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UniProtKB - A7E2V4 (ZSWM8_HUMAN)

Entry version 105 (10 Feb 2021)
Sequence version 1 (11 Sep 2007)
Previous versions | rss
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Protein

Zinc finger SWIM domain-containing protein 8

Gene

ZSWIM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri172 – 208SWIM-typePROSITE-ProRule annotationAdd BLAST37

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • regulation of axon guidance Source: GO_Central
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A7E2V4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9010553, Regulation of expression of SLITs and ROBOs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger SWIM domain-containing protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZSWIM8
Synonyms:KIAA0913
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23528, ZSWIM8

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A7E2V4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000214655.10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000214655

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134885317

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		A7E2V4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZSWIM8

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003118021 – 1837Zinc finger SWIM domain-containing protein 8Add BLAST1837

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei36PhosphoserineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei53PhosphoserineBy similarity1
Modified residuei437PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1
Modified residuei1139PhosphothreonineCombined sources1
Modified residuei1153PhosphoserineBy similarity1
Modified residuei1156PhosphoserineBy similarity1
Modified residuei1160PhosphoserineCombined sources1
Modified residuei1267PhosphoserineCombined sources1
Modified residuei1836PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		A7E2V4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		A7E2V4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A7E2V4

MaxQB - The MaxQuant DataBase

More...MaxQBi		A7E2V4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		A7E2V4

PeptideAtlas

More...PeptideAtlasi		A7E2V4

PRoteomics IDEntifications database

More...PRIDEi		A7E2V4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		1797 [A7E2V4-1]
1798 [A7E2V4-2]
1799 [A7E2V4-3]
1800 [A7E2V4-4]
1801 [A7E2V4-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A7E2V4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		A7E2V4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000214655, Expressed in adenohypophysis and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A7E2V4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		A7E2V4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000214655, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116690, 26 interactors

Protein interaction database and analysis system

More...IntActi		A7E2V4, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000381693

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		A7E2V4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A7E2V4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi56 – 65Poly-Gly10
Compositional biasi546 – 602Gly-richAdd BLAST57
Compositional biasi1143 – 1204Ser-richAdd BLAST62
Compositional biasi1471 – 1474Poly-Ala4
Compositional biasi1493 – 1658Pro-richAdd BLAST166

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 208SWIM-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3615, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156999

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		A7E2V4

Identification of Orthologs from Complete Genome Data

More...OMAi		GSAQFKD

Database of Orthologous Groups

More...OrthoDBi		88229at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A7E2V4

