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UniProtKB - A7E2F4 (GOG8A_HUMAN)

Protein

Golgin subfamily A member 8A

Gene

GOLGA8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in maintaining Golgi structure.By similarity

Caution

A family of highly similar proteins (GOLGA8A, GOLGA8B, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G) are encoded by a repeated region on chromosome 15q11-15q13. Our sequences are in agreement with HGNC nomenclature.Curated

GO - Biological processi

  • Golgi organization Source: GO_Central
View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 8A
Alternative name(s):
88 kDa Golgi matrix protein
Short name:
GM88
GM88 autoantigen
Gene namesi
Name:GOLGA8A
Synonyms:KIAA0855
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000175265.17
HGNCiHGNC:31972 GOLGA8A
MIMi616180 gene
neXtProtiNX_A7E2F4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000175265

Polymorphism and mutation databases

BioMutaiGOLGA8A

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900701 – 631Golgin subfamily A member 8AAdd BLAST631

Proteomic databases

MaxQBiA7E2F4
PaxDbiA7E2F4
PRIDEiA7E2F4
ProteomicsDBi1791
1792 [A7E2F4-3]

PTM databases

GlyConnecti1282
iPTMnetiA7E2F4
PhosphoSitePlusiA7E2F4

Expressioni

Gene expression databases

BgeeiENSG00000175265 Expressed in 232 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_GOLGA8A
GenevisibleiA7E2F4 HS

Organism-specific databases

HPAiHPA051808

Interactioni

Protein-protein interaction databases

BioGridi116657, 2 interactors
IntActiA7E2F4, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliA7E2F4
SMRiA7E2F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni519 – 631Golgi-targeting domainBy similarityAdd BLAST113

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili110 – 468Sequence analysisAdd BLAST359

Sequence similaritiesi

Belongs to the GOLGA8 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOVERGENiHBG051752
InParanoidiA7E2F4
OMAiHIGELEW
OrthoDBiEOG091G0DDT
PhylomeDBiA7E2F4
TreeFamiTF316990

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: A7E2F4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPVDGEERK SEGSDTEGDR TSPCAVSSAT LKDLEVGGSG RRCSDPAGQP 
        60         70         80         90        100
SNLLPQRGLG APLPAETAHT QPSPNDRSLY LSPKSSSASS SLHARQSPCQ 
       110        120        130        140        150
EQAAVLNSRS IKISRLNDTI KSLKQQKKQV EHQLEEEKKA NNEKQKAERE 
       160        170        180        190        200
LEGQIQRLNT EKKKLNTDLY HMKHSLRYFE EESKDLAGRL QRSSQRIGEL 
       210        220        230        240        250
EWSLCAVAAT QKKKPDGFSS RSKALLKRQL EQSIREQILL KGHVTQLKES 
       260        270        280        290        300
LKEVQLERDQ YAEQIKGERA QWQQRMRKMS QEVCTLKEEK KHDTHRVEEL 
       310        320        330        340        350
ERSLSRLKNQ MAEPLPPDAP AVSSEVELQD LRKELERVAG ELQAQVENNQ 
       360        370        380        390        400
CISLLNRGQK ERLREQEERL QEQQERLRER EKRLQQLAEP QSDLEELKHE 
       410        420        430        440        450
NKSALQLEQQ VKELQEKLGQ VMETLTSAEK EPEAAVPASG TGGESSGLMD 
       460        470        480        490        500
LLEEKADLRE HVEKLELGFI QYRRERCHQK VHRLLTEPGD SAKDASPGGG 
       510        520        530        540        550
HHQAGPGQGG EEGEAAGAAG DGVAACGSYS EGHGKFLAAA RNPAAEPSPG 
       560        570        580        590        600
APAPQELGAA DKHGDLCEAS LTNSVEPAQG EAREGSSQDN PTAQPVVQLL 
       610        620        630 
GEMQDHQEHP GLGSNCCVPC FCWAWLPRRR R
Length:631
Mass (Da):70,117
Last modified:March 8, 2011 - v3
Checksum:i521BE39BFFBC6842
GO
Isoform 2 (identifier: A7E2F4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: MLPVDGEERK...NDRSLYLSPK → MAEETGQSKL...ASGGCHSSEA

