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UniProtKB - A7HK39 (LON_FERNB)
Protein
Lon protease
Gene
lon
Organism
Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1)
Status
Functioni
ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
UniRule annotationCatalytic activityi
- Hydrolysis of proteins in presence of ATP.UniRule annotation EC:3.4.21.53
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 697 | UniRule annotation | 1 | |
Active sitei | 740 | UniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 376 – 383 | ATPUniRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-UniRule
- ATP-dependent peptidase activity Source: UniProtKB-UniRule
- ATP hydrolysis activity Source: UniProtKB-UniRule
- sequence-specific DNA binding Source: UniProtKB-UniRule
- serine-type endopeptidase activity Source: UniProtKB-UniRule
GO - Biological processi
- cellular response to heat Source: UniProtKB-UniRule
- protein quality control for misfolded or incompletely synthesized proteins Source: UniProtKB-UniRule
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Protein family/group databases
MEROPSi | S16.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)Alternative name(s): ATP-dependent protease LaUniRule annotation |
Gene namesi | Name:lonUniRule annotation Ordered Locus Names:Fnod_0407 |
Organismi | Fervidobacterium nodosum (strain ATCC 35602 / DSM 5306 / Rt17-B1) |
Taxonomic identifieri | 381764 [NCBI] |
Taxonomic lineagei | Bacteria › Thermotogae › Thermotogales › Fervidobacteriaceae › Fervidobacterium › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000396563 | 1 – 810 | Lon proteaseAdd BLAST | 810 |
Proteomic databases
PRIDEi | A7HK39 |
Expressioni
Inductioni
By heat shock.UniRule annotation
Interactioni
Subunit structurei
Homohexamer. Organized in a ring with a central cavity.
UniRule annotationProtein-protein interaction databases
STRINGi | 381764.Fnod_0407 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 32 – 224 | Lon N-terminalPROSITE-ProRule annotationAdd BLAST | 193 | |
Domaini | 612 – 791 | Lon proteolyticPROSITE-ProRule annotationAdd BLAST | 180 |
Sequence similaritiesi
Belongs to the peptidase S16 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0466, Bacteria |
HOGENOMi | CLU_004109_4_3_0 |
OMAi | GAWQVVD |
OrthoDBi | 128102at2 |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit 3.40.50.300, 1 hit |
HAMAPi | MF_01973, lon_bact, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR027543, Lon_bac IPR004815, Lon_bac/euk-typ IPR008269, Lon_proteolytic IPR027065, Lon_Prtase IPR003111, Lon_substr-bd IPR027417, P-loop_NTPase IPR008268, Peptidase_S16_AS IPR015947, PUA-like_sf IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr |
PANTHERi | PTHR10046, PTHR10046, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF05362, Lon_C, 1 hit PF02190, LON_substr_bdg, 1 hit |
PIRSFi | PIRSF001174, Lon_proteas, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00464, LON, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF54211, SSF54211, 1 hit SSF88697, SSF88697, 1 hit |
TIGRFAMsi | TIGR00763, lon, 1 hit |
PROSITEi | View protein in PROSITE PS51787, LON_N, 1 hit PS51786, LON_PROTEOLYTIC, 1 hit PS01046, LON_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
