UniProtKB - A6YR21 (COC1B_CONCL)
Protein
Mu-conotoxin cal12b
Gene
N/A
Organism
Californiconus californicus (California cone) (Conus californicus)
Status
Functioni
Mu-conotoxins block voltage-gated sodium channels. This toxin reversibly blocks voltage-gated sodium channel in cephalopods (tested on squid giant-fiber-lobe neurons) with an inhibitor constant (Ki) of 15 nmol/l, with no alteration in the voltage dependence of sodium conductance or on the kinetics of inactivation. Has no effect on sodium channels of the two gastropod S.luhuanus and A.californica (which are not natural prey).1 Publication
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
GO - Biological processi
- pathogenesis Source: InterPro
Keywordsi
Molecular function | Ion channel impairing toxin, Neurotoxin, Toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Mu-conotoxin cal12bAlternative name(s): Conotoxin Cal 12.1.1b Conotoxin CalTx 12.1.1B |
Organismi | Californiconus californicus (California cone) (Conus californicus) |
Taxonomic identifieri | 1736779 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Californiconus |
Organism-specific databases
ConoServeri | 794, Cal12.1.1b precursor |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
PropeptideiPRO_0000392264 | 20 – 42 | 1 PublicationAdd BLAST | 23 | |
PeptideiPRO_0000392265 | 43 – 87 | Mu-conotoxin cal12bAdd BLAST | 45 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 58 | Curated | ||
Disulfide bondi | 53 ↔ 70 | By similarity | ||
Modified residuei | 59 | 6'-bromotryptophan1 Publication | 1 | |
Disulfide bondi | 60 ↔ 75 | By similarity | ||
Modified residuei | 65 | 4-hydroxyproline1 Publication | 1 | |
Disulfide bondi | 69 ↔ 81 | By similarity | ||
Modified residuei | 79 | 6'-bromotryptophan1 Publication | 1 | |
Modified residuei | 80 | 6'-bromotryptophan1 Publication | 1 | |
Modified residuei | 82 | 4-hydroxyproline1 Publication | 1 | |
Modified residuei | 86 | 6'-bromotryptophan1 Publication | 1 |
Keywords - PTMi
Bromination, Disulfide bond, HydroxylationExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Family & Domainsi
Domaini
The cysteine framework is XII (C-C-C-C-CC-C-C).
Sequence similaritiesi
Belongs to the conotoxin O1 superfamily.Curated
Keywords - Domaini
SignalFamily and domain databases
InterProi | View protein in InterPro IPR004214, Conotoxin |
Pfami | View protein in Pfam PF02950, Conotoxin, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
A6YR21-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLTCVLVVL LLLLPYGDLI TNNYIRGAAR KVTPWRRNLK TRDVCDSLVG
60 70 80
GHCIHNGCWC DQDAPHGNCC DTDGCTAAWW CPGTKWD
Mass spectrometryi
Molecular mass is 5194 Da. Determined by MALDI. 1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF644175 mRNA Translation: ABR92945.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | EF644175 mRNA Translation: ABR92945.1 |
3D structure databases
SMRi | A6YR21 |
ModBasei | Search... |
Organism-specific databases
ConoServeri | 794, Cal12.1.1b precursor |
Family and domain databases
InterProi | View protein in InterPro IPR004214, Conotoxin |
Pfami | View protein in Pfam PF02950, Conotoxin, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | COC1B_CONCL | |
Accessioni | A6YR21Primary (citable) accession number: A6YR21 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 23, 2010 |
Last sequence update: | August 21, 2007 | |
Last modified: | April 22, 2020 | |
This is version 27 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families