UniProtKB - A7E2F4 (GOG8A_HUMAN)
Protein
Golgin subfamily A member 8A
Gene
GOLGA8A
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in maintaining Golgi structure.By similarity
Caution
A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.Curated
GO - Biological processi
- Golgi organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | A7E2F4 |
Names & Taxonomyi
Protein namesi | Recommended name: Golgin subfamily A member 8AAlternative name(s): 88 kDa Golgi matrix protein Short name: GM88 GM88 autoantigen |
Gene namesi | Name:GOLGA8A Synonyms:KIAA0855 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31972, GOLGA8A |
MIMi | 616180, gene |
neXtProti | NX_A7E2F4 |
VEuPathDBi | HostDB:ENSG00000175265.17 |
Subcellular locationi
Golgi apparatus
- Golgi stack membrane By similarity; Peripheral membrane protein By similarity
Cytosol
- cytosol Source: HPA
Golgi apparatus
- cis-Golgi network Source: GO_Central
- Golgi apparatus Source: HPA
- Golgi cis cisterna Source: GO_Central
- Golgi cisterna membrane Source: GO_Central
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23015 |
OpenTargetsi | ENSG00000175265 |
Miscellaneous databases
Pharosi | A7E2F4, Tbio |
Genetic variation databases
BioMutai | GOLGA8A |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190070 | 1 – 631 | Golgin subfamily A member 8AAdd BLAST | 631 |
Proteomic databases
jPOSTi | A7E2F4 |
MassIVEi | A7E2F4 |
MaxQBi | A7E2F4 |
PaxDbi | A7E2F4 |
PeptideAtlasi | A7E2F4 |
PRIDEi | A7E2F4 |
ProteomicsDBi | 1791 [A7E2F4-1] 1792 [A7E2F4-3] |
PTM databases
GlyConnecti | 1282, 3 N-Linked glycans (1 site) |
GlyGeni | A7E2F4, 1 site |
iPTMneti | A7E2F4 |
PhosphoSitePlusi | A7E2F4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000175265, Expressed in left lobe of thyroid gland and 242 other tissues |
Genevisiblei | A7E2F4, HS |
Organism-specific databases
HPAi | ENSG00000175265, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116657, 3 interactors |
IntActi | A7E2F4, 2 interactors |
MINTi | A7E2F4 |
STRINGi | 9606.ENSP00000352111 |
Miscellaneous databases
RNActi | A7E2F4, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 519 – 631 | Golgi-targeting domainBy similarityAdd BLAST | 113 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 110 – 468 | Sequence analysisAdd BLAST | 359 |
Sequence similaritiesi
Belongs to the GOLGA8 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG4725, Eukaryota |
GeneTreei | ENSGT00530000062932 |
HOGENOMi | CLU_012403_1_2_1 |
InParanoidi | A7E2F4 |
OMAi | DMHRVEK |
OrthoDBi | 358120at2759 |
PhylomeDBi | A7E2F4 |
TreeFami | TF316990 |
Family and domain databases
InterProi | View protein in InterPro IPR043937, GM130_C IPR043976, GOLGA_cons_dom IPR024858, Golgin_A |
PANTHERi | PTHR10881, PTHR10881, 1 hit |
Pfami | View protein in Pfam PF19046, GM130_C, 1 hit PF15070, GOLGA2L5, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: A7E2F4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLPVDGEERK SEGSDTEGDR TSPCAVSSAT LKDLEVGGSG RRCSDPAGQP
60 70 80 90 100
SNLLPQRGLG APLPAETAHT QPSPNDRSLY LSPKSSSASS SLHARQSPCQ
110 120 130 140 150
EQAAVLNSRS IKISRLNDTI KSLKQQKKQV EHQLEEEKKA NNEKQKAERE
160 170 180 190 200
LEGQIQRLNT EKKKLNTDLY HMKHSLRYFE EESKDLAGRL QRSSQRIGEL
210 220 230 240 250
EWSLCAVAAT QKKKPDGFSS RSKALLKRQL EQSIREQILL KGHVTQLKES
260 270 280 290 300
LKEVQLERDQ YAEQIKGERA QWQQRMRKMS QEVCTLKEEK KHDTHRVEEL
310 320 330 340 350
ERSLSRLKNQ MAEPLPPDAP AVSSEVELQD LRKELERVAG ELQAQVENNQ
360 370 380 390 400
CISLLNRGQK ERLREQEERL QEQQERLRER EKRLQQLAEP QSDLEELKHE
410 420 430 440 450
NKSALQLEQQ VKELQEKLGQ VMETLTSAEK EPEAAVPASG TGGESSGLMD
460 470 480 490 500
LLEEKADLRE HVEKLELGFI QYRRERCHQK VHRLLTEPGD SAKDASPGGG
510 520 530 540 550
HHQAGPGQGG EEGEAAGAAG DGVAACGSYS EGHGKFLAAA RNPAAEPSPG
560 570 580 590 600
APAPQELGAA DKHGDLCEAS LTNSVEPAQG EAREGSSQDN PTAQPVVQLL
610 620 630
GEMQDHQEHP GLGSNCCVPC FCWAWLPRRR R
Sequence cautioni
The sequence AAI44610 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI50330 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence AAI52411 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAA74878 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 95 | R → P in AAH93673 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 380 | R → Q in AAH93673 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 422 | M → T in AAH93673 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 596 | V → I in AAF28463 (Ref. 1) Curated | 1 | |
Sequence conflicti | 596 | V → I in BAA74878 (PubMed:10048485).Curated | 1 | |
