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Protein

Myosin-7B

Gene

MYH7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in muscle contraction.1 Publication

Miscellaneous

Expression does not vary in normal patients compared to patients with acute monocytic leukemia.
The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase.

Caution

This protein sequence has been named 'Slow A' MYH14, but it also appears also as 'Slow B' MYH15 within the reference.1 Publication
Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi219 – 226ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Motor protein, Muscle protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-7B
Alternative name(s):
Antigen MLAA-21
Myosin cardiac muscle beta chain
Myosin heavy chain 7B, cardiac muscle beta isoform
Slow A MYH14
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYH7B
Synonyms:KIAA1512
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000078814.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:15906 MYH7B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609928 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A7E2Y1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Thick filament

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
57644

MalaCards human disease database

More...
MalaCardsi
MYH7B

Open Targets

More...
OpenTargetsi
ENSG00000078814

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
54260 Left ventricular noncompaction

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31375

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3831286

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MYH7B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003493121 – 1983Myosin-7BAdd BLAST1983

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A7E2Y1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A7E2Y1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A7E2Y1

PRoteomics IDEntifications database

More...
PRIDEi
A7E2Y1

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1802
1803 [A7E2Y1-2]
1804 [A7E2Y1-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A7E2Y1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A7E2Y1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
A7E2Y1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Found in fetal liver and brain.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000078814 Expressed in 143 organ(s), highest expression level in apex of heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_MYH7B

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A7E2Y1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A7E2Y1 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SMYD1Q8NB122EBI-2880253,EBI-8463848

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121681, 38 interactors

Protein interaction database and analysis system

More...
IntActi
A7E2Y1, 23 interactors

Molecular INTeraction database

More...
MINTi
A7E2Y1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000262873

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A7E2Y1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A7E2Y1

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini72 – 122Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini126 – 827Myosin motorPROSITE-ProRule annotationAdd BLAST702
Domaini830 – 859IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni704 – 726Actin-bindingBy similarityAdd BLAST23
Regioni806 – 820Actin-bindingBy similarityAdd BLAST15

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili888 – 1977Sequence analysisAdd BLAST1090

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0161 Eukaryota
COG5022 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160950

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004704

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7E2Y1

KEGG Orthology (KO)

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KOi
K10352

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDEECTN

Database of Orthologous Groups

More...
OrthoDBi
47111at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A7E2Y1

