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Protein

Lactaldehyde dehydrogenase

Gene

MmarC7_0731

Organism
Methanococcus maripaludis (strain C7 / ATCC BAA-1331)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate.By similarity

Catalytic activityi

(S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH.

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei240PROSITE-ProRule annotation1
Active sitei274PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi220 – 225NADBy similarity6

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMMAR426368:MMARC7_RS03715-MONOMER
UniPathwayiUPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
Lactaldehyde dehydrogenase (EC:1.2.1.22)
Gene namesi
Ordered Locus Names:MmarC7_0731
OrganismiMethanococcus maripaludis (strain C7 / ATCC BAA-1331)
Taxonomic identifieri426368 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000002298 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425911 – 465Lactaldehyde dehydrogenaseAdd BLAST465

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi426368.MmarC7_0731

Structurei

3D structure databases

ProteinModelPortaliA6VH72
SMRiA6VH72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiarCOG01252 Archaea
COG1012 LUCA
HOGENOMiHOG000271509
KOiK19266
OMAiSFGYTRR
OrthoDBiPOG093Z01H3

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

A6VH72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFIDGKWIIR DDIDVFDPYT LKNIEKITAL DREETKNAIE ITEKNKEVMK
60 70 80 90 100
NLSPSKRYSI LMKIAEQISL KKDLFAKTIS IDVGKPIKQS KIEVDRTLTA
110 120 130 140 150
FRLSAFYAKE LRGETINSEN GLIFTKKEPL GVVGAITPFN FPLNLITHKI
160 170 180 190 200
GPAIATGNSV ILHPSSKAPI AAIYLTKIIE HVLKQMDIPR GVFNLATGNG
210 220 230 240 250
DIVGDEISKN DKINMVSFTG SVEIGESISK NAKMKKVTLE LGGNNPMIVL
260 270 280 290 300
KDSDIKLAAK SAVKSKFLNA GQVCISVGQV LVEEEVLETF TKYIIDETKN
310 320 330 340 350
LVLGNPLDTK TDIGPLISPE SALRIENLIK ESVNEGGELL IGGNRQNSLI
360 370 380 390 400
FPAVINIDED NLLSKIETFG PVLPILKVKN SEEAVSIANN SKYGLQAGVF
410 420 430 440 450
TNDINKAMKI ADSLEYGGIM INSSPTFRKD NMPFGGVKKS GLGREGIKYT
460
VEEMCETKTV VIHNI
Length:465
Mass (Da):51,010
Last modified:August 21, 2007 - v1
Checksum:i6E7A60209265F421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000745 Genomic DNA Translation: ABR65798.1
RefSeqiWP_011977118.1, NC_009637.1

Genome annotation databases

EnsemblBacteriaiABR65798; ABR65798; MmarC7_0731
GeneIDi5327882
KEGGimmz:MmarC7_0731

Similar proteinsi

Entry informationi

Entry nameiLADH_METM7
AccessioniPrimary (citable) accession number: A6VH72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: August 21, 2007
Last modified: June 20, 2018
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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