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Protein

Rho GTPase-activating protein 31

Gene

Arhgap31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activator activity Source: MGI
  • SH3 domain binding Source: MGI

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-194840 Rho GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho GTPase-activating protein 31
Alternative name(s):
Cdc42 GTPase-activating protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgap31
Synonyms:Cdgap, Kiaa1204
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1333857 Arhgap31

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell projection

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi56R → A: 70% reduction of GAP activity; when associated with V-169. 1 Publication1
Mutagenesisi169N → V: 70% reduction of GAP activity; when associated with A-56. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003201151 – 1425Rho GTPase-activating protein 31Add BLAST1425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei272PhosphoserineCombined sources1
Modified residuei283PhosphothreonineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei346PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei464PhosphoserineCombined sources1
Modified residuei666PhosphothreonineCombined sources1
Modified residuei685PhosphoserineCombined sources1
Modified residuei690PhosphoserineCombined sources1
Modified residuei765PhosphoserineCombined sources1
Modified residuei769PhosphothreonineCombined sources1
Modified residuei776Phosphothreonine; by GSK32 Publications1
Modified residuei961PhosphoserineCombined sources1
Modified residuei1092PhosphoserineCombined sources1
Modified residuei1093PhosphoserineCombined sources1
Modified residuei1163PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on Thr-776 by GSK3; which reduces GAP activity.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A6X8Z5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A6X8Z5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A6X8Z5

PeptideAtlas

More...
PeptideAtlasi
A6X8Z5

PRoteomics IDEntifications database

More...
PRIDEi
A6X8Z5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
A6X8Z5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
A6X8Z5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at highest levels in heart and lung.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By serum (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000022799 Expressed in 243 organ(s), highest expression level in cumulus cell

CleanEx database of gene expression profiles

More...
CleanExi
MM_CDGAP

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A6X8Z5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
A6X8Z5 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA. Interacts with GTP-loaded RHOU (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Itsn1Q9Z0R43EBI-4325995,EBI-645386

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
198630, 2 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
A6X8Z5

Protein interaction database and analysis system

More...
IntActi
A6X8Z5, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000023487

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
A6X8Z5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6X8Z5

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 216Rho-GAPPROSITE-ProRule annotationAdd BLAST196

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi770 – 777Poly-Pro8

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410KCYW Eukaryota
ENOG410ZIYP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159458

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105825

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
A6X8Z5

KEGG Orthology (KO)

More...
KOi
K20646

Identification of Orthologs from Complete Genome Data

More...
OMAi
VFLHEMD

Database of Orthologous Groups

More...
OrthoDBi
1300981at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
A6X8Z5

TreeFam database of animal gene trees

More...
TreeFami
TF351451

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6X8Z5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNKGAKQKL KRKGAASAFG CDLTEYLESS GQDVPYVLKS CAEFIETHGI
60 70 80 90 100
VDGIYRLSGI TSNIQRLRQE FGSDQCPDLT REVYLQDIHC VGSLCKLYFR
110 120 130 140 150
ELPNPLLTYE LYEKFTEAVS HRPEEGQLAR IQNVILELPP PHYRTLEYLI
160 170 180 190 200
RHLAHIASFS SKTNMHARNL ALVWAPNLLR SKKIEATICN GDAAFLAVRV
210 220 230 240 250
QQVVIEFILN HADQIFNGGA PGALQQDESR TITKSLTLPA LSLPMKLVSL
260 270 280 290 300
EEAQARSLAT NHPARKERRE NSLPEIVPPP FHTVLELPDN KRKLSSKSKK
310 320 330 340 350
WKSIFNLGRS GSDSKSKLSR NGSVFVRGQR LSVEKATIRP AKSMDSLCSV
360 370 380 390 400
PVEGKENKGN FSRTVTTGGF FIPATKMHAS STGSSCDLSK EGEWGQEGMP
410 420 430 440 450
AGAEGGCEVG GQIRPLPEQL KVFRPIGDPE SEQSAPKLLG MFYTSSDSPG
460 470 480 490 500
KSVFTSSLFQ MEPSPRHQRK ALNISEPFAV SVPLRVSAVI STNSTPCRTP
510 520 530 540 550
PKELQSLSSL EEFSFQGSES GGWPEEEKPL GAESFPGSVT KKAATEDTKP
560 570 580 590 600
EPEVPGRAEC SQSPPLDPGT QVEKKTLHVS LGSQVSKEAE KRPKAEKVME
610 620 630 640 650
ESQGASQPKP STPQESLGAG TEPLILHEMD EEDLAQALIW PEIQQELKII
660 670 680 690 700
ESEEEFSSLP PAAQKTSPIP ESSPAPFPFP EAPGSLPSSS APREVWTRDA
710 720 730 740 750
ANQSIQEAAI LTDREKLEPV CSLLESESQQ ELSPDPASLA PLEMLLFEKV
760 770 780 790 800
SSPARIEIGG PRNLSPPLTP APPPPTPLEE EPEVLLSKEG PDREDAARDS
810 820 830 840 850
RTDVYTEQPT PKESPGIPTP CQREEAIASP NEKQNARHAV PENKGPGLPS
860 870 880 890 900
PTKEVDIIPQ EEGGAPHSAQ EPSDCDEDDT VTDPAQHGLE MVEPWEEPQW
910 920 930 940 950
VTSPLHSPTL KEVQESQTQG SQGHRLERRL CHRPSLRQSH SLDSKTTGNS
960 970 980 990 1000
HWTLEAPFSS SCANLETERN YEPLQPPAAR TKIAGLEEKA LKAFREFSGL
1010 1020 1030 1040 1050
KGLEVLPSQK GPSGIQPKPV ETNFMGLAEG KEQEPQLELS NRQMKHSDVP
1060 1070 1080 1090 1100
GPDSSKESSP RAQDSTLPGE HPLQLQLKNT ECGPSKGKHR PSSLNLDSAT
1110 1120 1130 1140 1150
PIADLFRLEN GAPFSSPGIE LSELGDTKVT WMSSSHCKAA PWNSQDTQDL
1160 1170 1180 1190 1200
DIVAHTLTGR RNSAPVSVSA VRTSFMVKMC QAKAVPVIPP KIQYTQIPQP
1210 1220 1230 1240 1250
LPSQSTGEGG AQPLERSQEE PGSTPEIPQK STKDDSPSSL GSPEEEQPKQ
1260 1270 1280 1290 1300
ETGASASRRQ ASITSCMYEG SSCSPEPSAS TLASTQDAVV QCRKRTSETE
1310 1320 1330 1340 1350
PSGDNLLSSK LERASGGPKA FHRSRPGRPQ SLILFPIMDH LPSSPTVIDS
1360 1370 1380 1390 1400
KVLLSPIRSP TQTVSPGLLC GELAENTWIT PEGVTLRNKM TIPKNGQRLE
1410 1420
TSTSCFYQPQ RRSVILDGRS GRQIE
Length:1,425
Mass (Da):155,276
Last modified:August 21, 2007 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00A39A0664D1A558
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292R → K in BAE33406 (PubMed:19468303).Curated1
Sequence conflicti1153V → F in BAE38872 (PubMed:19468303).Curated1
Sequence conflicti1153V → F in BAE38901 (PubMed:19468303).Curated1
Sequence conflicti1365S → C in BAE38872 (PubMed:19468303).Curated1
Sequence conflicti1365S → C in BAE38901 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK138417 mRNA Translation: BAE23651.1
AK149975 mRNA Translation: BAE29205.1
AK150109 mRNA Translation: BAE29314.1
AK155729 mRNA Translation: BAE33406.1
AK166583 mRNA Translation: BAE38872.1
AK166622 mRNA Translation: BAE38901.1
CT009576, AC154425 Genomic DNA Translation: CAO77869.1
AF151363 mRNA Translation: AAD38043.1
AK129309 mRNA Translation: BAC98119.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28172.1