TreeFam database of animal gene trees

More...TreeFami		TF324881

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007527, Znf_SWIM

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50966, ZF_SWIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: A7E2V4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELMFAEWED GERFSFEDSD RFEEDSLCSF ISEAESLCQN WRGWRKQSAG 
        60         70         80         90        100
PNSPTGGGGG GGSGGTRMRD GLVIPLVELS AKQVAFHIPF EVVEKVYPPV 
       110        120        130        140        150
PEQLQLRIAF WSFPENEEDI RLYSCLANGS ADEFQRGDQL FRMRAVKDPL 
       160        170        180        190        200
QIGFHLSATV VPPQMVPPKG AYNVAVMFDR CRVTSCSCTC GAGAKWCTHV 
       210        220        230        240        250
VALCLFRIHN ASAVCLRAPV SESLSRLQRD QLQKFAQYLI SELPQQILPT 
       260        270        280        290        300
AQRLLDELLS SQSTAINTVC GAPDPTAGPS ASDQSTWYLD ESTLTDNIKK 
       310        320        330        340        350
TLHKFCGPSP VVFSDVNSMY LSSTEPPAAA EWACLLRPLR GREPEGVWNL 
       360        370        380        390        400
LSIVREMFKR RDSNAAPLLE ILTDQCLTYE QITGWWYSVR TSASHSSASG 
       410        420        430        440        450
HTGRSNGQSE VAAHACASMC DEMVTLWRLA VLDPALSPQR RRELCTQLRQ 
       460        470        480        490        500
WQLKVIENVK RGQHKKTLER LFPGFRPAVE ACYFNWEEAY PLPGVTYSGT 
       510        520        530        540        550
DRKLALCWAR ALPSRPGASR SGGLEESRDR PRPLPTEPAV RPKEPGTKRK 
       560        570        580        590        600
GLGEGVPSSQ RGPRRLSAEG GDKALHKMGP GGGKAKALGG AGSGSKGSAG 
       610        620        630        640        650
GGSKRRLSSE DSSLEPDLAE MSLDDSSLAL GAEASTFGGF PESPPPCPLH 
       660        670        680        690        700
GGSRGPSTFL PEPPDTYEED GGVYFSEGPE PPTASVGPPG LLPGDVCTQD 
       710        720        730        740        750
DLPSTDESGN GLPKTKEAAP AVGEEDDDYQ AYYLNAQDGA GGEEEKAEGG 
       760        770        780        790        800
AGEEHDLFAG LKPLEQESRM EVLFACAEAL HAHGYSSEAS RLTVELAQDL 
       810        820        830        840        850
LANPPDLKVE PPPAKGKKNK VSTSRQTWVA TNTLSKAAFL LTVLSERPEH 
       860        870        880        890        900
HNLAFRVGMF ALELQRPPAS TKALEVKLAY QESEVAALLK KIPLGPSEMS 
       910        920        930        940        950
TMRCRAEELR EGTLCDYRPV LPLMLASFIF DVLCAPGSRP PSRNWNSETP 
       960        970        980        990       1000
GDEELGFEAA VAALGMKTTV SEAEHPLLCE GTRREKGDLA LALMITYKDD 
      1010       1020       1030       1040       1050
QAKLKKILDK LLDRESQTHK PQTLSSFYSS SRPTTASQRS PSKHGGPSAP 
      1060       1070       1080       1090       1100
GALQPLTSGS AGPAQPGSVA GAGPGPTEGF TEKNVPESSP HSPCEGLPSE 
      1110       1120       1130       1140       1150
AALTPRPEGK VPSRLALGSR GGYNGRGWGS PGRPKKKHTG MASIDSSAPE 
      1160       1170       1180       1190       1200
TTSDSSPTLS RRPLRGGWAP TSWGRGQDSD SISSSSSDSL GSSSSSGSRR 
      1210       1220       1230       1240       1250
ASASGGARAK TVEVGRYKGR RPESHAPHVP NQPSEAAAHF YFELAKTVLI 
      1260       1270       1280       1290       1300
KAGGNSSTSI FTHPSSSGGH QGPHRNLHLC AFEIGLYALG LHNFVSPNWL 
      1310       1320       1330       1340       1350
SRTYSSHVSW ITGQAMEIGS AALTILVECW DGHLTPPEVA SLADRASRAR 
      1360       1370       1380       1390       1400
DSNMVRAAAE LALSCLPHAH ALNPNEIQRA LVQCKEQDNL MLEKACMAVE 
      1410       1420       1430       1440       1450
EAAKGGGVYP EVLFEVAHQW FWLYEQTAGG SSTAREGATS CSASGIRAGG 
      1460       1470       1480       1490       1500
EAGRGMPEGR GGPGTEPVTV AAAAVTAAAT VVPVISVGSS LYPGPGLGHG 
      1510       1520       1530       1540       1550
HSPGLHPYTA LQPHLPCSPQ YLTHPAHPAH PMPHMPRPAV FPVPSSAYPQ 
      1560       1570       1580       1590       1600
GVHPAFLGAQ YPYSVTPPSL AATAVSFPVP SMAPITVHPY HTEPGLPLPT 
      1610       1620       1630       1640       1650
SVACELWGQG TVSSVHPAST FPAIQGASLP ALTTQPSPLV SGGFPPPEEE 
      1660       1670       1680       1690       1700
THSQPVNPHS LHHLHAAYRV GMLALEMLGR RAHNDHPNNF SRSPPYTDDV 
      1710       1720       1730       1740       1750
KWLLGLAAKL GVNYVHQFCV GAAKGVLSPF VLQEIVMETL QRLSPAHAHN 
      1760       1770       1780       1790       1800
HLRAPAFHQL VQRCQQAYMQ YIHHRLIHLT PADYDDFVNA IRSARSAFCL 
      1810       1820       1830 
TPMGMMQFND ILQNLKRSKQ TKELWQRVSL EMATFSP
Length:1,837
Mass (Da):197,297
Last modified:September 11, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i391CF6AE25E4F8C6
GO
Isoform 2 (identifier: A7E2V4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1604-1612: CELWGQGTV → L
     1712-1837: VNYVHQFCVG...VSLEMATFSP → DRHGDAAAAE...SGIYLAFINI

