UniProtKB - A7J8L3 (A7J8L3_CVHSA)

BLAST

>tr|A7J8L3|A7J8L3_CVHSA Polyprotein orf1a OS=Human SARS coronavirus OX=227859 GN=PP1a PE=1 SV=1
MESLVLGVNEKTHVQLSLPVLQVRDVLVRGFGDSVEEALSEAREHLKNGTCGLVELEKGV
LPQLEQPYVFIKRSDALSTNHGHKVVELVAEMDGIQYGRSGITLGVLVPHVGETPIAYRN
VLLRKNGNKGAGGHSYGIDLKSYDLGDELGTDPIEDYEQNWNTKHGSGALRELTRELNGG
AVTRYVDNNFCGPDGYPLDCIKDFLARAGKSMCTLSEQLDYIESKRGVYCCRDHEHEIAW
FTERSDKSYEHQTPFEIKSAKKFDTFKGECPKFVFPLNSKVKVIQPRVEKKKTEGFMGRI
RSVYPVASPQECNNMHLSTLMKCNHCDEVSWQTCDFLKATCEHCGTENLVIEGPTTCGYL
PTNAVVKMPCPACQDPEIGPEHSVADYHNHSNIETRLRKGGRTRCFGGCVFAYVGCYNKR
AYWVPRASADIGSGHTGITGDNVETLNEDLLEILSRERVNINIVGDFHLNEEVAIILASF
SASTSAFIDTIKSLDYKSFKTIVESCGNYKVTKGKPVKGAWNIGQQRSVLTPLCGFPSQA
AGVIRSIFARTLDAANHSIPDLQRAAVTILDGISEQSLRLVDAMVYTSDLLTNSVIIMAY
VTGGLVQQTSQWLSNLLGTTVEKLRPIFEWIEAKLSAGVEFLKDAWEILKFLITGVFDIV
KGQIQVASDNIKDCVKCFIDVVNKALEMCIDQVTIAGAKLRSLNLGEVFIAQSKGLYRQC
IRGKEQLQLLMPLKAPKEVTFLEGDSHDTVLTSEEVVLKNGELEALETPVDSFTNGAIVG
TPVCVNGLMLLEIKDKEQYCALSPGLLATNNVFRLKGGAPIKGVTFGEDTVWEVQGYKNV
RITFELDERVDKVLNEKCSVYTVESGTEVTEFACVVAEAVVKTLQPVSDLLTNMGIDLDE
WSVATFYLFDDAGEENFSSRMYCSFYPPDEEEEDDAECEEEEIDETCEHEYGTEDDYQGL
PLEFGASAETVRVEEEEEEDWLDDTTEQSEIEPEPEPTPEEPVNQFTGYLKLTDNVAIKC
VDIVKEAQSANPMVIVNAANIHLKHGGGVAGALNKATNGAMQKESDDYIKLNGPLTVGGS
CLLSGHNLAKKCLHVVGPNLNAGEDIQLLKAAYENFNSQDILLAPLLSAGIFGAKPLQSL
QVCVQTVRTQVYIAVNDKALYEQVVMDYLDNLKPRVEAPKQEEPPNTEDSKTEEKSVVQK
PVDVKPKIKACIDEVTTTLEETKFLTNKLLLFADINGKLYHDSQNMLRGEDMSFLEKDAP
YMVGDVITSGDITCVVIPSKKAGGTTEMLSRALKKVPVDEYITTYPGQGCAGYTLEEAKT
ALKKCKSAFYVLPSEAPNAKEEILGTVSWNLREMLAHAEETRKLMPICMDVRAIMATIQR
KYKGIKIQEGIVDYGVRFFFYTSKEPVASIITKLNSLNEPLVTMPIGYVTHGFNLEEAAR
CMRSLKAPAVVSVSSPDAVTTYNGYLTSSSKTSEEHFVETVSLAGSYRDWSYSGQRTELG
VEFLKRGDKIVYHTLESPVEFHLDGEVLSLDKLKSLLSLREVKTIKVFTTVDNTNLHTQL
VDMSMTYGQQFGPTYLDGADVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFL
GRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLALQQLEVKFNAPALQEAYYRAR
AGDAANFCALILAYSNKTVGELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLT
GVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSFVMMSAPPAEYKLQQGTFLC
ANEYTGNYQCGHYTHITAKETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVSYK
LDGVTYTEIEPKLDGYYKKDNAYYTEQPIDLVPTQPLPNASFDNFKLTCSNTKFADDLNQ
MTGFTKPASRELSVTFFPDLNGDVVAIDYRHYSASFKKGAKLLHKPIVWHINQATTKTTF
KPNTWCLRCLWSTKPVDTSNSFEVLAVEDTQGMDNLACESQQPTSEEVVENPTIQKEVIE
CDVKTTEVVGNVILKPSDEGVKVTQELGHEDLMAAYVENTSITIKKPNELSLALGLKTIA
