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Protein

Keratinocyte-associated protein 2

Gene

KRTCAP2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Biological processi

Enzyme and pathway databases

UniPathwayiUPA00378

Names & Taxonomyi

Protein namesi
Recommended name:
Keratinocyte-associated protein 2
Short name:
KCP-2
Gene namesi
Name:KRTCAP2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Organism-specific databases

VGNCiVGNC:30751 KRTCAP2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 5LumenalSequence analysis5
Transmembranei6 – 23HelicalSequence analysisAdd BLAST18
Topological domaini24 – 34CytoplasmicSequence analysisAdd BLAST11
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 75LumenalSequence analysisAdd BLAST20
Transmembranei76 – 108HelicalSequence analysisAdd BLAST33
Topological domaini109 – 136CytoplasmicSequence analysisAdd BLAST28

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003702221 – 136Keratinocyte-associated protein 2Add BLAST136

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei124PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiA6QQ59
PRIDEiA6QQ59

Expressioni

Gene expression databases

BgeeiENSBTAG00000010617

Interactioni

Subunit structurei

Accessory component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014035

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 136Prevents secretion from ERBy similarity4

Sequence similaritiesi

Belongs to the KRTCAP2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4615 Eukaryota
ENOG4111ZNW LUCA
GeneTreeiENSGT00390000003552
HOGENOMiHOG000006286
InParanoidiA6QQ59
OMAiLTCVSNA
OrthoDBiEOG091G0RKT
TreeFamiTF324347

Family and domain databases

InterProiView protein in InterPro
IPR018614 KRTCAP2
PANTHERiPTHR32001 PTHR32001, 1 hit
PfamiView protein in Pfam
PF09775 Keratin_assoc, 1 hit

Sequencei

Sequence statusi: Complete.

A6QQ59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVGTGTSLA LSSLLSLLLF AGMQMYSRQL ASTEWLTIQG GLLGSGLFVF
60 70 80 90 100
SLTAFNNLEN LVFGKGFQAK IFPEILLCLL LALFASGLIH RVCVTTCFIF
110 120 130
SMVGLYYINK ISSTLYQATA PVLTPAKVTG KGKKRN
Length:136
Mass (Da):14,679
Last modified:August 21, 2007 - v1
Checksum:i091227410817532B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC149659 mRNA Translation: AAI49660.1
RefSeqiNP_001094679.1, NM_001101209.1
UniGeneiBt.60960

Genome annotation databases

EnsembliENSBTAT00000014035; ENSBTAP00000014035; ENSBTAG00000010617
GeneIDi540389
KEGGibta:540389

Similar proteinsi

Entry informationi

Entry nameiKTAP2_BOVIN
AccessioniPrimary (citable) accession number: A6QQ59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: August 21, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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