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Entry version 95 (08 May 2019)
Sequence version 1 (11 Sep 2007)
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Protein

Zinc finger SWIM domain-containing protein 8

Gene

ZSWIM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri172 – 208SWIM-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • regulation of axon guidance Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9010553 Regulation of expression of SLITs and ROBOs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSWIM8
Synonyms:KIAA0913
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23528 ZSWIM8

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_A7E2V4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000214655

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134885317

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZSWIM8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003118021 – 1837Zinc finger SWIM domain-containing protein 8Add BLAST1837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei437PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei1139PhosphothreonineCombined sources1
Modified residuei1153PhosphoserineBy similarity1
Modified residuei1156PhosphoserineBy similarity1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1836PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A7E2V4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A7E2V4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
A7E2V4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A7E2V4

PRoteomics IDEntifications database

More...
PRIDEi
A7E2V4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1797
1798 [A7E2V4-2]
1799 [A7E2V4-3]
1800 [A7E2V4-4]
1801 [A7E2V4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A7E2V4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A7E2V4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000214655 Expressed in 218 organ(s), highest expression level in adenohypophysis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A7E2V4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A7E2V4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041244

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116690, 22 interactors

Protein interaction database and analysis system

More...
IntActi
A7E2V4, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381693

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A7E2V4

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 65Poly-Gly10
Compositional biasi546 – 602Gly-richAdd BLAST57
Compositional biasi1143 – 1204Ser-richAdd BLAST62
Compositional biasi1471 – 1474Poly-Ala4
Compositional biasi1493 – 1658Pro-richAdd BLAST166

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 208SWIM-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3615 Eukaryota
ENOG410XPG2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156999

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A7E2V4

Identification of Orthologs from Complete Genome Data

More...
OMAi
TEECMAC

Database of Orthologous Groups

More...
OrthoDBi
88229at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A7E2V4

TreeFam database of animal gene trees

More...
TreeFami
TF324881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007527 Znf_SWIM

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50966 ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A7E2V4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG
60 70 80 90 100
PNSPTGGGGG GGSGGTRMRD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV
110 120 130 140 150
PEQLQLRIAF WSFPENEEDI RLYSCLANGS ADEFQRGDQL FRMRAVKDPL
160 170 180 190 200
QIGFHLSATV VPPQMVPPKG AYNVAVMFDR CRVTSCSCTC GAGAKWCTHV
210 220 230 240 250
VALCLFRIHN ASAVCLRAPV SESLSRLQRD QLQKFAQYLI SELPQQILPT
260 270 280 290 300
AQRLLDELLS SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLTDNIKK
310 320 330 340 350
TLHKFCGPSP VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGVWNL
360 370 380 390 400
LSIVREMFKR RDSNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG
410 420 430 440 450
HTGRSNGQSE VAAHACASMC DEMVTLWRLA VLDPALSPQR RRELCTQLRQ
460 470 480 490 500
WQLKVIENVK RGQHKKTLER LFPGFRPAVE ACYFNWEEAY PLPGVTYSGT
510 520 530 540 550
DRKLALCWAR ALPSRPGASR SGGLEESRDR PRPLPTEPAV RPKEPGTKRK
560 570 580 590 600
GLGEGVPSSQ RGPRRLSAEG GDKALHKMGP GGGKAKALGG AGSGSKGSAG
610 620 630 640 650
GGSKRRLSSE DSSLEPDLAE MSLDDSSLAL GAEASTFGGF PESPPPCPLH
660 670 680 690 700
GGSRGPSTFL PEPPDTYEED GGVYFSEGPE PPTASVGPPG LLPGDVCTQD
710 720 730 740 750
DLPSTDESGN GLPKTKEAAP AVGEEDDDYQ AYYLNAQDGA GGEEEKAEGG
760 770 780 790 800
AGEEHDLFAG LKPLEQESRM EVLFACAEAL HAHGYSSEAS RLTVELAQDL
810 820 830 840 850
LANPPDLKVE PPPAKGKKNK VSTSRQTWVA TNTLSKAAFL LTVLSERPEH
860 870 880 890 900
HNLAFRVGMF ALELQRPPAS TKALEVKLAY QESEVAALLK KIPLGPSEMS
910 920 930 940 950
TMRCRAEELR EGTLCDYRPV LPLMLASFIF DVLCAPGSRP PSRNWNSETP
960 970 980 990 1000
GDEELGFEAA VAALGMKTTV SEAEHPLLCE GTRREKGDLA LALMITYKDD
1010 1020 1030 1040 1050
QAKLKKILDK LLDRESQTHK PQTLSSFYSS SRPTTASQRS PSKHGGPSAP
1060 1070 1080 1090 1100
GALQPLTSGS AGPAQPGSVA GAGPGPTEGF TEKNVPESSP HSPCEGLPSE
1110 1120 1130 1140 1150
AALTPRPEGK VPSRLALGSR GGYNGRGWGS PGRPKKKHTG MASIDSSAPE
1160 1170 1180 1190 1200
TTSDSSPTLS RRPLRGGWAP TSWGRGQDSD SISSSSSDSL GSSSSSGSRR
1210 1220 1230 1240 1250
ASASGGARAK TVEVGRYKGR RPESHAPHVP NQPSEAAAHF YFELAKTVLI
1260 1270 1280 1290 1300
KAGGNSSTSI FTHPSSSGGH QGPHRNLHLC AFEIGLYALG LHNFVSPNWL
1310 1320 1330 1340 1350
SRTYSSHVSW ITGQAMEIGS AALTILVECW DGHLTPPEVA SLADRASRAR
1360 1370 1380 1390 1400
DSNMVRAAAE LALSCLPHAH ALNPNEIQRA LVQCKEQDNL MLEKACMAVE
1410 1420 1430 1440 1450
EAAKGGGVYP EVLFEVAHQW FWLYEQTAGG SSTAREGATS CSASGIRAGG
1460 1470 1480 1490 1500
EAGRGMPEGR GGPGTEPVTV AAAAVTAAAT VVPVISVGSS LYPGPGLGHG
1510 1520 1530 1540 1550
HSPGLHPYTA LQPHLPCSPQ YLTHPAHPAH PMPHMPRPAV FPVPSSAYPQ
1560 1570 1580 1590 1600
GVHPAFLGAQ YPYSVTPPSL AATAVSFPVP SMAPITVHPY HTEPGLPLPT
1610 1620 1630 1640 1650
SVACELWGQG TVSSVHPAST FPAIQGASLP ALTTQPSPLV SGGFPPPEEE
1660 1670 1680 1690 1700
THSQPVNPHS LHHLHAAYRV GMLALEMLGR RAHNDHPNNF SRSPPYTDDV
1710 1720 1730 1740 1750
KWLLGLAAKL GVNYVHQFCV GAAKGVLSPF VLQEIVMETL QRLSPAHAHN
1760 1770 1780 1790 1800
HLRAPAFHQL VQRCQQAYMQ YIHHRLIHLT PADYDDFVNA IRSARSAFCL
1810 1820 1830
TPMGMMQFND ILQNLKRSKQ TKELWQRVSL EMATFSP
Length:1,837
Mass (Da):197,297
Last modified:September 11, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i391CF6AE25E4F8C6
GO
Isoform 2 (identifier: A7E2V4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1604-1612: CELWGQGTV → L
     1712-1837: VNYVHQFCVG...VSLEMATFSP → DRHGDAAAAE...SGIYLAFINI