THGIAAINSVPWSKILAYVKPFLGQAAITTSNCAKRLAQRVFNNYMPYVFTLLFQLCTFT
KSTNSRIRASLPTTIAKNSVKSVAKLCLDAGINYVKSPKFSKLFTIAMWLLLLSICLGSL
ICVTAAFGVLLSNFGAPSYCNGVRELYLNSSNVTTMDFCEGSFPCSICLSGLDSLDSYPA
LETIQVTISSYKLDLTILGLAAEWVLAYMLFTKFFYLLGLSAIMQVFFGYFASHFISNSW
LMWFIISIVQMAPVSAMVRMYIFFASFYYIWKSYVHIMDGCTSSTCMMCYKRNRATRVEC
TTIVNGMKRSFYVYANGGRGFCKTHNWNCLNCDTFCTGSTFISDEVARDLSLQFKRPINP
TDQSSYIVDSVAVKNGALHLYFDKAGQKTYERHPLSHFVNLDNLRANNTKGSLPINVIVF
DGKSKCDESASKSASVYYSQLMCQPILLLDQALVSDVGDSTEVSVKMFDAYVDTFSATFS
VPMEKLKALVATAHSELAKGVALDGVLSTFVSAARQGVVDTDVDTKDVIECLKLSHHSDL
EVTGDSCNNFMLTYNKVENMTPRDLGACIDCNARHINAQVAKSHNVSLIWNVKDYMSLSE
QLRKQIRSAAKKNNIPFRLTCATTRQVVNVITTKISLKGGKIVSTCFKLMLKATLLCVLA
ALVCYIVMPVHTLSIHDGYTNEIIGYKAIQDGVTRDIISTDDCFANKHAGFDAWFSQRGG
SYKNDKSCPVVAAIITREIGFIVPGLPGTVLRAINGDFLHFLPRVFSAVGNICYTPSKLI
EYSDFATSACVLAAECTIFKDAMGKPVPYCYDTNLLEGSISYSELRPDTRYVLMDGSIIQ
FPNTYLEGSVRVVTTFDAEYCRHGTCERSEVGICLSTSGRWVLNNEHYRALSGVFCGVDA
MNLIANIFTPLVQPVGALDVSASVVAGGIIAILVTCAAYYFMKFRRVFGEYNHVVAANAL
LFLMSFTILCLVPAYSFLPGVYSVFYLYLTFYFTNDVSFLAHLQWFAMFSPIVPFWITAI
YVFCISLKHCHWFFNNYLRKRVMFNGVTFSTFEEAALCTFLLNKEMYLKLRSETLLPLTQ
YNRYLALYNKYKYFSGALDTTSYREAACCHLAKALNDFSNSGADVLYQPPQTSITSAVLQ
SGFRKMAFPSGKVEGCMVQVTCGTTTLNGLWLDDTVYCPRHVICTAEDMLNPNYEDLLIR
KSNHSFLVQAGNVQLRVIGHSMQNCLLRLKVDTSNPKTPKYKFVRIQPGQTFSVLACYNG
SPSGVYQCAMRPNHTIKGSFLNGSCGSVGFNIDYDCVSFCYMHHMELPTGVHAGTDLEGK
FYGPFVDRQTAQAAGTDTTITLNVLAWLYAAVINGDRWFLNRFTTTLNDFNLVAMKYNYE
PLTQDHVDILGPLSAQTGIAVLDMCAALKELLQNGMNGRTILGSTILEDEFTPFDVVRQC
SGVTFQGKFKKIVKGTHHWMLLTFLTSLLILVQSTQWSLFFFVYENAFLPFTLGIMAIAA
CAMLLVKHKHAFLCLFLLPSLATVAYFNMVYMPASWVMRIMTWLELADTSLSGYRLKDCV
MYASALVLLILMTARTVYDDAARRVWTLMNVITLVYKVYYGNALDQAISMWALVISVTSN
YSGVVTTIMFLARAIVFVCVEYYPLLFITGNTLQCIMLVYCFLGYCCCCYFGLFCLLNRY
FRLTLGVYDYLVSTQEFRYMNSQGLLPPKSSIDAFKLNIKLLGIGGKPCIKVATVQSKMS
DVKCTSVVLLSVLQQLRVESSSKLWAQCVQLHNDILLAKDTTEAFEKMVSLLSVLLSMQG
AVDINRLCEEMLDNRATLQAIASEFSSLPSYAAYATAQEAYEQAVANGDSEVVLKKLKKS
LNVAKSEFDRDAAMQRKLEKMADQAMTQMYKQARSEDKRAKVTSAMQTMLFTMLRKLDND
ALNNIINNARDGCVPLNIIPLTTAAKLMVVVPDYGTYKNTCDGNTFTYASALWEIQQVVD
ADSKIVQLSEINMDNSPNLAWPLIVTALRANSAVKLQNNELSPVALRQMSCAAGTTQTAC
TDDNALAYYNNSKGGRFVLALLSDHQDLKWARFPKSDGTGTIYTELEPPCRFVTDTPKGP
KVKYLYFIKGLNNLNRGMVLGSLAATVRLQAGNATEVPANSTVLSFCAFAVDPAKAYKDY
LASGGQPITNCVKMLCTHTGTGQAITVTPEANMDQESFGGASCCLYCRCHIDHPNPKGFC
DLKGKYVQIPTTCANDPVGFTLRNTVCTVCGMWKGYGCSCDQLREPLMQSADASTFLNGF
AV

