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Protein

tRNA pseudouridine synthase A

Gene

truA

Organism
Anaeromyxobacter sp. (strain Fw109-5)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

tRNA uridine(38-40) = tRNA pseudouridine(38-40).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52NucleophileUniRule annotation1
Binding sitei110SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotation
Biological processtRNA processingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciASP404589:G1G9J-4339-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase AUniRule annotation (EC:5.4.99.12UniRule annotation)
Alternative name(s):
tRNA pseudouridine(38-40) synthaseUniRule annotation
tRNA pseudouridylate synthase IUniRule annotation
tRNA-uridine isomerase IUniRule annotation
Gene namesi
Name:truAUniRule annotation
Ordered Locus Names:Anae109_4191Imported
OrganismiAnaeromyxobacter sp. (strain Fw109-5)Imported
Taxonomic identifieri404589 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaMyxococcalesCystobacterineaeAnaeromyxobacteraceaeAnaeromyxobacter
Proteomesi
  • UP000006382 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi404589.Anae109_4191

Structurei

3D structure databases

ProteinModelPortaliA7HI23
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 97PseudoU_synth_1InterPro annotationAdd BLAST89
Domaini143 – 245PseudoU_synth_1InterPro annotationAdd BLAST103

Sequence similaritiesi

Belongs to the tRNA pseudouridine synthase TruA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR
OrthoDBiPOG091H010Q

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 2 hits
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit

Sequencei

Sequence statusi: Complete.

A7HI23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVVKLVLEY DGTRYVGWQV QPNGPSIQAE VERALATLHK EPRRVTAAGR
60 70 80 90 100
TDAGVHARGQ VVSFPEARPL PLAAYVKGMN ALLPDEVAVR AASVEPDGFD
110 120 130 140 150
ARRSARGKRY RYVLENLETR APLSRLQAWQ LFGALDVGAM REASRHLLGR
160 170 180 190 200
QDFAAFQAAD CACDHAVREV HRLDVLGEPS GRVELVVEAT AFVKHMVRNF
210 220 230 240
VGTLVEVGKG RRRAEDMPAL VASRDRTRAG RTAPPQGLFL EEVFY
Length:245
Mass (Da):27,050
Last modified:September 11, 2007 - v1
Checksum:iB6065E232666D0E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA Translation: ABS28369.1
RefSeqiWP_012099012.1, NC_009675.1

Genome annotation databases

EnsemblBacteriaiABS28369; ABS28369; Anae109_4191
KEGGiafw:Anae109_4191

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000769 Genomic DNA Translation: ABS28369.1
RefSeqiWP_012099012.1, NC_009675.1

3D structure databases

ProteinModelPortaliA7HI23
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi404589.Anae109_4191

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS28369; ABS28369; Anae109_4191
KEGGiafw:Anae109_4191

Phylogenomic databases

eggNOGiENOG4105DI7 Bacteria
COG0101 LUCA
HOGENOMiHOG000248674
KOiK06173
OMAiFLYGMVR
OrthoDBiPOG091H010Q

Enzyme and pathway databases

BioCyciASP404589:G1G9J-4339-MONOMER

Family and domain databases

Gene3Di3.30.70.660, 1 hit
HAMAPiMF_00171 TruA, 1 hit
InterProiView protein in InterPro
IPR020103 PsdUridine_synth_cat_dom_sf
IPR001406 PsdUridine_synth_TruA
IPR020097 PsdUridine_synth_TruA_a/b_dom
IPR020095 PsdUridine_synth_TruA_C
PANTHERiPTHR11142 PTHR11142, 1 hit
PfamiView protein in Pfam
PF01416 PseudoU_synth_1, 2 hits
PIRSFiPIRSF001430 tRNA_psdUrid_synth, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
TIGRFAMsiTIGR00071 hisT_truA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA7HI23_ANADF
AccessioniPrimary (citable) accession number: A7HI23
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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