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Entry version 29 (07 Apr 2021)
Sequence version 1 (21 Aug 2007)
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Protein
Submitted name:

Major ampullate spidroin 1

Gene

MaSp1

Organism
Latrodectus hesperus (Western black widow spider)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Major ampullate spidroin 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MaSp1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLatrodectus hesperus (Western black widow spider)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri256737 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeAraneomorphaeEntelegynaeAraneoideaTheridiidaeLatrodectus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500270557425 – 3129Sequence analysisAdd BLAST3105

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
A6YIY1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6YIY1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 149Spidroin_NInterPro annotationAdd BLAST121
Domaini3030 – 3113Spidroin_MaSpInterPro annotationAdd BLAST84

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1350, 1 hit
1.10.274.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021001, Spidroin_C
IPR038542, Spidroin_C_sf
IPR031913, Spidroin_N
IPR038243, Spidroin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11260, Spidroin_MaSp, 1 hit
PF16763, Spidroin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6YIY1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTWSTRLALS FLFVLCTQSL YALAQANTPW SSKANADAFI NSFISAASNT
60 70 80 90 100
GSFSQDQMED MSLIGNTLMA AMDNMGGRIT PSKLQALDMA FASSVAEIAA
110 120 130 140 150
SEGGDLGVTT NAIADALTSA FYQTTGVVNS RFISEIRSLI GMFAQASAND
160 170 180 190 200
VYASAGSSGG GGYGASSASA ASASAAAPSG VAYQAPAQAQ ISFTLRGQQP
210 220 230 240 250
VSYGQGGAGP GGAGAAAAAA AAAGGAGQGG QGGYGQGGYG QGGAGQGGSG
260 270 280 290 300
AAAAAAAAAG GTGQGGAGQG GAGAAAAAAA AAGGAGQGGQ GGYGQGGYGQ
310 320 330 340 350
GGTGQGGAGA AAAAAAAGGA GQGGQGGYGQ GGYGQGGYGQ GGSGAAAAAA
360 370 380 390 400
AAAGGAGQGG QGGYGQGGYG QGGAGQGGAG AAAAAAAAAG GAGQGGYGRG
410 420 430 440 450
GAGQGGAAAA AAAAAGAGQG GYGGQGAGQG GSGAAAAAAA AGGAGQGGQG
460 470 480 490 500
GYGQGGYGQG GSGAAAAAAA AGGAGQGGQG GYGQGGYGQG GAGQGGAGAA
510 520 530 540 550
AAAAAAGGAG QGGQGGYGQG GYGQGGAGQG GAGAAAAAAA AGGAGQGGQG
560 570 580 590 600
GYGQGGYGQG GAGQGGAGAA AAAAAAGGAG QGGQGGYGQG GYGQGGAGQG
610 620 630 640 650
GAAAAAAAAA GGAGQGGYGR GGAGQGGAAA AAGAGQGGYG GQGAGQGGAG
660 670 680 690 700