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History
Entry version 99 (16 Jan 2019)
Sequence version 1 (11 Sep 2007)
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Protein

Submitted name:

Polyprotein orf1a

Gene

PP1a

Organism

Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

cysteine-type endopeptidase activity Source: InterPro
omega peptidase activity Source: InterPro
RNA binding Source: UniProtKB-KW
RNA-directed 5'-3' RNA polymerase activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

induction by virus of host autophagy Source: UniProtKB-KW
viral genome replication Source: InterPro
viral protein processing Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protease, RNA-bindingSAAS annotation, Thiol proteaseSAAS annotation
Biological process	Activation of host autophagy by virusSAAS annotation, Host-virus interaction
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Polyprotein orf1aImported
Gene namesⁱ	Name:PP1aImported
Organismⁱ	Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)Imported
Taxonomic identifierⁱ	227859 [NCBI]
Taxonomic lineageⁱ	Viruses › ssRNA viruses › ssRNA positive-strand viruses, no DNA stage › Nidovirales › Coronaviridae › Coronavirinae › Betacoronavirus ›
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606] Paguma larvata (Masked palm civet) [TaxID: 9675]

Subcellular locationⁱ

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	2206 – 2231	HelicalSequence analysisAdd BLAST	26
Transmembraneⁱ	2314 – 2333	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	2340 – 2371	HelicalSequence analysisAdd BLAST	32
Transmembraneⁱ	2749 – 2768	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	3020 – 3042	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	3054 – 3078	HelicalSequence analysisAdd BLAST	25
Transmembraneⁱ	3115 – 3134	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	3559 – 3582	HelicalSequence analysisAdd BLAST	24
Transmembraneⁱ	3588 – 3606	HelicalSequence analysisAdd BLAST	19
Transmembraneⁱ	3613 – 3634	HelicalSequence analysisAdd BLAST	22
Transmembraneⁱ	3660 – 3678	HelicalSequence analysisAdd BLAST	19
Transmembraneⁱ	3685 – 3701	HelicalSequence analysisAdd BLAST	17
Transmembraneⁱ	3721 – 3743	HelicalSequence analysisAdd BLAST	23
Transmembraneⁱ	3755 – 3774	HelicalSequence analysisAdd BLAST	20

GO - Cellular componentⁱ

host cell membrane Source: UniProtKB-SubCell
host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cytoplasmSAAS annotation, Host membraneSAAS annotation, Membrane

Pathology & Biotechⁱ

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB08748 4-(DIMETHYLAMINO)BENZOIC ACID

