdd BLAST46
Alternative sequenceiVSP_034936613 – 2087Missing in isoform 3. 1 PublicationAdd BLAST1475

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB079856 mRNA Translation: BAC24802.1
AY194287 mRNA Translation: AAO43677.1
AB088416 mRNA Translation: BAM34446.1
EF127492 mRNA Translation: ABO33171.1
AB018255 mRNA Translation: BAA34432.2 Different initiation.
CH471065 Genomic DNA Translation: EAW67740.1
BC000277 mRNA Translation: AAH00277.2
BC104898 mRNA Translation: AAI04899.1
BC113429 mRNA Translation: AAI13430.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31718.1 [A7KAX9-2]
CCDS44769.1 [A7KAX9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001136157.1, NM_001142685.1 [A7KAX9-1]
NP_055530.2, NM_014715.3 [A7KAX9-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.440379

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310343; ENSP00000310561; ENSG00000134909 [A7KAX9-1]
ENST00000392657; ENSP00000376425; ENSG00000134909 [A7KAX9-2]
ENST00000527272; ENSP00000432862; ENSG00000134909 [A7KAX9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9743

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9743

UCSC genome browser

More...
UCSCi
uc001qez.4 human [A7KAX9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB079856 mRNA Translation: BAC24802.1
AY194287 mRNA Translation: AAO43677.1
AB088416 mRNA Translation: BAM34446.1
EF127492 mRNA Translation: ABO33171.1
AB018255 mRNA Translation: BAA34432.2 Different initiation.
CH471065 Genomic DNA Translation: EAW67740.1
BC000277 mRNA Translation: AAH00277.2
BC104898 mRNA Translation: AAI04899.1
BC113429 mRNA Translation: AAI13430.1
CCDSiCCDS31718.1 [A7KAX9-2]
CCDS44769.1 [A7KAX9-1]
RefSeqiNP_001136157.1, NM_001142685.1 [A7KAX9-1]
NP_055530.2, NM_014715.3 [A7KAX9-2]
UniGeneiHs.440379

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IUGX-ray1.77A/B367-577[»]
ProteinModelPortaliA7KAX9
SMRiA7KAX9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115091, 45 interactors
IntActiA7KAX9, 23 interactors
MINTiA7KAX9
STRINGi9606.ENSP00000310561

PTM databases

iPTMnetiA7KAX9
PhosphoSitePlusiA7KAX9

Polymorphism and mutation databases

BioMutaiARHGAP32

Proteomic databases

EPDiA7KAX9
jPOSTiA7KAX9
MaxQBiA7KAX9
PaxDbiA7KAX9
PRIDEiA7KAX9
ProteomicsDBi1805
1806 [A7KAX9-2]
1807 [A7KAX9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310343; ENSP00000310561; ENSG00000134909 [A7KAX9-1]
ENST00000392657; ENSP00000376425; ENSG00000134909 [A7KAX9-2]
ENST00000527272; ENSP00000432862; ENSG00000134909 [A7KAX9-2]
GeneIDi9743
KEGGihsa:9743
UCSCiuc001qez.4 human [A7KAX9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9743
DisGeNETi9743
EuPathDBiHostDB:ENSG00000134909.18

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ARHGAP32

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0010264
HGNCiHGNC:17399 ARHGAP32
HPAiHPA038382
HPA038389
HPA061505
MIMi608541 gene
neXtProtiNX_A7KAX9
OpenTargetsiENSG00000134909
PharmGKBiPA165543138

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1449 Eukaryota
ENOG410Y1FN LUCA
GeneTreeiENSGT00940000154313
HOGENOMiHOG000090208
HOVERGENiHBG108407
InParanoidiA7KAX9
KOiK20647
OMAiDQPPSYL
OrthoDBi1300981at2759
PhylomeDBiA7KAX9
TreeFamiTF351451

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
SignaLinkiA7KAX9
SIGNORiA7KAX9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ARHGAP32 human
EvolutionaryTraceiA7KAX9

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
RICS_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9743

Protein Ontology

More...
PROi
PR:A7KAX9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134909 Expressed in 205 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiA7KAX9 baseline and differential
GenevisibleiA7KAX9 HS

Family and domain databases

Gene3Di1.10.555.10, 1 hit
3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00787 PX, 1 hit
PF00620 RhoGAP, 1 hit
PF14604 SH3_9, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF50044 SSF50044, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG32_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7KAX9
Secondary accession number(s): I7H0B0
, O94820, Q86YL6, Q8IUG4, Q9BWG3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: September 11, 2007
Last modified: January 16, 2019
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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