TreeFam database of animal gene trees

More...
TreeFami
TF314375

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193 MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242 MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A7E2Y1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGNKRGSRA SCPHRGAECL LPWAALNLQG FQLLLLHPSA TAMMDVSELG
60 70 80 90 100
ESARYLRQGY QEMTKVHTIP WDGKKRVWVP DEQDAYVEAE VKSEATGGRV
110 120 130 140 150
TVETKDQKVL MVREAELQPM NPPRFDLLED MAMMTHLNEA SVLHNLRQRY
160 170 180 190 200
ARWMIYTYSG LFCVTINPYK WLPVYTASVV AAYKGKRRSD SPPHIYAVAD
210 220 230 240 250
NAYNDMLRNR DNQSMLITGE SGAGKTVNTK RVIQYFAIVA ALGDGPGKKA
260 270 280 290 300
QFLATKTGGT LEDQIIEANP AMEAFGNAKT LRNDNSSRFG KFIRIHFGPS
310 320 330 340 350
GKLASADIDS YLLEKSRVIF QLPGERSYHV YYQILSGRKP ELQDMLLLSM
360 370 380 390 400
NPYDYHFCSQ GVITVDNMND GEELIATDHA MDILGFSVDE KCACYKIVGA
410 420 430 440 450
LLHFGNMKFK QKQREEQAEA DGTESADKAA YLMGVSSGDL LKGLLHPRVR
460 470 480 490 500
VGNEYVTKGQ SVEQVVFAVG ALAKATYDRL FRWLVSRINQ TLDTKLPRQF
510 520 530 540 550
FIGVLDIAGF EIFEFNSFEQ LCINFTNEKL QQFFNQHMFV LEQEEYKREG
560 570 580 590 600
IDWVFIDFGL DLQPCIDLIE KPLGILSILE EECMFPKASD ASFRAKLYDN
610 620 630 640 650
HAGKSPNFQQ PRPDKKRKYQ AHFEVVHYAG VVPYSIVGWL EKNKDPLNET
660 670 680 690 700
VVPIFQKSQN RLLATLYENY AGSCSTEPPK SGVKEKRKKA ASFQTVSQLH
710 720 730 740 750
KENLNKLMTN LRATQPHFVR CIVPNENKTP GVMDAFLVLH QLRCNGVLEG
760 770 780 790 800
IRICRQGFPN RLLYTDFRQR YRILNPSAIP DDTFMDSRKA TEKLLGSLDL
810 820 830 840 850
DHTQYQFGHT KVFFKAGLLG VLEELRDQRL AKVLTLLQAR SRGRLMRLEY
860 870 880 890 900
QRLLGGRDAL FTIQWNIRAF NAVKNWSWMK LFFKMKPLLR SAQAEEELAA
910 920 930 940 950
LRAELRGLRG ALAAAEAKRQ ELEETHVSIT QEKNDLALQL QAEQDNLADA
960 970 980 990 1000
EERCHLLIKS KVQLEGKVKE LSERLEDEEE VNADLAARRR KLEDECTELK
1010 1020 1030 1040 1050
KDIDDLELTL AKAEKEKQAT ENKVKNLTEE MAALDESVAR LTKEKKALQE
1060 1070 1080 1090 1100
AHQQALGDLQ AEEDRVSALT KAKLRLEQQV EDLECSLEQE KKLRMDTERA
1110 1120 1130 1140 1150
KRKLEGDLKL TQESVADAAQ DKQQLEEKLK KKDSELSQLS LRVEDEQLLG
1160 1170 1180 1190 1200
AQMQKKIKEL QARAEELEEE LEAERAARAR VEKQRAEAAR ELEELSERLE
1210 1220 1230 1240 1250
EAGGASAGQR EGCRKREAEL GRLRRELEEA ALRHEATVAA LRRKQAEGAA
1260 1270 1280 1290 1300
ELGEQVDSLQ RVRQKLEKEK SELRMEVDDL AANVETLTRA KASAEKLCRT
1310 1320 1330 1340 1350
YEDQLSEAKI KVEELQRQLA DASTQRGRLQ TESGELSRLL EEKECLISQL
1360 1370 1380 1390 1400
SRGKALAAQS LEELRRQLEE ESKAKSALAH AVQALRHDCD LLREQHEEEA
1410 1420 1430 1440 1450
EAQAELQRLL SKANAEVAQW RSKYEADAIQ RTEELEEAKK KLALRLQEAE
1460 1470 1480 1490 1500
EGVEAANAKC SSLEKAKLRL QTESEDVTLE LERATSAAAA LDKKQRHLER
1510 1520 1530 1540 1550
ALEERRRQEE EMQRELEAAQ RESRGLGTEL FRLRHGHEEA LEALETLKRE
1560 1570 1580 1590 1600
NKNLQEEISD LTDQVSLSGK SIQELEKTKK ALEGEKSEIQ AALEEAEGAL
1610 1620 1630 1640 1650
ELEETKTLRI QLELSQVKAE VDRKLAEKDE ECANLRRNHQ RAVESLQASL
1660 1670 1680 1690 1700
DAETRARNEA LRLKKKMEGD LNDLELQLGH ATRQATEAQA ATRLMQAQLK
1710 1720 1730 1740 1750
EEQAGRDEEQ RLAAELHEQA QALERRASLL AAELEELRAA LEQGERSRRL
1760 1770 1780 1790 1800
AEQELLEATE RLNLLHSQNT GLLNQKKKLE ADLAQLSGEV EEAAQERREA
1810 1820 1830 1840 1850
EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKTLEQTVR ELQARLEEAE
1860 1870 1880 1890 1900
QAALRGGKKQ VQKLEAKVRE LEAELDAEQK KHAEALKGVR KHERRVKELA
1910 1920 1930 1940 1950
YQAEEDRKNL ARMQDLVDKL QSKVKSYKRQ FEEAEQQANT NLAKYRKAQH
1960 1970 1980
ELDDAEERAD MAETQANKLR ARTRDALGPK HKE
Length:1,983
Mass (Da):225,845
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i407E723E41DEB9A8
GO
Isoform 2 (identifier: A7E2Y1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     219-1983: Missing.

Show »
Length:176
Mass (Da):20,442
Checksum:i91A61F7A24A55CA2
GO
Isoform 3 (identifier: A7E2Y1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1809: Missing.
     1810-1811: DA → MP