Note: No experimental confirmation available.
Show »
Length:1,892
Mass (Da):201,521
Checksum:i2A3771D8E5FB1B29
GO
Isoform 3 (identifier: A7E2V4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-936: P → PVVSPT
     1006-1006: K → KVTASVFQ
     1604-1612: CELWGQGTV → L

Note: No experimental confirmation available.
Show »
Length:1,841
Mass (Da):197,653
Checksum:i9686990176C4841E
GO
Isoform 4 (identifier: A7E2V4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-936: P → PVVSPT

Note: No experimental confirmation available.
Show »
Length:1,842
Mass (Da):197,781
Checksum:i9218AB3CF6511CEB
GO
Isoform 5 (identifier: A7E2V4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1604-1612: CELWGQGTV → L

Note: No experimental confirmation available.
Show »
Length:1,829
Mass (Da):196,436
Checksum:i8AC63F718E8FD28A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R410S4R410_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,834Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3H3S4R3H3_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,655Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ52H7BZ52_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R393S4R393_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,796Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCW2H0YCW2_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
904Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3U7S4R3U7_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3B3S4R3B3_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C453H7C453_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3S6S4R3S6_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI37250 differs from that shown. Probable cloning artifact.Curated
The sequence AAI37251 differs from that shown. Probable cloning artifact.Curated
The sequence BAA74936 differs from that shown. Aberrant splicing.Curated
The sequence BAA74936 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB14664 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03709 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti751A → D in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti762K → M in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti774F → S in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1052A → T in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1136K → M in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1165R → Q in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1184S → N in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1252A → T in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1401E → V in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1775R → S in BAB14664 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029586936P → PVVSPT in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0295871006K → KVTASVFQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_0295901604 – 1612CELWGQGTV → L in isoform 2, isoform 3 and isoform 5. 2 Publications9
Alternative sequenceiVSP_0295911712 – 1837VNYVH…ATFSP → DRHGDAAAAESRSCPQPPAC PGLPPTGAALPAGIHAVHPP PLDSPDSCGLRRLCECDPEC PQRLLPDAHGHDAVQRHPTE PQAQQTDQGAVAAGLTRDGH LLPLSLSPLGSYTGTQACGY GGPSHRGSETWLDRSSSLSS LVAQTDSCSWAIAWGQDVSH PRSLGLGETALSGRGRWVAS GIYLAFINI in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB020720 mRNA Translation: BAA74936.2 Sequence problems.
AC022400 Genomic DNA No translation available.
BC040726 mRNA Translation: AAH40726.1
BC063694 mRNA Translation: AAH63694.1
BC111006 mRNA Translation: AAI11007.1
BC117205 mRNA Translation: AAI17206.1
BC137249 mRNA Translation: AAI37250.1 Sequence problems.
BC137250 mRNA Translation: AAI37251.1 Sequence problems.
BC151206 mRNA Translation: AAI51207.1
AK023742 mRNA Translation: BAB14664.1 Different initiation.
AK091621 mRNA Translation: BAC03709.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44440.1 [A7E2V4-4]
CCDS60560.1 [A7E2V4-1]

