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Entry version 94 (31 Jul 2019)
Sequence version 1 (11 Sep 2007)
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Protein
Submitted name:

CAP-GLY domain containing linker protein 2

Gene

CLIP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CAP-GLY domain containing linker protein 2Imported
Submitted name:
Cytoplasmic linker 2, isoform CRA_aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLIP2Imported
Synonyms:CYLN2Imported
ORF Names:hCG_18038Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27085

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 141CAP-GlyInterPro annotationAdd BLAST43
Domaini239 – 281CAP-GlyInterPro annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 71DisorderedSequence analysisAdd BLAST71
Regioni143 – 162DisorderedSequence analysisAdd BLAST20
Regioni195 – 215DisorderedSequence analysisAdd BLAST21
Regioni313 – 339DisorderedSequence analysisAdd BLAST27
Regioni982 – 1011DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili354 – 381Sequence analysisAdd BLAST28
Coiled coili396 – 455Sequence analysisAdd BLAST60
Coiled coili529 – 577Sequence analysisAdd BLAST49
Coiled coili640 – 667Sequence analysisAdd BLAST28
Coiled coili669 – 765Sequence analysisAdd BLAST97
Coiled coili818 – 852Sequence analysisAdd BLAST35
Coiled coili901 – 928Sequence analysisAdd BLAST28
Coiled coili948 – 975Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 55PolarSequence analysisAdd BLAST38
Compositional biasi195 – 210PolarSequence analysisAdd BLAST16
Compositional biasi985 – 1001PolarSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4568 Eukaryota
COG5244 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000092755

Database of Orthologous Groups

More...
OrthoDBi
1110101at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.30.190, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028394 CLIP2

The PANTHER Classification System

More...
PANTHERi
PTHR18916:SF10 PTHR18916:SF10, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01302 CAP_GLY, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01052 CAP_GLY, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74924 SSF74924, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7E2F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKPSGLKPP GRGGKHSSPM GRTSTGSASS SAAVAASSKE GSPLHKQSSG
60 70 80 90 100
PSSSPAAAAA PEKPGPKAAE VGDDFLGDFV VGERVWVNGV KPGVVQYLGE
110 120 130 140 150
TQFAPGQWAG VVLDDPVGKN DGAVGGVRYF ECPALQGIFT RPSKLTRQPT
160 170 180 190 200
AEGSGSDAHS VESLTAQNLS LHSGTATPPL TSRVIPLRES VLNSSVKTGN
210 220 230 240 250
ESGSNLSDSG SVKRGEKDLR LGDRVLVGGT KTGVVRYVGE TDFAKGEWCG
260 270 280 290 300
VELDEPLGKN DGAVAGTRYF QCPPKFGLFA PIHKVIRIGF PSTSPAKAKK
310 320 330 340 350
TKRMAMGVSA LTHSPSSSSI SSVSSVASSV GGRPSRSGLL TETSSRYARK
360 370 380 390 400
ISGTTALQEA LKEKQQHIEQ LLAERDLERA EVAKATSHIC EVEKEIALLK
410 420 430 440 450
AQHEQYVAEA EEKLQRARLL VESVRKEKVD LSNQLEEERR KVEDLQFRVE
460 470 480 490 500
EESITKGDLE LTTVAEKSRV LQLEEELTLR RGEIEELQQC LLHSGPPPPD
510 520 530 540 550
HPDAAEILRL RERLLSASKE HQRESGVLRD KYEKALKAYQ AEVDKLRAAN
560 570 580 590 600
EKYAQEVAGL KDKVQQATSE NMGLMDNWKS KLDSLASDHQ KSLEDLKATL
610 620 630 640 650
NSGPGAQQKE IGELKAVMEG IKMEHQLELG NLQAKHDLET AMHVKEKEAL
660 670 680 690 700
REKLQEAQEE LAGLQRHWRA QLEVQASQHR LELQEAQDQR RDAELRVHEL
710 720 730 740 750
EKLDVEYRGQ AQAIEFLKEQ ISLAEKKMLD YERLQRAEAQ GKQEVESLRE
760 770 780 790 800
KLLVAENRLQ AVEALCSSQH THMIESNDIS EETIRTKETV EGLQDKLNKR
810 820 830 840 850
DKEVTALTSQ TEMLRAQVSA LESKCKSGEK KVDALLKEKR RLEAELETVS
860 870 880 890 900
RKTHDASGQL VLISQELLRK ERSLNELRVL LLEANRHSPG PERDLSREVH
910 920 930 940 950
KAEWRIKEQK LKDDIRGLRE KLTGLDKEKS LSDQRRYSLI DPSSAPELLR
960 970 980 990 1000
LQHQLMSTED ALRDALDQAQ QVEKLMEAMR SCPDKAQTIG NSGSANGIHQ
1010
QDKAQKQEDK H
Length:1,011
Mass (Da):111,723
Last modified:September 11, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2E745BB10115487C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC150332 mRNA Translation: AAI50333.1
CH471200 Genomic DNA Translation: EAW69603.1

NCBI Reference Sequences

More...
RefSeqi
NP_115797.1, NM_032421.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7461

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150332 mRNA Translation: AAI50333.1
CH471200 Genomic DNA Translation: EAW69603.1
RefSeqiNP_115797.1, NM_032421.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7461
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi7461

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7461
PharmGKBiPA27085

Phylogenomic databases

eggNOGiKOG4568 Eukaryota
COG5244 LUCA
HOGENOMiHOG000092755
OrthoDBi1110101at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CLIP2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7461

Family and domain databases

Gene3Di2.30.30.190, 2 hits
InterProiView protein in InterPro
IPR036859 CAP-Gly_dom_sf
IPR000938 CAP-Gly_domain
IPR028394 CLIP2
PANTHERiPTHR18916:SF10 PTHR18916:SF10, 2 hits
PfamiView protein in Pfam
PF01302 CAP_GLY, 2 hits
SMARTiView protein in SMART
SM01052 CAP_GLY, 2 hits
SUPFAMiSSF74924 SSF74924, 2 hits
PROSITEiView protein in PROSITE
PS00845 CAP_GLY_1, 2 hits
PS50245 CAP_GLY_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA7E2F7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7E2F7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: July 31, 2019
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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