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Protein

NAD kinase

Gene

nadK

Organism
Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Proton acceptorUniRule annotation1
Binding sitei68NADUniRule annotation1
Binding sitei142NADUniRule annotation1
Binding sitei159NADUniRule annotation1
Binding sitei161NADUniRule annotation1
Binding sitei196NAD; via carbonyl oxygenUniRule annotation1
Binding sitei230NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 64NADUniRule annotation2
Nucleotide bindingi131 – 132NADUniRule annotation2
Nucleotide bindingi172 – 177NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciMBOO456442:G1G9N-1445-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:Mboo_1352
OrganismiMethanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)
Taxonomic identifieri456442 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanomicrobialesMethanoregulaceaeMethanoregula
Proteomesi
  • UP000002408 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000598771 – 270NAD kinaseAdd BLAST270

Interactioni

Protein-protein interaction databases

STRINGi456442.Mboo_1352

Structurei

3D structure databases

ProteinModelPortaliA7I809
SMRiA7I809
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01348 Archaea
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG093Z07HH

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

A7I809-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCFLVSRID MPGALDCASR MKTALERAGH TVVLDPDTAS MLGGSGHSIN
60 70 80 90 100
KVSADMAVVI GGDGTILRTV QQLHEQIPII GINHGEVGFL ADLEPEEAGA
110 120 130 140 150
FVRSLAPGFD VEERMRLSLW NEEDHLGDAL NEGLIVTTRP AKMLRFSILV
160 170 180 190 200
DGRLTEQFRS DGILVSTPTG STAYAMSAGG PIVDPRIEGF LLVPLAPYLL
210 220 230 240 250
SSRPHLISSS RRLEIRLESS KPAKLVIDGQ NTVELGSAVS LVIQKAASPA
260 270
RFIDVHRNFF EKVDRKLRKL
Length:270
Mass (Da):29,305
Last modified:September 11, 2007 - v1
Checksum:i562E4D3C53D6301D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000780 Genomic DNA Translation: ABS55870.1
RefSeqiWP_012106903.1, NC_009712.1

Genome annotation databases

EnsemblBacteriaiABS55870; ABS55870; Mboo_1352
GeneIDi5410288
KEGGimbn:Mboo_1352

Similar proteinsi

Entry informationi

Entry nameiNADK_METB6
AccessioniPrimary (citable) accession number: A7I809
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: September 11, 2007
Last modified: June 20, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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