DrugBankⁱ

DB08748 4-(DIMETHYLAMINO)BENZOIC ACID

Interactionⁱ

Chemistry databases

BindingDBⁱ

A7J8L3

Structureⁱ

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VJ1	X-ray	2.25	A/B	3242-3544	[»]
SMRⁱ	A7J8L3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1003 – 1169	MacroInterPro annotationAdd BLAST	167
Domainⁱ	1611 – 1875	Peptidase C16InterPro annotationAdd BLAST	265
Domainⁱ	3241 – 3546	Peptidase C30InterPro annotationAdd BLAST	306

Sequence similaritiesⁱ

Belongs to the coronaviruses polyprotein 1ab family.SAAS annotation

Keywords - Domainⁱ

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation, Zinc-fingerSAAS annotation

Family and domain databases

Gene3Dⁱ	1.10.150.420, 1 hit 1.10.8.370, 1 hit 2.30.30.590, 1 hit 2.40.10.250, 1 hit 3.10.20.350, 1 hit 3.40.220.20, 1 hit
InterProⁱ	View protein in InterPro IPR032505 Corona_NSP4_C IPR002589 Macro_dom IPR032592 NAR_dom IPR021590 NSP1 IPR036333 NSP10_sf IPR038030 NSP1_sf IPR024375 Nsp3_coronavir IPR038400 Nsp3_coronavir_sf IPR022733 Nsp3_PL2pro IPR038166 Nsp3_PL2pro_sf IPR038123 NSP4_C_sf IPR014828 NSP7 IPR037204 NSP7_sf IPR014829 NSP8 IPR037230 NSP8_sf IPR014822 NSP9 IPR036499 NSP9_sf IPR008740 Peptidase_C30 IPR013016 Peptidase_C30/C16 IPR009003 Peptidase_S1_PA IPR038083 pp1a/1ab IPR018995 RNA_synth_NSP10_coronavirus IPR024358 SARS-CoV_Nsp3_N IPR014827 Viral_protease
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF16348 Corona_NSP4_C, 1 hit PF12379 DUF3655, 1 hit PF01661 Macro, 1 hit PF16251 NAR, 1 hit PF11501 Nsp1, 1 hit PF09401 NSP10, 1 hit PF12124 Nsp3_PL2pro, 1 hit PF08716 nsp7, 1 hit PF08717 nsp8, 1 hit PF08710 nsp9, 1 hit PF05409 Peptidase_C30, 1 hit PF11633 SUD-M, 1 hit PF08715 Viral_protease, 1 hit
SMARTⁱ	View protein in SMART SM00506 A1pp, 1 hit
SUPFAMⁱ	SSF101816 SSF101816, 1 hit SSF140367 SSF140367, 1 hit SSF143076 SSF143076, 1 hit SSF144246 SSF144246, 1 hit SSF159936 SSF159936, 1 hit SSF160099 SSF160099, 1 hit SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS51442 M_PRO, 1 hit PS51154 MACRO, 1 hit PS51124 PEPTIDASE_C16, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A7J8L3-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT 
        60         70         80         90        100
CGLVELEKGV LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS 
       110        120        130        140        150
GITLGVLVPH VGETPIAYRN VLLRKNGNKG AGGHSYGIDL KSYDLGDELG 
       160        170        180        190        200
TDPIEDYEQN WNTKHGSGAL RELTRELNGG AVTRYVDNNF CGPDGYPLDC 
       210        220        230        240        250
IKDFLARAGK SMCTLSEQLD YIESKRGVYC CRDHEHEIAW FTERSDKSYE 
       260        270        280        290        300
HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI 
       310        320        330        340        350
RSVYPVASPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEHCGTENLV 
       360        370        380        390        400
IEGPTTCGYL PTNAVVKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG 
