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Protein

Mitochondrial import receptor subunit TOM40B

Gene

TOMM40L

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Potential channel-forming protein implicated in import of protein precursors into mitochondria.By similarity

GO - Molecular functioni

  • protein transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40B
Alternative name(s):
Protein TOMM40-like
Gene namesi
Name:TOMM40LBy similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:49581 TOMM40L

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126861 – 308Mitochondrial import receptor subunit TOM40BAdd BLAST308

Proteomic databases

PaxDbiA6QR22
PRIDEiA6QR22

Expressioni

Gene expression databases

BgeeiENSBTAG00000009213 Expressed in 10 organ(s), highest expression level in heart
ExpressionAtlasiA6QR22 baseline

Interactioni

Subunit structurei

Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012142

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni281 – 308Required for mitochondrial targetingBy similarityAdd BLAST28

Sequence similaritiesi

Belongs to the Tom40 family.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiA6QR22
KOiK11518

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
InterProiView protein in InterPro
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A6QR22-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNTLGLAPM GALPRRSPRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL
60 70 80 90 100
VVNKVLSSHF QVAHTVHMSA LGLPGYHLHA AYAGDWQLSP TEVFPTVVGD
110 120 130 140 150
MDSGGSLNAQ VLLLLAERLR AKAVFQTQQA KFLTWQFDGE YRGDDYTATL
160 170 180 190 200
TLGNPDLIGE SVIVVAHFLQ SLTHRLVLGG ELVYHRRPGE EGAILTLAGK
210 220 230 240 250
YSAVHWVATL NVGSGGAHAS YYHRANEQVQ VGVEFEANTR LQDTTFSFGY
260 270 280 290 300
HLTLPQANMV FRGLVDSNWC VGAVLEKKMP PLPVTLALGA FLNHWRNRFH

CGFSITVG
Length:308
Mass (Da):33,811
Last modified:August 21, 2007 - v1
Checksum:iBF449D83CF3CBE30
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G1K1G6G1K1G6_BOVIN
Mitochondrial import receptor subun...
TOMM40L
399Annotation score:

Sequence cautioni

The sequence AAX46580 differs from that shown. Reason: Frameshift at position 279.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021733 mRNA Translation: AAX46580.1 Frameshift.
BC150081 mRNA Translation: AAI50082.1
RefSeqiNP_001014853.1, NM_001014853.1
XP_005203529.1, XM_005203472.3
UniGeneiBt.26739

Genome annotation databases

EnsembliENSBTAT00000054884; ENSBTAP00000052024; ENSBTAG00000009213
GeneIDi505393
KEGGibta:505393

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT021733 mRNA Translation: AAX46580.1 Frameshift.
BC150081 mRNA Translation: AAI50082.1
RefSeqiNP_001014853.1, NM_001014853.1
XP_005203529.1, XM_005203472.3
UniGeneiBt.26739

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012142

Proteomic databases

PaxDbiA6QR22
PRIDEiA6QR22

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000054884; ENSBTAP00000052024; ENSBTAG00000009213
GeneIDi505393
KEGGibta:505393

Organism-specific databases

CTDi84134
VGNCiVGNC:49581 TOMM40L

Phylogenomic databases

eggNOGiKOG3296 Eukaryota
ENOG410XS2U LUCA
GeneTreeiENSGT00390000003308
HOGENOMiHOG000007440
HOVERGENiHBG054707
InParanoidiA6QR22
KOiK11518

Gene expression databases

BgeeiENSBTAG00000009213 Expressed in 10 organ(s), highest expression level in heart
ExpressionAtlasiA6QR22 baseline

Family and domain databases

CDDicd07305 Porin3_Tom40, 1 hit
InterProiView protein in InterPro
IPR027246 Porin_Euk/Tom40
IPR037930 Tom40
PANTHERiPTHR10802 PTHR10802, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM40L_BOVIN
AccessioniPrimary (citable) accession number: A6QR22
Secondary accession number(s): Q58D64
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: August 21, 2007
Last modified: November 7, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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