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Entry version 80 (12 Aug 2020)
Sequence version 1 (11 Sep 2007)
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Protein
Submitted name:

BZRAP1 protein

Gene

BZRAP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
BZRAP1 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BZRAP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394545

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A7E2C5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A7E2C5, HS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini593 – 660SH3InterPro annotationAdd BLAST68
Domaini731 – 822Fibronectin type-IIIInterPro annotationAdd BLAST92
Domaini824 – 916Fibronectin type-IIIInterPro annotationAdd BLAST93
Domaini921 – 1021Fibronectin type-IIIInterPro annotationAdd BLAST101
Domaini1565 – 1633SH3InterPro annotationAdd BLAST69
Domaini1704 – 1771SH3InterPro annotationAdd BLAST68

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 103DisorderedSequence analysisAdd BLAST103
Regioni224 – 261DisorderedSequence analysisAdd BLAST38
Regioni505 – 569DisorderedSequence analysisAdd BLAST65
Regioni669 – 729DisorderedSequence analysisAdd BLAST61
Regioni1023 – 1251DisorderedSequence analysisAdd BLAST229
Regioni1270 – 1419DisorderedSequence analysisAdd BLAST150
Regioni1441 – 1541DisorderedSequence analysisAdd BLAST101
Regioni1663 – 1701DisorderedSequence analysisAdd BLAST39
Regioni1762 – 1797DisorderedSequence analysisAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili123 – 150Sequence analysisAdd BLAST28
Coiled coili159 – 186Sequence analysisAdd BLAST28
Coiled coili270 – 332Sequence analysisAdd BLAST63
Coiled coili357 – 461Sequence analysisAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi540 – 563PolarSequence analysisAdd BLAST24
Compositional biasi679 – 703PolarSequence analysisAdd BLAST25
Compositional biasi1052 – 1075Pro-richSequence analysisAdd BLAST24
Compositional biasi1138 – 1159PolarSequence analysisAdd BLAST22
Compositional biasi1199 – 1215AcidicSequence analysisAdd BLAST17
Compositional biasi1219 – 1236PolarSequence analysisAdd BLAST18
Compositional biasi1351 – 1367PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1494 – 1510PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1782 – 1797PolyampholyteSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RIMBP family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K19922

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 1 hit
cd12012, SH3_RIM-BP_2, 1 hit
cd12013, SH3_RIM-BP_3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR035753, RIM-BP_SH3_2
IPR035755, RIM-BP_SH3_3
IPR040325, RIMBP1/2/3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