       410        420        430        440        450
GRTRCFGGCV FAYVGCYNKR AYWVPRASAD IGSGHTGITG DNVETLNEDL 
       460        470        480        490        500
LEILSRERVN INIVGDFHLN EEVAIILASF SASTSAFIDT IKSLDYKSFK 
       510        520        530        540        550
TIVESCGNYK VTKGKPVKGA WNIGQQRSVL TPLCGFPSQA AGVIRSIFAR 
       560        570        580        590        600
TLDAANHSIP DLQRAAVTIL DGISEQSLRL VDAMVYTSDL LTNSVIIMAY 
       610        620        630        640        650
VTGGLVQQTS QWLSNLLGTT VEKLRPIFEW IEAKLSAGVE FLKDAWEILK 
       660        670        680        690        700
FLITGVFDIV KGQIQVASDN IKDCVKCFID VVNKALEMCI DQVTIAGAKL 
       710        720        730        740        750
RSLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV 
       760        770        780        790        800
LTSEEVVLKN GELEALETPV DSFTNGAIVG TPVCVNGLML LEIKDKEQYC 
       810        820        830        840        850
ALSPGLLATN NVFRLKGGAP IKGVTFGEDT VWEVQGYKNV RITFELDERV 
       860        870        880        890        900
DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE 
       910        920        930        940        950
WSVATFYLFD DAGEENFSSR MYCSFYPPDE EEEDDAECEE EEIDETCEHE 
       960        970        980        990       1000
YGTEDDYQGL PLEFGASAET VRVEEEEEED WLDDTTEQSE IEPEPEPTPE 
      1010       1020       1030       1040       1050
EPVNQFTGYL KLTDNVAIKC VDIVKEAQSA NPMVIVNAAN IHLKHGGGVA 
      1060       1070       1080       1090       1100
GALNKATNGA MQKESDDYIK LNGPLTVGGS CLLSGHNLAK KCLHVVGPNL 
      1110       1120       1130       1140       1150
NAGEDIQLLK AAYENFNSQD ILLAPLLSAG IFGAKPLQSL QVCVQTVRTQ 
      1160       1170       1180       1190       1200
VYIAVNDKAL YEQVVMDYLD NLKPRVEAPK QEEPPNTEDS KTEEKSVVQK 
      1210       1220       1230       1240       1250
PVDVKPKIKA CIDEVTTTLE ETKFLTNKLL LFADINGKLY HDSQNMLRGE 
      1260       1270       1280       1290       1300
DMSFLEKDAP YMVGDVITSG DITCVVIPSK KAGGTTEMLS RALKKVPVDE 
      1310       1320       1330       1340       1350
YITTYPGQGC AGYTLEEAKT ALKKCKSAFY VLPSEAPNAK EEILGTVSWN 
      1360       1370       1380       1390       1400
LREMLAHAEE TRKLMPICMD VRAIMATIQR KYKGIKIQEG IVDYGVRFFF 
      1410       1420       1430       1440       1450
YTSKEPVASI ITKLNSLNEP LVTMPIGYVT HGFNLEEAAR CMRSLKAPAV 
      1460       1470       1480       1490       1500
VSVSSPDAVT TYNGYLTSSS KTSEEHFVET VSLAGSYRDW SYSGQRTELG 
      1510       1520       1530       1540       1550
VEFLKRGDKI VYHTLESPVE FHLDGEVLSL DKLKSLLSLR EVKTIKVFTT 
      1560       1570       1580       1590       1600
VDNTNLHTQL VDMSMTYGQQ FGPTYLDGAD VTKIKPHVNH EGKTFFVLPS 
      1610       1620       1630       1640       1650
DDTLRSEAFE YYHTLDESFL GRYMSALNHT KKWKFPQVGG LTSIKWADNN 
      1660       1670       1680       1690       1700
CYLSSVLLAL QQLEVKFNAP ALQEAYYRAR AGDAANFCAL ILAYSNKTVG 
      1710       1720       1730       1740       1750
