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Entry version 63 (11 Dec 2019)
Sequence version 2 (10 Jun 2008)
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Protein

Myosin-1

Gene

myoA

Organism
Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi132 – 139ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Hydrolase, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin-1
Alternative name(s):
Class I unconventional myosin
Type I myosin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:myoA
ORF Names:BC1G_10821
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBotryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri332648 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:Bcin05g00360

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003385421 – 1222Myosin-1Add BLAST1222

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
A6SED8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A6SED8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 713Myosin motorPROSITE-ProRule annotationAdd BLAST675
Domaini717 – 737IQ 1Add BLAST21
Domaini738 – 763IQ 2Add BLAST26
Domaini771 – 961TH1PROSITE-ProRule annotationAdd BLAST191
Domaini1076 – 1153SH3PROSITE-ProRule annotationAdd BLAST78

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni403 – 485Actin-bindingBy similarityAdd BLAST83

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi960 – 1170Pro-richAdd BLAST211
Compositional biasi1012 – 1039Ala-richAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.By similarity
The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, SH3 domain

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01378, MYSc_Myo1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR010926, Myosin_TH1
IPR036072, MYSc_Myo1
IPR027417, P-loop_NTPase
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00063, Myosin_head, 1 hit
PF06017, Myosin_TH1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00193, MYOSINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00242, MYSc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51456, MYOSIN_MOTOR, 1 hit
PS50002, SH3, 1 hit
PS51757, TH1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A6SED8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGISRRPKGN NNASAAESAP SGKPNIQKAQ FDTTKKKEVG VSDLTLISKV
60 70 80 90 100
SNEAINENLK KRFDNREIYT YIGHVLVSVN PFRDLGIYTD AVLDSYKGKN
110 120 130 140 150
RLEMPPHVFA VAESAYYNMN GYKDNQCVII SGESGAGKTE AAKRIMQYIA
160 170 180 190 200
NVSGGSNSSI QEIKDMVLAT NPLLESFGNA KTLRNNNSSR FGKYLQLQFN
210 220 230 240 250
AQGEPVGADI TNYLLEKTRV VTQIKDERNF HIFYQFTKGA SQAYRENFGI
260 270 280 290 300
QQPSQYLYTS KAGCFDVDGI DDLAEYQDTL NAMKIIGLSQ AEQDEIFRML
310 320 330 340 350
AAILWTGNIQ FREDEDGYAA VVDQSVVDFL AYLLDCDAGH VIQAITIRIL
360 370 380 390 400
TPRNGEVIES PANVPQALAT RDALAKAIYN NLFDWIVERV NKSLTARSAT
410 420 430 440 450
SNSIGILDIY GFEIFEKNSF EQLCINYVNE KLQQIFIQLT LKTEQEEYAR
460 470 480 490 500
EQIQWTPIKY FDNKIVCDLI ESMRPPGIFS AMKDATKTAH ADPAACDRTF
510 520 530 540 550
MQAISGMSNP HLTPRQGNFI VKHYAGDVSY TVEGITDKNK DQLLKGLLNL
560 570 580 590 600
FGQSKNQFIH ELFPHQVDQD NRKQPPSAGD KIKASANDLV ATLMKATPSY
610 620 630 640 650
IRTIKPNENK SPTEYNEKNV LHQVKYLGLQ ENVRIRRAGF AYRQTFDKFV
660 670 680 690 700
ERFYLLSPKT SYAGDYIWTG DSKTGAMQIL KDTNIPVEEY QMGVTKAFIK
710 720 730 740 750
APETLFALEH MRDRYWHNMA ARIQRVWRAF LQIRIEAATR IQRMFRKKRE
760 770 780 790 800
GKEFLELREK GHQVLQGRKE RRRYSLLGSR RFMGDYLGIA ATTGPGSKIR
810 820 830 840 850
GSINLPANEA TIFSCRGEIL ETKFGRSSKL SPRIFIMTKA KFYIVSQQLV
860 870 880 890 900
NKQVQIAVEK AIPLGAIKFV SISTCRDDWF SLGVGSPQEA DPLLTCVFKT
910 920 930 940 950
ELFTHMQGAM PGGGFNLKIG DSIEYAKKPN KMQLIKVVKD SQQAQDHYKS
960 970 980 990 1000
ATIHTQAGEP PTSRSKPLPK GKPVAPKPFT SGRLIKPGGP GGRPSKLTNG
1010 1020 1030 1040 1050
NRPTPKPVPS PAAARPVPTP AAAAMPIPAP IPAANPIAAS IPVHTRNPSL
1060 1070 1080 1090 1100
QSAQSTRAVP PPPPPAPPAP PPAPASKEPQ YRVLYEFAGQ SANEFSLKQG
1110 1120 1130 1140 1150
EIETVLQKRQ WKWHRHPPPP IASRLTPPPP PGPPKMNGAN GAAVRSKHTP
1160 1170 1180 1190 1200
PAPPAKRPVA GRKPAPPPAP RDSGMSISSN GSGNNSGRST PTPSLAGGLA
1210 1220
EALRARQSAM QGNAKKEDED DW
Length:1,222
Mass (Da):135,374
Last modified:June 10, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0C5A3835A86FF132
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EDN32293 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CH476921 Genomic DNA Translation: EDN32293.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
XP_001550348.1, XM_001550298.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476921 Genomic DNA Translation: EDN32293.1 Sequence problems.
RefSeqiXP_001550348.1, XM_001550298.1

3D structure databases

SMRiA6SED8
ModBaseiSearch...

Proteomic databases

PRIDEiA6SED8

Organism-specific databases

EuPathDBiFungiDB:Bcin05g00360

Family and domain databases

CDDicd01378, MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR036961, Kinesin_motor_dom_sf
IPR001609, Myosin_head_motor_dom
IPR010926, Myosin_TH1
IPR036072, MYSc_Myo1
IPR027417, P-loop_NTPase
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
PfamiView protein in Pfam
PF00063, Myosin_head, 1 hit
PF06017, Myosin_TH1, 1 hit
PRINTSiPR00193, MYOSINHEAVY
SMARTiView protein in SMART
SM00242, MYSc, 1 hit
SUPFAMiSSF50044, SSF50044, 1 hit
SSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456, MYOSIN_MOTOR, 1 hit
PS50002, SH3, 1 hit
PS51757, TH1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYO1_BOTFB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A6SED8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: December 11, 2019
This is version 63 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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