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Protein
Submitted name:

SIGLEC-I

Gene

Siglec15

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • regulation of actin cytoskeleton organization Source: MGI
  • regulation of bone resorption Source: MGI
  • regulation of osteoclast development Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-2172127 DAP12 interactions

Names & Taxonomyi

Protein namesi
Submitted name:
SIGLEC-IImported
Submitted name:
Sialic acid-binding Ig-like lectin 15Imported
Gene namesi
Name:Siglec15Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3646642 Siglec15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei263 – 283HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_501508655124 – 342Sequence analysisAdd BLAST319

Expressioni

Gene expression databases

BgeeiENSMUSG00000091055 Expressed in 8 organ(s), highest expression level in female gonad

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126901

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 145Ig-likeInterPro annotationAdd BLAST106
Domaini169 – 250Ig-likeInterPro annotationAdd BLAST82

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFJR Eukaryota
ENOG4111T39 LUCA
GeneTreeiENSGT00390000011536
HOVERGENiHBG099550
KOiK16352
OMAiVYLFRFR
OrthoDBiEOG091G0PY1
TreeFamiTF351096

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

A7E1W8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGSLQLLAC LACVLQMGSL VKTRRDASGD LLNTEAHSAP AQRWSMQVPA
60 70 80 90 100
EVNAEAGDAA VLPCTFTHPH RHYDGPLTAI WRSGEPYAGP QVFRCTAAPG
110 120 130 140 150
SELCQTALSL HGRFRLLGNP RRNDLSLRVE RLALADSGRY FCRVEFTGDA
160 170 180 190 200
HDRYESRHGV RLRVTAAAPR IVNISVLPGP AHAFRALCTA EGEPPPALAW
210 220 230 240 250
SGPAPGNSSA ALQGQGHGYQ VTAELPALTR DGRYTCTAAN SLGRAEASVY
260 270 280 290 300
LFRFHGAPGT STLALLLGAL GLKALLLLGI LGARATRRRL DHLVPQDTPP
310 320 330 340
RSQAQESNYE NLSQMSPPGH QLPRVCCEEL LSHHHLVIHH EK
Length:342
Mass (Da):36,917
Last modified:September 11, 2007 - v1
Checksum:i0B6932242B458754
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126553 Genomic DNA No translation available.
AY971517 mRNA Translation: AAY40744.1
RefSeqiNP_001094508.1, NM_001101038.1
UniGeneiMm.35607

Genome annotation databases

EnsembliENSMUST00000170760; ENSMUSP00000126901; ENSMUSG00000091055
GeneIDi620235
KEGGimmu:620235
UCSCiuc008fsb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126553 Genomic DNA No translation available.
AY971517 mRNA Translation: AAY40744.1
RefSeqiNP_001094508.1, NM_001101038.1
UniGeneiMm.35607

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126901

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000170760; ENSMUSP00000126901; ENSMUSG00000091055
GeneIDi620235
KEGGimmu:620235
UCSCiuc008fsb.1 mouse

Organism-specific databases

CTDi284266
MGIiMGI:3646642 Siglec15

Phylogenomic databases

eggNOGiENOG410IFJR Eukaryota
ENOG4111T39 LUCA
GeneTreeiENSGT00390000011536
HOVERGENiHBG099550
KOiK16352
OMAiVYLFRFR
OrthoDBiEOG091G0PY1
TreeFamiTF351096

Enzyme and pathway databases

ReactomeiR-MMU-2172127 DAP12 interactions

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091055 Expressed in 8 organ(s), highest expression level in female gonad

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiA7E1W8_MOUSE
AccessioniPrimary (citable) accession number: A7E1W8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 11, 2007
Last sequence update: September 11, 2007
Last modified: September 12, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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