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Protein
Submitted name:

Dipeptidyl-peptidase 6

Gene

DPP6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Protein family/group databases

ESTHERihuman-DPP6 DPP4N_Peptidase_S9

Names & Taxonomyi

Protein namesi
Submitted name:
Dipeptidyl-peptidase 6Imported
Gene namesi
Name:DPP6Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 53HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PeptideAtlasiA7E2E4
PRIDEiA7E2E4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini131 – 497DPPIV_NInterPro annotationAdd BLAST367
Domaini579 – 784Peptidase_S9InterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the peptidase S9B family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
HOGENOMiHOG000231875
HOVERGENiHBG105877

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

A7E2E4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKEKAMIKTA KMQGNVMELV GSNPPQRNWK GIAIALLVIL VICSLIVTSV
60 70 80 90 100
ILLTPAEDNS LSQKKKVTVE DLFSEDFKIH DPEAKWISDT EFIYREQKGT
110 120 130 140 150
VRLWNVETNT STVLIEGKKI ESLRAIRYEI SPDREYALFS YNVEPIYQHS
160 170 180 190 200
YTGYYVLSKI PHGDPQSLDP PEVSNAKLQY AGWGPKGQQL IFIFENNIYY
210 220 230 240 250
CAHVGKQAIR VVSTGKEGVI YNGLSDWLYE EEILKTHIAH WWSPDGTRLA
260 270 280 290 300
YAAINDSRVP IMELPTYTGS IYPTVKPYHY PKAGSENPSI SLHVIGLNGP
310 320 330 340 350
THDLEMMPPD DPRMREYYIT MVKWATSTKV AVTWLNRAQN VSILTLCDAT
360 370 380 390 400
TGVCTKKHED ESEAWLHRQN EEPVFSKDGR KFFFIRAIPQ GGRGKFYHIT
410 420 430 440 450
VSSSQPNSSN DNIQSITSGD WDVTKILAYD EKGNKIYFLS TEDLPRRRQL
460 470 480 490 500
YSANTVGNFN RQCLSCDLVE NCTYFSASFS HSMDFFLLKC EGPGVPMVTV
510 520 530 540 550
HNTTDKKKMF DLETNEHVKK AINDRQMPKV EYRDIEIDDY NLPMQILKPA
560 570 580 590 600
TFTDTTHYPL LLVVDGTPGS QSVAEKFEVS WETVMVSSHG AVVVKCEGRG
610 620 630 640 650
SGFRGTKLLH EVRRRLGLLE EKDQMEAVRT MLKEQYIDRT RVAVFGKDYG
660 670 680 690 700
GYLSTYILPA KGENQGQTFT CGSALSPITD FKLYASAFSE RYLGLHGLDN
710 720 730 740 750
RAYEMTKVAH RVSALEEQQF LIIHPTADEK IHFQHTAELI TQLIRGKANY
760 770 780 790 800
SLQIYPDESH YFTSSSLKQH LYRSIINFFV ECFRIQDKLL TVTAKEDEEE

D
Length:801
Mass (Da):91,288
Last modified:September 11, 2007 - v1
Checksum:iAA00AAAF2EEC4BDF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150304 mRNA Translation: AAI50305.1
RefSeqiNP_001034439.1, NM_001039350.2
NP_001277181.1, NM_001290252.1
NP_001927.3, NM_001936.4
NP_570629.2, NM_130797.3
UniGeneiHs.490684
Hs.551097
Hs.669076
Hs.703229

Genome annotation databases

GeneIDi1804
KEGGihsa:1804

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150304 mRNA Translation: AAI50305.1
RefSeqiNP_001034439.1, NM_001039350.2
NP_001277181.1, NM_001290252.1
NP_001927.3, NM_001936.4
NP_570629.2, NM_130797.3
UniGeneiHs.490684
Hs.551097
Hs.669076
Hs.703229

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERihuman-DPP6 DPP4N_Peptidase_S9

Proteomic databases

PeptideAtlasiA7E2E4
PRIDEiA7E2E4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1804
KEGGihsa:1804

Organism-specific databases

CTDi1804

Phylogenomic databases

eggNOGiKOG2100 Eukaryota
COG1506 LUCA
HOGENOMiHOG000231875
HOVERGENiHBG105877

Miscellaneous databases

ChiTaRSiDPP6 human
GenomeRNAii1804

Family and domain databases

Gene3Di2.140.10.30, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001375 Peptidase_S9
IPR002469 Peptidase_S9B_N
IPR038554 Peptidase_S9B_N_sf
PfamiView protein in Pfam
PF00930 DPPIV_N, 1 hit
PF00326 Peptidase_S9, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA7E2E4_HUMAN
AccessioniPrimary (citable) accession number: A7E2E4
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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