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Protein

3-ketoacyl-CoA thiolase

Gene

fadI

Organism
Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.UniRule annotation

Catalytic activityi

Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei99Acyl-thioester intermediateUniRule annotation1
Active sitei392Proton acceptorUniRule annotation1
Active sitei422Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciKPNE272620:G1G8J-2924-MONOMER
UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
3-ketoacyl-CoA thiolaseUniRule annotation (EC:2.3.1.16UniRule annotation)
Alternative name(s):
ACSsUniRule annotation
Acetyl-CoA acyltransferaseUniRule annotation
Acyl-CoA ligaseUniRule annotation
Beta-ketothiolaseUniRule annotation
Fatty acid oxidation complex subunit betaUniRule annotation
Gene namesi
Name:fadIUniRule annotation
Ordered Locus Names:KPN78578_26800
ORF Names:KPN_02724
OrganismiKlebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)
Taxonomic identifieri272620 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeKlebsiella
Proteomesi
  • UP000000265 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000695021 – 4363-ketoacyl-CoA thiolaseAdd BLAST436

Proteomic databases

PRIDEiA6TC20

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).UniRule annotation

Protein-protein interaction databases

STRINGi272620.KPN_02724

Structurei

3D structure databases

ProteinModelPortaliA6TC20
SMRiA6TC20
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thiolase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CHU Bacteria
COG0183 LUCA
HOGENOMiHOG000012240
KOiK00632
OMAiMTAFPEP

Family and domain databases

CDDicd00751 thiolase, 1 hit
Gene3Di3.40.47.10, 1 hit
HAMAPiMF_01618 FadI, 1 hit
InterProiView protein in InterPro
IPR012806 Ac-CoA_C-AcTrfase_FadI
IPR002155 Thiolase
IPR016039 Thiolase-like
IPR020615 Thiolase_acyl_enz_int_AS
IPR020610 Thiolase_AS
IPR020617 Thiolase_C
IPR020613 Thiolase_CS
IPR020616 Thiolase_N
PANTHERiPTHR18919:SF113 PTHR18919:SF113, 1 hit
PfamiView protein in Pfam
PF02803 Thiolase_C, 1 hit
PF00108 Thiolase_N, 1 hit
PIRSFiPIRSF000429 Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
TIGRFAMsiTIGR01930 AcCoA-C-Actrans, 1 hit
TIGR02446 FadI, 1 hit
PROSITEiView protein in PROSITE
PS00098 THIOLASE_1, 1 hit
PS00737 THIOLASE_2, 1 hit
PS00099 THIOLASE_3, 1 hit

Sequencei

Sequence statusi: Complete.

A6TC20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQALPLITR QGDRIAIVTG LRTPFARQAT AFHGVPAIDL GKMVVGEMLA
60 70 80 90 100
RSDIPAEVIE QLVFGQVVQM PEAPNIAREI VLGTGMSVHT DAYSVSRACA
110 120 130 140 150
TSFQAVANVA ESLMAGTIRA GIAGGADSSS VLPIGVSKTL ARTLVDANKA
160 170 180 190 200
RTLSQKLKLF SRLRPRDLLP VPPAVAEYST GLRMGDTAEQ MAKSWGISRE
210 220 230 240 250
QQDALAHRSH QLAAKAWEEG KLSAEVMTAY APPFREPLEQ DNNIRKNSTL
260 270 280 290 300
ADYQKLRPAF DRKHGTVTAA NSTPLTDGAA AVILMTESRA KELGLRPLGY
310 320 330 340 350
LRSYAFTAID VWQDMLLGPA WSTPLALERA GLTLADLTLI DMHEAFAAQT
360 370 380 390 400
LANLQCLASD RFAREVLGRS QATGEVDESK FNVLGGSIAY GHPFAATGAR
410 420 430
MITQTLHEVR RRGGGFGLVT ACAAGGLGAA MIVEAE
Length:436
Mass (Da):46,519
Last modified:August 21, 2007 - v1
Checksum:i2B58A54242BDC991
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000647 Genomic DNA Translation: ABR78141.1
RefSeqiWP_015958774.1, NC_009648.1

Genome annotation databases

EnsemblBacteriaiABR78141; ABR78141; KPN_02724
KEGGikpn:KPN_02724

Similar proteinsi

Entry informationi

Entry nameiFADI_KLEP7
AccessioniPrimary (citable) accession number: A6TC20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: August 21, 2007
Last modified: June 20, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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