ELGDVRETMT HLLQHANLES AKRVLNVVCK HCGQKTTTLT GVEAVMYMGT 
      1760       1770       1780       1790       1800
LSYDNLKTGV SIPCVCGRDA TQYLVQQESS FVMMSAPPAE YKLQQGTFLC 
      1810       1820       1830       1840       1850
ANEYTGNYQC GHYTHITAKE TLYRIDGAHL TKMSEYKGPV TDVFYKETSY 
      1860       1870       1880       1890       1900
TTTIKPVSYK LDGVTYTEIE PKLDGYYKKD NAYYTEQPID LVPTQPLPNA 
      1910       1920       1930       1940       1950
SFDNFKLTCS NTKFADDLNQ MTGFTKPASR ELSVTFFPDL NGDVVAIDYR 
      1960       1970       1980       1990       2000
HYSASFKKGA KLLHKPIVWH INQATTKTTF KPNTWCLRCL WSTKPVDTSN 
      2010       2020       2030       2040       2050
SFEVLAVEDT QGMDNLACES QQPTSEEVVE NPTIQKEVIE CDVKTTEVVG 
      2060       2070       2080       2090       2100
NVILKPSDEG VKVTQELGHE DLMAAYVENT SITIKKPNEL SLALGLKTIA 
      2110       2120       2130       2140       2150
THGIAAINSV PWSKILAYVK PFLGQAAITT SNCAKRLAQR VFNNYMPYVF 
      2160       2170       2180       2190       2200
TLLFQLCTFT KSTNSRIRAS LPTTIAKNSV KSVAKLCLDA GINYVKSPKF 
      2210       2220       2230       2240       2250
SKLFTIAMWL LLLSICLGSL ICVTAAFGVL LSNFGAPSYC NGVRELYLNS 
      2260       2270       2280       2290       2300
SNVTTMDFCE GSFPCSICLS GLDSLDSYPA LETIQVTISS YKLDLTILGL 
      2310       2320       2330       2340       2350
AAEWVLAYML FTKFFYLLGL SAIMQVFFGY FASHFISNSW LMWFIISIVQ 
      2360       2370       2380       2390       2400
MAPVSAMVRM YIFFASFYYI WKSYVHIMDG CTSSTCMMCY KRNRATRVEC 
      2410       2420       2430       2440       2450
TTIVNGMKRS FYVYANGGRG FCKTHNWNCL NCDTFCTGST FISDEVARDL 
      2460       2470       2480       2490       2500
SLQFKRPINP TDQSSYIVDS VAVKNGALHL YFDKAGQKTY ERHPLSHFVN 
      2510       2520       2530       2540       2550
LDNLRANNTK GSLPINVIVF DGKSKCDESA SKSASVYYSQ LMCQPILLLD 
      2560       2570       2580       2590       2600
QALVSDVGDS TEVSVKMFDA YVDTFSATFS VPMEKLKALV ATAHSELAKG 
      2610       2620       2630       2640       2650
VALDGVLSTF VSAARQGVVD TDVDTKDVIE CLKLSHHSDL EVTGDSCNNF 
      2660       2670       2680       2690       2700
MLTYNKVENM TPRDLGACID CNARHINAQV AKSHNVSLIW NVKDYMSLSE 
      2710       2720       2730       2740       2750
QLRKQIRSAA KKNNIPFRLT CATTRQVVNV ITTKISLKGG KIVSTCFKLM 
      2760       2770       2780       2790       2800
LKATLLCVLA ALVCYIVMPV HTLSIHDGYT NEIIGYKAIQ DGVTRDIIST 
      2810       2820       2830       2840       2850
DDCFANKHAG FDAWFSQRGG SYKNDKSCPV VAAIITREIG FIVPGLPGTV 
      2860       2870       2880       2890       2900
LRAINGDFLH FLPRVFSAVG NICYTPSKLI EYSDFATSAC VLAAECTIFK 
      2910       2920       2930       2940       2950
DAMGKPVPYC YDTNLLEGSI SYSELRPDTR YVLMDGSIIQ FPNTYLEGSV 
      2960       2970       2980       2990       3000
RVVTTFDAEY CRHGTCERSE VGICLSTSGR WVLNNEHYRA LSGVFCGVDA 
      3010       3020       3030       3040       3050
MNLIANIFTP LVQPVGALDV SASVVAGGII AILVTCAAYY FMKFRRVFGE 