The PANTHER Classification System

More...
PANTHERi
PTHR14234, PTHR14234, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07653, SH3_2, 2 hits
PF14604, SH3_9, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060, FN3, 3 hits
SM00326, SH3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 2 hits
SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 3 hits
PS50002, SH3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A7E2C5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQLTTLPRP GDPGAMEPWA LPTWHSWTPG RGGEPSSAAP SIADTPPAAL
60 70 80 90 100
QLQELRSEES SKPKGDGSSR PVGGTDPEGA EACLPSLGQQ ASSSGPACQR
110 120 130 140 150
PEDEEVEAFL KAKLNMSFGD RPNLELLRAL GELRQRCAIL KEENQMLRKS
160 170 180 190 200
SFPETEEKVR RLKRKNAELA VIAKRLEERA RKLQETNLRV EGPQWLHVRD
210 220 230 240 250
FDRLLRESQR EVLRLQRQIA LRNQRETLPL PPSWPPGPAL QARAGAPAPG
260 270 280 290 300
APGEATPQED ADNLPVILGE PEKEQRVQQL ESELSKKRKK CESLEQEARK
310 320 330 340 350
KQRRCEELEL QLRQAQNENA RLVEENSRLS GRATEKEQVE WENAELRGQL
360 370 380 390 400
LGVTQERDSA LRKSQGLQSK LESLEQVLKH MREVAQRRQQ LEVEHEQARL
410 420 430 440 450
SLREKQEEVR RLQQAQAEAQ REHEGAVQLL ESTLDSMQAR VRELEEQCRS
460 470 480 490 500
QTEQFSLLAQ ELQAFRLHPG PLDLLTSALD CGSLGDCPPP PCCCSIPQPC
510 520 530 540 550
RGSGPKDLDL PPGSPGRCTP KSSEPAPATL TGVPRRTAKK AESLSNSSHS
560 570 580 590 600
ESIHNSPKSC PTPEVDTASE VEELEADSVS LLPAAPEGSR GGARIQVFLA
610 620 630 640 650
RYSYNPFEGP NENPEAELPL TAGEYIYIYG NMDEDGFFEG ELMDGRRGLV
660 670 680 690 700
PSNFVERVSD DDLLTSLPPE LADLSHSSGP ELSFLSVGGG GSSSGGQSSV
710 720 730 740 750
GRSQPRPEEE DAGDELSLSP SPEGLGEPPA VPYPRRLVVL KQLAHSVVLA
760 770 780 790 800
WEPPPERVEL HGFHICVNGE LRQALGPGAP PKAVLENLDL RAGPLHISVQ
810 820 830 840 850
ALTSRGSSDP LRCCLAVGAR AGVVPSQLRV HRLTATSAEI TWVPGNSNLA
860 870 880 890 900
HAIYLNGEEC PPASPSTYWA TFCHLRPGTP YQAQVEAQLP PQGPWEPGWE
910 920 930 940 950
RLEQRAATLQ FTTLPAGPPD APLDVQIEPG PSPGILIISW LPVTIDAAGT
960 970 980 990 1000
SNGVRVTGYA IYADGQKIME VASPTAGSVL VELSQLQLLQ VCREVVVRTM
1010 1020 1030 1040 1050
SPHGESADSI PAPITPALAP ASLPARVSCP SPHPSPEARA PLASASPGPG
1060 1070 1080 1090 1100
DPSSPLQLPA PLGTQEPPGA PPASPSREMP KGSHEDPPAP CSQEEAGAAV
1110 1120 1130 1140 1150
LGTSEERTAS TSTLGEKDPG PAAPSLAKQE AEWTAGEACP ASSSTQGARA
1160 1170 1180 1190 1200
QQAPNTEMCQ GGDPGSGLRP RAEKEDTAEL GVHLVNSLVD HGRNSDLSDI
1210 1220 1230 1240 1250
QEEEEEEEEE EEEELGSRTC SFQKQVAGNS IRENGAKSQP DPFCETDSDE
1260 1270 1280 1290 1300
EILEQILELP LQQFCSKKLF SIPEEEEEEE EDEEEEKSGA GCSSRDPGPP
1310 1320 1330 1340 1350
EPALLGLGCD SGQPRRPGQC PLSPESSRAG DCLEDMPGLV GGSSRRRGGG
1360 1370 1380 1390 1400
SPEKPPSRRR PPDPREHCSR LLSNNGPQAS GRLGPTRERG GLPVIEGPRT
1410 1420 1430 1440 1450
GLEASGRGRL GPSRRCSRGR ALEPGLASCL SPKCLEISIE YDSEDEQEAG
1460 1470 1480 1490 1500
SGGISITSSC YPGDGEAWGT ATVGRPRGPP KANSGPKPYP RLPAWEKGEP
1510 1520 1530 1540 1550
ERRGRSATGR AKEPLSRATE TGEARGQDGS GRRGPQKRGV RVLRPSTAEL
1560 1570 1580 1590 1600
VPARSPSETL AYQHLPVRIF VALFDYDPVS MSPNPDAGEE ELPFREGQIL
1610 1620 1630 1640 1650
KVFGDKDADG FYQGEGGGRT GYIPCNMVAE VAVDSPAGRQ QLLQRGYLSP
1660 1670 1680 1690 1700
DILLEGSGNG PFVYSTARTT GPPPKPRRSK KAESEGPAQP CPGPPKLVPS
1710 1720 1730 1740 1750
ADLKAPHSMV AAFDYNPQES SPNMDVEAEL PFRAGDVITV FGGMDDDGFY
1760 1770 1780 1790
YGELNGQRGL VPSNFLEGPG PEAGGLDREP RTPQAESQRT RRRRVQC
Length:1,797
Mass (Da):193,518
Last modified:September 11, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D4B8E255EF945F3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC150279 mRNA Translation: AAI50280.1

NCBI Reference Sequences

More...
RefSeqi
NP_001248764.1, NM_001261835.1
NP_004749.2, NM_004758.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9256

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9256

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC150279 mRNA Translation: AAI50280.1
RefSeqiNP_001248764.1, NM_001261835.1
NP_004749.2, NM_004758.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiA7E2C5

Genome annotation databases

GeneIDi9256
KEGGihsa:9256

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9256
PharmGKBiPA128394545

Phylogenomic databases

KOiK19922

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
9256, 7 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TSPOAP1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9256

Gene expression databases

GenevisibleiA7E2C5, HS

Family and domain databases

CDDicd00063, FN3, 1 hit
cd12012, SH3_RIM-BP_2, 1 hit
cd12013, SH3_RIM-BP_3, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR035753, RIM-BP_SH3_2
IPR035755, RIM-BP_SH3_3
IPR040325, RIMBP1/2/3
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PANTHERiPTHR14234, PTHR14234, 1 hit
PfamiView protein in Pfam
PF07653, SH3_2, 2 hits
PF14604, SH3_9, 1 hit
SMARTiView protein in SMART
SM00060, FN3, 3 hits
SM00326, SH3, 3 hits
SUPFAMiSSF49265, SSF49265, 2 hits
SSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 3 hits
PS50002, SH3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA7E2C5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A7E2C5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: August 12, 2020
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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