Show »
Length:603
Mass (Da):67,264
Checksum:iE31466F22DCAC0E4
GO

Sequence cautioni

The sequence AAI44610 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI50330 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAI52411 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAA74878 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAH18214 differs from that shown. Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95R → P in AAH93673 (PubMed:15489334).Curated1
Sequence conflicti380R → Q in AAH93673 (PubMed:15489334).Curated1
Sequence conflicti422M → T in AAH93673 (PubMed:15489334).Curated1
Sequence conflicti596V → I in AAF28463 (Ref. 1) Curated1
Sequence conflicti596V → I in BAA74878 (PubMed:10048485).Curated1
Sequence conflicti596V → I in AAI44610 (PubMed:15489334).Curated1
Sequence conflicti596V → I in AAI50330 (PubMed:15489334).Curated1
Sequence conflicti596V → I in AAI52411 (PubMed:15489334).Curated1
Sequence conflicti596V → I in CAH18214 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064650480K → N4 PublicationsCorresponds to variant dbSNP:rs347880Ensembl.1
Natural variantiVAR_064651530S → N4 PublicationsCorresponds to variant dbSNP:rs238639Ensembl.1
Natural variantiVAR_064652541R → Q4 PublicationsCorresponds to variant dbSNP:rs347879Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0407531 – 84MLPVD…YLSPK → MAEETGQSKLAAAKKKFKEY WQRNRPGVPAAAKRNTKANG SSPETAASGGCHSSEA in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204231 mRNA Translation: AAF28463.1
AB020662 mRNA Translation: BAA74878.1 Different initiation.
AC025678 Genomic DNA No translation available.
BC093673 mRNA Translation: AAH93673.1
BC144609 mRNA Translation: AAI44610.1 Different initiation.
BC150329 mRNA Translation: AAI50330.1 Different initiation.
BC152410 mRNA Translation: AAI52411.1 Different initiation.
CR749361 mRNA Translation: CAH18214.1 Sequence problems.
CCDSiCCDS10038.1 [A7E2F4-3]
RefSeqiNP_851422.1, NM_181077.3 [A7E2F4-3]
UniGeneiHs.182982
Hs.720151

Genome annotation databases

EnsembliENST00000359187; ENSP00000352111; ENSG00000175265 [A7E2F4-3]
ENST00000432566; ENSP00000402791; ENSG00000175265 [A7E2F4-1]
GeneIDi23015
KEGGihsa:23015
UCSCiuc001zii.4 human [A7E2F4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204231 mRNA Translation: AAF28463.1
AB020662 mRNA Translation: BAA74878.1 Different initiation.
AC025678 Genomic DNA No translation available.
BC093673 mRNA Translation: AAH93673.1
BC144609 mRNA Translation: AAI44610.1 Different initiation.
BC150329 mRNA Translation: AAI50330.1 Different initiation.
BC152410 mRNA Translation: AAI52411.1 Different initiation.
CR749361 mRNA Translation: CAH18214.1 Sequence problems.
CCDSiCCDS10038.1 [A7E2F4-3]
RefSeqiNP_851422.1, NM_181077.3 [A7E2F4-3]
UniGeneiHs.182982
Hs.720151

3D structure databases

ProteinModelPortaliA7E2F4
SMRiA7E2F4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116657, 2 interactors
IntActiA7E2F4, 1 interactor

PTM databases

GlyConnecti1282
iPTMnetiA7E2F4
PhosphoSitePlusiA7E2F4

Polymorphism and mutation databases

BioMutaiGOLGA8A

Proteomic databases

MaxQBiA7E2F4
PaxDbiA7E2F4
PRIDEiA7E2F4
ProteomicsDBi1791
1792 [A7E2F4-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359187; ENSP00000352111; ENSG00000175265 [A7E2F4-3]
ENST00000432566; ENSP00000402791; ENSG00000175265 [A7E2F4-1]
GeneIDi23015
KEGGihsa:23015
UCSCiuc001zii.4 human [A7E2F4-1]

Organism-specific databases

CTDi23015
EuPathDBiHostDB:ENSG00000175265.17
GeneCardsiGOLGA8A
H-InvDBiHIX0012094
HIX0012524
HIX0172811
HIX0172850
HIX0172851
HGNCiHGNC:31972 GOLGA8A
HPAiHPA051808
MIMi616180 gene
neXtProtiNX_A7E2F4
OpenTargetsiENSG00000175265
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4725 Eukaryota
ENOG410ZIE4 LUCA
GeneTreeiENSGT00530000062932
HOVERGENiHBG051752
InParanoidiA7E2F4
OMAiHIGELEW
OrthoDBiEOG091G0DDT
PhylomeDBiA7E2F4
TreeFamiTF316990

Miscellaneous databases

ChiTaRSiGOLGA8A human
GenomeRNAii23015
PROiPR:A7E2F4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175265 Expressed in 232 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_GOLGA8A
GenevisibleiA7E2F4 HS

Family and domain databases

InterProiView protein in InterPro
IPR024858 Golgin_A
PANTHERiPTHR10881 PTHR10881, 1 hit
PfamiView protein in Pfam
PF15070 GOLGA2L5, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiGOG8A_HUMAN
AccessioniPrimary (citable) accession number: A7E2F4
Secondary accession number(s): A7MCY9
, B7ZMK5, O94937, Q52M46, Q68DK6, Q9NZG8, Q9NZW0, Q9NZW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 8, 2011
Last modified: November 7, 2018
This is version 86 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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