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UniProtKB - A6ZTG5 (AGP1_YEAS7)
Protein
General amino acid permease AGP1
Gene
AGP1
Organism
Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Status
Functioni
Broad substrate range permease which transports asparagine and glutamine with intermediate specificity. Also transports Ala, Cys, Gly, Ile, Leu, Met, Phe, Ser, Thr, Tyr and Val. Important for the utilization of amino acids as a nitrogen source (By similarity).
By similarityGO - Biological processi
- amino acid transport Source: UniProtKB-KW
- transmembrane transport Source: InterPro
Keywordsi
Biological process | Amino-acid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: General amino acid permease AGP1Alternative name(s): Asparagine/glutamine permease |
Gene namesi | Name:AGP1 ORF Names:SCY_0558 |
Organismi | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) |
Taxonomic identifieri | 307796 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 124 | CytoplasmicSequence analysisAdd BLAST | 124 | |
Transmembranei | 125 – 145 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 146 – 148 | ExtracellularSequence analysis | 3 | |
Transmembranei | 149 – 169 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 170 – 197 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 198 – 218 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 219 – 231 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 232 – 252 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 253 – 260 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 261 – 281 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 282 – 313 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 314 – 334 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 335 – 352 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 353 – 373 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 374 – 392 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 393 – 413 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 414 – 452 | CytoplasmicSequence analysisAdd BLAST | 39 | |
Transmembranei | 453 – 473 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 474 – 477 | ExtracellularSequence analysis | 4 | |
Transmembranei | 478 – 498 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 499 – 531 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 532 – 552 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 553 – 557 | ExtracellularSequence analysis | 5 | |
Transmembranei | 558 – 578 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 579 – 633 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000330042 | 1 – 633 | General amino acid permease AGP1Add BLAST | 633 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 6 | PhosphoserineBy similarity | 1 | |
Cross-linki | 11 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Lipidationi | 633 | S-palmitoyl cysteineBy similarity | 1 |
Post-translational modificationi
Palmitoylated by PFA4.By similarity
Keywords - PTMi
Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
PRIDEi | A6ZTG5 |
Expressioni
Inductioni
Induced by transcription factors DAL81 and STP1, which are activated by a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system in response to external amino acid levels.By similarity
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 54 | DisorderedSequence analysisAdd BLAST | 54 | |
Regioni | 87 – 116 | DisorderedSequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 12 – 28 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 34 – 50 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 100 – 115 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_007946_12_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004762, Amino_acid_permease_fungi IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR00913, 2A0310, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
A6ZTG5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSKSPYEL KDLKNSSTEI HATEQDNEIE YFETGSNDRP SSQPHLGYEQ
60 70 80 90 100
HNTSAVRRFF DSFKRADQGP QDEVEATQMN DLTSAISPSS RRAQELEKNE
110 120 130 140 150
SSDNIGANTG HKSDSLKKTI QPRHVLMIAL GTGIGTGLLV GNGTALVHAG
160 170 180 190 200
PAGLLIGYAI MGSILYCIIQ ACGEMALVYS NLTGGYNAYP SFLVDDGFGF
210 220 230 240 250
AVAWVYCLQW LCVCPLELVT ASMTIKYWTT SVNPDVFVII FYVLVITINI
260 270 280 290 300
FGARGYAEAE FFFNCCKILM MTGFFILGII IDVGGAGNDG FIGGKYWHDP
310 320 330 340 350
GAFNGKHAID RFKGVVATLV TAAFAFGGSE FIAITTAEQS NPRKAIPGAA
360 370 380 390 400
KQMIYRILFL FLATIILLGF LVPYNSDQLL GSTGGGTKAS PYVIAVASHG
410 420 430 440 450
VRVVPHFINA VILLSVLSMA NSSFYSSARL FLTLSEQGYA PKVFSYIDRA
460 470 480 490 500
GRPLIAMGVS ALFAVIAFCA ASPKEEQVFT WLLAISGLSQ LFTWTAICLS
510 520 530 540 550
HLRFRRAMKV QGRSLGELGF KSQTGVWGSA YACIMMILIL IAQFWVAIAP
560 570 580 590 600
IGEGKLDAQA FFENYLAMPI LIALYVGYKV WHKDWKLFIR ADKIDLDSHR
610 620 630
QIFDEELIKQ EDEEYRERLR NGPYWKRVVA FWC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFW02000089 Genomic DNA Translation: EDN62104.1 |
Genome annotation databases
EnsemblFungii | EDN62104; EDN62104; SCY_0558 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFW02000089 Genomic DNA Translation: EDN62104.1 |
3D structure databases
SMRi | A6ZTG5 |
ModBasei | Search... |
Proteomic databases
PRIDEi | A6ZTG5 |
Genome annotation databases
EnsemblFungii | EDN62104; EDN62104; SCY_0558 |
Phylogenomic databases
HOGENOMi | CLU_007946_12_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004762, Amino_acid_permease_fungi IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
TIGRFAMsi | TIGR00913, 2A0310, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AGP1_YEAS7 | |
Accessioni | A6ZTG5Primary (citable) accession number: A6ZTG5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | September 11, 2007 | |
Last modified: | February 23, 2022 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |