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Protein

Myosin-7B

Gene

MYH7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in muscle contraction.1 Publication

Miscellaneous

Expression does not vary in normal patients compared to patients with acute monocytic leukemia.
The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

Caution

This protein sequence has been named 'Slow A' MYH14, but it also appears also as 'Slow B' MYH15 within the reference.1 Publication
Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi219 – 226ATPBy similarity8

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-7B
Alternative name(s):
Antigen MLAA-21
Myosin cardiac muscle beta chain
Myosin heavy chain 7B, cardiac muscle beta isoform
Slow A MYH14
Gene namesi
Name:MYH7B
Synonyms:KIAA1512
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000078814.15
HGNCiHGNC:15906 MYH7B
MIMi609928 gene
neXtProtiNX_A7E2Y1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Thick filament

Pathology & Biotechi

Organism-specific databases

DisGeNETi57644
MalaCardsiMYH7B
OpenTargetsiENSG00000078814
Orphaneti54260 Left ventricular noncompaction
PharmGKBiPA31375

Chemistry databases

ChEMBLiCHEMBL3831286

Polymorphism and mutation databases

BioMutaiMYH7B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493121 – 1983Myosin-7BAdd BLAST1983

Proteomic databases

EPDiA7E2Y1
PaxDbiA7E2Y1
PRIDEiA7E2Y1
ProteomicsDBi1802
1803 [A7E2Y1-2]
1804 [A7E2Y1-3]

PTM databases

iPTMnetiA7E2Y1
PhosphoSitePlusiA7E2Y1
SwissPalmiA7E2Y1

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.1 Publication

Developmental stagei

Found in fetal liver and brain.1 Publication

Gene expression databases

BgeeiENSG00000078814 Expressed in 143 organ(s), highest expression level in apex of heart
CleanExiHS_MYH7B
ExpressionAtlasiA7E2Y1 baseline and differential
GenevisibleiA7E2Y1 HS

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
SMYD1Q8NB122EBI-2880253,EBI-8463848

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121681, 38 interactors
IntActiA7E2Y1, 23 interactors
MINTiA7E2Y1
STRINGi9606.ENSP00000262873

Structurei

3D structure databases

ProteinModelPortaliA7E2Y1
SMRiA7E2Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini72 – 122Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini126 – 827Myosin motorPROSITE-ProRule annotationAdd BLAST702
Domaini830 – 859IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni704 – 726Actin-bindingBy similarityAdd BLAST23
Regioni806 – 820Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili888 – 1977Sequence analysisAdd BLAST1090

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOVERGENiHBG004704
InParanoidiA7E2Y1
KOiK10352
OMAiKDEECTN
OrthoDBiEOG091G07UM
PhylomeDBiA7E2Y1
TreeFamiTF314375

