UniProtKB - A7E2V4 (ZSWM8_HUMAN)
Protein
Zinc finger SWIM domain-containing protein 8
Gene
ZSWIM8
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 172 – 208 | SWIM-typePROSITE-ProRule annotationAdd BLAST | 37 |
GO - Molecular functioni
- zinc ion binding Source: InterPro
GO - Biological processi
- regulation of axon guidance Source: GO_Central
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | A7E2V4 |
Reactomei | R-HSA-9010553, Regulation of expression of SLITs and ROBOs |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger SWIM domain-containing protein 8 |
Gene namesi | Name:ZSWIM8 Synonyms:KIAA0913 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23528, ZSWIM8 |
neXtProti | NX_A7E2V4 |
VEuPathDBi | HostDB:ENSG00000214655.10 |
Subcellular locationi
Other locations
- Cul2-RING ubiquitin ligase complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000214655 |
PharmGKBi | PA134885317 |
Miscellaneous databases
Pharosi | A7E2V4, Tdark |
Genetic variation databases
BioMutai | ZSWIM8 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000311802 | 1 – 1837 | Zinc finger SWIM domain-containing protein 8Add BLAST | 1837 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 36 | PhosphoserineCombined sources | 1 | |
Modified residuei | 48 | PhosphoserineCombined sources | 1 | |
Modified residuei | 53 | PhosphoserineBy similarity | 1 | |
Modified residuei | 437 | PhosphoserineCombined sources | 1 | |
Modified residuei | 567 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1139 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1153 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1156 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1160 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1267 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1836 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | A7E2V4 |
jPOSTi | A7E2V4 |
MassIVEi | A7E2V4 |
MaxQBi | A7E2V4 |
PaxDbi | A7E2V4 |
PeptideAtlasi | A7E2V4 |
PRIDEi | A7E2V4 |
ProteomicsDBi | 1797 [A7E2V4-1] 1798 [A7E2V4-2] 1799 [A7E2V4-3] 1800 [A7E2V4-4] 1801 [A7E2V4-5] |
PTM databases
iPTMneti | A7E2V4 |
PhosphoSitePlusi | A7E2V4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000214655, Expressed in adenohypophysis and 229 other tissues |
ExpressionAtlasi | A7E2V4, baseline and differential |
Genevisiblei | A7E2V4, HS |
Organism-specific databases
HPAi | ENSG00000214655, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116690, 26 interactors |
IntActi | A7E2V4, 22 interactors |
STRINGi | 9606.ENSP00000381693 |
Miscellaneous databases
RNActi | A7E2V4, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 56 – 65 | Poly-Gly | 10 | |
Compositional biasi | 546 – 602 | Gly-richAdd BLAST | 57 | |
Compositional biasi | 1143 – 1204 | Ser-richAdd BLAST | 62 | |
Compositional biasi | 1471 – 1474 | Poly-Ala | 4 | |
Compositional biasi | 1493 – 1658 | Pro-richAdd BLAST | 166 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 172 – 208 | SWIM-typePROSITE-ProRule annotationAdd BLAST | 37 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3615, Eukaryota |
GeneTreei | ENSGT00940000156999 |
InParanoidi | A7E2V4 |
OMAi | GSAQFKD |
OrthoDBi | 88229at2759 |
PhylomeDBi | A7E2V4 |