AAAAAAAAGG AGQGGQGGYG RGGYGQGGAG QGGAGAAAAA AAAGGAGQGG
710 720 730 740 750
QGGYGQGGYG QGGAGQGGAA AAAAAAGGAG QGGYGRGGAG QGGAAAAAAA
760 770 780 790 800
AAGAGQGGYG GQGAGQGGAG AAAAAAAAGG AGQGGQGDYG RGGYGQGGAG
810 820 830 840 850
QGGAGAAAAA AAAGGAGQGG QGGYGQGGYG QGGAGQGGAA AAASAAAAGG
860 870 880 890 900
AGQGGYGRGG AGQGGAAAAA GAGQGGYGGQ GAGQGGAGAA AAAAAAGGAG
910 920 930 940 950
QGGQGGYGRG GYGQGGAGQG GAGAAAAATA AGGAGQGGQG GYGQGGYGQG
960 970 980 990 1000
GAGQGGAAAA AAAAAGGAGQ GGYGRGGAGQ GGAAAAAAAA AGAGQGGYGG
1010 1020 1030 1040 1050
QGAGQGGAGA AAAAAGGAGQ GGQGGYGRGG YGQGGAGQGG AGAAAAAAAA
1060 1070 1080 1090 1100
GGAGQGGQGG YGQGGYGQGG AGQGGAAAAA AAAAGGAGQG GYGRGGAGQG
1110 1120 1130 1140 1150
GAAAAAGAGQ GGYGGQGAGQ GGAGAAAAAS RGAGQGGQGG YGRGGYGQGG
1160 1170 1180 1190 1200
AGQGGAGAAA AAAAAGGAGQ GGQGGYGQGG YGQGGAGQGG AAAAAAAAGG
1210 1220 1230 1240 1250
AGQGGYGRGG AGQGGAAAAA GAGQGGYGGQ GAGQGGAGAA AAAAAAGGAG
1260 1270 1280 1290 1300
QGGQGGYGRG GYGQGGAGQG GAGAAAAAAA AGGAGQGGQG GYGQGGYGQG
1310 1320 1330 1340 1350
GAGQGGAAAA AAAAAGGAGQ GGYGRGGAGQ GGAAAAAAAA AGSGQGGYGG
1360 1370 1380 1390 1400
QGAGQGGAGA AAAAAAAGGA GQGGQGGYGR GGYGQGGAGQ GGAGAAAAAA
1410 1420 1430 1440 1450
AAGGAGQGGQ GGYGQGGYGQ GGAGQGGAAA AAAAAAAGGA GQGGYGRGGA
1460 1470 1480 1490 1500
GQGGAAAAAG AGQGGYGGQG AGQGGAGAAA AAAAAGGAGQ GGQGGYGRGG
1510 1520 1530 1540 1550
YGQGGAGQGG AGTAAAAAAA GGAGQGGQGG YGQGGYGQGG AGQGGAAAAA
1560 1570 1580 1590 1600
AAAAGGAGQG GYGRGGAGQG GAAAAAAAAA GAGQGGYGGQ GAGQGGAGAA
1610 1620 1630 1640 1650
AAAAAAGGAG QGGQGGYGRG GYGQGGAGQG GAGAAAAAAA AGGASQGGQG
1660 1670 1680 1690 1700
GYGQGDYGQG GAGQGGAAAA AAAAGGAGQG GYGRGGAGQG GAAAAAGAGQ
1710 1720 1730 1740 1750
GGYGGQGAGQ GGAGAAAAAA AAGGAGRGGQ GGYGRGGYGQ GGAGQGGAGA
1760 1770 1780 1790 1800
AAAAAAAGGA GQGGQGGYGQ GGYGQGGTGQ GGAAAAAAAA AGGAGQGGYG
1810 1820 1830 1840 1850
RGGAGQGGAA AAAAAAAGAG QGGYGGQGAG QGGAGAAAAA AAAGGAGQGG
1860 1870 1880 1890 1900
QGGYGRGGYG QGGAGQGGAG AAAAAAAAGG AGQGGQGGYG QGGYGQGGYG
1910 1920 1930 1940 1950
QGGAGQGGAA AAAAAAGGAG QGGYGRGGAG QGGAAAAAGA GQGGYGGQGA
1960 1970 1980 1990 2000
GQGGAGAAAA AAAAGGAGQG GQGGYGRGGY GQGGAGQGGA GAAAAAAAAG
2010 2020 2030 2040 2050
GAGQGGQGGY GQGGYGQGGA GQGGAAAAAA AAAGGAGQGG YGRGGAGQGG
2060 2070 2080 2090 2100
AAAAAAAAAG SGQGGYGGQG AGQGGAGAAA AAAAAGGAGQ GGQGGYGRGG
2110 2120 2130 2140 2150
YGQGGAGQGG AGAAAAAAAA GGAGQGGQGG YGQGGYGQGG YGQGGAGQGG
2160 2170 2180 2190 2200
AAAAAAAAAA GGAGQGGYGR GGAGQGGAAA AAGAGQGGYG GQGAGQGGAG
2210 2220 2230 2240 2250