      3060       3070       3080       3090       3100
YNHVVAANAL LFLMSFTILC LVPAYSFLPG VYSVFYLYLT FYFTNDVSFL 
      3110       3120       3130       3140       3150
AHLQWFAMFS PIVPFWITAI YVFCISLKHC HWFFNNYLRK RVMFNGVTFS 
      3160       3170       3180       3190       3200
TFEEAALCTF LLNKEMYLKL RSETLLPLTQ YNRYLALYNK YKYFSGALDT 
      3210       3220       3230       3240       3250
TSYREAACCH LAKALNDFSN SGADVLYQPP QTSITSAVLQ SGFRKMAFPS 
      3260       3270       3280       3290       3300
GKVEGCMVQV TCGTTTLNGL WLDDTVYCPR HVICTAEDML NPNYEDLLIR 
      3310       3320       3330       3340       3350
KSNHSFLVQA GNVQLRVIGH SMQNCLLRLK VDTSNPKTPK YKFVRIQPGQ 
      3360       3370       3380       3390       3400
TFSVLACYNG SPSGVYQCAM RPNHTIKGSF LNGSCGSVGF NIDYDCVSFC 
      3410       3420       3430       3440       3450
YMHHMELPTG VHAGTDLEGK FYGPFVDRQT AQAAGTDTTI TLNVLAWLYA 
      3460       3470       3480       3490       3500
AVINGDRWFL NRFTTTLNDF NLVAMKYNYE PLTQDHVDIL GPLSAQTGIA 
      3510       3520       3530       3540       3550
VLDMCAALKE LLQNGMNGRT ILGSTILEDE FTPFDVVRQC SGVTFQGKFK 
      3560       3570       3580       3590       3600
KIVKGTHHWM LLTFLTSLLI LVQSTQWSLF FFVYENAFLP FTLGIMAIAA 
      3610       3620       3630       3640       3650
CAMLLVKHKH AFLCLFLLPS LATVAYFNMV YMPASWVMRI MTWLELADTS 
      3660       3670       3680       3690       3700
LSGYRLKDCV MYASALVLLI LMTARTVYDD AARRVWTLMN VITLVYKVYY 
      3710       3720       3730       3740       3750
GNALDQAISM WALVISVTSN YSGVVTTIMF LARAIVFVCV EYYPLLFITG 
      3760       3770       3780       3790       3800
NTLQCIMLVY CFLGYCCCCY FGLFCLLNRY FRLTLGVYDY LVSTQEFRYM 
      3810       3820       3830       3840       3850
NSQGLLPPKS SIDAFKLNIK LLGIGGKPCI KVATVQSKMS DVKCTSVVLL 
      3860       3870       3880       3890       3900
SVLQQLRVES SSKLWAQCVQ LHNDILLAKD TTEAFEKMVS LLSVLLSMQG 
      3910       3920       3930       3940       3950
AVDINRLCEE MLDNRATLQA IASEFSSLPS YAAYATAQEA YEQAVANGDS 
      3960       3970       3980       3990       4000
EVVLKKLKKS LNVAKSEFDR DAAMQRKLEK MADQAMTQMY KQARSEDKRA 
      4010       4020       4030       4040       4050
KVTSAMQTML FTMLRKLDND ALNNIINNAR DGCVPLNIIP LTTAAKLMVV 
      4060       4070       4080       4090       4100
VPDYGTYKNT CDGNTFTYAS ALWEIQQVVD ADSKIVQLSE INMDNSPNLA 
      4110       4120       4130       4140       4150
WPLIVTALRA NSAVKLQNNE LSPVALRQMS CAAGTTQTAC TDDNALAYYN 
      4160       4170       4180       4190       4200
NSKGGRFVLA LLSDHQDLKW ARFPKSDGTG TIYTELEPPC RFVTDTPKGP 
      4210       4220       4230       4240       4250
KVKYLYFIKG LNNLNRGMVL GSLAATVRLQ AGNATEVPAN STVLSFCAFA 
      4260       4270       4280       4290       4300
VDPAKAYKDY LASGGQPITN CVKMLCTHTG TGQAITVTPE ANMDQESFGG 
      4310       4320       4330       4340       4350
ASCCLYCRCH IDHPNPKGFC DLKGKYVQIP TTCANDPVGF TLRNTVCTVC 
      4360       4370       4380 
GMWKGYGCSC DQLREPLMQS ADASTFLNGF AV

