Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Reduction of activated sulfate into sulfite.UniRule annotation

Catalytic activityi

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes sulfite from sulfate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase (sat)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

UniPathwayi
UPA00140;UER00206

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoadenosine phosphosulfate reductaseUniRule annotation (EC:1.8.4.8UniRule annotation)
Alternative name(s):
3'-phosphoadenylylsulfate reductaseUniRule annotation
PAPS reductase, thioredoxin dependentUniRule annotation
PAPS sulfotransferaseUniRule annotation
PAdoPS reductaseUniRule annotation
Gene namesi
Name:cysHUniRule annotation
Ordered Locus Names:Bcer98_1143
OrganismiBacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)
Taxonomic identifieri315749 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002300 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000750691 – 234Phosphoadenosine phosphosulfate reductaseAdd BLAST234

Interactioni

Protein-protein interaction databases

STRINGi315749.Bcer98_1143

Structurei

3D structure databases

ProteinModelPortaliA7GMW0
SMRiA7GMW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAPS reductase family. CysH subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0175 LUCA
HOGENOMiHOG000249397
KOiK00390
OMAiVGDWHSS
OrthoDBiPOG091H04I4

Family and domain databases

CDDicd01713 PAPS_reductase, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00063 CysH, 1 hit
InterProiView protein in InterPro
IPR004511 PAPS/APS_Rdtase
IPR002500 PAPS_reduct
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01507 PAPS_reduct, 1 hit
PIRSFiPIRSF000857 PAPS_reductase, 1 hit
TIGRFAMsiTIGR00434 cysH, 1 hit

Sequencei

Sequence statusi: Complete.

A7GMW0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTYETWEED SMSFSERDET KGALAVLEWA YKQYNDEIVY ACSFGVEGMV
60 70 80 90 100
LLHLINEVNP FAQVVFLDTN VHFCETYALI ERVRQRFPKL NIIEKQPGLT
110 120 130 140 150
LEEQEDKYGK DLWEHNPNLC CKLRKILPLE ELLANKNAWI SGLRREQSET
160 170 180 190 200
RKHTKFINQD HRFQSIKICP LIHWTWKEVW RYVYKHNLPY NPLHDVGYPS
210 220 230
IGCEKCTLPV GKYGSSRDGR WAGSVKTECG LHDQ
Length:234
Mass (Da):27,513
Last modified:September 11, 2007 - v1
Checksum:iC5E3FCCD2A6C873A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS21468.1
RefSeqiWP_011984221.1, NC_009674.1

Genome annotation databases

EnsemblBacteriaiABS21468; ABS21468; Bcer98_1143
GeneIDi33896497
KEGGibcy:Bcer98_1143

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000764 Genomic DNA Translation: ABS21468.1
RefSeqiWP_011984221.1, NC_009674.1

3D structure databases

ProteinModelPortaliA7GMW0
SMRiA7GMW0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi315749.Bcer98_1143

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABS21468; ABS21468; Bcer98_1143
GeneIDi33896497
KEGGibcy:Bcer98_1143

Phylogenomic databases

eggNOGiCOG0175 LUCA
HOGENOMiHOG000249397
KOiK00390
OMAiVGDWHSS
OrthoDBiPOG091H04I4

Enzyme and pathway databases

UniPathwayi
UPA00140;UER00206

Family and domain databases

CDDicd01713 PAPS_reductase, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00063 CysH, 1 hit
InterProiView protein in InterPro
IPR004511 PAPS/APS_Rdtase
IPR002500 PAPS_reduct
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01507 PAPS_reduct, 1 hit
PIRSFiPIRSF000857 PAPS_reductase, 1 hit
TIGRFAMsiTIGR00434 cysH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCYSH_BACCN
AccessioniPrimary (citable) accession number: A7GMW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: September 11, 2007
Last modified: October 10, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again