AAAAAAAAGG AGQGGQGGYG RGGYGQGGAG QGGAGAAAAA AAAGGAGQGG
2260 2270 2280 2290 2300
QGGYGQGGNG QGGAGQGGAA AAAAAAGGAG QGGYGRGGAG QGGAAAAAAA
2310 2320 2330 2340 2350
AAGAGQGGYG GQGAGQGGAG AAAAAAAAGG AGQGGQGGYG RGGYGQGGAG
2360 2370 2380 2390 2400
QGGAGAAAAA AAAGGASQGG QGGYGQGDYG QGGAGQGGAA AAAAAAGGAG
2410 2420 2430 2440 2450
QGGYGRGGAG QGGAAAAAGA GQGGYGGQGA GQGGAGAAAA AAAAGGAGRG
2460 2470 2480 2490 2500
GQGGYGRGGY GQGGAGQGGA GAAAAAAAAG GAGQGGQGGY GQGGYGQGGA
2510 2520 2530 2540 2550
GQGGAAAAAA AAAGGAGQGG YGRGGAGQGG AAAAAGAGQG GYGGQGAGQG
2560 2570 2580 2590 2600
GAGAAAAAAA AGGAGRGGQG GYGRGGYGQG GAGQGGAGAA AAAAAAGGAG
2610 2620 2630 2640 2650
QGGQGGYGQG GYGQGGAGQG GAAAAAAAAV GGAGQGGYGR GGAGQGGAAA
2660 2670 2680 2690 2700
AAAAAAAGSG QGGYGGQGAG QGGAGAAAAA AAAGGAGQGG QGGYGGGGYG
2710 2720 2730 2740 2750
QGGAGQGGAG AAAAAAAAGG AGQGGQGGYG QGGYGQGGAG QGGAAAAAAA
2760 2770 2780 2790 2800
AAGGAGQGGY GRGGAGQGGA AAATGAGQGG YGGQGAGQGG AGAAAAAAAA
2810 2820 2830 2840 2850
GGAGQGGQGG YGRGGYGQGG AGQGGAGAAA AAAAAGGAGQ GGQGGYGQGG
2860 2870 2880 2890 2900
YGQGGAGQGG AAAAAAAAGG AGQGGYGRGG AGQGGAAAAA AAAAGAGQGG
2910 2920 2930 2940 2950
YGGQGAGQGG AGAAAAAAAA GGAGQGGQGG YGRGGYGQGG AGQGGAGAAA
2960 2970 2980 2990 3000
AGGAGQGGQG GYGQGGYGQG GAGQGGAAAA AAAAAAGGAG QGGYGGYGQQ
3010 3020 3030 3040 3050
GGAGAAAAAA SGPGQIYYGP QSVAAPAAAA ASALAAPATS ARISSHASAL
3060 3070 3080 3090 3100
LSNGPTNPAS ISNVISNAVS QISSSNPGAS ACDVLVQALL ELVTALLTII
3110 3120
GSSNIGSVNY DSSGQYAQVV TQSVQNAFA
Length:3,129
Mass (Da):250,258
Last modified:August 21, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9044B4CDE50FFB11
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF595246 Genomic DNA Translation: ABR68856.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF595246 Genomic DNA Translation: ABR68856.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2N3ENMR-A25-157[»]
BMRBiA6YIY1
SMRiA6YIY1
ModBaseiSearch...
PDBe-KBiSearch...

Family and domain databases

Gene3Di1.10.10.1350, 1 hit
1.10.274.70, 1 hit
InterProiView protein in InterPro
IPR021001, Spidroin_C
IPR038542, Spidroin_C_sf
IPR031913, Spidroin_N
IPR038243, Spidroin_N_sf
PfamiView protein in Pfam
PF11260, Spidroin_MaSp, 1 hit
PF16763, Spidroin_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6YIY1_LATHE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6YIY1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: April 7, 2021
This is version 29 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
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