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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Pseudomonas aeruginosa (strain PA7)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi217 – 224ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotationSAAS annotation
Gene namesi
Name:dnaAUniRule annotationImported
Ordered Locus Names:PSPA7_0001Imported
OrganismiPseudomonas aeruginosa (strain PA7)Imported
Taxonomic identifieri381754 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000001582 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA6UX62
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 418AAAInterPro annotationAdd BLAST210
Domaini420 – 489Bac_DnaA_CInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000235659
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

A6UX62-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELWQQCVDL LRDELPSQQF NTWIRPLQVE AEGDELRVYA PNRFVLDWVN
60 70 80 90 100
EKYLGRLLEL LGERGEGQLP ALSLLIGSKR SRTPRAAIVP SQSHVAPPPP
110 120 130 140 150
VAPPPAPVQP VSAAPVVVPR EELPPVAAVS SVTADSYEAE EPSIDPLAVA
160 170 180 190 200
MPAGAAPAIR TERNVQVEGA LKHTSYLNRT FTFENFVEGK SNQLARAAAW
210 220 230 240 250
QVADNLKHGY NPLFLYGGVG LGKTHLMHAV GNHLLKKNPN AKVVYLHSER
260 270 280 290 300
FVADMVKALQ LNAINEFKRF YRSVDALLID DIQFFARKER SQEEFFHTFN
310 320 330 340 350
ALLEGGQQVI LTSDRYPKEI EGLEERLKSR FGWGLTVAVE PPELETRVAI
360 370 380 390 400
LMKKAEQAKI ELPHDAAFFI AQRIRSNVRE LEGALKRVIA HSHFMGRPIT
410 420 430 440 450
IELIRESLKD LLALQDKLVS IDNIQRTVAE YYKIKISDLL SKRRSRSVAR
460 470 480 490 500
PRQVAMALSK ELTNHSLPEI GVAFGGRDHT TVLHACRKIA QLRESDADIR
510
EDYKNLLRTL TT
Length:512
Mass (Da):57,516
Last modified:August 21, 2007 - v1
Checksum:iC81207B65F744F69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA Translation: ABR86781.1

Genome annotation databases

EnsemblBacteriaiABR86781; ABR86781; PSPA7_0001
KEGGipap:PSPA7_0001

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000744 Genomic DNA Translation: ABR86781.1

3D structure databases

ProteinModelPortaliA6UX62
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR86781; ABR86781; PSPA7_0001
KEGGipap:PSPA7_0001

Phylogenomic databases

HOGENOMiHOG000235659
KOiK02313
OMAiREFNPLF

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA6UX62_PSEA7
AccessioniPrimary (citable) accession number: A6UX62
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: July 18, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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