Length:4,382

Mass (Da):486,373

Last modified:September 11, 2007 - v1

Checksum:ⁱE1F65D5FD5DFF828

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JX163926 Genomic RNA Translation: AFR58712.1 JX163927 Genomic RNA Translation: AFR58726.1
NCBI Reference Sequences More...RefSeqⁱ	NP_828850.1, NC_004718.3

Genome annotation databases

GeneIDⁱ	1489680

GeneIDⁱ

1489680

Keywords - Coding sequence diversityⁱ

Ribosomal frameshiftingSAAS annotation

Protein	Similar proteins		Species	Score	Length	Source
A7J8L3	Replicase polyprotein 1a	)	CVHSA		4382	UniRef100_P0C6U8
Putative orf1ab polyprotein		SARS coronavirus PUMC01		7073
Orf1a polyprotein		SARS coronavirus HKU-39849		4382
Orf1a polyprotein		SARS coronavirus CUHK-AG03		4382
Orf1a polyprotein		SARS coronavirus CUHK-AG01		4382
+13

Protein	Similar proteins		Species	Score	Length	Source
A7J8L3	Replicase polyprotein 1ab		BC279		7079	UniRef90_P0C6V9
RNA-dependent RNA polymerase (Fragment)		Bat SARS-like coronavirus		134
RNA-dependent RNA polymerase (Fragment)		SARS-related bat coronavirus RsSHC014		129
RNA-dependent RNA polymerase (Fragment)		SARS-related betacoronavirus Rp3/2004		129
RNA-dependent RNA polymerase (Fragment)		BCHK3		129
+300

Protein	Similar proteins		Species	Score	Length	Source
A7J8L3	Replicase polyprotein 1ab		BC279		7079	UniRef50_P0C6V9
RNA-dependent RNA polymerase (Fragment)		Bat SARS-like coronavirus		134
RNA-dependent RNA polymerase (Fragment)		SARS-related bat coronavirus RsSHC014		129
RNA-dependent RNA polymerase (Fragment)		SARS-related betacoronavirus Rp3/2004		129
RNA-dependent RNA polymerase (Fragment)		BCHK3		129
+324

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	JX163926 Genomic RNA Translation: AFR58712.1 JX163927 Genomic RNA Translation: AFR58726.1
RefSeqⁱ	NP_828850.1, NC_004718.3

3D structure databases

Select the link destinations: PDBeⁱ RCSB PDBⁱ PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2VJ1	X-ray	2.25	A/B	3242-3544	[»]
SMRⁱ	A7J8L3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Chemistry databases

BindingDBⁱ	A7J8L3
DrugBankⁱ	DB08748 4-(DIMETHYLAMINO)BENZOIC ACID

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	1489680

GeneIDⁱ

1489680

Family and domain databases

Gene3Dⁱ	1.10.150.420, 1 hit 1.10.8.370, 1 hit 2.30.30.590, 1 hit 2.40.10.250, 1 hit 3.10.20.350, 1 hit 3.40.220.20, 1 hit
InterProⁱ	View protein in InterPro IPR032505 Corona_NSP4_C IPR002589 Macro_dom IPR032592 NAR_dom IPR021590 NSP1 IPR036333 NSP10_sf IPR038030 NSP1_sf IPR024375 Nsp3_coronavir IPR038400 Nsp3_coronavir_sf IPR022733 Nsp3_PL2pro IPR038166 Nsp3_PL2pro_sf IPR038123 NSP4_C_sf IPR014828 NSP7 IPR037204 NSP7_sf IPR014829 NSP8 IPR037230 NSP8_sf IPR014822 NSP9 IPR036499 NSP9_sf IPR008740 Peptidase_C30 IPR013016 Peptidase_C30/C16 IPR009003 Peptidase_S1_PA IPR038083 pp1a/1ab IPR018995 RNA_synth_NSP10_coronavirus IPR024358 SARS-CoV_Nsp3_N IPR014827 Viral_protease
Pfamⁱ	View protein in Pfam PF16348 Corona_NSP4_C, 1 hit PF12379 DUF3655, 1 hit PF01661 Macro, 1 hit PF16251 NAR, 1 hit PF11501 Nsp1, 1 hit PF09401 NSP10, 1 hit PF12124 Nsp3_PL2pro, 1 hit PF08716 nsp7, 1 hit PF08717 nsp8, 1 hit PF08710 nsp9, 1 hit PF05409 Peptidase_C30, 1 hit PF11633 SUD-M, 1 hit PF08715 Viral_protease, 1 hit
SMARTⁱ	View protein in SMART SM00506 A1pp, 1 hit
SUPFAMⁱ	SSF101816 SSF101816, 1 hit SSF140367 SSF140367, 1 hit SSF143076 SSF143076, 1 hit SSF144246 SSF144246, 1 hit SSF159936 SSF159936, 1 hit SSF160099 SSF160099, 1 hit SSF50494 SSF50494, 1 hit
PROSITEⁱ	View protein in PROSITE PS51442 M_PRO, 1 hit PS51154 MACRO, 1 hit PS51124 PEPTIDASE_C16, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A7J8L3_CVHSA
Accessionⁱ	A7J8L3Primary (citable) accession number: A7J8L3
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 11, 2007
	Last sequence update:	September 11, 2007
	Last modified:	January 16, 2019
	This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structureCombined sources

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UniProtKB - A7J8L3 (A7J8L3_CVHSA)

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Polyprotein orf1a

PP1a

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Family and domain databases

Sequence databases

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

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Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