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Entry version 70 (08 May 2019)
Sequence version 1 (11 Sep 2007)
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Protein

Rho GTPase-activating protein 7

Gene

DLC1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 7
Alternative name(s):
Deleted in liver cancer 1 protein homolog
Short name:
DLC-1
Rho-type GTPase-activating protein 7
START domain-containing protein 12
Short name:
StARD12
StAR-related lipid transfer protein 12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DLC1
Synonyms:ARHGAP7, STARD12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003820271 – 1112Rho GTPase-activating protein 7Add BLAST1112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei112PhosphoserineBy similarity1
Modified residuei115PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A7E300

PRoteomics IDEntifications database

More...
PRIDEi
A7E300

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000020664

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A7E300

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini37 – 104SAMAdd BLAST68
Domaini662 – 868Rho-GAPPROSITE-ProRule annotationAdd BLAST207
Domaini898 – 1105STARTPROSITE-ProRule annotationAdd BLAST208

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni296 – 468Focal adhesion-targeting (FAT)By similarityAdd BLAST173
Regioni635 – 657Polybasic cluster (PBR)By similarityAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi319 – 352Ser-richAdd BLAST34
Compositional biasi452 – 458Poly-Ser7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SAM domain mediates interaction with EF1A1, and functions as an autoinhibitory regulator of RhoGAP Activity.By similarity
The polybasic cluster is required for activation and mediates binding to phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) containing membranes.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2200 Eukaryota
ENOG410XQ10 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000039960

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7E300

KEGG Orthology (KO)

More...
KOi
K20632

Database of Orthologous Groups

More...
OrthoDBi
218349at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
3.30.530.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028854 DLC1
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom

The PANTHER Classification System

More...
PANTHERi
PTHR12659:SF2 PTHR12659:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7E300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPLRAPLR RSFSDHIRDS TARALDVIWK NTRDRRLAEI EAKEACDWLR
60 70 80 90 100
AAGFPQYAQL YEDLLFPIDI SSVKREHDFL DRDAIEALCR RLNTLNKCAV
110 120 130 140 150
MKLEISPHRK RSEDSDEDEP CAISGKWTFQ RDSKRWSRLE EFDVFSPKQD
160 170 180 190 200
PIPGSPDAVH LKSAPSHENM QTDLSDRQEV ASVHSTGSLT THAPQRGEAA
210 220 230 240 250
PARTNSVLSV CSSGTFVGND DSFCSLPSPK ELSSFSFSMK GHEKAAKSKT
260 270 280 290 300
HSLLKRMESL KLKGSHHSKH KAPSKLGLII SGPILQEGVD EEKLKQLNCV
310 320 330 340 350
EISALNGNHI NVPMVRKRSI SSSTQTSSSS SQSETSSNVS TPSPVTRTRS
360 370 380 390 400
LSACNKRGGM YLEGFDPFNQ STFNNVMEQN CKNRESYPED TVFYIPEDHK
410 420 430 440 450
PGTFPKALSN GSFSPSGNNS SVNWRTGSFH GPGHISLRRE NSSPKELKRR
460 470 480 490 500
NSSSSVSSRL SIYDNVPGSI LYSSSGDLAD LENEDIFPEL DDILYHVKGM
510 520 530 540 550
QRIVNQWSEK FSDEGDSDSA LDSVSPCPSS PKQIHLDVDN DRATPSDLDS
560 570 580 590 600
TGNSLNEPEE PSDIPERRDS GVGASLTRSN RHRLRWHSFQ SSHRPSLNSV
610 620 630 640 650
SLQINCQSVA QMNLLQKYSL LKLTALLEKY TPSNKHGFSW AVPKFMKRIK
660 670 680 690 700
VPDYKDRNVF GVPLTVNVQR TGQPLPQSIQ QAMRYLRNHC LDQVGLFRKS
710 720 730 740 750
GVKSRIQALR QMNESTIDCV NYEGQSAYDV ADMLKQYFRD LPEPLMTNKL
760 770 780 790 800
SETFLQIYQY VPKDQRLQAI KAAIMLLPDE NREVLQTLLY FLSDVTAAVK
810 820 830 840 850
ENQMTPTNLA VCLAPSLFHL NTLKRENSSP RVMQRKQSLG KPDQKDLNEN
860 870 880 890 900
LAATQGLAHM IAECKKLFQV PEEMSRCRNS YTEQELKPLT LEALGRLCND
910 920 930 940 950
DSADYQHFLQ DCVDSLFKEV KEKFKGWVSY STSEQAELSY KKVSEGPPLR
960 970 980 990 1000
LWRATIEVPA TPEEILKRLL KEQHLWDVDL LDSKVIEILD SQTEIYQYVQ
1010 1020 1030 1040 1050
NSMAPHPARD YVVLRTWRTN LPKGACALLL TSVDHDRAPV VGVRVNVLLA
1060 1070 1080 1090 1100
RYLIEPCGSG KSKLTYMCRA DLRGHMPEWY TKSFGHLCAA EVVKIRDSFS
1110
HQNTETKDTK SR
Length:1,112
Mass (Da):125,468
Last modified:September 11, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AE63CBAA1295112
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC151638 mRNA Translation: AAI51639.1

NCBI Reference Sequences

More...
RefSeqi
NP_001095963.1, NM_001102493.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
511433

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:511433

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC151638 mRNA Translation: AAI51639.1
RefSeqiNP_001095963.1, NM_001102493.1

3D structure databases

SMRiA7E300
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000020664

Proteomic databases

PaxDbiA7E300
PRIDEiA7E300

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi511433
KEGGibta:511433

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10395

Phylogenomic databases

eggNOGiKOG2200 Eukaryota
ENOG410XQ10 LUCA
HOGENOMiHOG000039960
InParanoidiA7E300
KOiK20632
OrthoDBi218349at2759

Family and domain databases

Gene3Di1.10.555.10, 1 hit
3.30.530.20, 1 hit
InterProiView protein in InterPro
IPR028854 DLC1
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
IPR023393 START-like_dom_sf
IPR002913 START_lipid-bd_dom
PANTHERiPTHR12659:SF2 PTHR12659:SF2, 1 hit
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
PF07647 SAM_2, 1 hit
PF01852 START, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SM00234 START, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit
PS50848 START, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG07_BOVIN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7E300
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: September 11, 2007
Last modified: May 8, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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