Show »
Length:1,892
Mass (Da):201,521
Checksum:i2A3771D8E5FB1B29
GO
Isoform 3 (identifier: A7E2V4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-936: P → PVVSPT
     1006-1006: K → KVTASVFQ
     1604-1612: CELWGQGTV → L

Show »
Length:1,841
Mass (Da):197,653
Checksum:i9686990176C4841E
GO
Isoform 4 (identifier: A7E2V4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     936-936: P → PVVSPT

Show »
Length:1,842
Mass (Da):197,781
Checksum:i9218AB3CF6511CEB
GO
Isoform 5 (identifier: A7E2V4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1604-1612: CELWGQGTV → L

Show »
Length:1,829
Mass (Da):196,436
Checksum:i8AC63F718E8FD28A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R410S4R410_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,834Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BZ52H7BZ52_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,336Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R393S4R393_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,796Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3H3S4R3H3_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,655Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCW2H0YCW2_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
904Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C453H7C453_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,112Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3B3S4R3B3_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3U7S4R3U7_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
1,232Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R3S6S4R3S6_HUMAN
Zinc finger SWIM domain-containing ...
ZSWIM8
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI37250 differs from that shown. Probable cloning artifact.Curated
The sequence AAI37251 differs from that shown. Probable cloning artifact.Curated
The sequence BAA74936 differs from that shown. Aberrant splicing.Curated
The sequence BAA74936 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAB14664 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC03709 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti751A → D in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti762K → M in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti774F → S in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1052A → T in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1136K → M in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1165R → Q in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1184S → N in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1252A → T in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1401E → V in BAB14664 (PubMed:14702039).Curated1
Sequence conflicti1775R → S in BAB14664 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029586936P → PVVSPT in isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_0295871006K → KVTASVFQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_0295901604 – 1612CELWGQGTV → L in isoform 2, isoform 3 and isoform 5. 2 Publications9
Alternative sequenceiVSP_0295911712 – 1837VNYVH…ATFSP → DRHGDAAAAESRSCPQPPAC PGLPPTGAALPAGIHAVHPP PLDSPDSCGLRRLCECDPEC PQRLLPDAHGHDAVQRHPTE PQAQQTDQGAVAAGLTRDGH LLPLSLSPLGSYTGTQACGY GGPSHRGSETWLDRSSSLSS LVAQTDSCSWAIAWGQDVSH PRSLGLGETALSGRGRWVAS GIYLAFINI in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020720 mRNA Translation: BAA74936.2 Sequence problems.
AC022400 Genomic DNA No translation available.
BC040726 mRNA Translation: AAH40726.1
BC063694 mRNA Translation: AAH63694.1
BC111006 mRNA Translation: AAI11007.1
BC117205 mRNA Translation: AAI17206.1
BC137249 mRNA Translation: AAI37250.1 Sequence problems.
BC137250 mRNA Translation: AAI37251.1 Sequence problems.
BC151206 mRNA Translation: AAI51207.1
AK023742 mRNA Translation: BAB14664.1 Different initiation.
AK091621 mRNA Translation: BAC03709.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44440.1 [A7E2V4-4]
CCDS60560.1 [A7E2V4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001229416.1, NM_001242487.1 [A7E2V4-1]
NP_001229417.1, NM_001242488.1 [A7E2V4-2]
NP_055852.2, NM_015037.3 [A7E2V4-4]
XP_006717788.1, XM_006717725.3 [A7E2V4-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000398706; ENSP00000381693; ENSG00000214655 [A7E2V4-4]
ENST00000605216; ENSP00000474748; ENSG00000214655 [A7E2V4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23053