Sequence conflicti | 596 | V → I in AAI44610 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 596 | V → I in AAI50330 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 596 | V → I in AAI52411 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 596 | V → I in CAH18214 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_064650 | 480 | K → N4 PublicationsCorresponds to variant dbSNP:rs347880Ensembl. | 1 | |
Natural variantiVAR_064651 | 530 | S → N4 PublicationsCorresponds to variant dbSNP:rs238639Ensembl. | 1 | |
Natural variantiVAR_064652 | 541 | R → Q4 PublicationsCorresponds to variant dbSNP:rs347879Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040753 | 1 – 84 | MLPVD…YLSPK → MAEETGQSKLAAAKKKFKEY WQRNRPGVPAAAKRNTKANG SSPETAASGGCHSSEA in isoform 2. 1 PublicationAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF204231 mRNA Translation: AAF28463.1 AB020662 mRNA Translation: BAA74878.1 Different initiation. AC025678 Genomic DNA No translation available. BC093673 mRNA Translation: AAH93673.1 BC144609 mRNA Translation: AAI44610.1 Different initiation. BC150329 mRNA Translation: AAI50330.1 Different initiation. BC152410 mRNA Translation: AAI52411.1 Different initiation. CR749361 mRNA Translation: CAH18214.1 Sequence problems. |
CCDSi | CCDS10038.1 [A7E2F4-3] |
RefSeqi | NP_851422.1, NM_181077.3 [A7E2F4-3] |
Genome annotation databases
Ensembli | ENST00000359187; ENSP00000352111; ENSG00000175265 [A7E2F4-3] ENST00000432566; ENSP00000402791; ENSG00000175265 [A7E2F4-1] |
GeneIDi | 23015 |
KEGGi | hsa:23015 |
UCSCi | uc001zii.4, human [A7E2F4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF204231 mRNA Translation: AAF28463.1 AB020662 mRNA Translation: BAA74878.1 Different initiation. AC025678 Genomic DNA No translation available. BC093673 mRNA Translation: AAH93673.1 BC144609 mRNA Translation: AAI44610.1 Different initiation. BC150329 mRNA Translation: AAI50330.1 Different initiation. BC152410 mRNA Translation: AAI52411.1 Different initiation. CR749361 mRNA Translation: CAH18214.1 Sequence problems. |
CCDSi | CCDS10038.1 [A7E2F4-3] |
RefSeqi | NP_851422.1, NM_181077.3 [A7E2F4-3] |
3D structure databases
SMRi | A7E2F4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116657, 3 interactors |
IntActi | A7E2F4, 2 interactors |
MINTi | A7E2F4 |
STRINGi | 9606.ENSP00000352111 |
PTM databases
GlyConnecti | 1282, 3 N-Linked glycans (1 site) |
GlyGeni | A7E2F4, 1 site |
iPTMneti | A7E2F4 |
PhosphoSitePlusi | A7E2F4 |
Genetic variation databases
BioMutai | GOLGA8A |
Proteomic databases
jPOSTi | A7E2F4 |
MassIVEi | A7E2F4 |
MaxQBi | A7E2F4 |
PaxDbi | A7E2F4 |
PeptideAtlasi | A7E2F4 |
PRIDEi | A7E2F4 |
ProteomicsDBi | 1791 [A7E2F4-1] 1792 [A7E2F4-3] |
Protocols and materials databases
Antibodypediai | 67268, 48 antibodies |
Genome annotation databases
Ensembli | ENST00000359187; ENSP00000352111; ENSG00000175265 [A7E2F4-3] ENST00000432566; ENSP00000402791; ENSG00000175265 [A7E2F4-1] |
GeneIDi | 23015 |
KEGGi | hsa:23015 |
UCSCi | uc001zii.4, human [A7E2F4-1] |
Organism-specific databases
CTDi | 23015 |
DisGeNETi | 23015 |
GeneCardsi | GOLGA8A |
HGNCi | HGNC:31972, GOLGA8A |
HPAi | ENSG00000175265, Low tissue specificity |
MIMi | 616180, gene |
neXtProti | NX_A7E2F4 |
OpenTargetsi | ENSG00000175265 |
VEuPathDBi | HostDB:ENSG00000175265.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4725, Eukaryota |
GeneTreei | ENSGT00530000062932 |
HOGENOMi | CLU_012403_1_2_1 |
InParanoidi | A7E2F4 |
OMAi | DMHRVEK |
OrthoDBi | 358120at2759 |
PhylomeDBi | A7E2F4 |
TreeFami | TF316990 |
Enzyme and pathway databases
PathwayCommonsi | A7E2F4 |
Miscellaneous databases
BioGRID-ORCSi | 23015, 7 hits in 206 CRISPR screens |
ChiTaRSi | GOLGA8A, human |
GenomeRNAii | 23015 |
Pharosi | A7E2F4, Tbio |
PROi | PR:A7E2F4 |
RNActi | A7E2F4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175265, Expressed in left lobe of thyroid gland and 242 other tissues |
Genevisiblei | A7E2F4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR043937, GM130_C IPR043976, GOLGA_cons_dom IPR024858, Golgin_A |
PANTHERi | PTHR10881, PTHR10881, 1 hit |
Pfami | View protein in Pfam PF19046, GM130_C, 1 hit PF15070, GOLGA2L5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GOG8A_HUMAN | |
Accessioni | A7E2F4Primary (citable) accession number: A7E2F4 Secondary accession number(s): A7MCY9 Q9NZW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | March 8, 2011 | |
Last modified: | April 7, 2021 | |
This is version 102 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families