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Protein

Adenylyl-sulfate kinase

Gene

cysC

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of activated sulfate.UniRule annotationSAAS annotation

Catalytic activityi

ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate.UniRule annotationSAAS annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (sat)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei106Phosphoserine intermediateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 39ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationSAAS annotationImported, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00140; UER00205

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylyl-sulfate kinaseUniRule annotationSAAS annotation (EC:2.7.1.25UniRule annotationSAAS annotation)
Alternative name(s):
APS kinaseUniRule annotation
ATP adenosine-5'-phosphosulfate 3'-phosphotransferaseUniRule annotation
Adenosine-5'-phosphosulfate kinaseUniRule annotation
Gene namesi
Name:cysCUniRule annotation
Ordered Locus Names:Bcer98_1145Imported
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)Imported
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

PTM / Processingi

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_1145

Structurei

3D structure databases

ProteinModelPortaliA7GMW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APS kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108I67 Bacteria
COG0529 LUCA
HOGENOMiHOG000228204
KOiK00860
OMAiVSPFRAD
OrthoDBiPOG091H04O4

Family and domain databases

CDDicd02027 APSK, 1 hit
HAMAPiMF_00065 Adenylyl_sulf_kinase, 1 hit
InterProiView protein in InterPro
IPR002891 APS_kinase
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00455 apsK, 1 hit

Sequencei

Sequence statusi: Complete.

A7GMW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTNITWHTA SVSKEERRKR NGHHSFVIWF TGLSASGKST VANAVARKLF
60 70 80 90 100
DRNIGNYVLD GDNIRYGLNK DLSFSERDRA ENIRRIGEVS KLFVDQGTIV
110 120 130 140 150
LTAFISPFRA DRQQVRAIFE KDEFIEVFVK CPIEECEKRD PKGLYEKARQ
160 170 180 190
GEIKLFTGID SPYEEPEKAE LTVETNRYSI EECAEQIIHY LQERSFI
Length:197
Mass (Da):22,816
Last modified:September 11, 2007 - v1
Checksum:i98B07128802491BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS21470.1
RefSeqiWP_011984223.1, NC_009674.1

Genome annotation databases

EnsemblBacteriaiABS21470; ABS21470; Bcer98_1145
GeneIDi33896499
KEGGibcy:Bcer98_1145

Similar proteinsi

Entry informationi

Entry nameiA7GMW2_BACCN
AccessioniPrimary (citable) accession number: A7GMW2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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