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23053

UCSC genome browser

More...UCSCi		uc001jve.4, human [A7E2V4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020720 mRNA Translation: BAA74936.2 Sequence problems.
AC022400 Genomic DNA No translation available.
BC040726 mRNA Translation: AAH40726.1
BC063694 mRNA Translation: AAH63694.1
BC111006 mRNA Translation: AAI11007.1
BC117205 mRNA Translation: AAI17206.1
BC137249 mRNA Translation: AAI37250.1 Sequence problems.
BC137250 mRNA Translation: AAI37251.1 Sequence problems.
BC151206 mRNA Translation: AAI51207.1
AK023742 mRNA Translation: BAB14664.1 Different initiation.
AK091621 mRNA Translation: BAC03709.1 Sequence problems.
CCDSiCCDS44440.1 [A7E2V4-4]
CCDS60560.1 [A7E2V4-1]
RefSeqiNP_001229416.1, NM_001242487.1 [A7E2V4-1]
NP_001229417.1, NM_001242488.1 [A7E2V4-2]
NP_055852.2, NM_015037.3 [A7E2V4-4]
XP_006717788.1, XM_006717725.3 [A7E2V4-5]

3D structure databases

SMRiA7E2V4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116690, 26 interactors
IntActiA7E2V4, 22 interactors
STRINGi9606.ENSP00000381693

PTM databases

iPTMnetiA7E2V4
PhosphoSitePlusiA7E2V4

Genetic variation databases

BioMutaiZSWIM8

Proteomic databases

EPDiA7E2V4
jPOSTiA7E2V4
MassIVEiA7E2V4
MaxQBiA7E2V4
PaxDbiA7E2V4
PeptideAtlasiA7E2V4
PRIDEiA7E2V4
ProteomicsDBi1797 [A7E2V4-1]
1798 [A7E2V4-2]
1799 [A7E2V4-3]
1800 [A7E2V4-4]
1801 [A7E2V4-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		48437, 5 antibodies

Genome annotation databases

EnsembliENST00000398706; ENSP00000381693; ENSG00000214655 [A7E2V4-4]
ENST00000605216; ENSP00000474748; ENSG00000214655 [A7E2V4-1]
GeneIDi23053
KEGGihsa:23053
UCSCiuc001jve.4, human [A7E2V4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23053

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZSWIM8
HGNCiHGNC:23528, ZSWIM8
HPAiENSG00000214655, Low tissue specificity
neXtProtiNX_A7E2V4
OpenTargetsiENSG00000214655
PharmGKBiPA134885317
VEuPathDBiHostDB:ENSG00000214655.10

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3615, Eukaryota
GeneTreeiENSGT00940000156999
InParanoidiA7E2V4
OMAiGSAQFKD
OrthoDBi88229at2759
PhylomeDBiA7E2V4
TreeFamiTF324881

Enzyme and pathway databases

PathwayCommonsiA7E2V4
ReactomeiR-HSA-9010553, Regulation of expression of SLITs and ROBOs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23053, 70 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZSWIM8, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23053
PharosiA7E2V4, Tdark

Protein Ontology

More...PROi		PR:A7E2V4
RNActiA7E2V4, protein

Gene expression databases

BgeeiENSG00000214655, Expressed in adenohypophysis and 229 other tissues
ExpressionAtlasiA7E2V4, baseline and differential
GenevisibleiA7E2V4, HS

Family and domain databases

InterProiView protein in InterPro
IPR007527, Znf_SWIM
PROSITEiView protein in PROSITE
PS50966, ZF_SWIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSWM8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7E2V4
Secondary accession number(s): B2RP37
, O94987, Q17RS8, Q2TAB8, Q6P439, Q8IW81, Q8NB34, Q9H8F3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: September 11, 2007
Last modified: February 10, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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