Note: No experimental confirmation available.
Show »
Length:174
Mass (Da):20,273
Checksum:i58BEBBCBC47DE8AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X0T3A0A087X0T3_HUMAN
Myosin-7B
MYH7B
1,982Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW45Q5JW45_HUMAN
Myosin-7B
MYH7B
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW48Q5JW48_HUMAN
Myosin-7B
MYH7B
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW46Q5JW46_HUMAN
Myosin-7B
MYH7B
122Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW47Q5JW47_HUMAN
Myosin-7B
MYH7B
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JW49Q5JW49_HUMAN
Myosin-7B
MYH7B
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96036 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti979E → G in AAH07808 (PubMed:15489334).Curated1
Sequence conflicti1900A → V in AAQ93060 (PubMed:15755502).Curated1
Sequence conflicti1903A → T in AAQ93060 (PubMed:15755502).Curated1
Sequence conflicti1939N → S in AAQ93060 (PubMed:15755502).Curated1
Sequence conflicti1973T → S in AAQ93060 (PubMed:15755502).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04635970P → T. Corresponds to variant dbSNP:rs17092199Ensembl.1
Natural variantiVAR_046360501F → Y. Corresponds to variant dbSNP:rs754511Ensembl.1
Natural variantiVAR_046361780P → S. Corresponds to variant dbSNP:rs3746442Ensembl.1
Natural variantiVAR_0548141007E → K. Corresponds to variant dbSNP:rs2425015Ensembl.1
Natural variantiVAR_0463621552K → N. Corresponds to variant dbSNP:rs3746435Ensembl.1
Natural variantiVAR_0463631581A → V. Corresponds to variant dbSNP:rs6060147Ensembl.1
Natural variantiVAR_0463641698Q → R. Corresponds to variant dbSNP:rs6060148Ensembl.1
Natural variantiVAR_0463651917V → E. Corresponds to variant dbSNP:rs7273482Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0353591 – 1809Missing in isoform 3. 1 PublicationAdd BLAST1809
Alternative sequenceiVSP_0594971 – 42Missing in isoform 2. 2 PublicationsAdd BLAST42
Alternative sequenceiVSP_059498219 – 1983Missing in isoform 2. 2 PublicationsAdd BLAST1765
Alternative sequenceiVSP_0353611810 – 1811DA → MP in isoform 3. 1 Publication2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY288964 mRNA Translation: AAQ93060.1
AB040945 mRNA Translation: BAA96036.2 Different initiation.
AK000947 mRNA Translation: BAA91440.1
AL133324 Genomic DNA No translation available.
AL132825 Genomic DNA No translation available.
KF456882 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76237.1
BC007808 mRNA Translation: AAH07808.1
BC069327 mRNA Translation: AAH69327.2
BC069406 mRNA Translation: AAH69406.2
BC151242 mRNA Translation: AAI51243.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS42869.1 [A7E2Y1-1]

NCBI Reference Sequences

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RefSeqi
NP_065935.3, NM_020884.4 [A7E2Y1-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.414122

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000262873; ENSP00000262873; ENSG00000078814 [A7E2Y1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
57644

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:57644

UCSC genome browser

More...
UCSCi
uc061wko.1 human [A7E2Y1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288964 mRNA Translation: AAQ93060.1
AB040945 mRNA Translation: BAA96036.2 Different initiation.
AK000947 mRNA Translation: BAA91440.1
AL133324 Genomic DNA No translation available.
AL132825 Genomic DNA No translation available.
KF456882 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76237.1
BC007808 mRNA Translation: AAH07808.1
BC069327 mRNA Translation: AAH69327.2
BC069406 mRNA Translation: AAH69406.2
BC151242 mRNA Translation: AAI51243.1
CCDSiCCDS42869.1 [A7E2Y1-1]
RefSeqiNP_065935.3, NM_020884.4 [A7E2Y1-1]
UniGeneiHs.414122

3D structure databases

ProteinModelPortaliA7E2Y1
SMRiA7E2Y1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121681, 38 interactors
IntActiA7E2Y1, 23 interactors
MINTiA7E2Y1
STRINGi9606.ENSP00000262873

Chemistry databases

ChEMBLiCHEMBL3831286

PTM databases

iPTMnetiA7E2Y1
PhosphoSitePlusiA7E2Y1
SwissPalmiA7E2Y1

Polymorphism and mutation databases

BioMutaiMYH7B

Proteomic databases

EPDiA7E2Y1
jPOSTiA7E2Y1
PaxDbiA7E2Y1
PRIDEiA7E2Y1
ProteomicsDBi1802
1803 [A7E2Y1-2]
1804 [A7E2Y1-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262873; ENSP00000262873; ENSG00000078814 [A7E2Y1-1]
GeneIDi57644
KEGGihsa:57644
UCSCiuc061wko.1 human [A7E2Y1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57644
DisGeNETi57644
EuPathDBiHostDB:ENSG00000078814.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MYH7B
HGNCiHGNC:15906 MYH7B
MalaCardsiMYH7B
MIMi609928 gene
neXtProtiNX_A7E2Y1
OpenTargetsiENSG00000078814
Orphaneti54260 Left ventricular noncompaction
PharmGKBiPA31375

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00940000160950
HOVERGENiHBG004704
InParanoidiA7E2Y1
KOiK10352
OMAiKDEECTN
OrthoDBi47111at2759
PhylomeDBiA7E2Y1
TreeFamiTF314375

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MYH7B human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MYH7B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
57644

Protein Ontology

More...
PROi
PR:A7E2Y1

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000078814 Expressed in 143 organ(s), highest expression level in apex of heart
CleanExiHS_MYH7B
ExpressionAtlasiA7E2Y1 baseline and differential
GenevisibleiA7E2Y1 HS

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 1 hit
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYH7B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7E2Y1
Secondary accession number(s): Q5JVW7
, Q6NT44, Q6NT57, Q6WG75, Q96I57, Q9NWE2, Q9P216
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 28, 2018
Last modified: January 16, 2019
This is version 105 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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