TreeFami | TF324881 |
Family and domain databases
InterProi | View protein in InterPro IPR007527, Znf_SWIM |
PROSITEi | View protein in PROSITE PS50966, ZF_SWIM, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: A7E2V4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG
60 70 80 90 100
PNSPTGGGGG GGSGGTRMRD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV
110 120 130 140 150
PEQLQLRIAF WSFPENEEDI RLYSCLANGS ADEFQRGDQL FRMRAVKDPL
160 170 180 190 200
QIGFHLSATV VPPQMVPPKG AYNVAVMFDR CRVTSCSCTC GAGAKWCTHV
210 220 230 240 250
VALCLFRIHN ASAVCLRAPV SESLSRLQRD QLQKFAQYLI SELPQQILPT
260 270 280 290 300
AQRLLDELLS SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLTDNIKK
310 320 330 340 350
TLHKFCGPSP VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGVWNL
360 370 380 390 400
LSIVREMFKR RDSNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG
410 420 430 440 450
HTGRSNGQSE VAAHACASMC DEMVTLWRLA VLDPALSPQR RRELCTQLRQ
460 470 480 490 500
WQLKVIENVK RGQHKKTLER LFPGFRPAVE ACYFNWEEAY PLPGVTYSGT
510 520 530 540 550
DRKLALCWAR ALPSRPGASR SGGLEESRDR PRPLPTEPAV RPKEPGTKRK
560 570 580 590 600
GLGEGVPSSQ RGPRRLSAEG GDKALHKMGP GGGKAKALGG AGSGSKGSAG
610 620 630 640 650
GGSKRRLSSE DSSLEPDLAE MSLDDSSLAL GAEASTFGGF PESPPPCPLH
660 670 680 690 700
GGSRGPSTFL PEPPDTYEED GGVYFSEGPE PPTASVGPPG LLPGDVCTQD
710 720 730 740 750
DLPSTDESGN GLPKTKEAAP AVGEEDDDYQ AYYLNAQDGA GGEEEKAEGG
760 770 780 790 800
AGEEHDLFAG LKPLEQESRM EVLFACAEAL HAHGYSSEAS RLTVELAQDL
810 820 830 840 850
LANPPDLKVE PPPAKGKKNK VSTSRQTWVA TNTLSKAAFL LTVLSERPEH
860 870 880 890 900
HNLAFRVGMF ALELQRPPAS TKALEVKLAY QESEVAALLK KIPLGPSEMS
910 920 930 940 950
TMRCRAEELR EGTLCDYRPV LPLMLASFIF DVLCAPGSRP PSRNWNSETP
960 970 980 990 1000
GDEELGFEAA VAALGMKTTV SEAEHPLLCE GTRREKGDLA LALMITYKDD
1010 1020 1030 1040 1050
QAKLKKILDK LLDRESQTHK PQTLSSFYSS SRPTTASQRS PSKHGGPSAP
1060 1070 1080 1090 1100
GALQPLTSGS AGPAQPGSVA GAGPGPTEGF TEKNVPESSP HSPCEGLPSE
1110 1120 1130 1140 1150
AALTPRPEGK VPSRLALGSR GGYNGRGWGS PGRPKKKHTG MASIDSSAPE
1160 1170 1180 1190 1200
TTSDSSPTLS RRPLRGGWAP TSWGRGQDSD SISSSSSDSL GSSSSSGSRR
1210 1220 1230 1240 1250
ASASGGARAK TVEVGRYKGR RPESHAPHVP NQPSEAAAHF YFELAKTVLI
1260 1270 1280 1290 1300
KAGGNSSTSI FTHPSSSGGH QGPHRNLHLC AFEIGLYALG LHNFVSPNWL
1310 1320 1330 1340 1350
SRTYSSHVSW ITGQAMEIGS AALTILVECW DGHLTPPEVA SLADRASRAR
1360 1370 1380 1390 1400
DSNMVRAAAE LALSCLPHAH ALNPNEIQRA LVQCKEQDNL MLEKACMAVE
1410 1420 1430 1440 1450
EAAKGGGVYP EVLFEVAHQW FWLYEQTAGG SSTAREGATS CSASGIRAGG
1460 1470 1480 1490 1500
EAGRGMPEGR GGPGTEPVTV AAAAVTAAAT VVPVISVGSS LYPGPGLGHG
1510 1520 1530 1540 1550
HSPGLHPYTA LQPHLPCSPQ YLTHPAHPAH PMPHMPRPAV FPVPSSAYPQ
1560 1570 1580 1590 1600
GVHPAFLGAQ YPYSVTPPSL AATAVSFPVP SMAPITVHPY HTEPGLPLPT
1610 1620 1630 1640 1650
SVACELWGQG TVSSVHPAST FPAIQGASLP ALTTQPSPLV SGGFPPPEEE
1660 1670 1680 1690 1700
THSQPVNPHS LHHLHAAYRV GMLALEMLGR RAHNDHPNNF SRSPPYTDDV
1710 1720 1730 1740 1750
KWLLGLAAKL GVNYVHQFCV GAAKGVLSPF VLQEIVMETL QRLSPAHAHN
1760 1770 1780 1790 1800
HLRAPAFHQL VQRCQQAYMQ YIHHRLIHLT PADYDDFVNA IRSARSAFCL
1810 1820 1830
TPMGMMQFND ILQNLKRSKQ TKELWQRVSL EMATFSP
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R410 | S4R410_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 1,834 | Annotation score: | ||
