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Entry version 41 (07 Oct 2020)
Sequence version 1 (21 Aug 2007)
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Protein
Submitted name:

Centrosomal protein cep290

Gene

cep290

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Centrosomal protein cep290Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cep290Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6Y7R7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Coiled coilARBA annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16533

Database of Orthologous Groups

More...
OrthoDBi
27774at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032321, Cep209_CC5
IPR026201, Cep290

The PANTHER Classification System

More...
PANTHERi
PTHR18879, PTHR18879, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16574, CEP209_CC5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6Y7R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPPNINWKEI IKVDPDDLPR QEELADNLLV SLSKVEISEL KHASQENVIH
60 70 80 90 100
LFRITQSLMK MKAQEVELAL EEVEKAGEEQ AKFENQLKTK VMKLENELEM
110 120 130 140 150
AQQSAGGRDT RFLRDEIRQL EKQLEQKDRE LEDMEKELEK EKKVNEQLAL
160 170 180 190 200
RNEEAENENS KLRRENKRLK KKNEQLRQDI VDYQKQIDSQ KETLLSRRGE
210 220 230 240 250
DSDYRSQLSK KNYELVQYLD EIQTLTEANE KIEVQNQEMR KNLEESVQEM
260 270 280 290 300
EKMTDEYNRM KAIVHQTDNI MDQLKKENDH YRLQVQELTD LLKAKNEEDD
310 320 330 340 350
PVMAAVNAKV EEWKLILSSK DDEIIEYQQM LHNLREKLKN AQLDADKSSV
360 370 380 390 400
MALQQGIQER DSQIKMLTEQ VEQYTKEMEK NTFIIEDLKN ELQRNKGAST
410 420 430 440 450
LSQQTHYMKI QSKVQMLEEK TKEAERTAEL AEADAREKDK ELVETLKRLK
460 470 480 490 500
DYESGIYGLE DAVIEIKNCK NQIKIRDREI EVLTKEINKL ELKINDFLDE
510 520 530 540 550
NEALRERMGL EPKTMIDLTE FRNSKSLKQQ QYRAENQILL KEIESLEEER
560 570 580 590 600
LDLKKKIRQM AQERGKRAAT SGLTIEDLNL TENFSQENRV GERKFDFTSL
610 620 630 640 650
KNISETQLKN EFLSRELIEK ERDLERGRTV ITKFQNKLKE LVEENKQLEE
660 670 680 690 700
GMKEILQAIK EMQKDPDVKG ETSLIIPSLE RLVNAIESKN AEGIFDANLH
710 720 730 740 750
LKAQVDQLTG RNEELRQELR ESRKEAINYS QQLAKANLKI DHLEKEAILL
760 770 780 790 800
RESEGSNVVF KGVDLPDGIA PSSANIINSQ NEYLIRILQE LEYKENKLQN
810 820 830 840 850
LEDSLEDYNR KFAVIRHQQS LLYKEYLSEK ETWKTESETM KEEKKKLEDQ
860 870 880 890 900
IQQGAIKVKE YNNLLSALQM DSDEMKKTLS EYSRKITVLQ VNEKSLIRQY
910 920 930 940 950
TTLVELERQL RKENGKQKNE LISMEAEVGE KIGRLQRFKE MAIFKIAALQ
960 970 980 990 1000
KVIDNSVSLS ELELANKQYN ELTAKYRDIL QKDNMLVQRT NNLEHLECEN
1010 1020 1030 1040 1050
ASLKEQVESI NKELEITKEK LYTVEQAWEQ ETKLGNESNM DKAKKSITNS
1060 1070 1080 1090 1100
EIVSISKKIT MLEMKELNER QRAEHSQKMY EHARTSLKQM EERNFELETK
1110 1120 1130 1140 1150
FAELTKINLE AQKVEQMLRD ELADSVSKTV SDADRQRILE LEKNEMELKV
1160 1170 1180 1190 1200
EVSKLREISD IAKRQVEILN AQQQSREKEV ESVRMQLLDY QAQSDEKALI
1210 1220 1230 1240 1250
AKLHQHVVSL QISEATALGK LESVTSKLQK MEACNLRLEQ KLDEKEQALY
1260 1270 1280 1290 1300
YARLEGRNRA KHLRQTIQSL RRQFSGALPL AQQEKFSKTM IQLQNDKLKI
1310 1320 1330 1340 1350
MQEMKTSQQE HRNMENKAME MELKLKGLEE LISTLKDARG AQKVISWHMK
1360 1370 1380 1390 1400
IEELRLQELK LNRELVKDKE EIKYLNNIIS EYEHTISSLE EEIVQQNKFH