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A7E2Y1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGNKRGSRA SCPHRGAECL LPWAALNLQG FQLLLLHPSA TAMMDVSELG
60 70 80 90 100
ESARYLRQGY QEMTKVHTIP WDGKKRVWVP DEQDAYVEAE VKSEATGGRV
110 120 130 140 150
TVETKDQKVL MVREAELQPM NPPRFDLLED MAMMTHLNEA SVLHNLRQRY
160 170 180 190 200
ARWMIYTYSG LFCVTINPYK WLPVYTASVV AAYKGKRRSD SPPHIYAVAD
210 220 230 240 250
NAYNDMLRNR DNQSMLITGE SGAGKTVNTK RVIQYFAIVA ALGDGPGKKA
260 270 280 290 300
QFLATKTGGT LEDQIIEANP AMEAFGNAKT LRNDNSSRFG KFIRIHFGPS
310 320 330 340 350
GKLASADIDS YLLEKSRVIF QLPGERSYHV YYQILSGRKP ELQDMLLLSM
360 370 380 390 400
NPYDYHFCSQ GVITVDNMND GEELIATDHA MDILGFSVDE KCACYKIVGA
410 420 430 440 450
LLHFGNMKFK QKQREEQAEA DGTESADKAA YLMGVSSGDL LKGLLHPRVR
460 470 480 490 500
VGNEYVTKGQ SVEQVVFAVG ALAKATYDRL FRWLVSRINQ TLDTKLPRQF
510 520 530 540 550
FIGVLDIAGF EIFEFNSFEQ LCINFTNEKL QQFFNQHMFV LEQEEYKREG
560 570 580 590 600
IDWVFIDFGL DLQPCIDLIE KPLGILSILE EECMFPKASD ASFRAKLYDN
610 620 630 640 650
HAGKSPNFQQ PRPDKKRKYQ AHFEVVHYAG VVPYSIVGWL EKNKDPLNET
660 670 680 690 700
VVPIFQKSQN RLLATLYENY AGSCSTEPPK SGVKEKRKKA ASFQTVSQLH
710 720 730 740 750
KENLNKLMTN LRATQPHFVR CIVPNENKTP GVMDAFLVLH QLRCNGVLEG
760 770 780 790 800
IRICRQGFPN RLLYTDFRQR YRILNPSAIP DDTFMDSRKA TEKLLGSLDL
810 820 830 840 850
DHTQYQFGHT KVFFKAGLLG VLEELRDQRL AKVLTLLQAR SRGRLMRLEY
860 870 880 890 900
QRLLGGRDAL FTIQWNIRAF NAVKNWSWMK LFFKMKPLLR SAQAEEELAA
910 920 930 940 950
LRAELRGLRG ALAAAEAKRQ ELEETHVSIT QEKNDLALQL QAEQDNLADA
960 970 980 990 1000
EERCHLLIKS KVQLEGKVKE LSERLEDEEE VNADLAARRR KLEDECTELK
1010 1020 1030 1040 1050
KDIDDLELTL AKAEKEKQAT ENKVKNLTEE MAALDESVAR LTKEKKALQE
1060 1070 1080 1090 1100
AHQQALGDLQ AEEDRVSALT KAKLRLEQQV EDLECSLEQE KKLRMDTERA
1110 1120 1130 1140 1150
KRKLEGDLKL TQESVADAAQ DKQQLEEKLK KKDSELSQLS LRVEDEQLLG
1160 1170 1180 1190 1200
AQMQKKIKEL QARAEELEEE LEAERAARAR VEKQRAEAAR ELEELSERLE
1210 1220 1230 1240 1250
EAGGASAGQR EGCRKREAEL GRLRRELEEA ALRHEATVAA LRRKQAEGAA
1260 1270 1280 1290 1300
ELGEQVDSLQ RVRQKLEKEK SELRMEVDDL AANVETLTRA KASAEKLCRT
1310 1320 1330 1340 1350
YEDQLSEAKI KVEELQRQLA DASTQRGRLQ TESGELSRLL EEKECLISQL
1360 1370 1380 1390 1400
SRGKALAAQS LEELRRQLEE ESKAKSALAH AVQALRHDCD LLREQHEEEA
1410 1420 1430 1440 1450
EAQAELQRLL SKANAEVAQW RSKYEADAIQ RTEELEEAKK KLALRLQEAE
1460 1470 1480 1490 1500
EGVEAANAKC SSLEKAKLRL QTESEDVTLE LERATSAAAA LDKKQRHLER
1510 1520 1530 1540 1550
ALEERRRQEE EMQRELEAAQ RESRGLGTEL FRLRHGHEEA LEALETLKRE
1560 1570 1580 1590 1600
NKNLQEEISD LTDQVSLSGK SIQELEKTKK ALEGEKSEIQ AALEEAEGAL
1610 1620 1630 1640 1650
ELEETKTLRI QLELSQVKAE VDRKLAEKDE ECANLRRNHQ RAVESLQASL
1660 1670 1680 1690 1700
DAETRARNEA LRLKKKMEGD LNDLELQLGH ATRQATEAQA ATRLMQAQLK
1710 1720 1730 1740 1750
EEQAGRDEEQ RLAAELHEQA QALERRASLL AAELEELRAA LEQGERSRRL
1760 1770 1780 1790 1800
AEQELLEATE RLNLLHSQNT GLLNQKKKLE ADLAQLSGEV EEAAQERREA
1810 1820 1830 1840 1850
EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKTLEQTVR ELQARLEEAE
1860 1870 1880 1890 1900
QAALRGGKKQ VQKLEAKVRE LEAELDAEQK KHAEALKGVR KHERRVKELA
1910 1920 1930 1940 1950
YQAEEDRKNL ARMQDLVDKL QSKVKSYKRQ FEEAEQQANT NLAKYRKAQH
1960 1970 1980
ELDDAEERAD MAETQANKLR ARTRDALGPK HKE
Length:1,983
Mass (Da):225,845
Last modified:March 28, 2018 - v4
Checksum:i407E723E41DEB9A8
GO
Isoform 2 (identifier: A7E2Y1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     219-1983: Missing.

Show »
Length:176
Mass (Da):20,442
Checksum:i91A61F7A24A55CA2
GO
Isoform 3 (identifier: A7E2Y1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1809: Missing.
     1810-1811: DA → MP

Note: No experimental confirmation available.
Show »
Length:174
Mass (Da):20,273
Checksum:i58BEBBCBC47DE8AF
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0T3A0A087X0T3_HUMAN
Myosin-7B
MYH7B
1,982Annotation score:
Q5JW45Q5JW45_HUMAN
Myosin-7B
MYH7B
149Annotation score:
Q5JW46Q5JW46_HUMAN
Myosin-7B
MYH7B
122Annotation score:
Q5JW48Q5JW48_HUMAN
Myosin-7B
MYH7B
144Annotation score:
Q5JW47Q5JW47_HUMAN
Myosin-7B
MYH7B
143Annotation score:
Q5JW49Q5JW49_HUMAN
Myosin-7B
MYH7B
149Annotation score:

Sequence cautioni

The sequence BAA96036 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti979E → G in AAH07808 (PubMed:15489334).Curated1
Sequence conflicti1900A → V in AAQ93060 (PubMed:15755502).Curated1
Sequence conflicti1903A → T in AAQ93060 (PubMed:15755502).Curated1
Sequence conflicti1939N → S in AAQ93060 (PubMed:15755502).Curated1
Sequence conflicti1973T → S in AAQ93060 (PubMed:15755502).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04635970P → T. Corresponds to variant dbSNP:rs17092199Ensembl.1
Natural variantiVAR_046360501F → Y. Corresponds to variant dbSNP:rs754511Ensembl.1
Natural variantiVAR_046361780P → S. Corresponds to variant dbSNP:rs3746442Ensembl.1
Natural variantiVAR_0548141007E → K. Corresponds to variant dbSNP:rs2425015Ensembl.1
Natural variantiVAR_0463621552K → N. Corresponds to variant dbSNP:rs3746435Ensembl.1
Natural variantiVAR_0463631581A → V. Corresponds to variant dbSNP:rs6060147Ensembl.1
Natural variantiVAR_0463641698Q → R. Corresponds to variant dbSNP:rs6060148Ensembl.1
Natural variantiVAR_0463651917V → E. Corresponds to variant dbSNP:rs7273482Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0353591 – 1809Missing in isoform 3. 1 PublicationAdd BLAST1809
Alternative sequenceiVSP_0594971 – 42Missing in isoform 2. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_059498219 – 1983Missing in isoform 2. 2 PublicationsAdd BLAST1765
Alternative sequenceiVSP_0353611810 – 1811DA → MP in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288964 mRNA Translation: AAQ93060.1
AB040945 mRNA Translation: BAA96036.2 Different initiation.
AK000947 mRNA Translation: BAA91440.1
AL133324 Genomic DNA No translation available.
AL132825 Genomic DNA No translation available.
KF456882 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76237.1
BC007808 mRNA Translation: AAH07808.1
BC069327 mRNA Translation: AAH69327.2
BC069406 mRNA Translation: AAH69406.2
BC151242 mRNA Translation: AAI51243.1
CCDSiCCDS42869.1 [A7E2Y1-1]
RefSeqiNP_065935.3, NM_020884.4 [A7E2Y1-1]
UniGeneiHs.414122

Genome annotation databases

EnsembliENST00000262873; ENSP00000262873; ENSG00000078814 [A7E2Y1-1]
GeneIDi57644
KEGGihsa:57644
UCSCiuc061wko.1 human [A7E2Y1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288964 mRNA Translation: AAQ93060.1
AB040945 mRNA Translation: BAA96036.2 Different initiation.
AK000947 mRNA Translation: BAA91440.1
AL133324 Genomic DNA No translation available.
AL132825 Genomic DNA No translation available.
KF456882 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76237.1
BC007808 mRNA Translation: AAH07808.1
BC069327 mRNA Translation: AAH69327.2
BC069406 mRNA Translation: AAH69406.2
BC151242 mRNA Translation: AAI51243.1
CCDSiCCDS42869.1 [A7E2Y1-1]
RefSeqiNP_065935.3, NM_020884.4 [A7E2Y1-1]
UniGeneiHs.414122

3D structure databases

ProteinModelPortaliA7E2Y1
SMRiA7E2Y1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121681, 38 interactors
IntActiA7E2Y1, 23 interactors
MINTiA7E2Y1
STRINGi9606.ENSP00000262873

Chemistry databases

ChEMBLiCHEMBL3831286

PTM databases

iPTMnetiA7E2Y1
PhosphoSitePlusiA7E2Y1
SwissPalmiA7E2Y1

Polymorphism and mutation databases

BioMutaiMYH7B

Proteomic databases

EPDiA7E2Y1
PaxDbiA7E2Y1
PRIDEiA7E2Y1
ProteomicsDBi1802
1803 [A7E2Y1-2]
1804 [A7E2Y1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262873; ENSP00000262873; ENSG00000078814 [A7E2Y1-1]
GeneIDi57644
KEGGihsa:57644
UCSCiuc061wko.1 human [A7E2Y1-1]

Organism-specific databases

CTDi57644
DisGeNETi57644
EuPathDBiHostDB:ENSG00000078814.15
GeneCardsiMYH7B
HGNCiHGNC:15906 MYH7B
MalaCardsiMYH7B
MIMi609928 gene
neXtProtiNX_A7E2Y1
OpenTargetsiENSG00000078814
Orphaneti54260 Left ventricular noncompaction
PharmGKBiPA31375
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOVERGENiHBG004704
InParanoidiA7E2Y1
KOiK10352
OMAiKDEECTN
OrthoDBiEOG091G07UM
PhylomeDBiA7E2Y1
TreeFamiTF314375

Miscellaneous databases

ChiTaRSiMYH7B human
GeneWikiiMYH7B
GenomeRNAii57644
PROiPR:A7E2Y1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000078814 Expressed in 143 organ(s), highest expression level in apex of heart
CleanExiHS_MYH7B
ExpressionAtlasiA7E2Y1 baseline and differential
GenevisibleiA7E2Y1 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYH7B_HUMAN
AccessioniPrimary (citable) accession number: A7E2Y1
Secondary accession number(s): Q5JVW7
, Q6NT44, Q6NT57, Q6WG75, Q96I57, Q9NWE2, Q9P216
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 103 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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