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UniProtKB - A7A082 (EMC3_YEAS7)
Protein
ER membrane protein complex subunit 3
Gene
AIM27
Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Functioni
The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).
By similarityNames & Taxonomyi
Protein namesi | Recommended name: ER membrane protein complex subunit 3Alternative name(s): Altered inheritance rate of mitochondria protein 27 |
Gene namesi | Name:AIM27 Synonyms:EMC3 ORF Names:SCY_3492 |
Organismi | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) |
Taxonomic identifieri | 307796 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000377675 | 1 – 253 | ER membrane protein complex subunit 3Add BLAST | 253 |
Interactioni
Subunit structurei
Component of the ER membrane protein complex (EMC), which is composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6.
By similarityFamily & Domainsi
Sequence similaritiesi
Belongs to the EMC3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_060791_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR008568, EMC3 IPR002809, EMC3/TMCO1 |
PANTHERi | PTHR13116, PTHR13116, 1 hit |
Pfami | View protein in Pfam PF01956, EMC3_TMCO1, 1 hit |
PIRSFi | PIRSF010045, DUF850_TM_euk, 1 hit |
SMARTi | View protein in SMART SM01415, DUF106, 1 hit |
i Sequence
Sequence statusi: Complete.
A7A082-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLLDDQLKYW VLLPISIVMV LTGVLKQYIM TLITGSSANE AQPRVKLTEW
60 70 80 90 100
QYLQWAQLLI GNGGNLSSDA FAAKKEFLVK DLTEERHLAK AKQQDGSQAG
110 120 130 140 150
EVPNPFNDPS MSNAMMNMAK GNMASFIPQT IIMWWVNHFF AGFILMQLPF
160 170 180 190 200
PLTAKFKEML QTGIICQDLD VRWVSSISWY FISVLGLNPV YNLIGLNDQD
210 220 230 240 250
MGIQAGIGGP QGPQGPPQSQ VDKAMHAMAN DLTIIQHETC LDNVEQRVLK
QYM
Sequence cautioni
The sequence EDN59821 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFW02000153 Genomic DNA Translation: EDN59821.1 Different initiation. |
Genome annotation databases
EnsemblFungii | EDN59821; EDN59821; SCY_3492 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFW02000153 Genomic DNA Translation: EDN59821.1 Different initiation. |
3D structure databases
SMRi | A7A082 |
ModBasei | Search... |
Genome annotation databases
EnsemblFungii | EDN59821; EDN59821; SCY_3492 |
Phylogenomic databases
HOGENOMi | CLU_060791_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR008568, EMC3 IPR002809, EMC3/TMCO1 |
PANTHERi | PTHR13116, PTHR13116, 1 hit |
Pfami | View protein in Pfam PF01956, EMC3_TMCO1, 1 hit |
PIRSFi | PIRSF010045, DUF850_TM_euk, 1 hit |
SMARTi | View protein in SMART SM01415, DUF106, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | EMC3_YEAS7 | |
Accessioni | A7A082Primary (citable) accession number: A7A082 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | June 16, 2009 | |
Last modified: | October 7, 2020 | |
This is version 45 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |