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Protein

DNA polymerase sliding clamp

Gene

pcn

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

BioCyciMVAN406327:G1G99-1043-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase sliding clampUniRule annotation
Alternative name(s):
Proliferating cell nuclear antigen homologUniRule annotation
Short name:
PCNAUniRule annotation
Gene namesi
Name:pcnUniRule annotation
Ordered Locus Names:Mevan_1013
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000191771 – 249DNA polymerase sliding clampAdd BLAST249

Interactioni

Subunit structurei

Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.UniRule annotation

Protein-protein interaction databases

STRINGi406327.Mevan_1013

Structurei

3D structure databases

ProteinModelPortaliA6UQZ4
SMRiA6UQZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00488 Archaea
COG0592 LUCA
HOGENOMiHOG000222371
KOiK04802
OMAiKCANSDD
OrthoDBiPOG093Z0814

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit

Sequencei

Sequence statusi: Complete.

A6UQZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKATCNSRD FKKVINATSN LVDEICFEVD ETGIKASAMD PSHVALVSMG
60 70 80 90 100
MPKEVFESYE GDIHDIGIDL EALKKIIARS KGDEKLILEL DDEKNKLNVT
110 120 130 140 150
FKSNVTRKFS IALYDVSSSN LKVPDISYPN QVSIKAGAFV EALKDAELVN
160 170 180 190 200
DHITLKVDED KFVIYSKGDL NQSETVFENN NDEYETLTEF KMSEPSKSTF
210 220 230 240
NLAYLKDLTK STSAEDILKI YLGSDMPVKI EYEVSGSKLV FLLAPRIES
Length:249
Mass (Da):27,865
Last modified:August 21, 2007 - v1
Checksum:iF0B51A0703188558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA Translation: ABR54916.1
RefSeqiWP_012065845.1, NC_009634.1

Genome annotation databases

EnsemblBacteriaiABR54916; ABR54916; Mevan_1013
GeneIDi5325624
KEGGimvn:Mevan_1013

Similar proteinsi

Entry informationi

Entry nameiPCNA_METVS
AccessioniPrimary (citable) accession number: A6UQZ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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