NCBI Reference Sequences

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RefSeqi
NP_064656.2, NM_020260.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.370848

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000023487; ENSMUSP00000023487; ENSMUSG00000022799

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12549

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:12549

UCSC genome browser

More...
UCSCi
uc007zfg.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138417 mRNA Translation: BAE23651.1
AK149975 mRNA Translation: BAE29205.1
AK150109 mRNA Translation: BAE29314.1
AK155729 mRNA Translation: BAE33406.1
AK166583 mRNA Translation: BAE38872.1
AK166622 mRNA Translation: BAE38901.1
CT009576, AC154425 Genomic DNA Translation: CAO77869.1
AF151363 mRNA Translation: AAD38043.1
AK129309 mRNA Translation: BAC98119.1
CCDSiCCDS28172.1
RefSeqiNP_064656.2, NM_020260.2
UniGeneiMm.370848

3D structure databases

ProteinModelPortaliA6X8Z5
SMRiA6X8Z5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198630, 2 interactors
ELMiA6X8Z5
IntActiA6X8Z5, 1 interactor
STRINGi10090.ENSMUSP00000023487

PTM databases

iPTMnetiA6X8Z5
PhosphoSitePlusiA6X8Z5

Proteomic databases

EPDiA6X8Z5
jPOSTiA6X8Z5
PaxDbiA6X8Z5
PeptideAtlasiA6X8Z5
PRIDEiA6X8Z5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023487; ENSMUSP00000023487; ENSMUSG00000022799
GeneIDi12549
KEGGimmu:12549
UCSCiuc007zfg.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57514
MGIiMGI:1333857 Arhgap31

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410KCYW Eukaryota
ENOG410ZIYP LUCA
GeneTreeiENSGT00940000159458
HOVERGENiHBG105825
InParanoidiA6X8Z5
KOiK20646
OMAiVFLHEMD
OrthoDBi1300981at2759
PhylomeDBiA6X8Z5
TreeFamiTF351451

Enzyme and pathway databases

ReactomeiR-MMU-194840 Rho GTPase cycle

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Arhgap31 mouse

Protein Ontology

More...
PROi
PR:A6X8Z5

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000022799 Expressed in 243 organ(s), highest expression level in cumulus cell
CleanExiMM_CDGAP
ExpressionAtlasiA6X8Z5 baseline and differential
GenevisibleiA6X8Z5 MM

Family and domain databases

Gene3Di1.10.555.10, 1 hit
InterProiView protein in InterPro
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHG31_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6X8Z5
Secondary accession number(s): Q3TL91
, Q3U1T7, Q3UDE7, Q3UUH4, Q6ZPW0, Q9WV94
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: August 21, 2007
Last modified: January 16, 2019
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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