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Protein

Methylenetetrahydrofolate reductase

Gene

Fnod_1279

Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tetrahydrofolate interconversion

This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

BioCyciFNOD381764:G1G9K-1325-MONOMER
UniPathwayi
UPA00193

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate reductaseUniRule annotation (EC:1.5.1.20UniRule annotation)
Gene namesi
Ordered Locus Names:Fnod_1279Imported
OrganismiFervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)Imported
Taxonomic identifieri381764 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeFervidobacterium
Proteomesi
  • UP000002415 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi381764.Fnod_1279

Structurei

3D structure databases

ProteinModelPortaliA7HMJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methylenetetrahydrofolate reductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105SYT Bacteria
COG0685 LUCA
HOGENOMiHOG000246233
KOiK00297
OMAiFIRAETG
OrthoDBiPOG091H02HI

Family and domain databases

CDDicd00537 MTHFR, 1 hit
InterProiView protein in InterPro
IPR029041 FAD-linked_oxidoreductase-like
IPR003171 Mehydrof_redctse
PfamiView protein in Pfam
PF02219 MTHFR, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit

Sequencei

Sequence statusi: Complete.

A7HMJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIVEKLRNE KIVSIEIIPP KRGEDVEKIF ATLDKLMDYN ISFINITRHP
60 70 80 90 100
SEIDYLETEN GIIKVQKIKR PGTIGLTAAL MKRYNIDVVP HLVCKGMNKF
110 120 130 140 150
EMEDILIDLS IMGVENVFVV RGEEVKSVAK SDYKYASDLV KQISDMNNGR
160 170 180 190 200
YLYTEAKPTN FCIGVAGYPE KHFEAPNLDV DLRFLKQKVD NGADFIITQM
210 220 230 240 250
VFDAAIYEKF VEKSRSMGIN IPIIPGVKPV VSKKSIYSIP KKFFVNIPQK
260 270 280 290 300
FVEKMEEAKS ESEEFEIGVR FTVELIKNLL EKDAPGVHIF TMGRGEEVCK
310
VLKLLREGGI LNV
Length:313
Mass (Da):35,602
Last modified:September 11, 2007 - v1
Checksum:iB78F4416EC01F4FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA Translation: ABS61126.1
RefSeqiWP_011994435.1, NC_009718.1

Genome annotation databases

EnsemblBacteriaiABS61126; ABS61126; Fnod_1279
KEGGifno:Fnod_1279

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000771 Genomic DNA Translation: ABS61126.1
RefSeqiWP_011994435.1, NC_009718.1

3D structure databases

ProteinModelPortaliA7HMJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi381764.Fnod_1279

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS61126; ABS61126; Fnod_1279
KEGGifno:Fnod_1279

Phylogenomic databases

eggNOGiENOG4105SYT Bacteria
COG0685 LUCA
HOGENOMiHOG000246233
KOiK00297
OMAiFIRAETG
OrthoDBiPOG091H02HI

Enzyme and pathway databases

UniPathwayi
UPA00193

BioCyciFNOD381764:G1G9K-1325-MONOMER

Family and domain databases

CDDicd00537 MTHFR, 1 hit
InterProiView protein in InterPro
IPR029041 FAD-linked_oxidoreductase-like
IPR003171 Mehydrof_redctse
PfamiView protein in Pfam
PF02219 MTHFR, 1 hit
SUPFAMiSSF51730 SSF51730, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA7HMJ3_FERNB
AccessioniPrimary (citable) accession number: A7HMJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: February 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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