H7BZ52 | H7BZ52_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 1,336 | Annotation score: | ||
S4R393 | S4R393_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 1,796 | Annotation score: | ||
S4R3H3 | S4R3H3_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 1,655 | Annotation score: | ||
H0YCW2 | H0YCW2_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 904 | Annotation score: | ||
H7C453 | H7C453_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 1,112 | Annotation score: | ||
S4R3B3 | S4R3B3_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 1,102 | Annotation score: | ||
S4R3U7 | S4R3U7_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 1,232 | Annotation score: | ||
S4R3S6 | S4R3S6_HUMAN | Zinc finger SWIM domain-containing ... | ZSWIM8 | 204 | Annotation score: |
Sequence cautioni
The sequence BAA74936 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14664 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 751 | A → D in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 762 | K → M in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 774 | F → S in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1052 | A → T in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1136 | K → M in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1165 | R → Q in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1184 | S → N in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1252 | A → T in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1401 | E → V in BAB14664 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1775 | R → S in BAB14664 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029586 | 936 | P → PVVSPT in isoform 3 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_029587 | 1006 | K → KVTASVFQ in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_029590 | 1604 – 1612 | CELWGQGTV → L in isoform 2, isoform 3 and isoform 5. 2 Publications | 9 | |
Alternative sequenceiVSP_029591 | 1712 – 1837 | VNYVH…ATFSP → DRHGDAAAAESRSCPQPPAC PGLPPTGAALPAGIHAVHPP PLDSPDSCGLRRLCECDPEC PQRLLPDAHGHDAVQRHPTE PQAQQTDQGAVAAGLTRDGH LLPLSLSPLGSYTGTQACGY GGPSHRGSETWLDRSSSLSS LVAQTDSCSWAIAWGQDVSH PRSLGLGETALSGRGRWVAS GIYLAFINI in isoform 2. 1 PublicationAdd BLAST | 126 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020720 mRNA Translation: BAA74936.2 Sequence problems. AC022400 Genomic DNA No translation available. BC040726 mRNA Translation: AAH40726.1 BC063694 mRNA Translation: AAH63694.1 BC111006 mRNA Translation: AAI11007.1 BC117205 mRNA Translation: AAI17206.1 BC137249 mRNA Translation: AAI37250.1 Sequence problems. BC137250 mRNA Translation: AAI37251.1 Sequence problems. BC151206 mRNA Translation: AAI51207.1 AK023742 mRNA Translation: BAB14664.1 Different initiation. AK091621 mRNA Translation: BAC03709.1 Sequence problems. |
CCDSi | CCDS44440.1 [A7E2V4-4] CCDS60560.1 [A7E2V4-1] |
RefSeqi | NP_001229416.1, NM_001242487.1 [A7E2V4-1] NP_001229417.1, NM_001242488.1 [A7E2V4-2] NP_055852.2, NM_015037.3 [A7E2V4-4] XP_006717788.1, XM_006717725.3 [A7E2V4-5] |
Genome annotation databases
Ensembli | ENST00000398706; ENSP00000381693; ENSG00000214655 [A7E2V4-4] ENST00000605216; ENSP00000474748; ENSG00000214655 [A7E2V4-1] |
