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Protein

Peripherin

Gene

PRPH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Class-III neuronal intermediate filament protein.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Peripherin
Gene namesi
Name:PRPH
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:33384 PRPH

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Intermediate filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004058051 – 469PeripherinAdd BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16Nitrated tyrosineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei49PhosphoserineBy similarity1
Modified residuei378Nitrated tyrosineBy similarity1
Modified residuei469PhosphotyrosineBy similarity1

Keywords - PTMi

Nitration, Phosphoprotein

Proteomic databases

PaxDbiA6QQJ3
PeptideAtlasiA6QQJ3
PRIDEiA6QQJ3

Expressioni

Gene expression databases

BgeeiENSBTAG00000017864 Expressed in 2 organ(s), highest expression level in colon

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023744

Structurei

3D structure databases

ProteinModelPortaliA6QQJ3
SMRiA6QQJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 406IF rodPROSITE-ProRule annotationAdd BLAST311

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98HeadAdd BLAST98
Regioni99 – 131Coil 1AAdd BLAST33
Regioni132 – 142Linker 1Add BLAST11
Regioni143 – 238Coil 1BAdd BLAST96
Regioni239 – 261Linker 2Add BLAST23
Regioni262 – 404Coil 2Add BLAST143
Regioni405 – 469TailBy similarityAdd BLAST65

Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE39 Eukaryota
ENOG410YCMG LUCA
GeneTreeiENSGT00910000143989
HOGENOMiHOG000230977
HOVERGENiHBG013015
InParanoidiA6QQJ3
KOiK07607
OMAiYDKVDFT
OrthoDBiEOG091G12MK
TreeFamiTF330122

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd
IPR002957 Keratin_I
IPR027700 PRPH/Plasticin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF29 PTHR23239:SF29, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

Sequencei

Sequence statusi: Complete.

A6QQJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHPSGLRSS VSSTSYRRTF GPPPSLSPGA FSYSSSSRFS SSRLLGSASP
60 70 80 90 100
GSSVRLGSFR GPRAGTGALL RLPSERLDFS MAEALNQEFL ATRSNEKQEL
110 120 130 140 150
QELNDRFANF IEKVRFLEQQ NAALRGELNQ ARGQEPARAD QLCQQELREL
160 170 180 190 200
RRELELLGRE RDRVQVERDG LAEDLAALKQ RLEEETRKRE DAEHNLVLFR
210 220 230 240 250
KDVDDATLSR LELERKIESL MDEIEFLKKL HEEELRDLQL SVESQQVQHV
260 270 280 290 300
EVEATVKPEL TAALRDIRAQ YESIAAKNLQ EAEEWYKSKY ADLSDAANRN
310 320 330 340 350
HEALRQAKQE MNESRRQIQS LTCEVDGLRG TNEALLRQLR ELEEQFALEA
360 370 380 390 400
GGYQAGAARL EEELRQLKEE MARHLREYQE LLNVKMALDI EIATYRKLLE
410 420 430 440 450
GEESRISVPV HSFASLSIKT TVPEVEPPQE THSRKMVLIR TIETRDGEQV
460
VTESQKEQHS ELDKSPQSY
Length:469
Mass (Da):53,631
Last modified:August 21, 2007 - v1
Checksum:i4889823E57A0501A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149862 mRNA Translation: AAI49863.1
RefSeqiNP_001095848.1, NM_001102378.1
UniGeneiBt.30375

Genome annotation databases

EnsembliENSBTAT00000023744; ENSBTAP00000023744; ENSBTAG00000017864
GeneIDi510082
KEGGibta:510082

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149862 mRNA Translation: AAI49863.1
RefSeqiNP_001095848.1, NM_001102378.1
UniGeneiBt.30375

3D structure databases

ProteinModelPortaliA6QQJ3
SMRiA6QQJ3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000023744

Proteomic databases

PaxDbiA6QQJ3
PeptideAtlasiA6QQJ3
PRIDEiA6QQJ3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000023744; ENSBTAP00000023744; ENSBTAG00000017864
GeneIDi510082
KEGGibta:510082

Organism-specific databases

CTDi5630
VGNCiVGNC:33384 PRPH

Phylogenomic databases

eggNOGiENOG410IE39 Eukaryota
ENOG410YCMG LUCA
GeneTreeiENSGT00910000143989
HOGENOMiHOG000230977
HOVERGENiHBG013015
InParanoidiA6QQJ3
KOiK07607
OMAiYDKVDFT
OrthoDBiEOG091G12MK
TreeFamiTF330122

Gene expression databases

BgeeiENSBTAG00000017864 Expressed in 2 organ(s), highest expression level in colon

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR006821 Intermed_filament_DNA-bd
IPR002957 Keratin_I
IPR027700 PRPH/Plasticin
PANTHERiPTHR23239 PTHR23239, 1 hit
PTHR23239:SF29 PTHR23239:SF29, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PF04732 Filament_head, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPERI_BOVIN
AccessioniPrimary (citable) accession number: A6QQJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: August 21, 2007
Last modified: September 12, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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