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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei185By similarity1
Active sitei384By similarity1
Active sitei446By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:HCAG_01993
OrganismiAjellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)
Taxonomic identifieri339724 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesAjellomycetaceaeHistoplasma
Proteomesi
  • UP000009297 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiFungiDB:HCAG_01993

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini34 – 517LumenalSequence analysisAdd BLAST484
Transmembranei518 – 538HelicalSequence analysisAdd BLAST21
Topological domaini539 – 634CytoplasmicSequence analysisAdd BLAST96

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 33Sequence analysisAdd BLAST33
ChainiPRO_000041189634 – 634Pheromone-processing carboxypeptidase KEX1Add BLAST601

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi435N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi443N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi495N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiA6QX86

Interactioni

Protein-protein interaction databases

STRINGi339724.XP_001544946.1

Structurei

3D structure databases

ProteinModelPortaliA6QX86
SMRiA6QX86
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi560 – 565Poly-Ser6

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6QX86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSEARAYR AFGGRSTWLT VFLALANSLA VSAKCAADYF VDSLPGQPDS
60 70 80 90 100
PQVQMHAGHI EINHKTSANL FFWHVANQHI ADKPRTVIWL NGGPGCSSED
110 120 130 140 150
GALMEIGPYR VTNDHLLNHT DGSWDEFANL LFVDQPVGTG FSYVSTGAYV
160 170 180 190 200
SELGEMASQF VTFLEKWFEL FPHYEKNDLY FAGESYAGQY IPYIARAILD
210 220 230 240 250
RNKKGESLTR WKLKGILIGN GWISPRHQYL SYLPYAYQEG IIQGGTDSSS
260 270 280 290 300
RVEAKLSKCL NKLNVEDSTG TVQISACEEV LQAIIDETHK GNRCINMYDI
310 320 330 340 350
RLTDEYSACG MNWPPDLENM APYLRFKNVT KALHINSDKQ TGWSECSGAV
360 370 380 390 400
SGHFRALKSK PSVELLPGLL EEGLPILLFS GQKDMICNHI GNEDLIKDMK
410 420 430 440 450
WSGGTGFELS PGVWAPRQDW IFEGESAGFY QQARNLTYVL FYNASHMVPF
460 470 480 490 500
NYPPRSREML DRFIGVDIAD IGGNPADSRI DGEKGPATSV RAHPNSTAAA
510 520 530 540 550
EREKEKVKSA MWKAYYKSGE VALIVVAIAA VIWGVFIWRS RQKHQDRGYE
560 570 580 590 600
FRGIYPMLGS SSSGSLPRYS NKRGRRGHDV EAVNIYEAEL DERPSRVVSA
610 620 630
RSSREQEPYV VGDEDGSDVD DDTSDERKRL VDKP
Length:634
Mass (Da):70,866
Last modified:August 21, 2007 - v1
Checksum:i40C8F861DEA7CEBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH476655 Genomic DNA Translation: EDN04128.1
RefSeqiXP_001544946.1, XM_001544896.1

Genome annotation databases

EnsemblFungiiEDN04128; EDN04128; HCAG_01993
GeneIDi5449542
KEGGiaje:HCAG_01993

Similar proteinsi

Entry informationi

Entry nameiKEX1_AJECN
AccessioniPrimary (citable) accession number: A6QX86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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