arnD

Functionⁱ

Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.UniRule annotation

Catalytic activityⁱ

4-deoxy-4-formamido-beta-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + H₂O = 4-amino-4-deoxy-alpha-L-arabinose di-trans,poly-cis-undecaprenyl phosphate + formate.UniRule annotation

Pathwayⁱ: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:

no protein annotated in this organism
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD (arnD)

This subpathway is part of the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate, the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis and in Glycolipid biosynthesis.

Pathwayⁱ: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

GO - Molecular functionⁱ

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
lipid A biosynthetic process Source: UniProtKB-KW
lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
response to antibiotic Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase
Biological process	Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis

Enzyme and pathway databases

UniPathwayⁱ	UPA00030 UPA00036; UER00496

UniPathwayⁱ

UPA00030
UPA00036; UER00496

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation)
Gene namesⁱ	Name:arnDUniRule annotation Ordered Locus Names:YpsIP31758_1728
Organismⁱ	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Taxonomic identifierⁱ	349747 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Yersiniaceae › Yersinia › Yersinia pseudotuberculosis
Proteomesⁱ	UP000002412 Componentⁱ: Chromosome

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000383558	1 – 301	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDAdd BLAST		301

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A7FHH5
SMRⁱ	A7FHH5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	2 – 261	NodB homologyUniRule annotationAdd BLAST		260

Sequence similaritiesⁱ

Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000261199
KEGG Orthology (KO) More...KOⁱ	K13014
OMAⁱ	KFLWKML

Family and domain databases

HAMAPⁱ	MF_01870 ArnD, 1 hit
InterProⁱ	View protein in InterPro IPR023557 ArnD IPR011330 Glyco_hydro/deAcase_b/a-brl IPR002509 NODB_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01522 Polysacc_deac_1, 1 hit
SUPFAMⁱ	SSF88713 SSF88713, 2 hits
PROSITEⁱ	View protein in PROSITE PS51677 NODB, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A7FHH5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKQVGLRIDV DTYRGTQYGV PSLLTVLEKH DIRASFFFSV GPDNMGRHLW 
        60         70         80         90        100
RLFRPRFLWK MLRSNAASLY GWDILLAGTA WPGKKIAKDF GPLMKAAAMA 
       110        120        130        140        150
GHEVGLHAWD HQGWQANVAS WSQQQLTEQV QRGVDTLQQS IGQPISCSAA 
       160        170        180        190        200
AGWRADERVL AVKQQFDFSY NSDCRGTHPF RPLLPNGSLG SVQIPVTLPT 
       210        220        230        240        250
YDEVVGGEVQ AENFNDFIID AILRDSGVSV YTIHAEVEGM SQAAMFEQLL 
       260        270        280        290        300
MRAKQQDIEF CPLSKLLPSD LQLLPVGKVI RAAFPGREGW LGCQSDIKDA 

E

Length:301

Mass (Da):33,504

Last modified:September 11, 2007 - v1

Checksum:ⁱABA3A1132D09A864

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000720 Genomic DNA Translation: ABS48440.1
NCBI Reference Sequences More...RefSeqⁱ	WP_002211822.1, NC_009708.1

Genome annotation databases

EnsemblBacteriaⁱ	ABS48440; ABS48440; YpsIP31758_1728
KEGGⁱ	ypi:YpsIP31758_1728

Protein	Similar proteins		Species	Score	Length
A7FHH5	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPA		301
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPB		301
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPE		301
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPG		301
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPN		301
+12

Protein	Similar proteins		Species	Score	Length
A7FHH5	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPY		301
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPA		301
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPB		301
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPE		301
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		YERPG		301
+25

Protein	Similar proteins		Species	Score	Length
A7FHH5	Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO57		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5E		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOLX		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECOCB		296
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD		ECO5C		296
+2269

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000720 Genomic DNA Translation: ABS48440.1
NCBI Reference Sequences More...RefSeqⁱ	WP_002211822.1, NC_009708.1

3D structure databases

ProteinModelPortalⁱ	A7FHH5
SMRⁱ	A7FHH5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABS48440; ABS48440; YpsIP31758_1728
KEGGⁱ	ypi:YpsIP31758_1728

Phylogenomic databases

HOGENOMⁱ	HOG000261199
KEGG Orthology (KO) More...KOⁱ	K13014
OMAⁱ	KFLWKML

Enzyme and pathway databases

UniPathwayⁱ	UPA00030 UPA00036; UER00496

UniPathwayⁱ

UPA00030
UPA00036; UER00496

Family and domain databases

HAMAPⁱ	MF_01870 ArnD, 1 hit
InterProⁱ	View protein in InterPro IPR023557 ArnD IPR011330 Glyco_hydro/deAcase_b/a-brl IPR002509 NODB_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01522 Polysacc_deac_1, 1 hit
SUPFAMⁱ	SSF88713 SSF88713, 2 hits
PROSITEⁱ	View protein in PROSITE PS51677 NODB, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ARND_YERP3
Accessionⁱ	A7FHH5Primary (citable) accession number: A7FHH5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
	Last sequence update:	September 11, 2007
	Last modified:	April 25, 2018
	This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

UniProtKB - A7FHH5 (ARND_YERP3)

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Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis

Pathwayⁱ: lipopolysaccharide biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

PTM / Processingⁱ

Molecule processing

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

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Proteomes

Annotation systems

Supporting data

UniProtKB - A7FHH5 (ARND_YERP3)

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Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD

arnD

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: lipopolysaccharide biosynthesis

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

Pathwayⁱ: lipopolysaccharide biosynthesis

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

PTM / Processingⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