A7HK39-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPNKNDNKGK YSRLEKEAKK AREEKISIPN VLPAIAMRSN MVIFPNTVVP
60 70 80 90 100
FYVGREISLM ALEEAMEKTN QIVFVVNQKD PAVETPTEKD LYKVGTIVRI
110 120 130 140 150
IQVGKLPDET FKVLVEGIAR AKWIKNVGEK FFKFEIEILR TRYGKSKRLI
160 170 180 190 200
ALMRMVKEEL HKYVQYSRKI PPETLMLLED VDNPDVFADI AASLCPGNIE
210 220 230 240 250
EKQQLLEIVH PANRLERILD ILARETELLE IEQQLDQKVK ERIEKSQREY
260 270 280 290 300
YLREKLRVIR DELGGEEDIE IKELKEKIEN NNYPEFVKEK ARAEINRLEK
310 320 330 340 350
MSPYAPEATV VRTYLDWILN LPWHEKTDDT DDINFAEKVL NEDHYGLDEP
360 370 380 390 400
KRRILEYLAT RKVSQKAKAP IICFVGPPGV GKTSLAKSIA RAMNRKFGRM
410 420 430 440 450
SLGGLRDEAE IRGHRRTYVG AMPGRIMQLI RKLGVKNPVI LLDEIDKMGI
460 470 480 490 500
SFQGDPASAL LEVLDPEQNK EFVDHYIELP YDLSEVLFVT TANVLYTIPP
510 520 530 540 550
ALRDRMEVIE ISSYTDVEKF YIAKNYIIPK IESEFVEKAD EIFSFKDTAI
560 570 580 590 600
KKIINEYTLE PGVRELEREI RSVVRKATLD AIKTGKKIVI SPEKVTEYLG
610 620 630 640 650
PSKIKDEDKL EKPMIGVTTG LAWTPNGGTT LYIESTLIPG NGGLIITGQL
660 670 680 690 700
GDVMKESVRI ALSLARKIVG DEYAEKFTKN DIHVHVPEGA VPKDGPSAGV
710 720 730 740 750
TITTALVSVV KNIPVRNDIA MTGEITLRGR VLPVGGIKEK VMAAYRKGIY
760 770 780 790 800
HVILPKKNEV DIEKVPEVVR TKMKFTFVET IEEVLEVALN EDNSKESRKG
810
RTRKGNSNTK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000771 Genomic DNA Translation: ABS60272.1 |
RefSeqi | WP_011993592.1, NC_009718.1 |
Genome annotation databases
EnsemblBacteriai | ABS60272; ABS60272; Fnod_0407 |
KEGGi | fno:Fnod_0407 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000771 Genomic DNA Translation: ABS60272.1 |
RefSeqi | WP_011993592.1, NC_009718.1 |
3D structure databases
SMRi | A7HK39 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 381764.Fnod_0407 |
Protein family/group databases
MEROPSi | S16.001 |
Proteomic databases
PRIDEi | A7HK39 |
Genome annotation databases
EnsemblBacteriai | ABS60272; ABS60272; Fnod_0407 |
KEGGi | fno:Fnod_0407 |
Phylogenomic databases
eggNOGi | COG0466, Bacteria |
HOGENOMi | CLU_004109_4_3_0 |
OMAi | GAWQVVD |
OrthoDBi | 128102at2 |
Family and domain databases
Gene3Di | 3.30.230.10, 1 hit 3.40.50.300, 1 hit |
HAMAPi | MF_01973, lon_bact, 1 hit |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR003959, ATPase_AAA_core IPR027543, Lon_bac IPR004815, Lon_bac/euk-typ IPR008269, Lon_proteolytic IPR027065, Lon_Prtase IPR003111, Lon_substr-bd IPR027417, P-loop_NTPase IPR008268, Peptidase_S16_AS IPR015947, PUA-like_sf IPR020568, Ribosomal_S5_D2-typ_fold IPR014721, Ribosomal_S5_D2-typ_fold_subgr |
PANTHERi | PTHR10046, PTHR10046, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF05362, Lon_C, 1 hit PF02190, LON_substr_bdg, 1 hit |
PIRSFi | PIRSF001174, Lon_proteas, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit SM00464, LON, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF54211, SSF54211, 1 hit SSF88697, SSF88697, 1 hit |
TIGRFAMsi | TIGR00763, lon, 1 hit |
PROSITEi | View protein in PROSITE PS51787, LON_N, 1 hit PS51786, LON_PROTEOLYTIC, 1 hit PS01046, LON_SER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LON_FERNB | |
Accessioni | A7HK39Primary (citable) accession number: A7HK39 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 10, 2010 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 23, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families