NCBI Reference Sequences

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RefSeqi
NP_001229416.1, NM_001242487.1 [A7E2V4-1]
NP_001229417.1, NM_001242488.1 [A7E2V4-2]
NP_055852.2, NM_015037.3 [A7E2V4-4]
XP_006717788.1, XM_006717725.3 [A7E2V4-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000398706; ENSP00000381693; ENSG00000214655 [A7E2V4-4]
ENST00000605216; ENSP00000474748; ENSG00000214655 [A7E2V4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23053

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23053

UCSC genome browser

More...
UCSCi
uc001jve.4 human [A7E2V4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020720 mRNA Translation: BAA74936.2 Sequence problems.
AC022400 Genomic DNA No translation available.
BC040726 mRNA Translation: AAH40726.1
BC063694 mRNA Translation: AAH63694.1
BC111006 mRNA Translation: AAI11007.1
BC117205 mRNA Translation: AAI17206.1
BC137249 mRNA Translation: AAI37250.1 Sequence problems.
BC137250 mRNA Translation: AAI37251.1 Sequence problems.
BC151206 mRNA Translation: AAI51207.1
AK023742 mRNA Translation: BAB14664.1 Different initiation.
AK091621 mRNA Translation: BAC03709.1 Sequence problems.
CCDSiCCDS44440.1 [A7E2V4-4]
CCDS60560.1 [A7E2V4-1]
RefSeqiNP_001229416.1, NM_001242487.1 [A7E2V4-1]
NP_001229417.1, NM_001242488.1 [A7E2V4-2]
NP_055852.2, NM_015037.3 [A7E2V4-4]
XP_006717788.1, XM_006717725.3 [A7E2V4-5]

3D structure databases

SMRiA7E2V4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116690, 22 interactors
IntActiA7E2V4, 14 interactors
STRINGi9606.ENSP00000381693

PTM databases

iPTMnetiA7E2V4
PhosphoSitePlusiA7E2V4

Polymorphism and mutation databases

BioMutaiZSWIM8

Proteomic databases

EPDiA7E2V4
jPOSTiA7E2V4
MaxQBiA7E2V4
PaxDbiA7E2V4
PRIDEiA7E2V4
ProteomicsDBi1797
1798 [A7E2V4-2]
1799 [A7E2V4-3]
1800 [A7E2V4-4]
1801 [A7E2V4-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398706; ENSP00000381693; ENSG00000214655 [A7E2V4-4]
ENST00000605216; ENSP00000474748; ENSG00000214655 [A7E2V4-1]
GeneIDi23053
KEGGihsa:23053
UCSCiuc001jve.4 human [A7E2V4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23053

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZSWIM8
HGNCiHGNC:23528 ZSWIM8
HPAiHPA041244
neXtProtiNX_A7E2V4
OpenTargetsiENSG00000214655
PharmGKBiPA134885317

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3615 Eukaryota
ENOG410XPG2 LUCA
GeneTreeiENSGT00940000156999
InParanoidiA7E2V4
OMAiTEECMAC
OrthoDBi88229at2759
PhylomeDBiA7E2V4
TreeFamiTF324881

Enzyme and pathway databases

ReactomeiR-HSA-9010553 Regulation of expression of SLITs and ROBOs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZSWIM8 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23053

Protein Ontology

More...
PROi
PR:A7E2V4

Gene expression databases

BgeeiENSG00000214655 Expressed in 218 organ(s), highest expression level in adenohypophysis
ExpressionAtlasiA7E2V4 baseline and differential
GenevisibleiA7E2V4 HS

Family and domain databases

InterProiView protein in InterPro
IPR007527 Znf_SWIM
PROSITEiView protein in PROSITE
PS50966 ZF_SWIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSWM8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7E2V4
Secondary accession number(s): B2RP37
, O94987, Q17RS8, Q2TAB8, Q6P439, Q8IW81, Q8NB34, Q9H8F3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: May 8, 2019
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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