1410 1420 1430 1440 1450
EERQMAWDQR EVELERQLDI FDHQQNEILK AAQKFEEATG SLPDPSLPLP
1460 1470 1480 1490 1500
NQLEIALRKI KENVRIILET RATCKSLEEK LKEKESALRL AEQNILSRDK
1510 1520 1530 1540 1550
VITELRLRLP ATAEREKLIA ELGRKEVEPK SHHTLKIAQQ TIANMQARLN
1560 1570 1580 1590 1600
QKEEVLKKYQ HLLEKAREEQ REIVKKHEED LHILHRKLEL QADSSLNKFK
1610 1620 1630 1640 1650
QTAWDLIKQS PTPVPTNKHF IRLAEMEQTV AEQDDSLSSL LAKLKEVSQD
1660 1670 1680 1690 1700
LERQKEITEL KIKEFENTKL RLQENHAYEV KKVKAEVEDL RCLLAQSQKE
1710 1720 1730 1740 1750
SQSLKSELQA QKEANSRAPT TTMRNLVERL KSQLALKEKQ QKALSRALLE
1760 1770 1780 1790 1800
LRTEMTAAAE ERIISATSQK EANLNVQQMV DRHTKELKSQ IEDLSENLLK
1810 1820 1830 1840 1850
LKEALKTSKN RENSLTDNLN DLTNELQKKQ KAYNKMLREK DGIDQENDEL
1860 1870 1880 1890 1900
KRQIKRLTSG LQGKSLLDNK QSLIEELQKK IKKLESQLER KVDEAEIKPM
1910 1920 1930 1940 1950
KEKSAKEELI RWEEGKKWQT KIEGIRNKLK EKEGEVYILT KQLNTLKDLF
1960 1970 1980 1990 2000
AKADKEKLTL QRKLKTTGIT VDQVMGVRAL ESEKELEELK KRNLDLENDI
2010 2020 2030 2040 2050
SYMRTRQALP RDSVIEDLHL QNRYLQEKLH VLEKQFSKDA YSRPSTSGIE
2060 2070 2080 2090 2100
SDEHCQREQE LQRENLKLSS ENIELKFQLE QANKDLPRLK NQVRDLKEMC
2110 2120 2130 2140 2150
EFLKKEKAEV ERKLGHVRGS GRSGKTIPEL EKTIGLMKKV VEKVQRENEQ
2160 2170 2180 2190 2200
LKKASGVLTS EKMANIELEN EKLKAELEKL KVHLGRQLSM HYESKTKGTE
2210 2220 2230 2240 2250
KIVAENERLR KELKKETEAA EKLRIAKNNL EILNEKMTVQ LEETGKRLQL
2260 2270 2280 2290 2300
AESRGPQLEG ADSKSWKSIV VTRMYETKLK ELETDIAKKT QNLTDLKQLV
2310 2320 2330 2340 2350
KQATEREQKA KKYTEDLEQQ IEILKHVPEG AETEQSLQRA LQVLRLANRQ
2360 2370 2380 2390 2400
LEKEKAELIH QLEVNKDQSG AESTISDLDQ LTEKVKDLET QLKTSDIEKQ
2410 2420 2430 2440 2450
YLKEEIKKLK KELENFDPSF FEEIEDLKYN YKEEVKKNIL LEEKLKKLSE
2460 2470
QFGVELSSPV AASEQSEDEE ESPANFPIY
Length:2,479
Mass (Da):290,312
Last modified:August 21, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCF7180EC872C3B43
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF028068 mRNA Translation: ABL74279.1

NCBI Reference Sequences

More...
RefSeqi
NP_001095128.1, NM_001101658.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100113471

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
fca:100113471

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF028068 mRNA Translation: ABL74279.1
RefSeqiNP_001095128.1, NM_001101658.1

3D structure databases

SMRiA6Y7R7
ModBaseiSearch...

Genome annotation databases

GeneIDi100113471
KEGGifca:100113471

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80184

Phylogenomic databases

KOiK16533
OrthoDBi27774at2759

Family and domain databases

InterProiView protein in InterPro
IPR032321, Cep209_CC5
IPR026201, Cep290
PANTHERiPTHR18879, PTHR18879, 2 hits
PfamiView protein in Pfam
PF16574, CEP209_CC5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA6Y7R7_FELCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6Y7R7
Secondary accession number(s): M3X5W5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: October 7, 2020
This is version 41 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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