GeneIDi | 23053 |
KEGGi | hsa:23053 |
UCSCi | uc001jve.4, human [A7E2V4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB020720 mRNA Translation: BAA74936.2 Sequence problems. AC022400 Genomic DNA No translation available. BC040726 mRNA Translation: AAH40726.1 BC063694 mRNA Translation: AAH63694.1 BC111006 mRNA Translation: AAI11007.1 BC117205 mRNA Translation: AAI17206.1 BC137249 mRNA Translation: AAI37250.1 Sequence problems. BC137250 mRNA Translation: AAI37251.1 Sequence problems. BC151206 mRNA Translation: AAI51207.1 AK023742 mRNA Translation: BAB14664.1 Different initiation. AK091621 mRNA Translation: BAC03709.1 Sequence problems. |
CCDSi | CCDS44440.1 [A7E2V4-4] CCDS60560.1 [A7E2V4-1] |
RefSeqi | NP_001229416.1, NM_001242487.1 [A7E2V4-1] NP_001229417.1, NM_001242488.1 [A7E2V4-2] NP_055852.2, NM_015037.3 [A7E2V4-4] XP_006717788.1, XM_006717725.3 [A7E2V4-5] |
3D structure databases
SMRi | A7E2V4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116690, 26 interactors |
IntActi | A7E2V4, 22 interactors |
STRINGi | 9606.ENSP00000381693 |
PTM databases
iPTMneti | A7E2V4 |
PhosphoSitePlusi | A7E2V4 |
Genetic variation databases
BioMutai | ZSWIM8 |
Proteomic databases
EPDi | A7E2V4 |
jPOSTi | A7E2V4 |
MassIVEi | A7E2V4 |
MaxQBi | A7E2V4 |
PaxDbi | A7E2V4 |
PeptideAtlasi | A7E2V4 |
PRIDEi | A7E2V4 |
ProteomicsDBi | 1797 [A7E2V4-1] 1798 [A7E2V4-2] 1799 [A7E2V4-3] 1800 [A7E2V4-4] 1801 [A7E2V4-5] |
Protocols and materials databases
Antibodypediai | 48437, 5 antibodies |
Genome annotation databases
Ensembli | ENST00000398706; ENSP00000381693; ENSG00000214655 [A7E2V4-4] ENST00000605216; ENSP00000474748; ENSG00000214655 [A7E2V4-1] |
GeneIDi | 23053 |
KEGGi | hsa:23053 |
UCSCi | uc001jve.4, human [A7E2V4-1] |
Organism-specific databases
CTDi | 23053 |
GeneCardsi | ZSWIM8 |
HGNCi | HGNC:23528, ZSWIM8 |
HPAi | ENSG00000214655, Low tissue specificity |
neXtProti | NX_A7E2V4 |
OpenTargetsi | ENSG00000214655 |
PharmGKBi | PA134885317 |
VEuPathDBi | HostDB:ENSG00000214655.10 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3615, Eukaryota |
GeneTreei | ENSGT00940000156999 |
InParanoidi | A7E2V4 |
OMAi | GSAQFKD |
OrthoDBi | 88229at2759 |
PhylomeDBi | A7E2V4 |
TreeFami | TF324881 |
Enzyme and pathway databases
PathwayCommonsi | A7E2V4 |
Reactomei | R-HSA-9010553, Regulation of expression of SLITs and ROBOs |
Miscellaneous databases
BioGRID-ORCSi | 23053, 70 hits in 873 CRISPR screens |
ChiTaRSi | ZSWIM8, human |
GenomeRNAii | 23053 |
Pharosi | A7E2V4, Tdark |
PROi | PR:A7E2V4 |
RNActi | A7E2V4, protein |
Gene expression databases
Bgeei | ENSG00000214655, Expressed in adenohypophysis and 229 other tissues |
ExpressionAtlasi | A7E2V4, baseline and differential |
Genevisiblei | A7E2V4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007527, Znf_SWIM |
PROSITEi | View protein in PROSITE PS50966, ZF_SWIM, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZSWM8_HUMAN | |
Accessioni | A7E2V4Primary (citable) accession number: A7E2V4 Secondary accession number(s): B2RP37 Q9H8F3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 10, 2021 | |
This is version 105 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM