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Protein

IMP cyclohydrolase

Gene

purO

Organism
Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cyclization of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP.UniRule annotation

Catalytic activityi

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. IMP cyclohydrolase (purO)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine biosynthesis

Enzyme and pathway databases

BioCyciMVAN406327:G1G99-638-MONOMER
UniPathwayiUPA00074; UER00135

Names & Taxonomyi

Protein namesi
Recommended name:
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purOUniRule annotation
Ordered Locus Names:Mevan_0620
OrganismiMethanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)
Taxonomic identifieri406327 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanococciMethanococcalesMethanococcaceaeMethanococcus
Proteomesi
  • UP000001107 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491661 – 201IMP cyclohydrolaseAdd BLAST201

Interactioni

Protein-protein interaction databases

STRINGi406327.Mevan_0620

Structurei

3D structure databases

ProteinModelPortaliA6UPV4
SMRiA6UPV4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal IMP cyclohydrolase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04727 Archaea
COG3363 LUCA
HOGENOMiHOG000015497
KOiK11176
OMAiSHVDPIA
OrthoDBiPOG093Z0CY5

Family and domain databases

Gene3Di3.60.20.20, 1 hit
HAMAPiMF_00705 IMP_cyclohydrol, 1 hit
InterProiView protein in InterPro
IPR010191 IMP_cyclohydrolase
IPR020600 IMP_cyclohydrolase-like
IPR036795 IMP_cyclohydrolase-like_sf
PfamiView protein in Pfam
PF07826 IMP_cyclohyd, 1 hit
PIRSFiPIRSF004866 IMP_cclhdr_arch, 1 hit
SUPFAMiSSF75569 SSF75569, 1 hit
TIGRFAMsiTIGR01922 purO_arch, 1 hit

Sequencei

Sequence statusi: Complete.

A6UPV4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYIGRFLVLG KTLNGKPFVT YRVSSRSFPN RIAKIMNDET VAILPKNLEE
60 70 80 90 100
MFKNPYITYN CVKIVGNIAV VTNGSHTDII ADKIRIGLPI RDALSYSLLT
110 120 130 140 150
MDYEKDDFNT PRIAAVLTDN EAYMGYVSDN DIRIKKVELE EGYAYYLSTY
160 170 180 190 200
EACKITEHQK IEVSKNTPED LCKFIMEHNE FEKPVTSTTV LMDSGFKIAT

L
Length:201
Mass (Da):22,905
Last modified:August 21, 2007 - v1
Checksum:iF93A24E5F4C6799D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000742 Genomic DNA Translation: ABR54526.1
RefSeqiWP_011972429.1, NC_009634.1

Genome annotation databases

EnsemblBacteriaiABR54526; ABR54526; Mevan_0620
GeneIDi5325073
KEGGimvn:Mevan_0620

Similar proteinsi

Entry informationi

Entry nameiPURO_METVS
AccessioniPrimary (citable) accession number: A6UPV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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