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UniProtKB - A7FHH5 (ARND_YERP3)
Protein
Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD
Gene
arnD
Organism
Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)
Status
Functioni
Catalyzes the deformylation of 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
UniRule annotationCatalytic activityi
- 4-deoxy-4-formamido-α-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-α-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formateUniRule annotationEC:3.5.1.n3UniRule annotation
: 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate.UniRule annotation This subpathway is part of the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis, which is itself part of Glycolipid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate, the pathway 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis and in Glycolipid biosynthesis.
Pathwayi: lipopolysaccharide biosynthesis
This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotationView all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.
GO - Molecular functioni
- hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides Source: UniProtKB-UniRule
GO - Biological processi
- 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process Source: UniProtKB-UniPathway
- lipid A biosynthetic process Source: UniProtKB-UniRule
- lipopolysaccharide biosynthetic process Source: UniProtKB-UniPathway
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Biological process | Antibiotic resistance, Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism, Lipopolysaccharide biosynthesis |
Enzyme and pathway databases
UniPathwayi | UPA00030 UPA00036;UER00496 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDUniRule annotation (EC:3.5.1.n3UniRule annotation) |
Gene namesi | Name:arnDUniRule annotation Ordered Locus Names:YpsIP31758_1728 |
Organismi | Yersinia pseudotuberculosis serotype O:1b (strain IP 31758) |
Taxonomic identifieri | 349747 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Yersiniaceae › Yersinia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000383558 | 1 – 301 | Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnDAdd BLAST | 301 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2 – 261 | NodB homologyUniRule annotationAdd BLAST | 260 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_084199_0_0_6 |
OMAi | KFLWKML |
Family and domain databases
HAMAPi | MF_01870, ArnD, 1 hit |
InterProi | View protein in InterPro IPR023557, ArnD IPR011330, Glyco_hydro/deAcase_b/a-brl IPR002509, NODB_dom |
Pfami | View protein in Pfam PF01522, Polysacc_deac_1, 1 hit |
SUPFAMi | SSF88713, SSF88713, 1 hit |
PROSITEi | View protein in PROSITE PS51677, NODB, 1 hit |
i Sequence
Sequence statusi: Complete.
A7FHH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQVGLRIDV DTYRGTQYGV PSLLTVLEKH DIRASFFFSV GPDNMGRHLW
60 70 80 90 100
RLFRPRFLWK MLRSNAASLY GWDILLAGTA WPGKKIAKDF GPLMKAAAMA
110 120 130 140 150
GHEVGLHAWD HQGWQANVAS WSQQQLTEQV QRGVDTLQQS IGQPISCSAA
160 170 180 190 200
AGWRADERVL AVKQQFDFSY NSDCRGTHPF RPLLPNGSLG SVQIPVTLPT
210 220 230 240 250
YDEVVGGEVQ AENFNDFIID AILRDSGVSV YTIHAEVEGM SQAAMFEQLL
260 270 280 290 300
MRAKQQDIEF CPLSKLLPSD LQLLPVGKVI RAAFPGREGW LGCQSDIKDA
E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000720 Genomic DNA Translation: ABS48440.1 |
RefSeqi | WP_002211822.1, NC_009708.1 |
Genome annotation databases
EnsemblBacteriai | ABS48440; ABS48440; YpsIP31758_1728 |
GeneIDi | 66841239 |
KEGGi | ypi:YpsIP31758_1728 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CP000720 Genomic DNA Translation: ABS48440.1 |
RefSeqi | WP_002211822.1, NC_009708.1 |
3D structure databases
AlphaFoldDBi | A7FHH5 |
SMRi | A7FHH5 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | ABS48440; ABS48440; YpsIP31758_1728 |
GeneIDi | 66841239 |
KEGGi | ypi:YpsIP31758_1728 |
Phylogenomic databases
HOGENOMi | CLU_084199_0_0_6 |
OMAi | KFLWKML |
Enzyme and pathway databases
UniPathwayi | UPA00030 UPA00036;UER00496 |
Family and domain databases
HAMAPi | MF_01870, ArnD, 1 hit |
InterProi | View protein in InterPro IPR023557, ArnD IPR011330, Glyco_hydro/deAcase_b/a-brl IPR002509, NODB_dom |
Pfami | View protein in Pfam PF01522, Polysacc_deac_1, 1 hit |
SUPFAMi | SSF88713, SSF88713, 1 hit |
PROSITEi | View protein in PROSITE PS51677, NODB, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARND_YERP3 | |
Accessioni | A7FHH5Primary (citable) accession number: A7FHH5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 22, 2009 |
Last sequence update: | September 11, 2007 | |
Last modified: | May 25, 2022 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families